{"id":139219,"date":"2018-05-19T14:00:46","date_gmt":"2018-05-19T06:00:46","guid":{"rendered":"\/\/m.iemloyee.com\/?p=139219"},"modified":"2018-05-17T18:00:26","modified_gmt":"2018-05-17T10:00:26","slug":"%e9%95%bf%e6%98%a5%e5%ba%94%e5%8c%96%e6%89%80%e5%bc%a0%e6%b4%aa%e6%9d%b0%e9%99%a2%e5%a3%abacs-nano-%e4%b8%80%e4%bd%93%e5%8c%96%e7%ba%b3%e7%b1%b3%e6%b4%bb%e6%80%a7%e5%89%82","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=139219","title":{"rendered":"\u957f\u6625\u5e94\u5316\u6240\u5f20\u6d2a\u6770\u9662\u58ebACS Nano: \u201c\u4e00\u4f53\u5316\u201d\u7eb3\u7c73\u6d3b\u6027\u5242\u2014\u2014\u589e\u5f3a\u6d3b\u6027\u6c27\u751f\u6210\u548c\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u80fd\u6709\u6548\u7684\u6d88\u706d\u80bf\u7624"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u5305\u62ec\u7f9f\u57fa\u81ea\u7531\u57fa\uff08.<\/sup>OH\uff09\u3001\u8d85\u6c27\u9634\u79bb\u5b50\uff08.<\/sup>O2<\/sub>–<\/sup>\uff09\u548c\u5355\u7ebf\u6001\u6c27\uff08O2<\/sub>.<\/sup>\uff09\uff0c\u5b83\u4eec\u53ef\u4ee5\u8bf1\u5bfc\u7ec6\u80de\u574f\u6b7b\u6216\u51cb\u4ea1\uff0c\u56e0\u6b64\u88ab\u89c6\u4e3a\u4e00\u79cd\u826f\u597d\u7684\u764c\u75c7\u6cbb\u7597\u8bd5\u5242\u3002\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u4f5c\u4e3a\u4e00\u79cdROS\u4ecb\u5bfc\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff0c\u76f8\u6bd4\u4e8e\u5176\u4ed6\u5e38\u89c4\u6cbb\u7597\u65b9\u6cd5\u6709\u8bb8\u591a\u4f18\u70b9\uff0c\u4f8b\u5982\u4fb5\u88ad\u6027\u5c0f\u3001\u526f\u4f5c\u7528\u4f4e\u3001\u9009\u62e9\u6027\u9ad8\u7b49\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4f20\u7edf\u7684\u6709\u673a\u5149\u654f\u5242\u7684\u7a33\u5b9a\u6027\u3001\u6eb6\u89e3\u6027\u3001\u8d1f\u8f7d\u80fd\u529b\u8f83\u5dee\uff0c\u4ee5\u53ca\u8f83\u65e9\u5730\u4ece\u8f7d\u4f53\u4e0a\u91ca\u653e\uff0cPDT\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5e94\u7528\u53d7\u5230\u4e86\u4e25\u91cd\u7684\u963b\u788d\u3002\u6700\u8fd1\uff0c\u4e00\u4e9b\u534a\u5bfc\u4f53\u548c\u5149\u50ac\u5316\u5242\u56e0\u5177\u6709\u9ad8\u7684\u5149\u7a33\u5b9a\u6027\u3001\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u5e7f\u6cdb\u7684\u5149\u54cd\u5e94\u8303\u56f4\uff08\u4ece\u7d2b\u5916\u5149\u5230\u53ef\u89c1\u5149\uff09\u7b49\u4f18\u70b9\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u4f5c\u4e3a\u6709\u673a\u5149\u654f\u5242\u6f5c\u5728\u7684\u66ff\u4ee3\u8005\u3002\u4f46\u662f\uff0cPDT\u5728\u672c\u8d28\u4e0a\u662f\u4e25\u91cd\u4f9d\u8d56\u4e8eO2<\/sub>\uff0c\u800c\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u662f\u4e4f\u6c27\u7684\uff0c\u5982\u4f55\u63d0\u9ad8\u6c27\u6c14\u542b\u91cf\uff0c\u6539\u5584PDT\u7684\u6cbb\u7597\u6548\u679c\uff0c\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001CFNs\u7684\u5408\u6210\u8fc7\u7a0b\u548c\u6cbb\u7597\u673a\u5236\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u00a0\u56fe\u4e8c\u3001CFNs\u7684\u8868\u5f81<\/strong>\u00a0<\/p>\n

\"\"<\/p>\n

\uff08a\uff09 CFNs\u7684SEM\u56fe\uff1b<\/p>\n

\uff08b, c\uff09CFNs\u7684TEM\u56fe\uff1b<\/p>\n

\uff08d\uff09CFNs\u7684HRTEM\u56fe\uff1b<\/p>\n

\uff08e\uff09CFNs\u7684\u9009\u5b9a\u533a\u57df\u7684\u7535\u5b50\u884d\u5c04\u56fe\uff1b<\/p>\n

\uff08f\uff09CFNs\u7684HHADF-STEM\u56fe\uff1b<\/p>\n

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\u56fe\u4e09\u3001CFNs\u7684\u5149\u589e\u5f3aCDT, \u5149\u52a8\u529b\u548c\u5149\u70ed\u6027\u80fd\u00a0<\/strong><\/p>\n

\"\"<\/strong>
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\uff08b\uff09 CFNs\uff08150 ug\/mL\uff09\u3001CFNs\uff08150 ug\/mL\uff09\u548cH2<\/sub>O2<\/sub>\uff082 mM\uff09\u7684\u4ea7\u751fO2\u5bf9\u6bd4\u56fe\uff1b<\/p>\n

\uff08c\uff09 \u7531\u4e8eO2<\/sub>–<\/sup>\u7684\u4ea7\u751f\uff0cDPBF\u7684\u6d88\u8017\uff1b<\/p>\n

\uff08d\uff09 \u7531\u4e8e.<\/sup>OH\u7684\u4ea7\u751f\uff0cMB\u7684\u9000\u5316\uff1b<\/p>\n

\uff08e\uff09 \u5728\u6ce2\u957f808 nm\u7684\u6fc0\u5149\uff081.3 W\/cm2<\/sup>\uff09\u4e0b\uff0c\u4e0d\u540c\u6d53\u5ea6\u7684CFNs\uff080\u300150\u3001100\u3001200\u3001400 ug\/mL\uff09\u7684\u6e29\u5ea6\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08f\uff09 \u5728\u4e0d\u540c\u6d53\u5ea6\u4e0b\uff0c\u7528808 nm\u6fc0\u5149\uff081.3 W\/cm2<\/sup>\uff09\u7167\u5c04\u7684CFNs\u6c34\u6eb6\u6db2\u7684\u7ea2\u5916\u70ed\u50cf\u56fe\u3002<\/p>\n

\u56fe\u56db\u3001CFNs\u7684\u7ec6\u80de\u5b9e\u9a8c\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

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\uff08b\uff09 \u7528CFNs (200 ug\/mL)\u5b75\u80b2HeLa\u7ec6\u80de\u540eROS\u548cO2<\/sub>\u751f\u6210\u7684CLSM\u56fe\uff1b<\/p>\n

\uff08c\uff09 \u4e0d\u540c\u6d53\u5ea6\u7684CFNs(0\u3001100\u3001200 ug\/mL)\u4e0b\uff0c\u7ec6\u80de\u5185\u8c37\u80f1\u7518\u80bd\u7684\u6d88\u8017\uff1b<\/p>\n

\uff08d\uff09 \u901a\u8fc7CCK-8\u7684\u5206\u6790\uff0c\u5bf9CFNs\u7684\u5149\u589e\u5f3a\u5242CDT\/PDT\/PTT\u591a\u5904\u7406\u7684\u8bc4\u4ef7\uff1b<\/p>\n

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\u56fe\u4e94\u3001CFNs\u7684MRI\u6548\u5e94<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u00a0\uff08a\uff09 CFNs\u7684\u78c1\u6ede\u56de\u7ebf\uff1b<\/p>\n

\uff08b\uff09 \u5bf9\u4e8e\u4e0d\u540c\u6d53\u5ea6\u7684Fe\u7684\u4f53\u5916T2<\/sub>-MRI\u548c\u677e\u5f1b\u5ea6r2<\/sub>\u7684\u503c\uff1b<\/p>\n

\uff08c\uff09 U14\u80bf\u7624\u5c0f\u9f20\u57280\u30012\u30014\u300112\u300124 h\u9759\u8109\u6ce8\u5c04CFNs\u524d\u540e\uff0c\u4f53\u5185\u7684MRI\u503c\u53d8\u5316;<\/p>\n

\uff08d\uff09 \u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u572824 h\u7684\u751f\u7269\u5206\u5e03\u3002<\/p>\n

\u56fe\u516d\u3001CFNs\u7684\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u00a0\uff08a\uff09 24 h\u540e\u7684\u5c0f\u9f20\u4f53\u5185\u70ed\u6210\u50cf;<\/p>\n

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\uff08c\uff09 \u5c0f\u9f20\u80bf\u7624\u4f53\u79ef\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09 \u5728\u7b2c30\u5929\u4eceU14\u80bf\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u5207\u7247\u4e2d\u7528H&E\u548cHIF-1\u67d3\u8272\uff1b<\/p>\n

\uff08e\uff09 \u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u901a\u8fc7\u4e00\u6b65\u6c34\u70ed\u6cd5\u5408\u6210\u4e86\u96c6MRI\u6210\u50cf\u3001CDT\u3001PDT\u548cPTT\u591a\u79cd\u529f\u80fd\u4e8e\u4e00\u4f53\u7684\u7eb3\u7c73\u6750\u6599CFNs\u3002\u4f5c\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u5149\u654f\u5242\uff0c\u5728650 nm\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cCFNs\u53ef\u4ee5\u5c06O2<\/sub>\u8f6c\u5316\u6210.<\/sup>O2<\/sub>–<\/sup>\u7528\u4e8ePDT\u6cbb\u7597\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5728650 nm\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cFenton\u53cd\u5e94\u53ef\u4ee5\u663e\u8457\u589e\u5f3a\uff0c\u4ece\u800c\u589e\u5f3a\u4e86CDT\u6548\u5e94\u3002\u5e76\u4e14\uff0cCFNs\u53ef\u4ee5\u901a\u8fc7\u50ac\u5316H2<\/sub>O2<\/sub>\u4ea7\u751fO2<\/sub>\u5e76\u6d88\u8017\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\uff0c\u4ece\u800c\u7f13\u89e3\u80bf\u7624\u7f3a\u6c27\u548c\u6297\u6c27\u5316\u80fd\u529b\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u5149\u589e\u5f3aCDT\u548cPDT\u7684\u6548\u7387\u3002\u540c\u65f6\uff0cCFNs\u5177\u6709\u5f88\u597d\u7684\u5149\u70ed\u8f6c\u6362\u6027\u80fd\u3002\u8fd9\u79cd\u201c\u4e00\u4f53\u5316\u201d\u7684\u7eb3\u7c73\u6750\u6599\u5c06\u5149\u589e\u5f3a\u7684CDT\u3001PDT\u3001PTT\u548cMRI\u6210\u50cf\u529f\u80fd\u4e0e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u8c03\u5236\u80fd\u529b\u7ed3\u5408\u8d77\u6765\uff0c\u4f53\u73b0\u4e86\u201c\u4e00\u4f53\u5316\u201d\u7684\u6982\u5ff5\uff0c\u5728\u764c\u75c7\u6cbb\u7597\u7814\u7a76\u4e2d\u5177\u6709\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen SpeciesGeneration and Modulating Tumor Eradication<\/strong><\/a>\uff08ACS Nano, 2018<\/strong>, DOI: 10.1021\/acsnano.8b01893\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a><\/strong>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n

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