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a.\u8d85\u758f\u6c34\u548c\u8d85\u4eb2\u6c34\u6027\u7684pH\u54cd\u5e94\u8d85\u6e7f\u8868\u9762\u6027\u8d28\u7684\u8f6c\u6362\u5de5\u4f5c\u539f\u7406\u3002AEPTMS\u7684\u767e\u5206\u6bd4\u662f10%\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff0c\u5c3a\u5bf8\u4e3a15,50\uff0c\u548c200\u7eb3\u7c73\u3002CA\u7684\u6c34\u6ef4\u5728pH\u503c\u4e0b\u964d\u52300\u00b0~ 1\u548c\u589e\u52a0\u5230161.4\u00b0\u00b16.2\u00b0pH\u503c13\uff1b<\/p>\n

b.SEM\u56fe\u50cf\u7684ph\u54cd\u5e94\u8d85\u6da6\u6e7f\u8868\u9762\u3002\u8d85\u6da6\u6e7f\u8868\u9762\u7684\u4f4e\u500d\u7387SEM\u56fe\u50cf\u663e\u793a\u4e86\u7c97\u7cd9\u8868\u9762\u7684\u4e00\u822c\u5f62\u8c8c(\u5de6)\u3002\u8d85\u6da6\u6e7f\u8868\u9762\u7684\u9ad8\u500d\u7387SEM\u56fe\u50cf\u663e\u793a\u51fa\u9ad8\u5ea6\u7684\u7c97\u7cd9\u5ea6(\u53f3)<\/p>\n

\u56fe<\/strong>2:\u00a0\u9178\u6027\u6eb6\u6db2\u4e2dCA\u4e0e\u6e7f\u6da6\u65f6\u95f4\u53ca\u4e0d\u540cPH\u7684\u5173\u7cfb<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u5728\u9178\u6027\u6eb6\u6db2\u4e2dCA\u4e0e\u6e7f\u6da6\u65f6\u95f4\u7684\u5173\u7cfb(pH 1)\uff1b<\/p>\n

b.\u5728\u78b1\u6027\u6eb6\u6db2\uff08pH 13\uff09\u5b58\u5728\u4e0bCA\u4e0e\u6da6\u6e7f\u65f6\u95f4\u7684\u5173\u7cfb\uff1b<\/p>\n

c.\u4ecepH 1\u523013\u7684\u5bbd\u8303\u56f4\u7684\u6821\u51c6\u66f2\u7ebf\uff0c\u8003\u5bdfCA\u548cpH\u4e4b\u95f4\u7684\u7ebf\u6027\u5173\u7cfb\uff1b<\/p>\n

d CA\u548cpH\u503c\u4ece1\u52307\uff1b<\/p>\n

e.\u5177\u6709\u4e0d\u540cpH\u503c\u7684\u6db2\u6ef4\u7684\u6da6\u6e7f\u72b6\u6001\uff1b<\/p>\n

f\u6da6\u6e7f\u72b6\u6001\uff1b<\/p>\n

g.\u7528pH 6\u6eb6\u6db2\u4ee3\u66ffpH 3\u548cpH 1\u6eb6\u6db2\u539f\u4f4d\u4e2d\u548c\u7684\u5bf9\u7167\u5b9e\u9a8c\u3002\u8bef\u5dee\u6761\u8868\u793a\u4e09\u6b21\u91cd\u590d\u7684\u6807\u51c6\u504f\u5dee\u3002\u4e0d\u540c\u989c\u8272\u7684\u6db2\u6ef4\u7684\u6570\u7801\u7167\u7247\u548cCA\u6d4b\u91cf<\/p>\n

\u56fe<\/strong>3:ph<\/strong>\u53cd\u5e94\u8d85\u6e7f\u8868\u9762\u7684\u5c3f\u7d20\u68c0\u6d4b\u793a\u610f\u56fe\u3002<\/strong><\/p>\n

\"\"<\/p>\n

a .\u5c3f\u7d20\u68c0\u6d4b\u7684\u539f\u7406\u56fe\uff0c\u57fa\u4e8eu\u50ac\u5316\u53cd\u5e94\u7684OH\u3002\u8868\u9762\u53ef\u4ee5\u5728\u6d17\u6da4\u548c\u5e72\u71e5\u540e\u91cd\u65b0\u4f7f\u7528\uff1b<\/p>\n

b.\u4e0d\u540c\u6d53\u5ea6\u5c3f\u7d20\u7684\u654f\u611f\u6027\u8bd5\u9a8c(100\u3001200\u3001400\u3001600\u3001800\u7eb3\u7c73\u548c1\u300110\u3001100\u3001200\u3001400\u3001600\u3001800\u30011\u30012\u30013\u6beb\u7c73)\uff1b<\/p>\n

c .Linear CA\u548c\u5c3f\u7d20\u6d53\u5ea6\u4e4b\u95f4\u7684\u5173\u7cfb\u4ece100\u7eb3\u7c73\u52301\u00b5M\uff1b<\/p>\n

d .\u5728\u7ebf\u6027\u8303\u56f4\u5185\uff0c\u5c3f\u7d20\u6d53\u5ea6\u4e0d\u540c\u7684\u6db2\u6ef4\u7684\u6da6\u6e7f\u72b6\u6001\uff1b<\/p>\n

e . CA\u53d8\u5316\u7684\u5173\u7cfb(CA = | CA CA0 |\uff0c CA\u548cCA0\u5206\u522b\u4e3a\u5b9e\u9a8c\u7ec4\u7684CAs\u548c\u7a7a\u767d\u5bf9\u7167\u7ec4)\u548c\u5e72\u6270\u5242(Na+\u3001K+\u3001\u6297\u574f\u8840\u9178\u3001\u8461\u8404\u7cd6\u3001\u7518\u6c28\u9178)\u3002<\/p>\n

\u56fe<\/strong>4:ph<\/strong>\u53cd\u5e94\u8d85\u6e7f\u6da6\u8868\u9762\u8461\u8404\u7cd6\u68c0\u6d4b\u56fe\u3002<\/strong><\/p>\n

\"\"<\/p>\n

a\u4e00\u79cd\u57fa\u4e8e\u8461\u8404\u7cd6\u9178\u7684\u8461\u8404\u7cd6\u68c0\u6d4b\u539f\u7406\u56fe\u3002\u8868\u9762\u53ef\u4ee5\u5728\u6d17\u6da4\u548c\u5e72\u71e5\u540e\u91cd\u65b0\u4f7f\u7528\uff1b<\/p>\n

b .\u4e0d\u540c\u6d53\u5ea6\u7684\u8461\u8404\u7cd6(1\u300110\u3001100\u3001200\u3001300\u3001400\u3001500\u3001600\u3001700\u3001800 nM\u548c1\u300110\u300150\u3001100 M\u3001500 M\u548c1 mM)\u7684\u654f\u611f\u6027\u8bd5\u9a8c\uff1b<\/p>\n

c . CA\u4e0e\u8461\u8404\u7cd6\u6d53\u5ea6\u4e4b\u95f4\u7684\u7ebf\u6027\u5173\u7cfb\uff0c\u4ece1 nM\u5230800 nM\u3002d .\u5728\u7ebf\u6027\u8303\u56f4\u5185\u4e0d\u540c\u6d53\u5ea6\u7684\u8461\u8404\u7cd6\u6ef4\u6da6\u6e7f\u72b6\u6001\uff1b<\/p>\n

e .\u5728\u4e0d\u540c\u7684\u8461\u8404\u7cd6\u6d53\u5ea6\u8303\u56f4\u5185(\u4ece1 nM\u5230800 nM)\u5b58\u5728\u7684\u7406\u8bba\u548c\u5b9e\u9a8cCA\u3002\u4ece\u54cd\u5e94\u66f2\u7ebf\u4e0a\u5f97\u5230\u4e86\u7406\u8bbaCA\uff1b<\/p>\n

f\u3002CA\u7684\u53d8\u5316\u4e4b\u95f4\u7684\u5173\u7cfb(\u2206CA = | CA\u2212CA0 |,CA\u548cCA0 CAs\u5b9e\u9a8c\u7ec4\u548c\u7a7a\u767d\u7684\u63a7\u5236,\u5206\u522b)\u548c\u5e72\u6270\u5242(\u679c\u7cd6\u3001\u7518\u9732\u7cd6\u3001\u963f\u62c9\u4f2f\u7cd6\u3001\u534a\u4e73\u7cd6\u3001\u6728\u7cd6\u548c\u8461\u8404\u7cd6)\u3002<\/p>\n

\u56fe<\/strong>5:<\/strong>\u5728<\/strong>ph<\/strong>\u53cd\u5e94\u8d85\u6e7f\u6da6\u8868\u9762\u7684\u5b9e\u9645\u73af\u5883\u4e2d\uff0c\u8461\u8404\u7cd6\u7684\u89c6\u89c9\u5b9a\u91cf\u68c0\u6d4b\u3002<\/strong><\/p>\n

\"\"<\/p>\n

a\u4fb5\u5165\u5f0f\u8461\u8404\u7cd6\u68c0\u6d4b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8840\u6db2\u6807\u672c\u6765\u81ea9\u548c9\u6b63\u5e38\u4eba\u8868\u660eCAs\u6b63\u5e38\u6837\u672c\u7684\u4eba\u8d85\u8fc7100\u00b0,\u76f8\u5e94\u7684\u758f\u6c34\u6027,\u4e0e\u60a3\u8005diabeties\u4e0b\u964d\u5230\u8fd150\u00b0,\u8868\u660e\u8868\u9762\u7684\u4eb2\u6c34\u6027\uff1b<\/p>\n

b\u975e\u4fb5\u5165\u6027\u68c0\u6d4b9\u4f8b\u7cd6\u5c3f\u75c5\u60a3\u8005\u548c6\u4f8b\u6b63\u5e38\u4eba\u7684\u553e\u6db2\u548c\u5c3f\u6db2\uff0c\u8bf4\u660eCA\u53ef\u7528\u4e8e\u533a\u5206\u7cd6\u5c3f\u75c5\u60a3\u8005\u548c\u6b63\u5e38\u4eba\u3002<\/p>\n

\u56fe<\/strong>6:<\/strong>\u5728\u81ea\u884c\u8f66\u8fd0\u52a8\u524d\u540e\u7684<\/strong>5<\/strong>\u540d\u5fd7\u613f\u8005\u7684\u524d\u989d\u3001\u80f8\u90e8\u548c\u80cc\u90e8\u91c7\u96c6\u4e86\u4e00\u7ec4\u7528\u4e8e\u65e0\u521b\u8840\u7cd6\u68c0\u6d4b\u7684\u6c57\u6db2\u6807\u672c\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u4ece\u524d\u989d\uff08B\uff09\u3001\u4e73\u623f\uff08C\uff09\u548c\u80cc\u90e8\uff08D\uff09\u7684\u6c57\u6db2\u6807\u672c\u4e2d\u7684CAs\u7684\u89c2\u5bdf\u968f\u6bcf\u4e00\u4e2a\u8fde\u7eed\u6536\u96c6\u65f6\u95f4\u4ece\u524d\u5230\u5faa\u73af\u540e\u7565\u6709\u589e\u52a0\u3002\u6d4b\u8bd5\u6db2\u6ef4\u7684\u4f53\u79ef\u4e3a2\u03bcL\u3002\u8bef\u5dee\u6761\u8868\u793a\u4e09\u6b21\u91cd\u590d\u7684\u6807\u51c6\u504f\u5dee\u3002<\/p>\n

\u3010\u603b\u7ed3\u4e0e\u5c55\u671b\u3011<\/strong><\/p>\n

\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u5feb\u901f\u7684pH\u54cd\u5e94\u8d85\u6da6\u6e7f\u8868\u9762\uff0c\u5177\u6709\u4f18\u5f02\u7684\u8d85\u6da6\u6e7f\u6027\uff0c\u4f5c\u4e3aPCT\u5e73\u53f0\uff0c\u7528\u4e8e\u8089\u773c\u6d4b\u5b9apH\u3001\u5c3f\u7d20\u548c\u8461\u8404\u7cd6\u3002\u8be5\u8868\u9762\u88ab\u8bc1\u660e\u662f\u4f5c\u4e3aPH\u503c\u7684\u51fd\u6570\u5728\u8d85\u4eb2\u6c34\u6027\u548c\u8d85\u758f\u6c34\u6027\u4e4b\u95f4\u5207\u6362\u3002\u4e0e\u5546\u4e1a\u8840\u7cd6\u4eea\u76f8\u6bd4\uff0c\u6240\u63d0\u51fa\u7684POCT\u5e73\u53f0\u5728\u7cd6\u5c3f\u75c5\u60a3\u8005\u6837\u54c1\u7684\u6d4b\u5b9a\u4e2d\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u51c6\u786e\u6027\u3002\u6b64\u5916\uff0c\u65e0\u521b\u6027\u8bca\u65ad\u7cd6\u5c3f\u75c5\u5c3f\u6db2\u548c\u553e\u6db2\u3002\u6240\u5f00\u53d1\u7684\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u79cd\u975e\u4fb5\u5165\u6027\u7684\u624b\u6bb5\uff0c\u7528\u4e8e\u76d1\u6d4b\u8fd0\u52a8\u8fc7\u7a0b\u4e2d\u8461\u8404\u7cd6\u6c34\u5e73\u7684\u53d8\u5316\u3002\u57fa\u4e8eCA\u7684\u8d85\u6da6\u6e7fPOCT\u5e73\u53f0\u5177\u6709\u5feb\u901f\u3001\u76f4\u89c2\u3001\u65e0\u9700\u8bbe\u5907\u548c\u4f4e\u6210\u672c\u7684\u4f18\u70b9\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5176\u6027\u80fd\u51e0\u4e4e\u4e0d\u53d7\u6c34\u6ef4\u7684\u6e29\u5ea6\u3001\u9ad8\u5ea6\u548c\u989c\u8272\u7684\u5f71\u54cd\uff0c\u4f7f\u5176\u9002\u5408\u4e8e\u8272\u76f2\u6216\u8272\u5f31\u7684\u4eba\uff0c\u5e76\u6269\u5c55\u5230\u6570\u4ebf\u4eba\u7684\u9002\u7528\u8303\u56f4\u3002\u5bf9\u4e8e\u81ea\u7136\u542f\u53d1\u7684\u8d85\u6da6\u6e7f\u7cfb\u7edf\uff0c\u8fd9\u79cd\u5feb\u901f\u54cd\u5e94\u7684\u4e00\u6b21\u6027POCT\u4f20\u611f\u5668\u53ef\u4ee5\u514b\u670d\u8d85\u6da6\u6e7f\u6750\u6599\u7684\u673a\u68b0\u7a33\u5b9a\u6027\u548c\u8010\u4e45\u6027\u7684\u5c40\u9650\u6027\uff0c\u4ece\u800c\u5ef6\u957f\u751f\u7269\u542f\u53d1\u7684\u8d85\u6da6\u6e7f\u7cfb\u7edf\u7684\u5de5\u4e1a\u89c4\u6a21\u5e94\u7528\u3002\u867d\u7136\u5728\u8be5\u7cfb\u7edf\u4e2d\u6536\u96c6\u7684\u5b9e\u9645\u7ed3\u679c\u662f\u521d\u6b65\u7684\uff0c\u672a\u6765\u7684\u7814\u7a76\u5c06\u81f4\u529b\u4e8e\u6784\u5efa\u8be6\u7ec6\u7684\u8eab\u4f53\u751f\u7269\u4f20\u611f\u5668\uff0c\u5c06\u8d85\u6da6\u6e7f\u8868\u9762\u4e0e\u5149\u7535\u7279\u6027\u3001\u6570\u636e\u5904\u7406\u548c\u65e0\u7ebf\u4f20\u8f93\u76f8\u7ed3\u5408\uff0c\u4ee5\u76d1\u6d4b\u66f4\u591a\u7684\u4e34\u5e8a\u76f8\u5173\u6c57\u6db2\u3002\u4ee3\u8c22\u7269\u3002\u6211\u4eec\u9884\u8ba1\uff0c\u8fd9\u4e00\u6982\u5ff5\u53ef\u4ee5\u6269\u5c55\u5230\u8fd0\u52a8\u7ee9\u6548\u8bc4\u4f30\u4ee5\u53ca\u4e00\u822c\u533b\u7597\u4fdd\u5065\u9886\u57df\u7684\u5176\u4ed6\u5e94\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/b>Naked-eye point-of-care testing platform based on a pH-responsive superwetting surface: toward the non-invasive detection of glucose<\/strong><\/a>(NPG Asia Materials, 2018, DOI\uff1a10.1038\/s41427-018-0024-7\uff09<\/p>\n

\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5b66\u672f\u7ec4Kevin<\/strong>\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406<\/strong>\u3002\u6b22\u8fce\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u7eb3\u7c73\u6750\u6599\u5b66\u672f\u4ea4\u6d41\u7fa4\uff08228686798\uff09\uff01<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

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