{"id":140264,"date":"2018-05-29T06:30:51","date_gmt":"2018-05-28T22:30:51","guid":{"rendered":"\/\/m.iemloyee.com\/?p=140264"},"modified":"2018-05-27T21:13:10","modified_gmt":"2018-05-27T13:13:10","slug":"nat-mater-%ef%bc%9a%e5%8f%8c%e5%8a%9f%e8%83%bd%e5%8f%af%e6%b3%a8%e5%b0%84%e8%a1%80%e7%ae%a1%e7%94%9f%e6%88%90%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e7%94%a8%e4%ba%8e%e4%b8%ad%e9%a3%8e%e8%84%91%e7%bb%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=140264","title":{"rendered":"Nat. Mater.\uff1a\u53cc\u529f\u80fd\u53ef\u6ce8\u5c04\u8840\u7ba1\u751f\u6210\u751f\u7269\u6750\u6599\u7528\u4e8e\u4e2d\u98ce\u8111\u7ec4\u7ec7\u4fee\u590d"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u4e2d\u98ce\u662f\u5bfc\u81f4\u5927\u8111\u635f\u4f24\u7684\u91cd\u8981\u539f\u56e0\uff0c\u800c\u4e14\u8840\u7ba1\u751f\u6210\u548c\u795e\u7ecf\u5143\u751f\u957f\u53d7\u5230\u4e25\u91cd\u9650\u5236\uff0c\u5bfc\u81f4\u5927\u8111\u53d7\u635f\u7ec4\u7ec7\u518d\u751f\u7684\u80fd\u529b\u6709\u9650\u3002\u4e2d\u98ce\u540e\uff0c\u708e\u75c7\u548c\u514d\u75ab\u53cd\u5e94\u5219\u4f1a\u8fdb\u4e00\u6b65\u5728\u6b63\u5e38\u8111\u7ec4\u7ec7\u4e2d\u4ea7\u751f\u4e2d\u98ce\u8154\u3002\u76ee\u524d\uff0c\u6cbb\u7597\u6027\u7684\u8840\u7ba1\u751f\u6210\u6750\u6599\u5df2\u7ecf\u7528\u4e8e\u5728\u635f\u4f24\u8111\u7ec4\u7ec7\u5904\u5f62\u6210\u8840\u7ba1\u7f51\u7edc\u6765\u4fee\u590d\u7f3a\u8840\u7ec4\u7ec7\u3002 \u7136\u800c\uff0c\u6cbb\u7597\u6027\u8840\u7ba1\u751f\u6210\u6750\u6599\u80fd\u5426\u5b9e\u73b0\u8111\u7ec4\u7ec7\u518d\u751f\u5e76\u4fc3\u8fdb\u795e\u7ecf\u4fee\u590d\u5374\u7814\u7a76\u751a\u5c11\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821<\/strong>\u7684S. Thomas Carmichael<\/strong>\u6559\u6388<\/strong>\u8bfe\u9898\u7ec4\u4e0e\u7f8e\u56fd\u675c\u514b\u5927\u5b66<\/strong>Tatiana Segura<\/strong>\u6559\u6388\u5408\u4f5c<\/strong>\uff0c\u5c06\u8d1f\u8f7d\u6709\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u6c34\u51dd\u80f6\u6ce8\u5c04\u5230\u4e2d\u98ce\u8154\u5185\uff0c\u4ece\u800c\u8bf1\u5bfc\u5f62\u6210\u4e86\u8840\u7ba1\u548c\u795e\u7ecf\u5143\uff0c\u5e76\u4e14\u6cbf\u7740\u8840\u7ba1\u751f\u6210\u4e86\u8f74\u7a81\u7f51\u7edc\u7ed3\u6784\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e9b\u8f74\u7a81\u7f51\u7edc\u80fd\u591f\u4fc3\u4f7f\u4e2d\u98ce\u53d7\u635f\u8111\u7ec4\u7ec7\u7684\u4fee\u590d\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a” Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke “<\/strong>\u53d1\u8868\u5728Nature Materials<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1<\/strong>\u4e2d\u98ce\u540e\u8840\u7ba1\u751f\u6210\u53cd\u5e94\u548c\u8840\u7ba1\u91cd\u5851<\/strong><\/p>\n

\"\"<\/p>\n

(a) DAPI\u67d3\u8272\u7684Glut-1\u8840\u7ba1\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(b) BrdU\u67d3\u8272\u7684Glut-1\u8840\u7ba1\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(c) PDGFR-\u03b2\u67d3\u8272\u7684Glut-1\u8840\u7ba1\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(d) \u5728\u6897\u585e\u5904\u548c\u6897\u585e\u5468\u56f4\u533a\u57df\u8840\u7ba1\u5bc6\u5ea6\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(e) \u5728\u6897\u585e\u5904\u548c\u6897\u585e\u5468\u56f4\u533a\u57df\u8840\u7ba1\u751f\u6210\u3002<\/p>\n

\u56fe<\/strong>2 <\/strong>\u4e2d\u98ce\u540e\u957f\u671f\u8840\u7ba1\u751f\u957f<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u51dd\u80f6\u79fb\u690d16\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u8840\u7ba1\u7684\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(b) \u4e2d\u98ce\u4f4d\u7f6e\u548c\u5468\u56f4\u533a\u57df\u8840\u7ba1\u5bc6\u5ea6\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(c) \u8840\u7ba1\u5f62\u8c8c\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(d) \u8840\u7ba1\u652f\u5316\u751f\u4ea7\u7684\u5b9a\u91cf\u7edf\u8ba1\u3002<\/p>\n

\u56fe3 \u4e2d\u98ce\u540e\u795e\u7ecf\u4ea7\u751f\u548c\u8f74\u7a81\u53d1\u82bd<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u51dd\u80f6\u79fb\u690d\u540e\u6210\u795e\u7ecf\u7ec6\u80de\uff08Dcx\uff09\u548c\u589e\u6b96\u6807\u8bb0\u7269BrdU\u7684\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(b) \u51dd\u80f6\u79fb\u690d2\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u548c\u5468\u56f4\u533a\u57df\u7684\u8f74\u7d22\u795e\u7ecf\u4e1d\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(c) \u540c\u4fa7\u8111\u5ba4\u4e2d\u6210\u795e\u7ecf\u7ec6\u80de\u548c\u589e\u6b96\u6210\u795e\u7ecf\u7ec6\u80de\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(d) \u8fc1\u79fb\u7684\u6210\u795e\u7ecf\u7ec6\u80de\u6570\u53ca\u5176\u8fc1\u79fb\u8ddd\u79bb\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(e) \u4e2d\u98ce\u4f4d\u7f6e\u548c\u5468\u56f4\u533a\u57df\u8f74\u7a81\u533a\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(f) \u4e2d\u98ce\u4f4d\u7f6e\u6e17\u900f\u8ddd\u79bb\u548c\u7a7f\u900f\u89d2\u5ea6\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(g) \u51dd\u80f6\u79fb\u690d16\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u548c\u5468\u56f4\u533a\u57df\u7684\u8f74\u7d22\u795e\u7ecf\u4e1d\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(h) \u51dd\u80f6\u6ce8\u5c0416\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u8f74\u7a81\u533a\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(i) \u51dd\u80f6\u6ce8\u5c0416\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u5468\u56f4\u533a\u57df\u8f74\u7a81\u533a\u7684\u5b9a\u91cf\u7edf\u8ba1<\/p>\n

(j) \u51dd\u80f6\u6ce8\u5c0416\u5468\u540e\u6e17\u900f\u8ddd\u79bb\u7684\u5b9a\u91cf\u7edf\u8ba1\uff1b<\/p>\n

(k) \u51dd\u80f6\u6ce8\u5c0416\u5468\u540e\u8f74\u7a81\u7a7f\u900f\u89d2\u7684\u5b9a\u91cf\u7edf\u8ba1\u3002<\/p>\n

\u56fe<\/strong>4 <\/strong>\u75c5\u53d8\u90e8\u4f4d\u8840\u7ba1\u4e0e\u8f74\u7d22\u7f51\u7edc\u4e4b\u95f4\u7684\u5173\u8054<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u51dd\u80f6\u79fb\u690d16\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u548c\u5468\u56f4\u533a\u57df\u8840\u7ba1\u548c\u8f74\u7d22\u795e\u7ecf\u4e1d\u7684\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(b) \u901a\u8fc7\u7edf\u8ba1\u8840\u7ba1\u4e0aNF-200\u9633\u6027\u4fe1\u53f7\u6765\u5b9a\u91cf\u8bc4\u4f30\u4e24\u4e2a\u7f51\u7edc\u4e4b\u95f4\u7684\u63a5\u8fd1\u5ea6\uff1b<\/p>\n

(c) \u901a\u8fc7\u7edf\u8ba1\u8840\u7ba150\u5fae\u7c73\u8ddd\u79bb\u5904NF-200\u9633\u6027\u533a\u57df\u6765\u5b9a\u91cf\u8bc4\u4f30\u4e24\u4e2a\u7f51\u7edc\u4e4b\u95f4\u7684\u63a5\u8fd1\u5ea6\uff1b<\/p>\n

(d) \u51dd\u80f6\u79fb\u690d16\u5468\u540e\u5728\u540c\u4fa7\u534a\u7403\u6ce8\u5c04\u51dd\u80f6\u548chcV\u7684\u5c0f\u9f20\u4e2d\u6897\u585e\u5468\u56f4\u661f\u5f62\u7ec6\u80de\u7622\u75d5\u548cBDA\u8ffd\u8e2a\u795e\u7ecf\u5143\u7684\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(e) hcV\u5904\u7406\u7684\u5c0f\u9f20\u7ecf\u51dd\u80f6\u79fb\u690d16\u5468\u540e\u5728\u4e2d\u98ce\u4f4d\u7f6e\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7528\u8840\u7ba1\u548c\u5e73\u6ed1\u808c\u7ec6\u80de\u5171\u67d3\u8272\u7684\u56fe\u7247\uff1b<\/p>\n

(f) hcV\u5904\u7406\u7684\u5c0f\u9f20\u7ecf\u51dd\u80f6\u79fb\u690d16\u5468\u540e\u5728\u4e2d\u98ce\u4f4d\u7f6e\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7528\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7ec8\u672b\u8db3\u67d3\u8272\u7684\u8367\u5149\u56fe\u7247\u3002<\/p>\n

\u56fe5 \u4e2d\u98ce\u540e\u795e\u7ecf\u6062\u590d<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u884c\u4e3a\u6d4b\u8bd5\u7684\u5b9e\u9a8c\u65f6\u95f4\u7ebf\uff1b<\/p>\n

(b) \u6c14\u7f38\u3001\u7f51\u683c\u548c\u9762\u98df\u6d4b\u8bd5\uff1b<\/p>\n

(c) \u51dd\u80f6\u6ce8\u5c04\u540e10\u5929\u5e76\u7ed9\u836f\u540e\u6c14\u7f38\u3001\u7f51\u683c\u548c\u9762\u98df\u6d4b\u8bd5\uff1b<\/p>\n

(d) \u786e\u5b9a\u51dd\u80f6\u548c hcV\u8bf1\u5bfc\u7684\u8f74\u7a81\u751f\u957f\u5bf9\u795e\u7ecf\u6062\u590d\u7684\u5f71\u54cd\u5b9e\u9a8c\u3002<\/p>\n

\u56fe<\/strong>6 <\/strong>\u4e2d\u98ce<\/strong>2<\/strong>\u5468\u540e\u5728<\/strong>hcV<\/strong>\u6cbb\u7597\u4e2d\u88f8\u809d\u7d20\u9897\u7c92\u7684\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e2d\u98ce2\u5468\u540e\u4e2d\u98ce\u4f4d\u7f6e\u548c\u5468\u56f4\u533a\u57df\u8840\u7ba1\u3001\u661f\u5f62\u7ec6\u80de\u7622\u75d5\u3001\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u8f74\u7a81\u795e\u7ecf\u4e1d\u7684\u8367\u5149\u56fe\u7247\uff1b<\/p>\n

(b) \u6897\u585e\u548c\u6897\u585e\u5468\u56f4\u533a\u57df\u7684\u8840\u7ba1\u9762\u79ef\u7684\u5b9a\u91cf\u8bc4\u4f30\uff1b<\/p>\n

(c) \u6897\u585e\u548c\u6897\u585e\u5468\u56f4\u533a\u57df\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u9762\u79ef\u7684\u5b9a\u91cf\u8bc4\u4f30\uff1b<\/p>\n

(d) \u6897\u585e\u548c\u6897\u585e\u5468\u56f4\u533a\u57df\u7684\u8f74\u7a81\u533a\u9762\u79ef\u7684\u5b9a\u91cf\u8bc4\u4f30\uff1b<\/p>\n

(e) \u6897\u585e\u548c\u6897\u585e\u5468\u56f4\u533a\u57df\u7684\u8f74\u7a81\u6d78\u6da6\u8ddd\u79bb\u548c\u661f\u5f62\u7ec6\u80de\u75a4\u75d5\u7684\u5b9a\u91cf\u8bc4\u4f30\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u62a5\u9053\u4e86\u4e0e\u4f20\u7edf\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u5728\u5927\u8111\u4e2d\u9012\u9001\u4e0d\u540c\u7684\u7814\u7a76\uff0c\u53d1\u73b0\u6c34\u51dd\u80f6\u4e2d\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u4ee5\u805a\u96c6\u7eb3\u7c73\u9897\u7c92\u5b58\u5728\uff0c\u80fd\u591f\u4fc3\u8fdb\u8840\u7ba1\u5316\u53d1\u80b2\uff0c\u6b64\u5916\u6c34\u51dd\u80f6\u8fd8\u4fc3\u8fdb\u8840\u7ba1\u5411\u5185\u751f\u957f\u8fdb\u5165\u6897\u585e\u8154\u5e76\u4ea7\u751f\u8f74\u7a81\u7f51\u7edc\u3002\u56e0\u800c\uff0c\u53ef\u4ee5\u5b9e\u73b0\u534f\u540c\u7684\u8840\u7ba1\u548c\u8f74\u7a81\u751f\u4ea7\u7684\u795e\u7ecf\u7ec4\u7ec7\u4fee\u590d\u8fc7\u7a0b\u3002\u53ef\u89c1\uff0c\u5229\u7528\u751f\u7269\u6750\u6599\u65b9\u6cd5\u80fd\u591f\u5728\u5df2\u7ecf\u6b7b\u4ea1\u7684\u7ec4\u7ec7\u5185\u4ea7\u751f\u518d\u751f\u795e\u7ecf\u5143\u8fde\u63a5\u7684\u8840\u7ba1\u5316\u7f51\u7edc\uff0c\u5e76\u4e14\u4e3a\u4f7f\u7528\u8840\u7ba1\u751f\u6210\u6750\u6599\u4fee\u590d\u5176\u4ed6\u795e\u7ecf\u75c5\u53d8\u7ec4\u7ec7\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aDual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke<\/a>\u00a0(Nat. Mater. 2018, DOI: 10.1038\/s41563-018-0083-8)<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u5206\u5b50\u548c\u751f\u7269\u5b66\u672f\u7ec4Gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002\u6750\u6599\u725b\u7f51\u7ad9\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u53ca\u884c\u4e1a\u4ece\u4e1a\u5458\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

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