{"id":140100,"date":"2018-05-28T14:00:24","date_gmt":"2018-05-28T06:00:24","guid":{"rendered":"\/\/m.iemloyee.com\/?p=140100"},"modified":"2018-05-27T16:42:28","modified_gmt":"2018-05-27T08:42:28","slug":"acs-nano-%e8%82%bf%e7%98%a4%e7%bb%86%e8%83%9e%e8%86%9c%e6%b6%82%e5%b1%82%e8%be%85%e5%8a%a9%e7%9a%84%e7%94%98%e9%9c%b2%e7%b3%96%e4%bf%ae%e9%a5%b0%e7%9a%84%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%ef%bc%8c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=140100","title":{"rendered":"ACS Nano: \u80bf\u7624\u7ec6\u80de\u819c\u6d82\u5c42\u8f85\u52a9\u7684\u7518\u9732\u7cd6\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\uff0c\u7528\u4e8e\u6709\u6548\u7684\u6297\u80bf\u7624\u75ab\u82d7\u63a5\u79cd"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u8fd1\u4e9b\u5e74\u6765\uff0c\u80bf\u7624\u9884\u9632\u548c\u80bf\u7624\u75ab\u82d7\u6cbb\u7597\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u5f15\u8d77\u4e86\u5e7f\u5927\u7814\u7a76\u8005\u6781\u5927\u7684\u5174\u8da3\u3002\u901a\u8fc7\u5229\u7528\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u800c\u4e0d\u662f\u7ec6\u80de\u6bd2\u6027\u836f\u7269\uff08\u5982\u5316\u7597\uff09\u6765\u8bc6\u522b\u548c\u7834\u574f\u764c\u7ec6\u80de\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7ecf\u5e38\u8868\u73b0\u51fa\u9ad8\u7279\u5f02\u6027\u548c\u4f4e\u6bd2\u6027\uff0c\u4ee5\u6839\u9664\u80bf\u7624\u5e76\u9632\u6b62\u80bf\u7624\u590d\u53d1\u3002\u76ee\u524d\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u5982\u764c\u75c7\u75ab\u82d7\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u514d\u75ab\u7597\u6cd5\u3001\u517b\u751f\u7ec6\u80de\u7597\u6cd5\uff08CAR-T\uff09\uff0c\u5728\u6cbb\u7597\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\u5df2\u7ecf\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u6548\u679c\u3002\u7136\u800c\uff0c\u5728\u4e0d\u540c\u79cd\u7c7b\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u4e2d\uff0c\u764c\u75c7\u75ab\u82d7\u7684\u7279\u70b9\u662f\u5177\u6709\u76f8\u5bf9\u8f83\u4f4e\u7684\u6210\u672c\u548c\u8f83\u9ad8\u7684\u7279\u5f02\u6027\u653b\u51fb\u80bf\u7624\u7ec6\u80de\u8868\u73b0\u4f4e\u526f\u4f5c\u7528\uff0c\u5177\u6709\u5f88\u5927\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u82cf\u5dde\u5927\u5b66\u7684\u5218\u5e84\u6559\u6388\u3001\u5f6d\u777f\u6559\u6388\u548c\u8bb8\u5229\u8015\u8001\u5e08\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u4e00\u79cd\u5c06\u514d\u75ab\u8f85\u52a9\u5242\u7eb3\u7c73\u9897\u7c92\u5c01\u88c5\u5728\u7518\u9732\u7cd6\u4fee\u9970\u7684\u764c\u7ec6\u80de\u819c\u4e0a\uff0c\u4ee5\u6784\u5efa\u764c\u75c7\u75ab\u82d7\u7684\u65b9\u6cd5\u3002\u9996\u5148\uff0c\u5c06PLGA\u7eb3\u7c73\u7c92\u5b50\u52a0\u8f7d\u5728toll\u6837\u53d7\u4f537\u62ee\u6297\u5242\u548cR837\u3002\u8fd9\u4e9b\u8f85\u52a9\u5242\u7eb3\u7c73\u9897\u7c92\uff08NP-R\uff09\u88ab\u6d82\u4e0a\u4e86\u764c\u7ec6\u80de\u819c\uff08NP-R@M\uff09,\u5176\u8868\u9762\u86cb\u767d\u53ef\u4ee5\u4f5c\u4e3a\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u3002\u901a\u8fc7\u5bf9NP-R@M-M\u7684\u8fdb\u4e00\u6b65\u4fee\u9970\uff0c\u83b7\u5f97\u7684\u7eb3\u7c73\u75ab\u82d7\u663e\u793a\u4e86\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08\u5982\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\uff09\u7684\u589e\u5f3a\u5438\u6536\uff0c\u8fdb\u800c\u523a\u6fc0\u5176\u6210\u719f\u72b6\u6001\uff0c\u4ece\u800c\u89e6\u53d1\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u968f\u7740\u9884\u9632\u514d\u75ab\u7684\u53d1\u5c55\uff0c\u5c06\u80bf\u7624\u7684\u53d1\u5c55\u4f5c\u4e3a\u4e00\u79cd\u9884\u9632\u75ab\u82d7\u7684\u6709\u6548\u624b\u6bb5\uff0c\u4e0eNP-R@M-M\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u5176\u6cbb\u7597\u80bf\u7624\u7684\u7597\u6548\u3002\u56e0\u6b64\uff0c\u8be5\u7814\u7a76\u63d0\u51fa\u7684\u4e00\u79cd\u521b\u65b0\u7684\u65b9\u6cd5\u5236\u5907\u51fa\u6765\u7684\u764c\u75c7\u7eb3\u7c73\u75ab\u82d7\uff0c\u5728\u539f\u5219\u4e0a\u662f\u53ef\u4ee5\u9002\u7528\u4e8e\u5e7f\u6cdb\u7684\u80bf\u7624\u7c7b\u578b\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cCancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>ACS Nano<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u8d1f\u8f7dR873\u548c\u7518\u9732\u7cd6\u4fee\u9970\u7684PLGA NPs(NP-R@M-M)\u53ca\u80bf\u7624\u7ec6\u80de\u819c\u7684\u7ed3\u6784<\/strong>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-140101\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/1-64.jpg\" alt=\"\" width=\"600\" height=\"426\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/1-64.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/1-64-300x213.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e8c\u3001\u7eb3\u7c73\u75ab\u82d7\u7684\u5236\u5907\u53ca\u8868\u5f81<\/strong>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-140102\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/2-67.jpg\" alt=\"\" width=\"600\" height=\"377\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/2-67.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/2-67-300x189.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09 NP-R@M-M\u7eb3\u7c73\u75ab\u82d7\u9010\u6b65\u5236\u5907\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 NP@M\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe\uff1b<\/p>\n<p>\uff08c\uff09 \u7531BCA\u5206\u6790\u786e\u5b9aPLGA NPs\u3001NP-R\u3001NP@M\u3001NP-R@M\u548cNP-R@M- M\u6837\u54c1\u7684\u86cb\u767d\u8d28\u542b\u91cf\uff1b<\/p>\n<p>\uff08d\uff09 \u7531\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u6d4b\u91cf\u7684PLGA NPs\u3001NP-R\u3001NP@M\u3001NP-R@M\u548cNP-R@M- M\u7684\u6c34\u52a8\u529b\u5927\u5c0f\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001BMDCs \u5bf9\u7eb3\u7c73\u75ab\u82d7\u7684\u7ec6\u80de\u5438\u6536\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-140103\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/3-59.jpg\" alt=\"\" width=\"600\" height=\"529\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/3-59.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/3-59-300x265.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u7528BMDCs\u5728\u4f53\u5916\u5bf9\u5df2\u8d1f\u8f7d\u7684NP@M\u548cNP@M-M\u7684\u6444\u53d6\uff1b<\/p>\n<p>\uff08b\uff09 \u7ec6\u80de\u6444\u53d6\u80fd\u529b\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n<p>\uff08c\uff09 \u7528NP@M\u548cNP@M-M\u5904\u7406\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001\u7eb3\u7c73\u75ab\u82d7\u7684\u4f53\u5916DCs\u6d3b\u5316\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-140104\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/4-61.jpg\" alt=\"\" width=\"600\" height=\"493\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/4-61.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/4-61-300x247.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u4e0d\u540c\u914d\u65b9\u7684NPs\u8bf1\u5bfc\u7684DC\u6210\u719f\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u4ee3\u8868\u6027\u6570\u636e\uff1b<\/p>\n<p>\uff08b\uff09 \u4e0d\u540c\u914d\u65b9\u7684NPs\u8bf1\u5bfc\u7684DC\u6210\u719f\u7684\u7edf\u8ba1\u6570\u636e\uff1b<\/p>\n<p>\uff08c\uff09 \u4e0d\u540c\u7684NP\u914d\u65b9\u6cbb\u7597DCs\u7684IL-12\u7684\u5206\u6ccc\u7269\uff1b<\/p>\n<p>\uff08d\uff09 \u4e0d\u540c\u7684NP\u914d\u65b9\u6cbb\u7597DCs\u7684TNF-\u03b1\uff08d\uff09\u7684\u5206\u6ccc\u7269\u3002<\/p>\n<p><strong>\u56fe\u4e94\u3001\u4f53\u5185\u5916\u8367\u5149\u6210\u50cf\u663e\u793a\u6dcb\u5df4\u7ed3\u4fdd\u7559\u7684\u7eb3\u7c73\u75ab\u82d7\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-140105\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/5-45.jpg\" alt=\"\" width=\"600\" height=\"435\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/5-45.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/5-45-300x218.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u5728\u76ae\u5185\u6ce8\u5c04\u540e\u57283\u4e2a\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5c0f\u9f20\u4f53\u5185\u8367\u5149\u56fe\u50cf\u7684\u4ee3\u8868\uff0c\u5728\u5176\u540e\u80a2\u4e0a\u6807\u8bb0\u4e3aNP-R@M\u6216NP-R@M-M\uff1b<\/p>\n<p>\uff08b\uff09 \u57fa\u4e8e\uff08a\uff09\u7684\u6d3b\u4f53\u6210\u50cf\u6570\u636e\u7684\u5f15\u6d41\u6dcb\u5df4\u7ed3\u7684\u5b9a\u91cf\u8367\u5149\u4fe1\u53f7\uff1b<\/p>\n<p>\uff08c\uff09 \u76ae\u5185\u6ce8\u5c04\u7eb3\u7c73\u9897\u7c92\u540e6\u5c0f\u65f6\u5185\u5206\u79bb\u6dcb\u5df4\u7ed3\u7684\u4f53\u5916\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n<p>\uff08d\uff09 \u57fa\u4e8e\uff08c\uff09\u5206\u79bb\u5f15\u6d41\u6dcb\u5df4\u7ed3(\u5de6)\u8367\u5149\u4fe1\u53f7\u7684\u91cf\u5316\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001\u5404\u79cdNP\u5236\u5242\u7684\u6297\u80bf\u7624\u6d3b\u6027\u4f5c\u4e3a\u9884\u9632\u75ab\u82d7\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-140106\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/6-23.jpg\" alt=\"\" width=\"600\" height=\"610\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/6-23.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/05\/6-23-295x300.jpg 295w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u80bf\u7624\u6311\u6218\u5b9e\u9a8c\u8bbe\u8ba1\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 B16-OVA\u80bf\u7624\u751f\u957f\u5728\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u548c\u4e0d\u540c\u9884\u5904\u7406\u540eNP\u914d\u65b9(n\u22655 * P &lt; 0.05)\uff1b<\/p>\n<p>\uff08c\uff09 \u7528B16-OVA\u7ec6\u80de\u819c\u5236\u5907\u7684NP-R@M-M\u5bf9\u5c0f\u9f204T1\u4e73\u817a\u764c\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08d\uff09 \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\u68c0\u6d4b\u7ec6\u80de\u5185\u6297\u539f\u67d3\u8272\u7684\u6240\u6709T\u7ec6\u80de\u4e2dCD107a\u9633\u6027\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n<p>\uff08e\uff09 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-1\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u65f6\u6709\u6548\u5730\u5bf9\u6297\u9ed1\u8272\u7d20\u7624\u7684\u8fdb\u5c55\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u79cd\u8584\u819c\u6d82\u5c42\u7684\u7eb3\u7c73\u75ab\u82d7\u4f7f\u7528\u7684\u6240\u6709\u6750\u6599\u90fd\u662f\u5b8c\u5168\u751f\u7269\u76f8\u5bb9\u6027\u7684\uff0c\u56e0\u800c\u6709\u7740\u5de8\u5927\u7684\u4e34\u5e8a\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.7b09041\" target=\"_blank\" rel=\"noopener\">Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination<\/a>\uff08ACS Nano, 2018, DOI: 10.1021\/acsnano.7b09041\uff09<\/p>\n<p><strong>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1<\/strong>\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 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