{"id":139644,"date":"2018-05-23T06:30:11","date_gmt":"2018-05-22T22:30:11","guid":{"rendered":"\/\/m.iemloyee.com\/?p=139644"},"modified":"2018-05-22T12:20:52","modified_gmt":"2018-05-22T04:20:52","slug":"%e4%b8%ad%e5%9b%bd%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%ad%a6nature-nanotechnology-%e5%9f%ba%e4%ba%8e%e5%b2%a9%e8%97%bb%e5%a4%9a%e7%b3%96%e7%9a%84%e7%a3%81%e6%80%a7%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=139644","title":{"rendered":"\u4e2d\u56fd\u533b\u79d1\u5927\u5b66Nature Nanotechnology: \u57fa\u4e8e\u5ca9\u85fb\u591a\u7cd6\u7684\u78c1\u6027\u7eb3\u7c73\u7c92\u5b50\u548c\u514d\u75ab\u8c03\u8282\u5242\u7684\u7ed3\u5408\u589e\u5f3a\u80bf\u7624\u5b9a\u4f4d\u514d\u75ab\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u533b\u79d1\u5927\u5b66<\/b><\/strong>\u7684San-Yuan Chen<\/b><\/strong>\u6559\u6388<\/b><\/strong>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u5ca9\u85fb\u591a\u7cd6\u7684\u78c1\u6027\u7eb3\u7c73\u836f\u7269(IO@FuDex3),\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(anti-PD-L1)\u548cT\u7ec6\u80de\u6fc0\u6d3b\u5242(anti-CD3\u548canti-CD28)\u76f8\u8fde\u3002IO@FuDex3\u53ef\u4ee5\u901a\u8fc7\u632f\u4f5c\u80bf\u7624\u6d78\u6da6\u7684\u6dcb\u5df4\u7ec6\u80de\u6765\u4fee\u590d\u6291\u5236\u514d\u75ab\u7684\u80bf\u7624\u5fae\u73af\u5883\uff0c\u540c\u65f6\u901a\u8fc7\u78c1\u6027\u5bfc\u5411\u80bf\u7624\u7684\u9776\u5411\u7eb3\u7c73\u836f\u7269\u6765\u589e\u52a0\u9776\u5411\u6027\u3002\u901a\u8fc7IO@FuDex3\u4e0e\u78c1\u6027\u5bfc\u5411\u7684\u7ed3\u5408\u6cbb\u7597\uff0c\u964d\u4f4e\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7684\u6982\u7387\uff0c\u6269\u592732-63\u5929\u7684\u5b58\u6d3b\u7387\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Combination of Fucoidan-Based Magnetic Nanoparticles and Immunomodulators Enhances Tumour-Localized Immunotheray<\/b><\/strong>“\u53d1\u8868\u5728Na<\/b><\/strong>ture Nanotechnology<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1<\/b><\/strong>.<\/b><\/strong>\u00a0<\/b><\/strong>IO@FuDex<\/b><\/strong>\u7684<\/b><\/strong>\u8868\u5f81<\/b><\/strong><\/p>\n

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\u56fe<\/b><\/strong>2<\/b><\/strong>.<\/b><\/strong>\u00a0\u5404\u79cdIO@FuDex\u5bf94T1\u7ec6\u80de\u548cCD8+ T\u7ec6\u80de\u7684\u9776\u5411\u80fd\u529b\u548c\u7ec6\u80de\u76f8\u5173\u884c\u4e3a<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>. <\/b><\/strong>\u78c1\u6027\u5bfc\u5411\u653e\u5927<\/b><\/strong>\u7eb3\u7c73<\/b><\/strong>\u836f\u7269\u5728\u80bf\u7624\u4e2d\u7684\u805a\u96c6\u6548\u679c<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u00a0125<\/sup>I\u6807\u8bb0\u7684IO@FuDex\u6216\u8005IO@FuDex3<\/sup>\u5728\u6ce8\u5165\u8001\u9f200,3,6,12\u548c24\u5c0f\u65f6\u540e\u7684\u65f6\u95f4\u6d3b\u6027\u66f2\u7ebf\uff1b<\/p>\n

(b).\u00a0125<\/sup>I\u6807\u8bb0\u7684IO@FuDex\u6216\u8005IO@FuDex3<\/sup>\u6ce8\u5165\u8001\u9f2024\u5c0f\u65f6\u540e\u7684\u751f\u7269\u4f53\u5206\u5e03\uff1b<\/p>\n

(c).\u00a0\u7ecf\u8fc7\u6ce8\u5c0424\u5c0f\u65f6\u540e\u7684\u5168\u8eabCT\u6210\u50cf\uff1b<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>. <\/b><\/strong>\u5404\u79cdIO@FuDex\u57284T1\u548cCT-26\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u6291\u5236\u548c\u6297\u8f6c\u79fb\u4f5c\u7528<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u00a0IO@FuDex\u5904\u7406\u8868\u8fbe\u8367\u5149\u7d20\u9176\u76844T1\u80bf\u7624\u56db\u5468\u540e\u7684IVIS\u6210\u50cf\uff1b<\/p>\n

(b,c). \u5728\u4e0d\u540cIO@FuDex\u5904\u7406\u8001\u9f20\u540e\u7684\u80bf\u7624\u4f53\u79ef\u548c\u5b58\u6d3b\u7387\u53d8\u5316\uff1b<\/p>\n

(d). \u80bf\u7624\u548c\u80ba\u7684\u56fe\u7247\uff1b<\/p>\n

(e). \u7ecf\u8fc7\u5904\u7406\u540e\uff0c\u80ba\u90e8\u7624\u6570\u76ee\u7684\u53d8\u5316\uff1b<\/p>\n

(f). \u7ecf\u8fc7\u4e00\u7cfb\u5217\u5904\u7406\u540e\uff0c\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

(g). \u79fb\u690d\u80bf\u7624\u540e\uff0cCT-26\u80bf\u7624\u7684IVIS\u6210\u50cf\uff1b<\/p>\n

(h,i). \u7ecf\u8fc7IO@FuDex\u5904\u7406\u540e\u7684\u80bf\u7624\u4f53\u79ef\u548c\u5c0f\u9f20\u5b58\u6d3b\u7387\u53d8\u5316\uff1b<\/p>\n

\u56fe<\/b><\/strong>5<\/b><\/strong>. <\/b><\/strong>\u80bf\u7624\u63a5\u79cd\u56db\u5468\u4ee5\u540eTILs\u548c\u7ec6\u80de\u6fc0\u7d20\u7684\u53d8\u5316<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a,b).IO@FuDex\u5904\u7406\u540e<\/p>\n

(c,d).\u6297\u80bf\u7624\u751f\u957f\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11<\/p>\n

(e,f).IO@FuDex\u5904\u7406\u540e\uff0c\u8868\u8fbeKi67\u548c\u8868\u8fbegranzyme B (Grb)\u7684TILs\u6570\u91cf\u589e\u52a0\uff1b<\/p>\n

\u56fe<\/b><\/strong>6<\/b><\/strong>. <\/b><\/strong>\u5168\u8eab\u4f5c\u7528\u548cirAEs\u8bc4\u5b9a<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aCombination of Fucoidan-Based Magnetic Nanoparticles and Immunomodulators Enhances Tumour-Localized Immunotheray<\/a>(Nat. Nanotech. 2018, DOI: 10.1038\/s41565-018-0146-7)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/strong><\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\uff0c\u6211\u4eec\u4f1a\u9080\u8bf7\u5404\u4f4d\u8001\u5e08\u52a0\u5165\u4e13\u5bb6\u7fa4\u3002 \u00a0<\/p>\n

\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u4ee5\u963b\u585e\u514d\u75ab\u7ec6\u80de\u7684\u8c03\u63a7\u901a\u8def\uff0c\u5728\u6297\u764c\u6d3b\u52a8\u4e2d\u6709\u5341\u5206\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5728\u4e24\u79cd\u53ef\u884c\u7684\u68c0\u67e5\u70b9\u514d\u75ab\u7597\u6cd5\u4e2d\uff0cPD-1-PD-L1\u7684\u963b\u585e\u76f8\u5bf9\u4e8eanti-CT…<\/p>\n","protected":false},"author":7336,"featured_media":139645,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75,33],"class_list":["post-139644","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial","tag-nano"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/139644"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=139644"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/139644\/revisions"}],"predecessor-version":[{"id":139813,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/139644\/revisions\/139813"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/139645"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=139644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=139644"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=139644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}