{"id":140758,"date":"2018-06-05T06:30:28","date_gmt":"2018-06-04T22:30:28","guid":{"rendered":"\/\/m.iemloyee.com\/?p=140758"},"modified":"2018-06-04T08:45:26","modified_gmt":"2018-06-04T00:45:26","slug":"adv-mater-%ef%bc%9a%e5%8f%af%e6%b3%a8%e5%b0%84%e7%94%9f%e7%89%a9%e5%93%8d%e5%ba%94%e6%80%a7%e5%87%9d%e8%83%b6%e5%ba%93%e7%94%a8%e4%ba%8e%e5%a2%9e%e5%bc%ba%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=140758","title":{"rendered":"Adv. Mater.\uff1a\u53ef\u6ce8\u5c04\u751f\u7269\u54cd\u5e94\u6027\u51dd\u80f6\u5e93\u7528\u4e8e\u589e\u5f3a\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u662f\u8fd1\u5e74\u6765\u8fc5\u901f\u53d1\u5c55\u7684\u4e00\u79cd\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u5c24\u5176\u662f\u9488\u5bf9\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f\u9014\u5f84\u3002\u76ee\u524d\uff0c\u8be5\u65b9\u6cd5\u5df2\u7ecf\u80fd\u591f\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u7684\u764c\u75c7\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u548c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7b49\u3002\u4f46\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u4e5f\u5b58\u5728\u4e00\u4e9b\u9700\u8981\u514b\u670d\u7684\u95ee\u9898\uff1a\u514d\u75ab\u5e94\u7b54\u6548\u7387\u4f4e\u548c\u5168\u8eab\u526f\u4f5c\u7528\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66<\/strong>\u7684\u987e\u81fb<\/strong>\u6559\u6388<\/strong>\u8bfe\u9898\u7ec4\u4e0e\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u7528\u5316\u5b66\u7814\u7a76\u6240\u9648\u5b66\u601d\u7814\u7a76\u5458\u3001\u8d3a\u8d85\u826f\u7814\u7a76\u5458<\/strong>\u5408\u4f5c<\/strong>\uff0c\u6784\u7b51\u4e86\u4e00\u79cdROS\u54cd\u5e94\u6027\u51dd\u80f6\u836f\u7269\u9012\u9001\u5e73\u53f0\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u7ec4\u5408\u5f0f\u764c\u75c7\u514d\u75ab\uff0c\u80fd\u591f\u6709\u6548\u6291\u5236\u514d\u75ab\u6291\u5236\u914d\u4f53PD-L1\u540c\u65f6\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a” Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade “<\/strong>\u53d1\u8868\u5728Advanced Materials<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1\u00a0<\/strong>\u751f\u7269\u523a\u6fc0<\/strong>aPD-L1<\/strong>\u548c<\/strong>D-1MT<\/strong>\u5c40\u90e8\u9012\u9001\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u805a\u591a\u80bd\u7684\u5206\u5b50\u7ed3\u6784\u548cROS\u8bf1\u53d1\u7684\u805a\u5408\u7269\u8212\u9002\u6027\u8f6c\u53d8\uff1b<\/p>\n

(B) \u5c40\u90e8\u6c34\u51dd\u80f6\u5f62\u6210\u548c\u751f\u7269\u523a\u6fc0\u836f\u7269\u91ca\u653e\u53ca\u534f\u540c\u514d\u75ab\u6cbb\u7597\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe2 \u805a\u591a\u80bd\u57fa\u6c34\u51dd\u80f6\u7684\u8868\u5f81\u7ed3\u679c<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u6c34\u4e2d\u805a\u591a\u80bd\u5f62\u6210\u80f6\u675f\u7684TEM\u56fe\u7247\u53ca\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n

(B) \u805a\u591a\u80bd\u7684\u6eb6\u80f6-\u51dd\u80f6\u8f6c\u53d8\u76f8\u56fe\u53ca\u51bb\u5e72\u51dd\u80f6\u7684SEM\u56fe\u7247\uff1b<\/p>\n

(C) \u805a\u591a\u80bd\u5f62\u6210\u51dd\u80f6\u7684\u6d41\u53d8\u6027\u80fd\u6d4b\u8bd5\uff1b<\/p>\n

(D) \u4e0d\u540c\u6761\u4ef6\u4e0b\u6eb6\u80f6-\u51dd\u80f6\u8f6c\u53d8\u7684\u7167\u7247\uff1b<\/p>\n

(E) \u805a\u591a\u80bd\u7684CD\u5149\u8c31\uff1b<\/p>\n

(F) \u805a\u591a\u80bd\u51dd\u80f6\u7684\u4f53\u5916\u964d\u89e3\u884c\u4e3a\uff1b<\/p>\n

(G) \u539f\u4f4d\u751f\u6210\u51dd\u80f6\u5728\u4f53\u5185\u964d\u89e3\u884c\u4e3a\u548c\u7ec4\u7ec7\u751f\u7269\u76f8\u5bb9\u6027\uff1b<\/p>\n

(H) PBS\u4e2dH2<\/sub>O2<\/sub>\u8bf1\u5bfc\u7684\u6c34\u51dd\u80f6\u964d\u89e3\u884c\u4e3a\uff1b<\/p>\n

(I) PBS\u4e2dH2<\/sub>O2<\/sub>\u8bf1\u5bfc\u7684IgG\u91ca\u653e\u884c\u4e3a\uff1b<\/p>\n

(J) \u4f53\u5916H2<\/sub>O2<\/sub>\u6e05\u9664\u5b9e\u9a8c\u3002<\/p>\n

\u56fe3 \u4f53\u5185\u6297\u80bf\u7624\u6548\u529b\u8bc4\u4f30<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u6e38\u79bbaPD-L1\u548c\u8d1f\u8f7daPD-L1\u7684\u51dd\u80f6\u5728\u4f53\u5185\u4e0d\u540c\u65f6\u95f4\u95f4\u9694\u5904\u7406\u6761\u4ef6\u4e0b\u7684\u80bf\u7624\u5185\u836f\u7269\u6ede\u7559\u884c\u4e3a\uff1b<\/p>\n

(B) \u9009\u5b9a\u6d4b\u8bd5\u70b9\u5904\u89c2\u5bdf\u7684B16F10\u80bf\u7624\u7684\u4f53\u5185\u751f\u7269\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(C) \u91cf\u5316\u7684\u4e2a\u4f53\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(D) \u5e73\u5747\u80bf\u7624\u4f53\u79ef\u66f2\u7ebf\uff1b<\/p>\n

(E) \u5e73\u5747\u4f53\u91cd\u66f2\u7ebf\uff1b<\/p>\n

(F) \u5404\u79cd\u6cbb\u7597\u5242\u6c34\u51dd\u80f6\u5904\u7406\u6761\u4ef6\u4e0b\u7684\u5b58\u6d3b\u66f2\u7ebf\u3002<\/p>\n

\u56fe4 \u4f53\u5185\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u663e\u793aCD8+<\/sup> T\u7ec6\u80de\u6d78\u6da6\u7684\u4ee3\u8868\u6027\u80bf\u7624\u514d\u75ab\u8367\u5149\uff1b<\/p>\n

(B) \u5728\u6cbb\u7597\u80bf\u7624\u4e2dCD45+<\/sup> T\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\uff1b<\/p>\n

(C) \u5728\u6cbb\u7597\u80bf\u7624\u4e2dCD8+<\/sup> \u548cCD4+<\/sup>T\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\uff1b<\/p>\n

(D) \u6839\u636eB\u56fe\u5f97\u5230\u7684\u80bf\u7624\u6d78\u6da6CD45+<\/sup> T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff1b<\/p>\n

(E) \u6839\u636eC\u56fe\u5f97\u5230\u7684\u80bf\u7624\u6d78\u6da6CD8+<\/sup> T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff1b<\/p>\n

(F) \u6709\u65e0\u51dd\u80f6\u5904\u740648\u5c0f\u65f6\u80bf\u7624\u5185H2<\/sub>O2<\/sub>\u6d53\u5ea6\u6d4b\u8bd5\uff1b<\/p>\n

(G) \u6839\u636eF\u56fe\u5f97\u5230\u7684\u80bf\u7624\u5185H2<\/sub>O2<\/sub>\u6d53\u5ea6\u7684\u6bd4\u4f8b\u3002<\/p>\n

\u00a0<\/strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u9488\u5bf9\u764c\u75c7\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u5b58\u5728\u7684\u514d\u75ab\u5e94\u7b54\u6548\u7387\u4f4e\u7684\u95ee\u9898\uff0c\u53d1\u5c55\u4e86\u4e00\u79cd\u7ec4\u5408\u5f0f\u514d\u75ab\u7597\u6cd5\u3002\u7814\u7a76\u8bc1\u5b9e\uff0c\u6c34\u51dd\u80f6\u4e0d\u4ec5\u80fd\u591f\u4fdd\u969cPD-L1\u548cD-1MT\u7684\u539f\u4f4d\u9012\u9001\uff0c\u8fd8\u53ef\u4ee5\u964d\u4f4e\u80bf\u7624\u5185ROS\u6c34\u5e73\u3002\u4f53\u5185\u7814\u7a76\u7ed3\u679c\u8868\u660e\u8f7d\u6709aPD-L1\u7684\u6c34\u51dd\u80f6\u53ef\u4ee5\u523a\u6fc0\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u5e76\u63d0\u9ad8\u6297\u80bf\u7624\u6548\u7387\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u591a\u80bd\u57fa\u751f\u7269\u591a\u6c34\u51dd\u80f6\u6709\u671b\u6210\u4e3a\u4ee5\u7b80\u5355\u7ed9\u836f\u65b9\u5f0f\u589e\u5f3a\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u5c40\u90e8\u836f\u7269\u9012\u9001\u5e73\u53f0\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aInjectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade<\/a>\u00a0(Adv. Mater. 2018, DOI: 10.1002\/adma.201801527)<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u5206\u5b50\u548c\u751f\u7269\u5b66\u672f\u7ec4Gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002\u6750\u6599\u725b\u7f51\u7ad9\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u53ca\u884c\u4e1a\u4ece\u4e1a\u5458\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenkefu\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c<\/strong>\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u662f\u8fd1\u5e74\u6765\u8fc5\u901f\u53d1\u5c55\u7684\u4e00\u79cd\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u5c24\u5176\u662f\u9488\u5bf9\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f\u9014\u5f84\u3002\u76ee\u524d\uff0c\u8be5\u65b9\u6cd5\u5df2\u7ecf\u80fd\u591f\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u7684\u764c\u75c7…<\/p>\n","protected":false},"author":7746,"featured_media":140759,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2600,3256,2805],"class_list":["post-140758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-2600","tag-3256","tag-2805"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/140758"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7746"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=140758"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/140758\/revisions"}],"predecessor-version":[{"id":141368,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/140758\/revisions\/141368"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/140759"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=140758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=140758"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=140758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}