{"id":138474,"date":"2018-05-15T14:00:55","date_gmt":"2018-05-15T06:00:55","guid":{"rendered":"\/\/m.iemloyee.com\/?p=138474"},"modified":"2018-05-15T21:18:11","modified_gmt":"2018-05-15T13:18:11","slug":"nat-chem-%ef%bc%9a%e5%af%b9%e5%8a%a8%e5%8a%9b%e5%ad%a6%e7%ba%b3%e7%b1%b3%e5%a4%9a%e5%ad%94%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%84%e4%bb%b6%e7%86%b5%e9%a9%b1%e5%8a%a8%e8%87%aa%e7%94%b1%e8%83%bd%e5%9b%be","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=138474","title":{"rendered":"Nat. Chem.\uff1a\u5bf9\u52a8\u529b\u5b66\u7eb3\u7c73\u591a\u5b54\u86cb\u767d\u8d28\u7ec4\u4ef6\u71b5\u9a71\u52a8\u81ea\u7531\u80fd\u56fe\u666f\u7684\u8c03\u63a7"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u662f\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\u5f62\u6210\u529f\u80fd\u6750\u6599\u548c\u5668\u4ef6\u7684\u4e3b\u5bfc\u65b9\u5f0f\uff0c\u5b9e\u9a8c\u5ba4\u7814\u7a76\u76ee\u524d\u901a\u5e38\u91c7\u7528\u7531\u4e0b\u5230\u4e0a\uff08bottom-up\uff09\u7684\u65b9\u5f0f\u6784\u5efa\u5408\u6210\u6750\u6599\u3002\u5bf9\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u57fa\u7840\u7269\u7406\u7406\u89e3\u5bf9\u4e8e\u76ee\u6807\u8d85\u5206\u5b50\u6784\u67b6\u7684\u5408\u7406\u8bbe\u8ba1\u81f3\u5173\u91cd\u8981\uff0c\u540c\u65f6\uff0c\u5bf9\u4e8e\u5176\u7ed3\u6784\u52a8\u529b\u5b66\u548c\u73af\u5883\u76f8\u5e94\u7684\u8c03\u63a7\u4e5f\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u53ef\u9884\u6d4b\u6027\u5730\u5207\u6362\u4e0d\u540c\u7684\u6784\u8c61\u6001\uff0c\u4ece\u5934\u8bbe\u8ba1\u548c\u6784\u5efa\u523a\u6fc0\u54cd\u5e94\u6027\u7684\u86cb\u767d\u8d28\u7ec4\u4ef6\uff0c\u81f3\u4eca\u5728\u751f\u7269\u5206\u5b50\u8bbe\u8ba1\u9886\u57df\u4ecd\u662f\u4e00\u4e2a\u5fc5\u8981\u4e14\u6781\u5177\u6311\u6218\u6027\u7684\u4efb\u52a1\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821<\/strong>\u7684F. Akif Tezcan<\/strong>\u6559\u6388<\/strong>\u548cFrancesco Paesani<\/strong>\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u5408\u4f5c<\/strong>\uff0c\u5728Nature Chemistry<\/strong>\u4e0a\u53d1\u8868\u4e86\u6700\u65b0\u7814\u7a76\u201cEngineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly<\/strong>\u201d\u3002\u6b64\u524d\uff0c\u6587\u7ae0\u4f5c\u8005\u62a5\u9053\u8fc7\u901a\u8fc7\u4e8c\u786b\u5316\u7269\u952e\u5408\u76f8\u4e92\u4f5c\u7528\u4eba\u5de5\u5408\u6210\u4e8c\u7ef4\u86cb\u767d\u8d28\u6676\u683c\u7ec4\u4ef6\uff0c\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u63d0\u51fa\u5168\u90e8\u539f\u5b50\u7684\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\uff0c\u63cf\u7ed8\u8fd9\u4e9b\u6676\u683c\u7684\u81ea\u7531\u80fd\u56fe\u666f\uff0c\u501f\u52a9\u7535\u5b50\u663e\u5fae\u6280\u672f\u8fdb\u884c\u5927\u91cf\u7ed3\u6784\u8868\u5f81\uff0c\u4ece\u800c\u9a8c\u8bc1\u8fd9\u4e9b\u56fe\u666f\uff0c\u63d0\u51fa\u81ea\u7531\u80fd\u56fe\u666f\u4e3b\u8981\u662f\u7531\u6eb6\u5242\u91cd\u6784\u71b5\u63a7\u5236\u7684\u3002\u968f\u540e\u5728\u9759\u7535\u6392\u65a5\u76f8\u4e92\u4f5c\u7528\u6761\u4ef6\u4e0b\uff0c\u5bf9\u86cb\u767d\u8d28\u8868\u9762\u7684\u518d\u8bbe\u8ba1\uff0c\u4f7f\u5f97\u4f5c\u8005\u9884\u6d4b\u6027\u5730\u5bf9\u81ea\u7531\u80fd\u56fe\u666f\u589e\u52a0\u6270\u52a8\uff0c\u5f97\u5230\u4e00\u79cd\u65b0\u7684\u86cb\u767d\u8d28\u6676\u683c\uff0c\u5176\u6784\u8c61\u52a8\u529b\u5b66\u53ef\u5728\u4e09\u79cd\u4e0d\u540c\u5316\u5b66\u3001\u673a\u68b0\u6027\u80fd\u548c\u4e0d\u540c\u5b54\u9699\u7387\u548c\u5206\u5b50\u5bc6\u5ea6\u7684\u72b6\u6001\u4e0b\u76f8\u4e92\u5207\u6362\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\uff1aC98<\/sup>RhuA\u6676\u4f53\u7684\u7ed3\u6784\u7279\u5f81\u3002<\/strong><\/p>\n

\"\"<\/p>\n

(a) C98<\/sup>RhuA\u56db\u805a\u4f53\u7684\u8868\u9762\u7279\u5f81\uff0c\u9ed1\u8272\u6807\u8bb0\u4e3a98\u4f4d\u70b9\uff0c\u6c27\u5316\u540e\u81ea\u7ec4\u88c5\u4e3a\u591a\u5b54\u4e8c\u7ef4\u6676\u4f53\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(b) C98<\/sup>RhuA\u6676\u683c\u6240\u5f97\u6784\u8c61\u6001\u7684TEM\u56fe\u50cf\u548c\u8349\u56fe\u8868\u793a\uff1b<\/p>\n

(c)\u4ece\u86cb\u767d\u8d28\u4e2d\u7a81\u51fa\u7684\u201c\u76f8\u4e92\u4f5c\u7528\u5e26\u201d\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(d)\u5b9e\u9a8c\u6d4b\u91cf\u5f97\u5230\u7684\u53c2\u6570E\u7684\u8ba1\u7b97\u4ee5\u53ca\u63a8\u5e7f\u5230\u03b6\u5750\u6807\u7684\u6982\u51b5\u3002<\/p>\n

\u56fe2\uff1aC98<\/sup>RhuA\u6676\u683c\u7ed3\u6784\u52a8\u529b\u5b66\u7684\u70ed\u529b\u5b66\u5206\u6790\u3002<\/strong><\/p>\n

\"\"<\/p>\n

(a)\u5728\u8fde\u7eed\u8303\u56f4\u7684C98<\/sup>RhuA\u6676\u683c\u6784\u8c61\u4e2d\uff0c\u8ba1\u7b97\u81ea\u7531\u80fd\u56fe\u666f\uff08\u4e0a\uff09\u548c\u968f\u4e4b\u4ea7\u751f\u7684\u6eb6\u5242\u71b5\u7684\u53d8\u5316\uff08\u4e0b\uff09\uff1b<\/p>\n

(b) \u5b9e\u9a8c\u6d4b\u91cf\u5f97\u5230\u7684\u548cPMF\u8ba1\u7b97\u5f97\u5230\u7684C98<\/sup>RhuA\u6676\u4f53\u7684\u5e73\u8861\u6784\u8c61\u6982\u7387\u76f4\u63a5\u6bd4\u8f83\u3002<\/p>\n

\u56fe3\uff1a\u6676\u683c\u538b\u7f29\u5bf9\u5b54\u5185\u6eb6\u5242\u7ed3\u6784\u7684\u5f71\u54cd\u3002<\/strong><\/p>\n

\"\"<\/p>\n

(a)\u4e0a\u56fe\u4e3a\u5f52\u4e00\u5316\u5b54\u5185\u6c34\u5bc6\u5ea6\u76842D\u56fe\uff0c\u4e0b\u56fe\u4e3a\u5bc6\u5ea6\u6cbf\u5b54\u7684\u4e8c\u7b49\u5206\u7ebf\u4e00\u7ef4\u5206\u5e03\u56fe\uff0c\u5bf9\u6570\u636e\u8fdb\u884c\u5b9a\u91cf\u89e3\u91ca\uff1b<\/p>\n

(b)\u8fd1\u86cb\u767d\u8d28\u8868\u9762\u6eb6\u5242\u5206\u5b50\u7684\u6570\u5206\u5e03\u3002<\/p>\n

\u56fe4\uff1aCEE<\/sup>RhuA\u6784\u578b\u7684\u8bbe\u8ba1\u548c\u5206\u6790\u3002<\/strong><\/p>\n

\"\"<\/p>\n

(a)CEE<\/sup>RhuA\u56db\u805a\u4f53\u7684\u8868\u9762\u5f62\u8c8c\uff1b<\/p>\n

(b) CEE<\/sup>RhuA\u6676\u683c\u52a8\u529b\u5b66\u7684\u793a\u610f\u56fe\u548c\u8bbe\u8ba1\u7684\u9884\u671f\u6548\u679c\uff1b<\/p>\n

(c)RhuA\u6676\u683c\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(d) CEE<\/sup>RhuA\u52a8\u529b\u5b66\u7684\u70ed\u529b\u5b66\u5206\u6790\u3002<\/p>\n

(e) CEE<\/sup>RhuA\u6784\u8c61\u5728\u6c89\u6dc0-\u518d\u60ac\u6d6e\u591a\u8f6e\u5faa\u73af\u671f\u95f4\u7684\u5b9e\u9a8c\u5206\u5e03\u3002<\/p>\n

\u56fe5\uff1aCEE<\/sup>RhuA\u6676\u4f53\u7684\u5316\u5b66\u548c\u529b\u5b66\u5207\u6362\u884c\u4e3a\u3002<\/strong><\/p>\n

\"\"<\/p>\n

(a)\u4e0a\u56fe\uff1a\u793a\u610f\u56fe\u63cf\u8ff0\u6240\u6709\u53ef\u80fd\u7684CEE<\/sup>RhuA\u6676\u683c\u5207\u6362\u6a21\u5f0f\uff0c\u4e0b\u56fe\uff1a\u5bf9\u5e94\u4e0a\u56fe\u72b6\u6001\u7684\u5b9e\u9a8c\u5206\u5e03\uff1b<\/p>\n

(b)RhuA\u6676\u4f53\u5207\u6362\u6a21\u5f0f\u7684\u603b\u7ed3\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u8be5\u5de5\u4f5c\u5448\u73b0\u4e86\u5b8c\u6574\u63cf\u7ed8\u81ea\u7531\u80fd\u56fe\u666f\u7684\u5408\u6210\u86cb\u767d\u8d28\u7ec4\u4ef6\uff0c\u7ecf\u9884\u6d4b\u6027\u8c03\u63a7\u53ef\u5177\u6709\u5316\u5b66\u548c\u529b\u5b66\u76f8\u5e94\u7ed3\u6784\u5207\u6362\u884c\u4e3a\u3002\u4e3a\u6b64\uff0c\u8bbe\u8ba1\u7684\u5173\u952e\u70b9\u5728\u4e8e\u4f7f\u7528\u5f3a\u4e14\u53ef\u9006\u7684\u5f39\u6027\u952e\u5408\u76f8\u4e92\u4f5c\u7528\uff0c\u7ec4\u88c5\u52302DRhuA\u6676\u683c\u4e2d\u3002\u4e8c\u786b\u952e\u5728\u86cb\u767d\u8d28\u8868\u9762\u7684\u5c0f\u8db3\u8ff9\u4e0d\u4ec5\u8d4b\u4e88RhuA\u6676\u683c\u4e00\u4e2a\u5927\u8303\u56f4\u7684\u6784\u8c61\u81ea\u7531\u5ea6\uff0c\u8fd8\u4f7f\u5f97\u5176\u5b83\u76f8\u4e92\u4f5c\u7528\u7c7b\u578b\u5904\u4e8e\u201c\u5de1\u6e38\u201d\u6001\uff0c\u9884\u6d4b\u6027\u5730\u6539\u53d8\u81ea\u7531\u80fd\u56fe\u666f\uff0c\u63a7\u5236\u7ed3\u6784\u52a8\u529b\u5b66\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly<\/a>\uff08Nat. Chem.\uff0c2018\uff0cDOI\uff1a10.1038\/s41557-018-0053-4\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u8ba1\u7b97\u6750\u6599\u7ec4Isobel\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n

\u6750\u6599\u4eba\u91cd\u78c5\u63a8\u51fa\u6750\u6599\u8ba1\u7b97\u89e3\u51b3\u65b9\u6848\uff0c\u7ec4\u5efa\u4e86\u4e00\u652f\u6765\u81ea\u5168\u56fd\u77e5\u540d\u9ad8\u6821\u8001\u5e08\u53ca\u4f01\u4e1a\u5de5\u7a0b\u5e08\u7684\u79d1\u6280\u987e\u95ee\u56e2\u961f\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u5927\u5bb6\u89e3\u51b3\u5404\u7c7b\u8ba1\u7b97\u6a21\u62df\u9700\u6c42\u3002\u5982\u679c\u60a8\u6709\u9700\u6c42\uff0c\u6b22\u8fce\u626b\u4ee5\u4e0b\u4e8c\u7ef4\u7801\u63d0\u4ea4\u60a8\u7684\u9700\u6c42\u3002\u6216\u70b9\u51fb\u94fe\u63a5\u63d0\u4ea4<\/a>\uff0c\u6216\u76f4\u63a5\u8054\u7cfb\u5fae\u4fe1\u5ba2\u670d\uff08\u5fae\u4fe1\u53f7\uff1aiceshigu\uff09<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u662f\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\u5f62\u6210\u529f\u80fd\u6750\u6599\u548c\u5668\u4ef6\u7684\u4e3b\u5bfc\u65b9\u5f0f\uff0c\u5b9e\u9a8c\u5ba4\u7814\u7a76\u76ee\u524d\u901a\u5e38\u91c7\u7528\u7531\u4e0b\u5230\u4e0a\uff08bottom-up\uff09\u7684\u65b9\u5f0f\u6784\u5efa\u5408\u6210\u6750\u6599\u3002\u5bf9\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u57fa\u7840\u7269…<\/p>\n","protected":false},"author":4765,"featured_media":138475,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2597,75,3183],"class_list":["post-138474","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-2597","tag-biomaterial","tag-3183"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/138474"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/4765"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=138474"}],"version-history":[{"count":5,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/138474\/revisions"}],"predecessor-version":[{"id":139176,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/138474\/revisions\/139176"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/138475"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=138474"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=138474"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=138474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}