{"id":145400,"date":"2018-07-12T06:30:58","date_gmt":"2018-07-11T22:30:58","guid":{"rendered":"\/\/m.iemloyee.com\/?p=145400"},"modified":"2018-07-09T18:47:17","modified_gmt":"2018-07-09T10:47:17","slug":"acs-nano-%e7%9a%ae%e4%b8%8b%e6%b3%a8%e5%b0%84%e5%85%b7%e6%9c%89%e8%8d%a7%e5%85%89%e7%9a%84%e4%ba%a4%e8%81%94%e8%b6%85%e5%88%86%e5%ad%90%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e6%8e%a7%e9%87%8a%e6%8a%97","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=145400","title":{"rendered":"ACS Nano: \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u8367\u5149\u7684\u4ea4\u8054\u8d85\u5206\u5b50\u7eb3\u7c73\u9897\u7c92\u63a7\u91ca\u6297\u771f\u83cc\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u7532\u771f\u83cc\u75c5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7532\u771f\u83cc\u75c5\u662f\u4e00\u79cd\u5177\u6709\u6e10\u8fdb\u6027\u7684\u3001\u4f20\u67d3\u6027\u7684\u548c\u590d\u53d1\u6027\u7684\u771f\u83cc\u611f\u67d3\u75c5,\u4e14\u5df2\u88ab\u8ba4\u4e3a\u5177\u6709\u9ad8\u53d1\u75c5\u7387\u3001\u6cbb\u6108\u7387\u4f4e\u7684\u201c\u4e34\u5e8a\u987d\u56fa\u7684\u75be\u75c5\u201d(\u5927\u7ea6\u5360\u7f8e\u56fd\u4eba\u53e3\u768410\u221212%)\u3002\u9664\u4e86\u7eaf\u7cb9\u7684\u7f8e\u5bb9\u95ee\u9898\u5916\uff0c\u7532\u771f\u83cc\u611f\u67d3\u8fd8\u4f1a\u5f15\u8d77\u4e25\u91cd\u7684\u5065\u5eb7\u95ee\u9898\uff0c\u5982\u5728\u540c\u4e00\u75c5\u4eba\u6216\u5176\u4ed6\u6613\u611f\u4eba\u7fa4\u4e2d\u6709\u9ad8\u98ce\u9669\u6027\u7684\u5176\u4ed6\u7684\u6307\u7532\u75c5\u611f\u67d3\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u6216\u8001\u5e74\u4eba\u5b58\u5728\u4e25\u91cd\u5e76\u53d1\u75c7\uff0c\u5982\u590d\u53d1\u6027\u8702\u7a9d\u7ec7\u708e\u548c\u8840\u6813\u6027\u9759\u8109\u708e\uff0c\u663e\u8457\u964d\u4f4e\u751f\u6d3b\u8d28\u91cf\u3002\u73b0\u6709\u7684\u65b9\u6cd5\u662f\u53e3\u670d\u836f\u7269\u548c\u5916\u7528\u836f\u818f\u53ea\u80fd\u5728\u771f\u83cc\u611f\u67d3\u90e8\u4f4d\u8fbe\u5230\u6682\u65f6\u6709\u6548\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u5bfc\u81f4\u5bf9\u7532\u771f\u83cc\u75c5\u7684\u6cbb\u7597\u6548\u679c\u6709\u9650\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u7532\u771f\u83cc\u75c5\uff0c\u7406\u60f3\u7684\u6cbb\u7597\u65b9\u6cd5\u666e\u904d\u8ba4\u4e3a\u662f\uff1a(1)\u3001\u5c06\u6297\u771f\u83cc\u836f\u7269\u76f4\u63a5\u5f15\u5165\u611f\u67d3\u90e8\u4f4d\uff1b(2)\u3001\u6709\u9650\u7684\u76ae\u5185\u6301\u7eed\u91ca\u653e\u4e14\u957f\u671f\u7ef4\u6301\u6709\u6548\u836f\u7269\u6c34\u5e73\uff1b(3)\u3001\u76d1\u6d4b\u836f\u7269\u6c34\u5e73\u7ef4\u6301\u7684\u68c0\u6d4b\u7cfb\u7edf\uff1b(4)\u3001\u771f\u83cc\u611f\u67d3\u90e8\u4f4d\u5468\u56f4\u4ee5\u6700\u4f4e\u6c34\u5e73\u7684\u708e\u75c7\u53cd\u5e94\u3002\u56e0\u800c\u5982\u4f55\u5b9e\u73b0\u7406\u60f3\u7684\u6cbb\u7597\u7532\u771f\u83cc\u75c5\u7684\u6548\u679c\u4e00\u76f4\u662f\u533b\u5b66\u754c\u548c\u836f\u7269\u5b66\u754c\u7814\u7a76\u70ed\u70b9\u548c\u96be\u70b9\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7684Paul S. Weiss\u6559\u6388\u548cHsian-Rong Tseng\u6559\u6388\u3001\u5357\u52a0\u5dde\u5927\u5b66\u7684\u9648\u51ef\u6559\u6388\u3001\u56fd\u7acb\u53f0\u6e7e\u5927\u5b66\u7684Hsu Cheng-Chih\u6559\u6388\u4ee5\u53ca\u590d\u65e6\u5927\u5b66\u7684\u6c6a\u957f\u6625\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u4e00\u79cd\u5c01\u88c5\u6709\u916e\u5eb7\u5511\u7684\u5177\u6709\u8367\u5149\u7684\u4ea4\u8054\u8d85\u5206\u5b50\u7eb3\u7c73\u9897\u7c92(KTZ\u2282c-FSMNPs)\u4f5c\u4e3a\u6cbb\u7597\u7532\u771f\u83cc\u75c5\u7684\u76ae\u5185\u6ce8\u5c04\u63a7\u5236\u91ca\u653e\u6eb6\u6db2\u3002\u91c7\u7528\u4e24\u6b65\u5408\u6210\u6cd5\u5236\u5907\u51fa\u5404\u79cd\u7684KTZ\u2282c-FSMNPs\u3002\u521d\u59cb\u7279\u5f81\u663e\u793a\u5c3a\u5bf8\u4e3a4800 nm\u7684KTZ\u2282c-FSMNPs\u5c55\u73b0\u51faKTZ\u5c01\u88c5\u6548\u7387\u548c\u5bb9\u91cf\u9ad8\uff0c\u4f18\u5f02\u7684\u8367\u5149\u6027\u8d28\uff0c\u548c\u6301\u7eedKTZ\u91ca\u653e\u3002\u968f\u540e\uff0c\u4f7f\u75284800 nm\u7684KTZ\u2282c-FSMNPs\u7684\u5c0f\u9f20\u6a21\u578b\u4f53\u5185\u7814\u7a76\uff0c\u53d1\u73b0\u901a\u8fc7\u521b\u4f24\u533a\u76ae\u4e0b\u6ce8\u5c04KTZ\u2282c-FSMNPs\u3002\u4ece\u4ee5\u4e0b\u65b9\u6cd5\uff1a(i)\u3001\u4f53\u5185\u8367\u5149\u6210\u50cf\u6280\u672f\uff1b(ii)\u3001HPLC\u5b9a\u91cf\u6d4b\u5b9aKTZ\u7684\u6b8b\u4f59\u91cf\uff1b(iii)\u4e8c\u7ef4\u7535\u6cf3\/\u7535\u79bb\u8d28\u8c31\u6210\u50cf\u7814\u7a76\u5728\u521b\u4f24\u533a\u57df\u7684\u76ae\u4e0bKTZ\u7684\u5206\u5e03\uff1b(iv)\u901a\u8fc7\u7ec4\u7ec7\u5b66\u6765\u8bc4\u4f30\u5c40\u90e8\u7684\u708e\u75c7\u53cd\u5e94\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3002\u83b7\u5f97\u7684\u7ed3\u679c\u8868\u660e4800 nm \u7684KTZ\u2282c-FSMNPs\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u6cbb\u7597\u7532\u771f\u83cc\u75c5\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cCross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug\u2014A Therapeutic Approach for Onychomycosis\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001KTZ\u2282c-FSMNPs\u7684\u5236\u5907\u548c\u4f5c\u7528\u673a\u7406\u00a0\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09\u4e24\u6b65\u5408\u6210\u65b9\u6cd5\u7528\u4e8e\u5236\u5907KTZ\u2282c-FSMNPs\uff1b<\/p>\n

\uff08b\uff09\u901a\u8fc7\u521b\u4f24\u533a\u76ae\u4e0b\u6ce8\u5c04KTZ\u2282c-FSMNPs\u7684\u4f5c\u7528\u673a\u7406\u793a\u610f\u56fe\u3002\u00a0<\/p>\n

\u56fe\u4e8c\u3001KTZ\u2282FSMNPs\u7684\u5c3a\u5bf8\u63a7\u5236\u8868\u5f81<\/strong>\u00a0<\/p>\n

\"\"<\/p>\n

\uff08a\uff09 DLS\u6570\u636e\u8868\u660eKTZ\u2282c-FSMNPs\u7684\u5c3a\u5bf8\u548c Ad-PAMAM \/CD-PEI\u7684\u6df7\u5408\u6bd4\u4f8b\u7684\u5173\u7cfb\u3002\uff1b<\/p>\n

\uff08b\uff09 \u589e\u52a0\u836f\u7269\u7684\u6d53\u5ea60.04 mg\/mL-0.4 mg\/mL \u6d4b\u5b9aKTZ\u2282FSMNPs\u5c01\u88c5\u836f\u7269\u7684\u6548\u7387\u548c\u5bb9\u91cf\uff1b<\/p>\n

\uff08c\uff09KTZ\u2282FSMNPs\u7684TEM\u56fe\uff1b<\/p>\n

\uff08d\uff09KTZ\u2282FSMNPs\u7684SEM\u5c3a\u5bf8\u548c Ad-PAMAM \/ CD-PEI\u7684\u6bd4\u4f8b\u3002<\/p>\n

\u56fe\u4e09\u3001KTZ\u2282c-FSMNPs\u7684\u5fae\u7c73\u5c3a\u5bf8\u7684\u5f62\u6210\u548c\u8868\u5f81\u00a0<\/strong><\/p>\n

\"\"<\/strong>
\n \uff08a\uff09 BS3\u4f5c\u4e3a\u4ea4\u8054\u5242\u5c06680 nm KTZ\u2282FSMNPs\u6eb6\u6db2\u5f62\u6210\u5fae\u7c73\u7ea7\u7684KTZ\u2282c-FSMNPs\uff1b<\/p>\n

\uff08b\uff09 \u5728\u4ea4\u8054\u5242BS3\u7684\u4e0d\u540c\u6d53\u5ea6\u4e0bKTZ\u2282FSMNPs\u7684\u4e0d\u540c\u5c3a\u5bf8\u7684TEM\u56fe\uff1b\u00a0<\/p>\n

\uff08c\uff09 \u5bf9\u6bd4free MPS-PPV\u3001680 nm KTZ\u2282FSMNPs\u548c4800 nm KTZ\u2282c-FSMNPs\u7684\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\uff08d\uff09 \u5bf9\u6bd4free MPS-PPV\u3001680 nm KTZ\u2282FSMNPs\u548c4800 nm KTZ\u2282c-FSMNPs\u7684\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

\uff08e\uff09 \u572837\u00b0C\u3001 50%\u4eba\u7c7b\u8840\u6e05\u7684\u6761\u4ef6\u4e0b\u6301\u7eed\u632f\u52a814 d\uff0c\u901a\u8fc7\u5f15\u5165680 nm KTZ\u2282FSMNPs\u548c4800 nm KTZ\u2282c-FSMNPs\u5bf9 KTZ\u5c01\u88c5\u80fd\u529b\u4e3a9.4 wt %\u3002<\/p>\n

\u56fe\u56db\u3001KTZ\u2282c-FSMNPs\u5c01\u88c5KTZ\u4e4b\u540e\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\u548cKTZ\u6b8b\u4f59\u91cf\u00a0<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 \u5728\u4e09\u79cd\u4e0d\u540c\u5149\u7167\u5c04\u4e0b\u4e09\u4e2a\u4e0d\u540c\u6570\u91cf\u7684KTZ\u2282c-FSMNPs\u5728\u5c0f\u9f20\u8868\u76ae\u4e0a\u4e09\u4e2a\u76f8\u90bb\u4f4d\u7f6e\u7684\u6548\u679c\uff1b<\/p>\n

\uff08b\uff09 \u8367\u5149\u5f3a\u5ea6\u548cKTZ\u6b8b\u4f59\u91cf\u4e0eKTZ\u2282c-FSMNPs\u5728\u9488\u523a\u5904\u7684\u91cf\u7684\u7ebf\u6027\u5173\u7cfb\u3002<\/p>\n

\u56fe\u4e94\u3001KTZ\u2282c-FSMNPs\u7684\u76ae\u4e0b\u6ede\u7559\u7814\u7a76\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 \u5229\u7528\u4e24\u79cd\u5149\u7167\u5c0414 d\u5728\u5c0f\u9f20\u76ae\u80a4\u4e0a\u4e09\u4e2a\u76f8\u90bb\u4f4d\u7f6e\u521b\u533a\u6ce8\u5c042.0 mg\u7684KTZ\u2282c-FSMNPs\u7684\u6548\u679c\uff1b<\/p>\n

\uff08b\uff09 KTZ\u2282c-FSMNPs\u5728\u521b\u4f24\u533a\u7684\u91cf\u4e0eKTZ\u6b8b\u4f59\u91cf\u548c\u8367\u5149\u4fe1\u53f7\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08c\uff09 KTZ\u7684\u6b8b\u4f59\u91cf\u5728\u521b\u4f24\u533a\u7684KTZ\u2282c-FSMNPs\u548cKTZ\u2282FSMNPs\uff0c\u4ee5\u53ca\u5c40\u90e8\u6cbb\u7597\u7684KTZ\u6cb9\u818f\u7684\u91cf\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08d\uff09 MALDI-MSI\u76f4\u63a5\u68c0\u6d4b\u523a\u4f24\u4e0b\u7684\u76ae\u4e0b\u90e8\u4f4dKTZ\u7684\u542b\u91cf\uff1b<\/p>\n

\uff08e\uff09 \u521b\u4f24\u533a\u76ae\u80a4\u5207\u7247\uff0c\u6b63\u5e38\u76ae\u80a4\u5207\u7247\uff0cfree KTZ\u7684MALDI-MS\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09 \u572814 d\u540e\uff0cH&E\u67d3\u8272\u7684KTZ\u2282c-FSMNPs\u5728\u5c0f\u9f20\u521b\u4f24\u533a\u76ae\u4e0b\u7684\u7d2f\u79ef\u91cf\u7684\u7ec4\u7ec7\u5207\u7247\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u901a\u8fc7\u4e24\u6b65\u5408\u6210\u65b9\u6cd5\u6210\u529f\u7684\u5236\u5907\u51faKTZ\u2282c-FSMNPs\u3002\u6bd4\u8f83KTZ\u2282FSMNPs\u548cKTZ\u2282c-FSMNPs\u7684\u5c3a\u5bf8\u3001\u5c01\u88c5\u6548\u7387\/\u5bb9\u91cf\u3001\u5149\u7269\u7406\u6027\u8d28\u548cKTZ\u63a7\u91ca\u60c5\u51b5\uff0c\u5f97\u51fa4800 nm KTZ\u2282c-FSMNPs\u7528\u4f5c\u4e3a\u5c0f\u9f20\u6a21\u578b\u4f53\u5185\u7814\u7a76\u3002\u540c\u65f6\uff0c\u5229\u7528(i) \u4f53\u5185\u8367\u5149\u6210\u50cf\u6280\u672f\u76d1\u6d4b\u65f6\u95f4\u8367\u5149\u8870\u53d8\uff1b(ii) HPLC\u5b9a\u91cf\u68c0\u6d4b\u76ae\u80a4\u7ec4\u7ec7\u5185\u7684KTZ\u6b8b\u4f59\u91cf\uff1b(iii) MALDI-MSI\u6620\u5c04\u76ae\u4e0b\u6ce8\u5c04KTZ\u5728\u521b\u4f24\u533a\u7684\u5206\u5e03\uff1b(iv) \u7ec4\u7ec7\u5b66\u8bc4\u4f30\u5c40\u90e8\u7684\u708e\u75c7\u53cd\u5e94\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3002\u7ed3\u679c\u663e\u793a4800 nm KTZ\u2282c-FSMNPs\u76ae\u5185\u6ce8\u5c04\u80fd\u6709\u6548\u7684\u6cbb\u7597\u7532\u771f\u83cc\u75c5\u3002\u8fd9\u5c06\u5141\u8bb8\u5fae\u521b\u3001\u5c40\u90e8\u548c\u6301\u7eed\u5730\u5c06\u6cbb\u7597\u836f\u7269\u76f4\u63a5\u8fd0\u9001\u5230\u75be\u75c5\u90e8\u4f4d\uff0c\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\uff0c\u907f\u514d\u7cfb\u7edf\u6027\u6bd2\u6027\u548c\u5c40\u90e8\u836f\u7269\u6d53\u5ea6\u4e0d\u8db3\u7684\u95ee\u9898\u3002\u6b64\u5916\uff0c\u8fd9\u4e9bc-FSMNP\u8f7d\u4f53\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u5e7f\u6cdb\u7684\u4e34\u5e8a\u987d\u56fa\u6027\u76ae\u80a4\u75c5\uff0c\u63d0\u4f9b\u6709\u6548\u7684\u5c40\u90e8\u836f\u7269\u6d53\u5ea6\u3002\u4e34\u5e8a\u7528KTZ\u2282c-FSMNPs\u4e3a\u7532\u771f\u83cc\u75c5\u60a3\u8005\u6cbb\u7597\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u6709\u5e0c\u671b\u63d0\u4f9b\u4e00\u4e2a\u6301\u7eed\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\uff0c\u4e14\u5229\u7528c-FSMNP\u8f7d\u4f53\u53ef\u4ee5\u6765\u6cbb\u7597\u4e34\u5e8a\u4e2d\u5176\u5b83\u987d\u56fa\u7684\u76ae\u80a4\u75c5\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug\u2014A Therapeutic Approach for Onychomycosis<\/a>\uff08ACS Nano, 2018, DOI: 10.1021\/acsnano.8b02099<\/strong>\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1<\/strong>\u3002<\/p>\n

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