{"id":143520,"date":"2018-06-23T06:30:28","date_gmt":"2018-06-22T22:30:28","guid":{"rendered":"\/\/m.iemloyee.com\/?p=143520"},"modified":"2018-06-22T16:10:39","modified_gmt":"2018-06-22T08:10:39","slug":"%e5%8d%81%e4%b8%80%e7%af%87%e6%96%87%e7%ab%a0%e5%b8%a6%e4%bd%a0%e5%88%9d%e6%ad%a5%e4%ba%86%e8%a7%a3dna%e7%ba%b3%e7%b1%b3%e6%8a%80%e6%9c%af%e7%9a%84%e5%8f%91%e5%b1%95%e5%8e%86%e7%a8%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=143520","title":{"rendered":"\u5341\u4e00\u7bc7\u6587\u7ae0\u5e26\u4f60\u521d\u6b65\u4e86\u89e3DNA\u7eb3\u7c73\u6280\u672f\u7684\u53d1\u5c55\u5386\u7a0b"},"content":{"rendered":"

\"\"<\/a><\/p>\n

\u81eaDNA\u7684\u53cc\u87ba\u65cb\u7ed3\u6784\u53d1\u73b0\u4ee5\u6765\uff0c\u6211\u4eec\u5370\u8c61\u4e2d\u7684DNA\u5c31\u662f\u8fd9\u6837\u7684\uff1a<\/p>\n

\"\"<\/p>\n

\u53ef\u5982\u4eca\uff0cDNA\u8fd8\u53ef\u4ee5\u662f\u4e0b\u9762\u8fd9\u6837\u7684\uff1a<\/p>\n

\"\"<\/p>\n

\u8fd9\u5c31\u662f\u901a\u8fc7DNA\u7eb3\u7c73\u6280\u672f\u5f97\u5230\u7684\u56fe\u5f62\u3002<\/p>\n

DNA\u7eb3\u7c73\u6280\u672f\u662f\u4e00\u79cd\u591a\u5b66\u79d1\u4ea4\u53c9\u7684\u7814\u7a76\u9886\u57df\uff0c\u4e3b\u8981\u5229\u7528DNA\uff08\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff09\u5c3a\u5bf8\u4e3a\u7eb3\u7c73\u7ea7\u522b\u3001\u521a\u6027\u7ed3\u6784\u3001\u7f16\u7801\u6027\u5f3a\u7684\u7279\u70b9\u6765\u6784\u9020\u5404\u79cd\u7eb3\u7c73\u7ed3\u6784\uff0c\u5e94\u7528\u4e8e\u751f\u7269\u533b\u5b66\u3001\u5316\u5b66\u3001\u6750\u6599\u7b49\u9886\u57df\u3002DNA\u7eb3\u7c73\u6280\u672f\u7684\u53d1\u5c55\u5237\u65b0\u4e86\u4eba\u4eec\u5bf9DNA\u8fd9\u4e00\u751f\u7269\u5927\u5206\u5b50\u7684\u8ba4\u8bc6\uff0c\u5b83\u4e0d\u4ec5\u4ec5\u80fd\u4f5c\u4e3a\u751f\u547d\u9057\u4f20\u4fe1\u606f\u7684\u8f7d\u4f53\uff0c\u8fd8\u80fd\u591f\u4f5c\u4e3a\u7eb3\u7c73\u7ed3\u6784\u7684\u6784\u5efa\u5de5\u5177\u3002\u81ea1982\u5e74\u4ee5\u67651<\/sup>\uff0cDNA\u7eb3\u7c73\u6280\u672f\u7ecf\u5386\u4e86\u8fd140\u5e74\u7684\u53d1\u5c55\uff0c\u6700\u521d\u51fa\u73b0\u662f\u7684Tile\u7ec4\u88c5\uff0c\u4ece\u7b80\u5355DNA\u5341\u5b57\u7ed3\u6784\u5230DNA\u7ed3\u6784\u6a21\u5757\u6784\u5efa\u767e\u5bb6\u4e89\u9e232<\/sup>\uff0c\u800c\u4f7f\u7528Tile\u7ec4\u88c5\u6784\u5efa\u5404\u79cdDNA\u7eb3\u7c73\u56fe\u5f62\u4e5f\u5f97\u4ee5\u5b9e\u73b03-5<\/sup>\uff0c\u81ea\u6b64DNA\u7eb3\u7c73\u6280\u672f\u9886\u57df\u521d\u6b65\u6210\u578b\u30022006\u5e74\uff0cDNA\u6298\u7eb8\u672f6<\/sup>\u7684\u53d1\u73b0\u5219\u5ba3\u793a\u4e86\u8be5\u9886\u57df\u4e00\u4e2a\u65b0\u7eaa\u5143\u7684\u5f00\u59cb\uff0c DNA\u7eb3\u7c73\u7ed3\u6784\u7684\u6784\u5efa\u66f4\u662f\u5f97\u5230\u4e86\u7a7a\u524d\u7684\u53d1\u5c557-10<\/sup>\u3002\u6700\u8fd1\uff0c\u4eba\u4eec\u5df2\u7ecf\u80fd\u591f\u5b9e\u73b0\u590d\u6742DNA\u56fe\u6848\u53ef\u63a7\u81ea\u7ec4\u88c5\u56fe\u5f62\u6784\u5efa\u4e8611<\/sup>\uff0c\u5176\u56fe\u5f62\u4e4b\u7cbe\u786e\u4ee4\u4eba\u60ca\u53f9\uff01\u672c\u6587\u5c06\u4eceDNA\u7eb3\u7c73\u6784\u56fe\u7684\u89d2\u5ea6\uff0c\u4ee5\u5341\u4e00\u7bc7\u6587\u732e\u8bb2\u8ff0DNA\u7eb3\u7c73\u6280\u672f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u95ee\u9898\u89e3\u51b3\u4e4b\u8def\uff0c\u5e0c\u671b\u80fd\u5e26\u9886\u8bfb\u8005\u5bf9DNA\u7eb3\u7c73\u6280\u672f\u7684\u53d1\u5c55\u6709\u4e00\u4e2a\u521d\u6b65\u7684\u4e86\u89e3\uff01<\/p>\n

 <\/p>\n

\u5f00\u521b\u7bc7<\/strong><\/p>\n

\"\"<\/p>\n

DNA\u7eb3\u7c73\u6280\u672f\u7684\u9f3b\u7956\u5f53\u5c5e\u7ebd\u7ea6\u5927\u5b66\u7684Ned Seeman\u6559\u6388\u4e86\u30021982\u5e74\uff0c\u7ebd\u7ea6\u5927\u5b66\u7684Seeman\u6559\u6388\u9996\u6b21\u63d0\u51fa\u4e86\u5341\u5b57\u53c9\u72b6\u7684Holiday\u7ed3\u6784\u4e0d\u540c\u4e8e\u5e38\u89c4\u7684\u7ebf\u72b6\u53cc\u94feDNA\uff0c\u5b83\u591a\u51fa\u4e86\u4e24\u4e2a\u65b9\u5411\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u7ed3\u6784\u5355\u5143\u7528\u4e8e\u5408\u6210\u66f4\u4e3a\u590d\u6742\u3001\u5c3a\u5bf8\u66f4\u5927\u7684\u4e8c\u7ef4\u7ed3\u6784\u3002\u53ea\u8981\u901a\u8fc7\u5408\u7406\u7684\u8bbe\u8ba1\uff0c\u4f7f\u5f97\u56db\u6761\u5355\u94fe\u4e4b\u95f4\u7684\u78b1\u57fa\u4e92\u8865\u914d\u5bf9\u5177\u6709\u552f\u4e00\u6027\uff0c\u51cf\u5c11\u5e8f\u5217\u7684\u5bf9\u79f0\u6027\uff0c\u5c31\u53ef\u4ee5\u5f97\u5230\u56fa\u5b9a\u7684\u3001\u5341\u5b57\u53c9\u72b6\u7684Holiday\u7c7b\u4f3c\u7ed3\u6784\u3002\u5018\u82e5\u5728\u8be5\u5341\u5b57\u7ed3\u6784\u7684\u56db\u6761\u81c2\u7684\u672b\u7aef\u6dfb\u52a0\u5408\u9002\u7684\u7c98\u6027\u672b\u7aef\uff0c\u5373\u53ef\u5b9e\u73b0\u5c06\u591a\u4e2a\u5341\u5b57\u53c9\u7ed3\u6784\u5355\u5143\u7ec4\u88c5\u6210\u8f83\u5927\u7684\u4e8c\u7ef4\u751a\u81f3\u4e09\u7ef4\u590d\u6742\u7ed3\u6784\u3002\u6b21\u5e74\uff0cSeeman\u56e2\u961f\u6b63\u5f0f\u8bbe\u8ba1\u51fa\u4e86\u8fd9\u79cd\u56fa\u5b9a\u7684\u5341\u5b57\u7ed3\u6784\uff0c\u79f0\u4e3a\u201c\u56db\u81c2\u7ed3\u201d\u3002\u4e00\u4e2a\u56db\u81c2\u7ed3\u88ab\u79f0\u4e3a\u4e00\u4e2aTile\uff0c\u591a\u4e2aTile\u53ef\u4ee5\u901a\u8fc7\u7c98\u6027\u672b\u7aef\u94fe\u63a5\u5230\u4e00\u8d77\uff0c\u5f97\u5230\u4e8c\u7ef4\u7ed3\u6784\uff0c\u4ece\u800c\u5f00\u521b\u4e86Tile\u7ec4\u88c5\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u56db\u81c2\u7ed3Tile \u7ed3\u6784\u7684\u6210\u529f\u6784\u5efa\u53ca\u4f7f\u7528\u9884\u793a\u7740DNA\u7eb3\u7c73\u6280\u672f\u9ec4\u91d1\u65f6\u4ee3\u7684\u5230\u6765\uff0cDNA\u4e0d\u518d\u53ea\u662f\u5355\u7eaf\u7684\u751f\u7269\u5927\u5206\u5b50\uff0c\u8fd8\u53ef\u4ee5\u662f\u7eb3\u7c73\u7ed3\u6784\u7684\u6784\u9020\u5de5\u5177\u3002\u4f46\u6b64\u65f6\u7684\u56db\u81c2\u7ed3Tile\u7ed3\u6784\u76f8\u5bf9\u7b80\u5355\uff0c\u4e14\u56db\u81c2\u5f20\u5f00\uff0c\u5177\u6709\u8f83\u5927\u7684\u7075\u6d3b\u6027\u3002\u5b58\u5728\u4ea7\u7269\u7ed3\u6784\u65e0\u6cd5\u9884\u6d4b\u7684\u95ee\u9898\u3002\u82e5\u8981\u6784\u5efa\u66f4\u4e3a\u591a\u6837\u7684\u56fe\u5f62\u5219\u9700\u8981\u5f00\u53d1\u66f4\u52a0\u575a\u56fa\u800c\u7a33\u5b9a\u7684Tile \u7ed3\u6784\u5355\u5143\u3002<\/p>\n

 <\/p>\n

\u53d1\u5c55\u7bc7<\/strong><\/p>\n

\"\"<\/p>\n

1993\u5e74\uff0cSeeman\u56e2\u961f\u5728\u56db\u81c2\u7ed3\u57fa\u7840\u4e0a\u8fdb\u884c\u6539\u8fdb\uff0c\u5c06\u4e24\u80a1\u53cc\u87ba\u65cb\u7ed3\u6784\u5e76\u5217\u6392\u5e03\uff0c\u5e76\u5728\u5176\u5185\u90e8\u5f15\u5165\u4ea4\u53c9\uff08crossover\uff09\uff0c\u5f62\u6210\u4e00\u79cd\u66f4\u4e3a\u7a33\u5b9a\u7684Tile\u7ed3\u6784\uff0c\u79f0\u4e4b\u4e3aDX\uff08Double Crossover\uff09\uff0cDX\u7684\u7c7b\u578b\u6709\u5f88\u591a\u79cd\uff0c\u4e3b\u8981\u4f9d\u636e\u4e24\u4e2aDNA\u53cc\u87ba\u65cb\u87ba\u65cb\u8f74\u7684\u76f8\u5bf9\u65b9\u5411\u662f\u5e73\u884c\u8fd8\u662f\u53cd\u5e73\u884c\u7684\u6765\u8fdb\u884c\u533a\u5206\u3002\u4f46\u7531\u4e8e\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u5e73\u884c\u7684DX\u5728\u7eb3\u7c73\u6784\u9020\u4e2d\u8868\u73b0\u6b20\u4f73\uff0c\u6545\u5728\u540e\u671f\u5e7f\u6cdb\u4f7f\u7528\u7684\u90fd\u662f\u53cd\u5e73\u884c\u7684DX\u5206\u5b50\u3002\u82e5\u4ea4\u53c9\u70b9\u4e2d\u95f4\u95f4\u9694\u4e86\u5076\u6570\u4e2a\u534a\u87ba\u65cb\u5219\u79f0\u4e3aDAE\uff08Double Antiparallel Even\uff09\uff0c\u82e5\u4ea4\u53c9\u70b9\u95f4\u7684\u534a\u87ba\u65cb\u6570\u76ee\u662f\u5947\u6570\uff0c\u5219\u79f0\u5176\u4e3aDAO\uff08Double Antiparallel Odd\uff09\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>DX\u7684\u6210\u529f\u6784\u5efa\uff0c\u89e3\u51b3\u4e86\u591a\u81c2\u7ed3\u7075\u6d3b\u5ea6\u9ad8\uff0c\u7ec4\u88c5\u4ea7\u7269\u7ed3\u6784\u4e0d\u786e\u5b9a\u7684\u5f0a\u7aef\uff0c\u4e3a\u540e\u671f\u7814\u7a76DNA\u7eb3\u7c73\u6784\u56fe\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u4f46\u5176\u7ed3\u6784\u7684\u7a33\u5b9a\u6027\u4ecd\u6709\u5f85\u63d0\u9ad8\u3002<\/p>\n

\"\"<\/p>\n

1998\u5e74\uff0c\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u7684Winfree\u56e2\u961f\u5728Wang Tile\u7684\u542f\u53d1\u4e0b\uff0c\u9996\u6b21\u4f7f\u7528DX\u4f5c\u4e3a\u7ed3\u6784\u57fa\u5143\u7ec4\u88c5\u51fa\u4e86\u5e26\u6709\u6761\u7eb9\u7684\u4e8c\u7ef4\u5e73\u9762\u7f51\u683c\u7ed3\u6784\uff0c\u5e76\u4e14\u8fd8\u4f7f\u7528\u539f\u5b50\u529b\u663e\u5fae\u955c\uff08AFM\uff09\u8bc1\u5b9e\u4e86\u4ea7\u7269\u7684\u5b58\u5728\uff0c\u8fd9\u9879\u7814\u7a76\u4ee5\u9898\u4e3a\u201cDesign and self-assembly of two-dimensional DNA crystals\u201d\u88ab\u53d1\u8868\u5728Nature\u6742\u5fd7\u4e0a\u3002\u4ece\u6b64\uff0cDNA\u7eb3\u7c73\u6280\u672f\u4e5f\u9010\u6e10\u53d7\u5230\u4eba\u4eec\u7684\u5173\u6ce8\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u8fd9\u9879\u5de5\u4f5c\u8bc1\u5b9e\u4e86DX\u53ef\u4ee5\u7528\u6765\u6784\u9020\u4e8c\u7ef4\u5e73\u9762\u7ed3\u6784\uff0c\u662fDNA\u7eb3\u7c73\u6784\u56fe\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891\u3002\u4f46\u5176\u4f9d\u7136\u5b58\u5728\u7ec4\u88c5\u5f62\u72b6\u5c3a\u5bf8\u4e0d\u53ef\u63a7\u4ee5\u53caDX\u56fa\u6709\u7684\u7ed3\u6784\u7a33\u5b9a\u6027\u7684\u95ee\u9898\u3002\u53e6\u5916\uff0c\u66f4\u590d\u6742\u7684\u4e09\u7ef4\u7ed3\u6784\u7684\u6784\u9020\u4ecd\u662f\u5f53\u65f6\u9762\u4e34\u7684\u6311\u6218\u3002<\/p>\n

\"\"<\/p>\n

2003\u5e74, \u989c\u98a2\u56e2\u961f\u5728\u56db\u81c2\u7ed3\u548cDX\u7684\u57fa\u7840\u4e0a\uff0c\u5c06\u56db\u81c2\u7ed3\u7684\u6bcf\u4e00\u6761\u81c2\u7684\u5355\u4e2a\u53cc\u87ba\u65cb\u66ff\u6362\u6210\u542b\u5185\u90e8\u4ea4\u53c9\u7684\u5e76\u6392\u7684\u53cc\u87ba\u65cb\u7ed3\u6784\uff08\u4e5f\u5c31\u662fDX\u7ed3\u6784\uff09\uff0c\u4ece\u800c\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u5341\u5b57Tile\u3002\u5176\u7ed3\u5408\u4e86\u56db\u81c2\u7ed3\u548cDX\u4e8c\u8005\u7684\u4f18\u70b9\uff0c\u7ed3\u6784\u7a33\u5b9a\u6027\u6709\u6240\u63d0\u9ad8\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u8fd9\u79cd\u5341\u5b57Tile\u8868\u73b0\u51fa\u66f4\u597d\u7684\u521a\u6027\uff0c\u5927\u5927\u4f18\u5316\u4e86\u7ec4\u88c5\u7ed3\u6784\u7684\u7a33\u5b9a\u6027\u3002<\/p>\n

\"\"<\/p>\n

2005\u5e74\uff0c\u989c\u98a2\u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd\u6709\u9650\u5c3a\u5bf8DNA\u7ec4\u88c5\u7ed3\u6784\u7684\u6784\u9020\u65b9\u6cd5\uff0c\u4ec5\u4ec5\u5229\u7528\u5c11\u91cf\u7684\u51e0\u79cd\u5e26\u6709\u7c98\u6027\u672b\u7aef\u7684Tile\u7ed3\u6784\uff0c\u5c31\u53ef\u4ee5\u7ec4\u88c5\u51fa\u8bbe\u5b9a\u5c3a\u5bf8\u7684\u4e8c\u7ef4\u9635\u5217\u56fe\u5f62\u3002\u6587\u4e2d\u5c1d\u8bd5\u4e86\u591a\u79cd\u7c7b\u578b\u7684Tile\u7ed3\u6784\uff0c\u90fd\u53ef\u4ee5\u5b9e\u73b0\u7ec4\u88c5\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u8fd9\u4e00\u6210\u679c\u8bc1\u5b9eTile\u7ec4\u88c5\u4e5f\u53ef\u4ee5\u5b9e\u73b0\u6709\u9650\u5c3a\u5bf8\u56fe\u5f62\u7684\u6784\u9020\uff0c\u4e3a\u89e3\u51b3Tile\u7ec4\u88c5\u4ea7\u7269\u5c3a\u5bf8\u4e0d\u53ef\u63a7\u7684\u95ee\u9898\u63d0\u4f9b\u4e86\u601d\u8def\u3002\u4f46Tile\u7ec4\u88c5\u7ed3\u6784\u4ea7\u7387\u4f4e\uff0c\u5bf9\u5316\u5b66\u8ba1\u91cf\u6bd4\u8981\u6c42\u8f83\u9ad8\u4e5f\u662f\u5c1a\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n

 <\/p>\n

\u8fdb\u9636\u7bc7<\/strong><\/p>\n

\"\"<\/p>\n

2006\u5e74\uff0c\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u7684Rothemund\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684DNA\u81ea\u7ec4\u88c5\u6280\u672f\uff0c\u79f0\u4e3aDNA\u6298\u7eb8\u672f\u3002\u4ed6\u4eec\u9009\u7528\u566c\u83cc\u4f53DNA M13mp18\u4f5c\u4e3a\u957f\u94fe\uff0c\u7136\u540e\u7528\u4e24\u767e\u591a\u6761\u77ed\u7684\u5355\u94feDNA\u901a\u8fc7\u78b1\u57fa\u4e92\u8865\u914d\u5bf9\u539f\u5219\uff0c\u5c06\u957f\u94fe\u6298\u53e0\u6210\u60f3\u8981\u7684\u4e8c\u7ef4\u56fe\u5f62\u3002Rothemund\u56e2\u961f\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\u5f97\u5230\u4e86\u77e9\u5f62\u3001\u4e09\u89d2\u5f62\u3001\u4e94\u89d2\u661f\u548c\u7b11\u8138\u7b49\u591a\u79cd\u5e73\u9762\u56fe\u6848\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u65b9\u6cd5\u6784\u9020\u7684\u7eb3\u7c73\u56fe\u5f62\u5177\u6709\u5f88\u597d\u7684\u53ef\u5bfb\u5740\u6027\uff0c\u5728\u5408\u9002\u7684\u4f4d\u7f6e\u5f15\u5165\u53d1\u5939\u7ed3\u6784\u8fd8\u53ef\u4ee5\u5f97\u5230\u5177\u6709\u4e0d\u540c\u56fe\u6848\u7684\u4e8c\u7ef4\u56fe\u5f62\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>DNA\u6298\u7eb8\u672f\u53ea\u9700\u8981\u5c06\u957f\u94fe\u548c\u82e5\u5e72\u77ed\u94fe\u6df7\u5408\u8d77\u6765\u8fdb\u884c\u9000\u706b\uff0c\u5c31\u53ef\u4ee5\u5f97\u5230\u60f3\u8981\u7684\u7ec4\u88c5\u7ed3\u6784\uff0c\u64cd\u4f5c\u76f8\u5bf9Tile\u7ec4\u88c5\u66f4\u52a0\u5bb9\u6613\uff0c\u5bf9\u5404\u7ec4\u5206\u7684\u6d53\u5ea6\u6bd4\u4f8b\u8981\u6c42\u66f4\u4f4e\u3002\u53e6\u5916\uff0cDNA\u6298\u7eb8\u672f\u53ef\u4ee5\u5f97\u5230\u7684\u4ea7\u7269\u590d\u6742\u5ea6\u66f4\u9ad8\uff0c\u4e0d\u518d\u662f\u7b80\u5355\u7684\u4e00\u4e9b\u89c4\u6574\u7684\u51e0\u4f55\u56fe\u5f62\u4e86\u3002\u7eb3\u7c73\u7ec4\u88c5\u7ed3\u6784\u7684\u5185\u90e8\u5177\u6709\u5f88\u591a\u7684\u4ea4\u53c9\u7ed3\u6784\uff0c\u5927\u5927\u589e\u52a0\u4e86\u7ed3\u6784\u7684\u7a33\u5b9a\u6027\uff0c\u4e3a\u5176\u5e94\u7528\u4e8e\u5176\u4ed6\u5404\u9886\u57df\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u540c\u65f6\uff0cRothemund\u8fd8\u5c066\u4e2a\u4e09\u89d2\u5f62\u7684\u56fe\u6848\u7ec4\u5408\u6210\u4e86\u4e00\u4e2a\u5927\u7684\u516d\u8fb9\u5f62\uff0c\u8fd9\u4e5f\u4e3a\u5927\u56fe\u5f62\u7684\u6784\u5efa\u63d0\u4f9b\u4e86\u601d\u8def\u3002\u4e0d\u5f97\u4e0d\u8bf4\uff0cDNA\u6298\u7eb8\u672f\u7684\u53d1\u73b0\u8ba9DNA\u7eb3\u7c73\u6280\u672f\u7684\u53d1\u5c55\u6709\u4e86\u4e00\u4e2a\u5f88\u5927\u7684\u98de\u8dc3\u3002<\/p>\n

\u4f46\u672c\u6587\u4ec5\u4ec5\u4f7f\u7528DNA\u6298\u7eb8\u672f\u6784\u5efa\u4e86\u4e00\u4e9b\u5bf9\u79f0\u7684\u4e8c\u7ef4\u56fe\u5f62\uff0c\u5bf9\u4e8e\u4e0d\u5bf9\u79f0\u7684\u6216\u8005\u4e09\u7ef4\u7684\u590d\u6742\u4e0d\u884c\u7684\u6784\u9020\u4ecd\u6709\u5f85\u63a2\u7d22\u3002\u53e6\u5916\uff0cDNA\u6298\u7eb8\u672f\u76f8\u5bf9\u4e0eTile\u7ec4\u88c5\u7684\u4e00\u70b9\u4e0d\u8db3\u5728\u4e8e\u5176\u53d7\u5230\u957f\u94fe\u957f\u5ea6\u7684\u9650\u5236\uff0c\u5bf9\u4e8e\u6784\u5efa\u5c3a\u5bf8\u8f83\u5927\u7684\u7ed3\u6784\u7a0d\u663e\u56f0\u96be\u3002<\/p>\n

\"\"<\/p>\n

2006\u5e74\uff0c\u5f53\u65f6\u8fd8\u5728\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u7684\u94b1\u7490\u7490\u7b49\u5f88\u5feb\u5c31\u5229\u7528DNA\u6298\u7eb8\u672f\u201c\u6298\u201d\u51fa\u4e86\u4e2d\u56fd\u5730\u56fe\u7684\u56fe\u6848\uff0c\u8fd9\u4e5f\u662f\u5229\u7528DNA\u6298\u7eb8\u672f\u7684\u65b9\u6cd5\u6784\u5efa\u7684\u7b2c\u4e00\u4e2a\u4e0d\u5bf9\u79f0\u7684\u7eb3\u7c73\u56fe\u5f62\u3002<\/p>\n

\"\"<\/p>\n

2008\u5e74\uff0c\u4e39\u9ea6\u7684Andersen E S\u7b49\u5728\u6b64\u57fa\u7840\u4e0a\u66f4\u8fdb\u4e00\u6b65\uff0c\u6210\u529f\u7ec4\u88c5\u9664\u4e86\u7eb3\u7c73\u5c3a\u5ea6\u7684\u6d77\u8c5a\u5f62\u72b6\uff0c\u5e76\u4e14\u6d77\u8c5a\u8fd8\u5177\u6709\u4e00\u6761\u53ef\u4ee5\u8fd0\u52a8\u7684\u5c3e\u5df4\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u8fd9\u4e9b\u6210\u679c\u90fd\u8bc1\u660e\u4e86DNA\u6298\u7eb8\u672f\u53ef\u4ee5\u5b9e\u73b0\u4e0d\u5bf9\u79f0\u56fe\u5f62\u7684\u7ec4\u88c5\uff0c\u751a\u81f3\u53ef\u4ee5\u7528\u4e8e\u52a8\u6001\u7ed3\u6784\u7684\u6784\u9020\u4e2d\u53bb\u3002\u4e0d\u8fc7\uff0c\u5f53\u65f6\u6240\u6784\u5efa\u7684\u56fe\u5f62\u4ecd\u7136\u57fa\u4e8e\u957f\u4e3a7000\u591abp\u7684\u957f\u94fe\uff0c\u56e0\u800c\u5c3a\u5bf8\u4e0d\u4f1a\u5f88\u5927\u3002<\/p>\n

\"\"<\/p>\n

2010\u5e74\uff0c\u989c\u98a2\u56e2\u961f\u610f\u8bc6\u5230DNA\u6298\u7eb8\u672f\u662f\u4e00\u79cd\u5341\u5206\u6709\u6f5c\u529b\u7684\u81ea\u7ec4\u88c5\u4f53\u7cfb\uff0c\u4f46\u5c3a\u5bf8\u53d7\u9650\u5374\u662f\u5176\u4e00\u5927\u75db\u70b9\uff0c\u5982\u4f55\u7a81\u7834\u957f\u94fe\u957f\u5ea6\u7684\u9650\u5236\u83b7\u5f97\u5c3a\u5bf8\u66f4\u5927\u7684\u7ec4\u88c5\u56fe\u5f62\u662fDNA\u6298\u7eb8\u672f\u7684\u4e00\u5927\u6311\u6218\u3002\u4ed6\u4eec\u4f7f\u7528\u957f\u4e3a1140 nt\u7684M13\u7684\u4e00\u90e8\u5206\u4f5c\u4e3a\u957f\u94fe\u9aa8\u67b6\u4e0e\u77ed\u94fe\u7ec4\u88c5\u6210\u4e8634 nm \u00d7 22 nm\u7684\u5c0f\u957f\u65b9\u5f62\uff0c\u518d\u7528\u53e6\u4e00\u6761\u957f\u94fe\u5c069\u4e2a\u8fd9\u6837\u7684\u5c0f\u957f\u65b9\u5f62\u8fde\u63a5\u8d77\u6765\uff0c\u5c31\u53ef\u4ee5\u5f97\u5230\u5c3a\u5bf8\u6269\u5927\u7684\u56fe\u5f62\u3002\u4f5c\u8005\u6307\u51fa\uff0c\u82e5\u4f7f\u752870 nm \u00d7 90 nm\u7684\u957f\u65b9\u5f62Origami\u6765\u6298\u53e0\u50cf\u03bbDNA\uff0845000 nt\uff09\uff08\u5018\u82e5\u53ef\u4ee5\u5f97\u5230\u7684\u8bdd\uff09\uff0c\u5c31\u53ef\u80fd\u5f97\u5230\u5c3a\u5bf8\u5230\u5fae\u7c73\u7ea7\u522b\u7684\u8d85\u7ea7DNA\u6298\u7eb8\u7ed3\u6784\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u672c\u6587\u63d0\u51fa\u4e86\u4e00\u79cd\u6269\u5927DNA\u6298\u7eb8\u56fe\u5f62\u5c3a\u5bf8\u7684\u601d\u8def\uff0c\u4e3a\u540e\u671f\u5173\u4e8eScale up Origami\u7684\u7814\u7a76\u7ed9\u51fa\u4e86\u4e00\u79cd\u53ef\u9009\u7684\u65b9\u6cd5\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4f9d\u7136\u9700\u8981\u7279\u6b8a\u7684\u957f\u94fe\uff0c\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\uff0c\u5bf9\u4e8e\u67d0\u4e9b\u5c3a\u5bf8\u8f83\u5927\u7684\u56fe\u5f62\u7684\u7ec4\u88c5\u4f9d\u7136\u4f1a\u53d7\u5230\u9650\u5236\u3002<\/p>\n

\"\"<\/p>\n

2011\u5e74\uff0cSeeman\u56e2\u961f\u8ba4\u4e3a\u60f3\u8981\u5c06DNA origami\u56fe\u5f62\u7684\u5c3a\u5bf8\u8fdb\u4e00\u6b65\u653e\u5927\u7684\u4e00\u6761\u601d\u8def\u5c31\u662f\u5c06\u5355\u4e2aDNA origami\u7b49\u4ef7\u4e8e\u4e00\u4e2aTile\u5355\u5143\uff0c\u90a3\u4e48DNA origami Tile\u7ed3\u6784\u56e0\u5176\u5185\u90e8\u591a\u4ea4\u53c9\uff0c\u5b9e\u9645\u4e0a\u5c31\u662f\u4e00\u4e2a\u66f4\u5927\u7248\u672c\u7684DX \uff08\u53cc\u4ea4\u53c9\uff09\u3002\u65e9\u671f\u5df2\u6709\u7814\u7a76\u8bc1\u660e\uff0cDX\u662f\u53ef\u4ee5\u6210\u529f\u5f62\u6210\u4e8c\u7ef4\u5927\u5c3a\u5bf8\u6676\u4f53\u7ed3\u6784\u7684\uff0c\u90a3\u4e48\u4f7f\u7528DNA origami\u7406\u5e94\u4e5f\u53ef\u4ee5\u5b9e\u73b0\u3002\u9057\u61be\u7684\u662f\uff0c\u4ed6\u4eec\u5931\u8d25\u4e86\u3002\u540e\u6765\uff0c\u4ed6\u4eec\u901a\u8fc7\u6539\u8fdb\uff0c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5341\u5b57\u5f62\u7684DNA origami\u7ed3\u6784\uff0c\u5b9e\u73b0\u4e86\u57fa\u4e8eDNA origami \u7684\u4e8c\u7ef4\u7ed3\u6784\u7684\u5f62\u6210\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong> \u8fd9\u4e00\u65b9\u6cd5\u5b9e\u73b0\u4e86DNA \u6298\u7eb8\u7528\u4e8e\u4e8c\u7ef4\u6676\u4f53\u5f62\u6210\u7684\u96f6\u7684\u7a81\u7834\uff0c\u4e14\u6784\u5efa\u4e86\u622a\u81f3\u76ee\u524d\u4e3a\u6b62\u6700\u5927\u7684\u4e8c\u7ef4DNA\u6298\u7eb8\u7ed3\u6784\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5f97\u5230\u7684\u56fe\u5f62\u5c3a\u5bf8\u96be\u4ee5\u63a7\u5236\uff0c\u5bf9\u4e8e\u4e00\u4e9b\u6709\u9650\u5c3a\u5bf8\u7684\u56fe\u5f62\u7ec4\u88c5\u5c06\u4e0d\u9002\u7528\u3002\u6b64\u5916\uff0c\u56e0\u6bcf\u4e00\u4e2aTile\u5728\u4e8c\u7ef4\u7ed3\u6784\u4e2d\u7684\u4f4d\u7f6e\u4e0d\u786e\u5b9a\uff0c\u56e0\u800c\u5229\u7528\u8fd9\u79cd\u65b9\u6cd5\u5f97\u5230\u5177\u6709\u590d\u6742\u56fe\u6848\u7684\u5f62\u72b6\u7684\u7814\u7a76\u96be\u4ee5\u5b9e\u73b0\u3002<\/p>\n

\"\"<\/p>\n

2017\u5e74\uff0c\u94b1\u7490\u7490\u56e2\u961f\u91c7\u7528\u4e86Scale up \u65b9\u6cd5\u4e2d\u7684\u53e6\u4e00\u79cd\uff1a\u5206\u5c42\u7ec4\u88c5\u3002\u4f7f\u752864\u79cdDNA\u6298\u7eb8\u5355\u5143\uff0c\u5148\u5f62\u62102\u00d72\u7684\u56fe\u5f62\uff0c\u518d\u5f62\u62104\u00d74\u7684\u56fe\u5f62\uff0c\u7136\u540e\u5f62\u62108\u00d78\u7684\u56fe\u5f62\uff0c\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\u5f97\u5230\u7684\u6700\u7ec8\u56fe\u5f62\u7684\u9762\u79ef\u662fRothemund\u66fe\u7ecf\u6298\u51fa\u7684\u7ecf\u5178DNA origami\u768464\u500d\uff0c\u5c3a\u5bf8\u8fbe\u5230\u5fae\u7c73\u7ea7\u522b\u3002\u4ed6\u4eec\u5c06\u6bcf\u4e00\u5757DNA origami\u5355\u5143\u7684\u8fb9\u7f18\u90fd\u8fdb\u884c\u7cbe\u5fc3\u8bbe\u8ba1\uff0c\u4fdd\u8bc1\u5176\u80fd\u5728\u7279\u5b9a\u7684\u4f4d\u7f6e\u540c\u7279\u5b9a\u7684DNA origami \u7ed3\u5408\u5230\u4e00\u8d77\uff0c\u4ece\u800c\u5f62\u6210\u5c3a\u5bf8\u53ef\u63a7\u7684\u7ed3\u6784\u3002\u53e6\u5916\uff0c\u4ed6\u4eec\u8fd8\u5f00\u53d1\u4e86\u76f8\u5e94\u7684\u8f6f\u4ef6\uff0c\u53ef\u4ee5\u5c06\u7528\u6237\u60f3\u8981\u7684\u56fe\u5f62\u8f6c\u6362\u6210\u76f8\u5e94\u7684\u5e26\u53d1\u5939\u7ed3\u6784\u7684DNA\u94fe\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u4e0d\u540c\u56fe\u6848\u7684\u5927\u5c3a\u5bf8DNA\u6298\u7eb8\u7684\u81ea\u7ec4\u88c5\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/strong>\u672c\u6587\u63d0\u4f9b\u4e86\u4e00\u79cd\u57fa\u4e8eDNA\u6298\u7eb8\u7684\u3001\u5c3a\u5bf8\u53ef\u63a7\u7684\u5927\u56fe\u5f62\u7684\u901a\u7528\u7ec4\u88c5\u65b9\u6cd5\uff0c\u5e76\u4e14\u53ef\u4ee5\u8bbe\u8ba1\u590d\u6742\u7684\u56fe\u6848\uff0c\u771f\u6b63\u5b9e\u73b0\u4e86\u63a7\u5236DNA\u6298\u7eb8\u81ea\u7ec4\u88c5\u5f62\u6210\u7528\u6237\u6307\u5b9a\u7684\u56fe\u6848\u7684\u4e8c\u7ef4\u56fe\u5f62\u3002<\/p>\n

\u7ed3\u8bed\uff1a<\/strong>DNA\u7eb3\u7c73\u6280\u672f\u53d1\u5c55\u81f3\u4eca\uff0c\u5df2\u7ecf\u53ef\u4ee5\u7ec4\u88c5\u51fa\u8bb8\u8bb8\u591a\u591a\u590d\u6742\u7684\u4e8c\u7ef4\u3001\u4e09\u7ef4\u751a\u81f3\u5e26\u6709\u66f2\u9762\u7684\u7ed3\u6784\u3002\u5176\u5e94\u7528\u9886\u57df\u4e5f\u6db5\u76d6\u4e86\u5316\u5b66\u3001\u751f\u7269\u533b\u5b66\u3001\u6750\u6599\u53ca\u7269\u7406\u7b49\u3002\u51e0\u5341\u5e74\u6765\uff0c\u7ecf\u8fc7\u82e5\u5e72\u79d1\u5b66\u5bb6\u7684\u52aa\u529b\uff0c\u8ba9\u8fd9\u4e00\u65b0\u5174\u9886\u57df\u9010\u6b65\u53d1\u5c55\u4e86\u8d77\u6765\uff0c\u6211\u4eec\u4e5f\u671f\u5f85\u672a\u6765DNA\u7eb3\u7c73\u6280\u672f\u5c06\u5728\u5404\u9886\u57df\u4e2d\u5927\u653e\u5f02\u5f69\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong>
\n 1.Seeman N C. Nucleic acid junctions and lattices.<\/a> J Theor Biol, 1982, 99: 237-247.
\n 2.Fu T J, Seeman N C. DNA double-crossover molecules.<\/a> Biochemistry,\u00a01993, 32: 3211\u20133220.
\n 3.Winfree E, Liu F, Wenzler L A, et al. Design and self-assembly of two-dimensional DNA crystals. <\/a>Nature, 1998, 394: 539-544.
\n 4.Yan H, Park S H, Finkelstein G, et al. DNA-templated self-assembly of protein arrays and highly conductive NWs. <\/a>Science, 2003, 301: 1882-1884.
\n 5.Liu Y, Ke Y, Yan H. Self-Assembly of Symmetric Finite-Size DNA Nanoarrays. <\/a>J Am Chem Soc ,\u00a02005,\u00a0127: 17140-17141.
\n 6.Rothemund P W. Folding DNA to create nanoscale shapes and patterns. <\/a>Nature, 2006, 440: 158-159.
\n 7.Qian L, Wang Y, Zhang Z, et al. Analogic China map constructed by DNA. <\/a>Chin Sci Bull, 2006, 51: 2973-2976.
\n 8.Andersen E S, Dong M, Nielsen M M, et al. DNA Origami Design of Dolphin-Shaped Structures with Flexible Tails. <\/a>ACS Nano, 2008, 2: 1213-1218.
\n 9.Zhao Z, Yan H, Liu Y. A Route to Scale Up DNA Origami Using DNA Tiles as Folding Staples. <\/a>Angew Chem, Int Ed, 2010,49: 1414-1417.
\n 10.Liu W, Zhong H, Wang R, et al. Crystalline Two-Dimensional DNA Origami Arrays.<\/a> Angew Chem, Int Ed, 2011, 123: 278-281.
\n 11.Tikhomirov G, Petersen P, Qian L. Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns. <\/a>Nature, 2017, 552: 67-71.<\/p>\n

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