{"id":141903,"date":"2018-06-13T06:30:27","date_gmt":"2018-06-12T22:30:27","guid":{"rendered":"\/\/m.iemloyee.com\/?p=141903"},"modified":"2018-06-12T09:06:00","modified_gmt":"2018-06-12T01:06:00","slug":"%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6adv-mater-%e7%94%a8%e4%ba%8e%e5%8f%8c%e9%87%8d%e5%8d%8f%e5%90%8c%e7%9a%84%e5%85%89%e7%ba%bf%e6%b2%bb%e7%96%97%e7%9a%84%e5%8f%af%e6%8e%a7%e5%85%89%e8%bd%ac","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=141903","title":{"rendered":"\u82cf\u5dde\u5927\u5b66Adv. Mater.: \u7528\u4e8e\u53cc\u91cd\u534f\u540c\u7684\u5149\u7ebf\u6cbb\u7597\u7684\u53ef\u63a7\u5149\u8f6c\u5316\u5171\u8f6d\u5149\u654f\u5242\u7684\u5408\u7406\u8bbe\u8ba1"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u5149\u654f\u5242\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u5730\u63a2\u7d22\u6210\u591a\u79cd\u7c7b\u578b\u7684\u591a\u7528\u9014\u5316\u5408\u7269\uff0c\u5305\u62ec\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u3001\u5149\u50ac\u5316\u3001\u7ec6\u80de\u4fe1\u53f7\u548c\u751f\u7269\u4f20\u611f\u5668\u3002\u5bf9\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u6fc0\u6d3b\u7684\u5149\u654f\u5242\u662f\u80fd\u591f\u4ea7\u751f\u9ad8\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u6c27\uff08ROS\uff09\u5982\u5355\u7ebf\u6001\u6c27\u901a\u8fc7\u7cfb\u95f4\u8dc3\u8fc1\uff08ISC\uff09\u4f7f\u5f97\u5355\u7ebf\u6001\u5411\u4e09\u7ebf\u6001\u8fc7\u6e21\u548c\u80fd\u91cf\u8f6c\u79fb\uff0c\u4ece\u800c\u5f15\u8d77\u7ec6\u80de\u51cb\u4ea1\u3002\u4e0e\u4f20\u7edf\u6cbb\u7597\u65b9\u6cd5\u76f8\u6bd4\uff0cPDT\u6709\u51e0\u4e2a\u660e\u663e\u7684\u4f18\u52bf\uff0c\u5373\u7cbe\u786e\u7684\u65f6\u7a7a\u63a7\u5236\u3001\u6700\u5c0f\u5316\u526f\u4f5c\u7528\u7684\u9009\u62e9\u6027\u6cbb\u7597\u548c\u53ef\u4ee5\u5ffd\u7565\u7684\u8010\u836f\u6027\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4ee5\u4e0b\u7c7b\u578b\u7684\u6709\u673a\u654f\u5316\u5242\u5373\u787c\u4e9a\u7532\u57fa\u4e8c\u5421\u54af\u3001\u915e\u83c1\u3001\u535f\u5549\u88ab\u5e7f\u6cdb\u5f00\u53d1\u5b9e\u73b0\u6709\u6548\u7684PDT\u6cbb\u7597\u3002\u4f46\u662f\u8fd9\u4e9b\u654f\u5316\u5242\u660e\u663e\u5b58\u5728\u4ee5\u4e0b\u7f3a\u70b9\uff1a\u5728\u53ef\u89c1\u5149\u533a\u57df\u7684\u7a7f\u900f\u6df1\u5ea6\u4e0d\u591f\u3001\u7edd\u5bf9\u6c27\u4f9d\u8d56\u6027\u3001\u4e0d\u5145\u8db3\u7684\u7ec6\u80de\u8d28\u836f\u7269\u6613\u4f4d\u548c\u5355\u7ebf\u6001\u6c27\u51cb\u4ea1\u7ec6\u80de\u635f\u4f24\u4e0d\u8db3\u3002\u56e0\u6b64\uff0c\u63a2\u7d22\u4e00\u79cd\u6709\u6548\u7684\u65b9\u6cd5\u6765\u4fc3\u8fdb\u6fc0\u52a8\u4eba\u5fc3\u7684\u5149\u654f\u5242\u7684\u5149\u8f6c\u5316\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u6297\u764c\u6548\u7387\u4f9d\u65e7\u662f\u4e00\u4e2a\u4e3b\u8981\u7684\u6311\u6218\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u82cf\u5dde\u5927\u5b66\u7684\u9648\u534e\u5175\u6559\u6388\u3001\u4f55\u6167\u6559\u6388\u548c\u90ed\u6b63\u537f\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u787c\u4e9a\u7532\u57fa\u4e8c\u5421\u54af\uff08BDP\uff09\u7684\u5171\u8f6d\u5149\u654f\u5242\uff08CPs\uff09\u7684\u5408\u7406\u8bbe\u8ba1\uff0c\u5b83\u53ef\u4ee5\u8bf1\u5bfc\u5149\u7167\u5c04\u4e0b\u7684\u53cc\u91cd\u534f\u540c\u5149\u6cbb\u7597\u3002BDP\u5355\u4f53\uff08mono<\/em>-BDP\uff09\u7684\u5171\u8f6d\u8026\u5408\u4f5c\u7528\u5f62\u6210\u4e8c\u805a\u4f53BDP\uff08di<\/em>-BDP\uff09\u6216\u4e09\u805a\u4f53BDP\uff08tri<\/em>-BDP\uff09\uff0c\u4f7f\u5f97\u8367\u5149\u4ece\u7cfb\u95f4\u8de8\u8d8a\u6216\u975e\u8f90\u5c04\u8dc3\u8fc1\u7ed3\u5408\u660e\u663e\u7684\u7ea2\u79fb\u5438\u6536\u8fdb\u5165\u8fd1\u7ea2\u5916\u533a\u57df\u3002\u7279\u522b\u662f\u7eb3\u7c73\u9897\u7c92\u5185\u7684tri<\/em>-BDP\u5728\u8fd1\u7ea2\u5916\u5149\u7167\u5c04\u4e0b\u8868\u73b0\u51fa\u8f83\u597d\u7684\u539f\u70ed\u6548\u5e94\u548c\u5355\u7ebf\u6001\u6c27\u8f6c\u5316\uff0c\u901a\u8fc7\u5176\u4e3b\u5bfc\u7684\u665a\u671f\u51cb\u4ea1\u548c\u4e2d\u5ea6\u65e9\u671f\u51cb\u4ea1\u6240\u5f15\u8d77\u7684\u534f\u540c\u6297\u764c\u6548\u5e94\uff0c\u663e\u8457\u5b9e\u73b0\u4e86\u80bf\u7624\u7684\u5149\u70e7\u8680\u800c\u6740\u6b7b\u80bf\u7624\u4e14\u4e0d\u518d\u751f\u3002\u8fd9\u4e00\u5408\u7406\u7684CPs\u8bbe\u8ba1\u53ef\u4ee5\u4e3a\u7cbe\u51c6\u533b\u7597\u9886\u57df\u7684\u764c\u75c7\u5149\u52a8\u529b\u6cbb\u7597\u63d0\u4f9b\u6709\u4ef7\u503c\u7684\u8303\u4f8b\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cRational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001CPs\u7684\u4f5c\u7528\u673a\u7406\u56fe\u00a0<\/strong><\/p>\n \uff08a\uff09 CPs\u7684\u5316\u5b66\u7ed3\u6784\u548c\u7eb3\u7c73\u9897\u7c92\uff1b<\/p>\n \uff08b\uff09 \u5404\u79cdCPs\u7684\u5149\u8f6c\u6362\u8def\u7ebf\u56fe\uff1b<\/p>\n \uff08c\uff09 \u5728\u5149\u7167\u6761\u4ef6\u4e0b\uff0c\u4e09\u805a\u4f53BDP-NPs\u901a\u8fc7PTT\/PDT\u534f\u540c\u5149\u7597\u6297\u80bf\u7624\u3002<\/p>\n \u56fe\u4e8c\u3001CPs\u7684\u5408\u6210\u8def\u7ebf\u548c\u8868\u5f81\u00a0<\/strong><\/p>\n \uff08a\uff09 mono<\/em>-BDP\u3001di<\/em>-BDP\u548ctri<\/em>-BDP\u7684\u5408\u6210\u8def\u7ebf\uff1b<\/p>\n \uff08b\uff09 tri<\/em>-BDP-NPs\u7684TEM\u56fe\uff1b<\/p>\n \uff08c\uff09 tri<\/em>-BDP-NPs\u7684\u7c92\u5f84\u5206\u5e03\u56fe\u3002<\/p>\n \u56fe\u4e09\u3001CPs\u7684\u7406\u5316\u8868\u5f81\u00a0<\/strong><\/p>\n \uff08a\uff09 mono<\/em>-BDP\u3001di<\/em>-BDP\u548ctri<\/em>-BDP\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n \uff08b\uff09 mono<\/em>-BDP\u3001di<\/em>-BDP\u548ctri<\/em>-BDP\u7684\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n \uff08c\uff09 di<\/em>-BDP\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\u4e0eHOMO\u548cLUMO\u80fd\u91cf\u8ba1\u7b97\u6700\u5c0f\u5316\u8ba1\u7b97\uff08\u9ad8\u65af\uff09\uff1b<\/p>\n \uff08d\uff09 tri<\/em>-BDP\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\u4e0eHOMO\u548cLUMO\u80fd\u91cf\u8ba1\u7b97\u6700\u5c0f\u5316\u8ba1\u7b97\uff08\u9ad8\u65af\uff09\u3002<\/p>\n \u56fe\u56db\u3001CPs\u7684PDT\u4f53\u5916\u6d4b\u8bd5\u5b9e\u9a8c\u00a0<\/strong><\/p>\n \uff08a\uff09 di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs\u5206\u522b\u5728660 nm\u548c785 nm\u5149\u7167\u4e0b\u7684ESR\u8c31\uff1b<\/p>\n \uff08b\uff09 di<\/em>-BDP-NPs\u5728660 nm\u548ctri<\/em>-BDP-NPs\u5728785 nm\u6fc0\u53d1\u4e0b\u8f7d660 nm\u5904\u7684\u8870\u53d8\u8ddf\u8e2a\u68c0\u6d4b\uff1b<\/p>\n \uff08c\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684di<\/em>-BDP-NPs\u6eb6\u6db2\u5728410 nm\u5904\u7684DPBF\u7684\u6807\u51c6\u5316\u5438\u5149\u5ea6\uff1b<\/p>\n \uff08d\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e09\u5206\u949f\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684tri<\/em>-BDP-NPs\u6eb6\u6db2\u5728410 nm\u5904\u7684DPBF\u7684\u6807\u51c6\u5316\u5438\u5149\u5ea6\uff1b<\/p>\n \uff08e\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684di<\/em>-BDP-NPs\u4e0b\u7684\u6e29\u5ea6\u53d8\u5316\u56fe\uff1b<\/p>\n \uff08f\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684tri<\/em>-BDP-NPs\u4e0b\u7684\u6e29\u5ea6\u53d8\u5316\u56fe\u3002<\/p>\n \u56fe\u4e94\u3001CPs\u7684\u7ec6\u80de\u5b9e\u9a8c\u00a0<\/strong><\/p>\n \uff08a\uff09 80.0 umol\/L \u7684di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs\u5206\u522b\u4e0e4T1\u7ec6\u80de\u5171\u5b75\u80b26 h, 24 h, 48 h\u540e\u7684\u7ec6\u80de\u6444\u53d6\u5b9e\u9a8c\uff1b<\/p>\n \uff08b\uff09 di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs\u57284T1\u80bf\u7624\u7ec6\u80de\u5185\u7684\u6807\u51c6\u5316\u5438\u5149\u5ea6\uff1b<\/p>\n \uff08c\uff09 \u5728660 nm\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u5242\u91cf\u7684di<\/em>-BDP-NPs\u5bf94T1\u7ec6\u80de\u7684\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n \uff08d\uff09 \u5728785 nm\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u5242\u91cf\u7684tri<\/em>-BDP-NPs\u5bf94T1\u7ec6\u80de\u7684\u6bd2\u6027\u5b9e\u9a8c\u3002<\/p>\n \uff08e\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0c1 umol\/L\u7684di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs\u4e0e4T1\u7ec6\u80de\u5171\u5b75\u80b224 h\u540e\u7684\u51cb\u4ea1\u60c5\u51b5\uff1b<\/p>\n \uff08f\uff09 \u5728785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0ctri<\/em>-BDP-NPs\u4e0e4T1\u7ec6\u80de\u5171\u5b75\u80b20.5 h\u540e\u7684CLSM\u56fe\u3002<\/p>\n \u56fe\u516d\u3001CPs\u7684\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u00a0<\/strong><\/p>\n \uff08a\uff09 di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs\u5728\u5c0f\u9f20\u4f53\u5185\u6ce8\u5c0424 h\u540e\u7684\u751f\u7269\u5206\u5e03\u56fe\uff1b<\/p>\n \uff08b\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0c\u5206\u522b\u6ce8\u5c048.0 mg\/Kg\u7684di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs 24 h\u540e\u5c0f\u9f20\u4f53\u5185\u80bf\u7624\u7684\u5347\u6e29\u60c5\u51b5\uff1b<\/p>\n \uff08c\uff09 \u5728660 nm\u6216785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0c\u5206\u522b\u6ce8\u5c048.0 mg\/Kg\u7684di<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs 24 h\u540e\u7684DHE\u67d3\u8272\u5c0f\u9f20\u80bf\u7624\u5207\u7247\uff1b<\/p>\n \uff08d\uff09 \u6709\u6216\u65e0785 nm\u5149\u7167\u5c04\u4e94\u5206\u949f\u4e0b\uff0c\u6ce8\u5c048.0 mg\/Kg\u7684 tri<\/em>-BDP-NPs\u7684\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u60c5\u51b5\uff1b<\/p>\n \uff08e\uff09 \u5b9e\u9a8c\u7ed3\u675f\u540e\u7684\u80bf\u7624\u7167\u7247\u56fe\u3002<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u7814\u7a76\u4e86\u4e00\u79cd\u57fa\u4e8eBDP\u7684CPs\u7684\u5408\u7406\u8bbe\u8ba1\uff0c\u8be5CPs\u80fd\u591f\u5728\u8fd1\u7ea2\u5916\u5149\u7167\u5c04\u4e0b\u5b9e\u73b0\u80bf\u7624\u7684\u5149\u6d88\u878d\u624b\u672f\u3002BDP\u5355\u4f53\u4e0edi<\/em>-BDP\u6216tri<\/em>-BDP\u7684\u5171\u8f6d\u8026\u5408\u5bfc\u81f4\u4e86\u4ece\u8367\u5149\u5230\u7cfb\u95f4\u8de8\u8d8a\u6216\u975e\u8f90\u5c04\u8dc3\u8fc1\u7684\u5149\u8f6c\u6362\uff0c\u5e76\u663e\u8457\u964d\u4f4e\u4e86\u8f90\u5c04\u8dc3\u8fc1\u548c\u7ea2\u79fb\u5438\u6536\u8fdb\u5165\u8fd1\u7ea2\u5916\u533a\u57df\u3002\u5728\u7eb3\u7c73\u7c92\u5b50\u5185\u7684\u5c01\u88c5\u4e2d\uff0cdi<\/em>-BDP-NPs\u548ctri<\/em>-BDP-NPs\u90fd\u5177\u6709\u5b9e\u73b0\u9ad8\u6548\u7684\u80bf\u7624\u5149\u7597\u7684\u7279\u6027\uff0c\u5305\u62ec\u589e\u5f3a\u7684\u7ec6\u80de\u6444\u53d6\u3001\u6709\u6548\u7684\u7ec6\u80de\u8d28\u6613\u4f4d\u548c\u8f83\u597d\u7684\u80bf\u7624\u79ef\u7d2f\u3002\u7531\u4e8eCPs\u5177\u6709\u660e\u663e\u7684\u7ea2\u79fb\u5438\u6536\u3001\u589e\u5f3a\u5bf9\u5149\u6f02\u767d\u7684\u62b5\u6297\u529b\u548c\u51cf\u5c11\u7f3a\u6c27\u548c\u80de\u8d28\u836f\u7269\u6613\u4f4d\u7684\u4f18\u70b9\uff0c\u4ee5\u53ca\u7ed3\u5408\u665a\u671f\u548c\u65e9\u671f\u7ec6\u80de\u51cb\u4ea1\u4f7f\u5f97\u6709\u5f88\u597d\u7684\u80bf\u7624\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u79cd\u7c7b\u578b\u7684CPs\u663e\u793a\u4e86\u8bbe\u8ba1\u51fa\u5177\u6709\u660e\u663e\u7ea2\u79fb\u5438\u6536\u7684\u9ad8\u5f3a\u5ea6\u5149\u654f\u5242\u7684\u65b0\u6f5c\u529b\uff0c\u4e14\u8fd9\u79cd\u5408\u7406\u7684\u8bbe\u8ba1\u53ef\u4ee5\u4e3a\u7cbe\u51c6\u533b\u5b66\u764c\u75c7\u5149\u7597\u534f\u540c\u63d0\u4f9b\u4e00\u4e2a\u5341\u5206\u6709\u4ef7\u503c\u7684\u8303\u4f8b\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1a<\/strong>Rational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy<\/a>\uff08Adv. Mater., 2018<\/strong>, DOI: \u00a010.1002\/adma.201801216\uff09<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1<\/strong>\u3002<\/p>\n \u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n<\/strong><\/p>\n
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