{"id":144175,"date":"2018-07-07T06:30:47","date_gmt":"2018-07-06T22:30:47","guid":{"rendered":"\/\/m.iemloyee.com\/?p=144175"},"modified":"2018-07-06T17:11:12","modified_gmt":"2018-07-06T09:11:12","slug":"nat-commun-%e5%8d%95%e5%a3%81%e7%a2%b3%e7%ba%b3%e7%b1%b3%e8%a7%92%e5%bc%95%e5%8f%91%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e4%b8%ad%e8%9b%8b%e7%99%bd%e8%b4%a8%e5%af%bc%e8%87%b4%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=144175","title":{"rendered":"Nat. Commun.: \u5355\u58c1\u78b3\u7eb3\u7c73\u89d2\u5f15\u53d1\u5de8\u566c\u7ec6\u80de\u4e2d\u86cb\u767d\u8d28\u5bfc\u81f4\u7ec6\u80de\u7126\u4ea1\/\u51cb\u4ea1\u63d0\u9ad8\u7eb3\u7c73\u7ba1\u7684\u751f\u7269\u76f8\u5bb9\u6027"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u5355\u58c1\u78b3\u7eb3\u7c73\u89d2(SNH)\u662f\u4e00\u79cd\u65b0\u578b\u7684\u7eb3\u7c73\u78b3\u5b50\uff0c\u7531\u4e8e\u5176\u72ec\u7279\u7684\u5f62\u6001\u548c\u7ed3\u6784\u800c\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002\u5355\u4e2a\u7eb3\u7c73\u89d2\u7531\u4e00\u4e2a\u76f4\u5f84\u4e3a2- 5nm\u3001\u957f\u5ea6\u4e3a40 &#8211; 80nm\u7684\u7531sp2\u952e\u7ed3\u5408\u7684\u78b3\u539f\u5b50\u7ec4\u6210\u3002\u7531\u4e8e\u539f\u5b50\u6392\u5217\u7684\u76f8\u4f3c\u6027\uff0c\u78b3\u7eb3\u7c73\u7ba1\u662fSNH\u6700\u63a5\u8fd1\u7684\u7ed3\u6784\u6a21\u62df\u3002\u5b9e\u9645\u4e0a\uff0cSNH\u7ee7\u627f\u4e86\u78b3\u7eb3\u7c73\u7ba1(CNT)\u7684\u7269\u7406\u5316\u5b66\u7279\u5f81\uff0c\u5728\u80fd\u91cf\u8f6c\u6362\u3001\u5316\u5b66\u5de5\u7a0b\u3001\u50ac\u5316\u5242\u3001\u71c3\u6599\u7535\u6c60\u548c\u7535\u5b50\u5e94\u7528\u7b49\u65b9\u9762\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002SNH\u7531\u4e8e\u5176\u7ed3\u6784\u7279\u70b9\uff0c\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\u6ca1\u6709\u4f7f\u7528\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u5728\u5ba4\u6e29\u4e0b\u53ef\u4ee5\u5927\u91cf\u751f\u4ea7\uff0c\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u53ef\u80fd\u6bd4CNT\u66f4\u5177\u6709\u4f18\u52bf\u3002\u76ee\u524d\uff0cSNH\u5df2\u88ab\u5e7f\u6cdb\u62a5\u9053\u4e3a\u4e00\u4e2a\u591a\u529f\u80fd\u7684\u836f\u7269\u4f20\u9012\u5e73\u53f0\uff0c\u5728\u4f53\u5185\u7684\u5149\u58f0\u6210\u50cf\u3001\u5149\u70ed\u7597\u6cd5\u7b49\u65b9\u9762\u3002\u7136\u800c\uff0c\u5173\u4e8eSNH\u7684\u7eb3\u7c73\u5b89\u5168\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u7684\u7814\u7a76\u8fd8\u975e\u5e38\u7f3a\u4e4f\uff0c\u66f4\u4e0d\u7528\u8bf4\u5b83\u7684\u5206\u5b50\u673a\u5236\u4e86\u3002\u53e6\u4e00\u65b9\u9762\uff0cSNH\u4e0eCNT\u7684\u5f62\u6001\u5b66\u5dee\u5f02\u5f88\u5927\u3002\u5bf9\u4e8e\u7a7a\u5fc3CNT\u6765\u8bf4\uff0c\u957f\u5bbd\u6bd4\u662f\u5f71\u54cd\u5176\u7eb3\u7c73\u6bd2\u6027\u7684\u5173\u952e\u56e0\u7d20\uff0c\u800c\u7531\u4e8e\u7403\u5f62\u7ed3\u6784\uff0cSNH\u5728\u4e09\u7ef4\u7acb\u4f53\u4e0a\u8fd1\u4f3c\u5404\u5411\u540c\u6027\u3002\u56e0\u6b64\uff0c\u4ece\u7eb3\u7c73\u6bd2\u6027\u548c\u539f\u7406\u4e0a\u5bf9\u8fd9\u4e24\u79cd\u78b3\u7eb3\u7c73\u7ba1\u8fdb\u884c\u6bd4\u8f83\u662f\u975e\u5e38\u5fc5\u8981\u7684\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u5317\u4eac\u5927\u5b66\u7684\u5f20\u5f3a\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u5728\u7ec6\u80de\u548c\u5206\u5b50\u6c34\u5e73\u7684\u7eb3\u7c73\u6bd2\u6027\u548c\u673a\u5236\u4e2dSNH\u4e0eCNT\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u4ece\u800c\u7ed8\u5236\u51fa\u7531\u8fd9\u4e24\u79cd\u7eb3\u7c73\u78b3\u5316\u7269\u5f15\u8d77\u7684\u7ec6\u80de\u6b7b\u4ea1\u7684\u5168\u8c8c\u3002\u7528\u5de8\u566c\u7ec6\u80de\u4f5c\u4e3a\u7ec6\u80de\u6a21\u578b\u8fdb\u884c\u7814\u7a76\u3002\u5c06SNH\u4e0e\u56db\u79cd\u7eb3\u7c73\u7ba1\u76f8\u6bd4\u8f83\uff0c\u5305\u62ec\u5355\u58c1\u78b3\u7eb3\u7c73\u7ba1\u548c\u591a\u58c1\u78b3\u7eb3\u7c73\u7ba1(MNT)\u3002\u9996\u6b21\u53d1\u73b0SNH\u548cCNT\u5728\u7ec6\u80de\u6444\u53d6\u3001\u78b3\u7ba1\u7eb3\u7c73\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3001\u574f\u6b7b\u3001\u7126\u4ea1\u3001\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u548c\u86cb\u767d\u8868\u8fbe\u3001\u6c34\u89e3\u9176\u6cc4\u6f0f\u3001\u6eb6\u9176\u4f53\u5e94\u6fc0\u3001\u819c\u5e72\u6270\u3001\u4e0e\u819c\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7b49\u591a\u65b9\u9762\u5b58\u5728\u5dee\u5f02\u3002\u91cd\u8981\u7684\u662f\uff0c\u901a\u8fc7\u591a\u79cd\u65b9\u6cd5\u8bc1\u660eSNH\u6bd4CNT\u5177\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3002\u57fa\u4e8e\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u5176\u4ed6\u7814\u7a76\uff0c\u4e00\u79cd\u5173\u952e\u7684\u8de8\u819c\u86cb\u767d\u2014\u7cd6\u86cb\u767d\u975e\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u86cb\u767dB (GPNMB)\u88ab\u53d1\u73b0\u53ef\u4ee5\u542f\u52a8\u7eb3\u7c73\u6bd2\u6027\u3002\u4e0eCNT\u7ec4\u76f8\u6bd4\uff0cSNH\u7ec4\u4e2d\u8f83\u5f31\u7684\u7eb3\u7c73-GPNMB\u7684\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u7eb3\u7c73\u819c\u76f8\u4e92\u4f5c\u7528\u7684\u7a0b\u5ea6\u964d\u4f4e\uff0c\u6eb6\u9176\u4f53\u5e94\u6fc0\u3001\u7ec6\u80de\u7126\u4ea1\/\u7ec6\u80de\u51cb\u4ea1\uff0c\u6700\u7ec8\u5bfc\u81f4\u5de8\u566c\u7ec6\u80de\u7684\u4f4e\u6bd2\u6027\uff0c\u800c\u574f\u6b7b\u6027\u51cb\u4ea1\u3001\u94c1\u6b7b\u4ea1\u3001\u81ea\u566c\u548c\u7ebf\u7c92\u4f53\u6e17\u900f\u6027\u8f6c\u79fb(MPT)\u4f9d\u8d56\u6027\u574f\u6b7b\u7684\u53c2\u4e0e\u57fa\u672c\u88ab\u6392\u9664\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cSingle-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Nat. Commun.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u5de8\u566c\u7ec6\u80de\u541e\u566c\u5438\u6536\u7684SNH\u3001CNT\u5bf9\u6bd4\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-144176\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/1-66.jpg\" alt=\"\" width=\"600\" height=\"742\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/1-66.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/1-66-243x300.jpg 243w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u7ec6\u80de\u57f9\u517b\u540e\u7ec6\u80de\u5185\u7684\u78b3\u7eb3\u7c73\u7684\u62c9\u66fc\u5149\u8c31\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 \u57fa\u4e8e\u6fc0\u5149\u53cd\u5c04(LR)\u4fe1\u53f7\u68c0\u6d4b\u7684\u4e94\u4e2a\u78b3\u7eb3\u7c73\u7684\u76f8\u5bf9\u7ec6\u80de\u5438\u6536\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08c\uff09 \u78b3\u7eb3\u7c73\u5b75\u80b2\u540e\u7ec6\u80de\u7684\u5171\u7126\u56fe\u50cf\uff1b<\/p>\n<p>\uff08d\uff09 \u78b3\u7eb3\u7c73\u57f9\u517b\u540e\u7ec6\u80de\u5185\u6eb6\u9176\u4f53\u7684\u900f\u5c04\u7535\u955c\u56fe\u50cf\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001SNH\u3001CNT\u7684\u7eb3\u7c73\u6bd2\u6027\u5bf9\u6bd4\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-144177\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/2-65.jpg\" alt=\"\" width=\"600\" height=\"650\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/2-65.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/2-65-277x300.jpg 277w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 MTT\u6cd5\u68c0\u6d4b\u4e0d\u540c\u78b3\u7eb3\u7c73\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08b\uff09 LDH\u91ca\u653e\u7814\u7a76\u4e2d\u68c0\u6d4b\u5230\u4e0d\u540c\u78b3\u7eb3\u7c73\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u7684\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08c\uff09 PI\u6807\u8bb0\u6cd5\u6d4b\u5b9a\u78b3\u7eb3\u7c73\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff1b<\/p>\n<p>\uff08d\uff09 \u5e26Baf\u548c\u4e0d\u5e26Baf\u7684\u78b3\u7eb3\u7c73\u5b75\u80b2\u540e\u7ec6\u80de\u7684\u5171\u7126\u56fe\u50cf\uff1b<\/p>\n<p>\uff08e\uff09 \u57fa\u4e8eLDH\u91ca\u653e\u5b9e\u9a8c\u7684\u4e0d\u540c\u78b3\u7eb3\u7c73\u7684\u7ec6\u80de\u6bd2\u6027\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001SNH\u3001CNT\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u548c\u574f\u6b7b\u5bf9\u6bd4<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-144178\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/3-67.jpg\" alt=\"\" width=\"600\" height=\"449\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/3-67.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/06\/3-67-300x225.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><br \/>\n \u00a0\uff08a\uff09 \u4e0d\u540c\u78b3\u7eb3\u7c73\u5b75\u80b2\u540e\u7684PARP\u86cb\u767d\u8d28\u5370\u8ff9\u5206\u6790\uff1b<\/p>\n<p>\uff08b\uff09 \u4e0d\u540c\u78b3\u7eb3\u7c73\u5b75\u80b2\u540e\u7684\u534a\u80f1\u6c28\u9178\u5929\u51ac\u6c28\u9178\u86cb\u767d\u9176-1\u88c2\u89e3\u86cb\u767d\u8d28\u5370\u8ff9\u5206\u6790\uff1b<\/p>\n<p>\uff08c\uff09 \u57fa\u4e8e\u86cb\u767d\u8d28\u5370\u8ff9\u5206\u6790\u7684\u96c6\u6210\u5149\u5bc6\u5ea6(IOD)\u503c\u68c0\u6d4b\uff0c\u5b9a\u91cf\u6d4b\u5b9a\u78b3\u7eb3\u7c73\u5b75\u80b2\u540e\u7ec6\u80de\u4e2d\u7684PARP\u7684\u89e3\u7406\u6bd4\uff1b<\/p>\n<p>\uff08d\uff09 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href=\"https:\/\/www.nature.com\/articles\/s41467-018-04700-z\" target=\"_blank\" rel=\"noopener\">Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages<\/a>\uff08Nat. Commun., <strong>2018<\/strong>, DOI: 10.1038\/s41467-018-04700-z\uff09<\/p>\n<p><strong>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/131937.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u5355\u58c1\u78b3\u7eb3\u7c73\u89d2(SNH)\u662f\u4e00\u79cd\u65b0\u578b\u7684\u7eb3\u7c73\u78b3\u5b50\uff0c\u7531\u4e8e\u5176\u72ec\u7279\u7684\u5f62\u6001\u548c\u7ed3\u6784\u800c\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002\u5355\u4e2a\u7eb3\u7c73\u89d2\u7531\u4e00\u4e2a\u76f4\u5f84\u4e3a2- 5nm\u3001\u957f\u5ea6\u4e3a40 &#8211;&#8230;<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[3361,3360],"class_list":["post-144175","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-gpnmb","tag-snh"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/144175"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=144175"}],"version-history":[{"count":8,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/144175\/revisions"}],"predecessor-version":[{"id":145119,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/144175\/revisions\/145119"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=144175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=144175"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=144175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}