{"id":137820,"date":"2018-05-13T06:30:22","date_gmt":"2018-05-12T22:30:22","guid":{"rendered":"\/\/m.iemloyee.com\/?p=137820"},"modified":"2018-05-10T23:02:22","modified_gmt":"2018-05-10T15:02:22","slug":"%e6%b0%a7%e7%bc%ba%e9%99%b7%e9%bb%91%e8%89%b2%e4%ba%8c%e6%b0%a7%e5%8c%96%e9%92%9b%e7%94%a8%e4%ba%8e%e5%a3%b0%e5%8a%a8%e5%8a%9b%e3%80%81%e5%85%89%e7%83%ad%e5%8d%8f%e5%90%8c%e6%b2%bb%e7%96%97%e8%82%bf","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=137820","title":{"rendered":"\u6c27\u7f3a\u9677\u9ed1\u8272\u4e8c\u6c27\u5316\u949b\u7528\u4e8e\u58f0\u52a8\u529b\u3001\u5149\u70ed\u534f\u540c\u6cbb\u7597\u80bf\u7624"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u7eb3\u7c73\u533b\u5b66\u7684\u53d1\u5c55\u4e3a\u80bf\u7624\u6cbb\u7597\u63d0\u4f9b\u4e86\u591a\u79cd\u6a21\u5f0f\u3002\u5176\u4e2d\uff0c\u5916\u90e8\u975e\u4fb5\u88ad\u6027\u80fd\u91cf\uff08\u58f0\u3001\u5149\u7b49\uff09\u89e6\u53d1\u80bf\u7624\u6d88\u878d\u88ab\u89c6\u4f5c\u6700\u5177\u53d1\u5c55\u524d\u666f\u7684\u6cbb\u7597\u6a21\u5f0f\uff0c\u56e0\u4e3a\u8d85\u58f0\u3001\u6fc0\u5149\u5728\u4f5c\u4e3a\u6cbb\u7597\u80bf\u7624\u7684\u5916\u90e8\u6fc0\u53d1\u56e0\u7d20\u65f6\u5177\u6709\u9ad8\u80bf\u7624\u7279\u5f02\u6027\u3001\u9ad8\u53ef\u63a7\u6027\u3001\u826f\u597d\u7684\u6cbb\u7597\u6548\u5e94\u53ca\u53ef\u5ffd\u7565\u7684\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u6bd2\u526f\u4f5c\u7528\u3002\u5c3d\u7ba1\u58f0\u52a8\u529b\u548c\u6fc0\u5149\u6cbb\u7597\u65b9\u9762\u7684\u7814\u7a76\u5df2\u7ecf\u5f88\u591a\uff0c\u4f46\u662f\u5c06\u58f0\u52a8\u529b\u548c\u5149\u70ed\u7ed3\u5408\u7684\u8fd8\u5f88\u5c11\u89c1\u3002\u53e6\u5916\uff0c\u7528\u4e8e\u7eb3\u7c73\u533b\u5b66\u7684\u6750\u6599\u5f88\u591a\uff0c\u65e0\u673a\u534a\u5bfc\u4f53\u7684\u5e94\u7528\u6709\u8fc7\u5f88\u591a\u62a5\u9053\uff0c\u4f46\u662f\u4f20\u7edf\u65e0\u673a\u534a\u5bfc\u4f53\u56e0\u5176\u7f3a\u4e4f\u5408\u9002\u4e14\u5b89\u5168\u7684\u5149\u7167\u6fc0\u53d1\uff0c\u6240\u4ee5\u5e76\u4e0d\u9002\u7528\u4e8e\u6d3b\u4f53\u7eb3\u7c73\u6cbb\u7597\u5242\u3002\u7136\u800c\uff0c\u901a\u8fc7\u9002\u5f53\u7684\u8bbe\u8ba1\u7eb3\u7c73\u7ed3\u6784\u548c\u63a7\u5236\u5176\u7269\u7406\u5316\u5b66\u6027\u8d28\u80fd\u5c06\u4f20\u7edf\u7684\u65e0\u673a\u534a\u5bfc\u4f53\u6750\u6599\u5e94\u7528\u5728\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u4e2d\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u8d85\u58f0\u79d1\u674e\u6500\u526f\u7814\u7a76\u5458<\/strong>\u4e0e\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u9648\u96e8\u7814\u7a76\u5458<\/strong>\u4f5c\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u8bbe\u8ba1\u4e86\u4e00\u79cd\u57fa\u4e8e\u4f20\u7edf\u534a\u5bfc\u4f53\u4e8c\u6c27\u5316\u949b\u7684\u7eb3\u7c73\u6750\u6599B-TiO2<\/sub>-x(TiO2<\/sub>@TiO2<\/sub>-x<\/a>)\u3002\u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u8be5\u5b9e\u9a8c\u56e2\u961f\u5229\u7528\u94dd\uff08Al\uff09\u8fd8\u539f\u5728TiO2<\/sub>\u7eb3\u7c73\u6676\u4f53\u8868\u9762\u751f\u6210\u4e00\u5c42\u65e0\u5b9a\u5f62\u7684\u6c27\u7f3a\u9677TiO2-x<\/sub>\u5c42\uff0c\u4ece\u800c\u4f20\u7edf\u7684\u767d\u8272\u65e0\u673a\u534a\u5bfc\u4f53TiO2<\/sub>\u53d8\u4e3a\u9ed1\u8272\u7684B-TiO2<\/sub>-x\u3002\u8fd9\u79cd\u6709\u7740\u5927\u91cf\u6c27\u7f3a\u9677\u7684TiO2-x<\/sub>\u5c42\u4fc3\u8fdb\u548c\u589e\u5f3a\u7535\u5b50e–<\/sup>\u548c\u7535\u7a74h+<\/sup>\u5728\u5916\u90e8\u8d85\u58f0\u7167\u5c04\u4e0b\u4ece\u80fd\u5e26\u7ed3\u6784\u4e2d\u5206\u79bb\uff0c\u663e\u8457\u5730\u63d0\u9ad8\u58f0\u52a8\u529b\u6cbb\u7597\u80bf\u7624\u7684\u6548\u679c\u3002\u53e6\u5916\uff0c\u8fd9\u79cd\u6709\u7740\u5927\u91cf\u6c27\u7f3a\u9677\u7684TiO2-x<\/sub>\u5c42\u4e5f\u8d4b\u4e88\u9ed1\u8272\u4e8c\u6c27\u5316\u949b\u7eb3\u7c73\u7c92\u5b50\u5728NIR-II\u751f\u7269\u7a97\uff081064nm\uff09\u5177\u6709\u9ad8\u7684\u5149\u70ed\u8f6c\u5316\u6548\u80fd\uff0839.8%\uff09\uff0c\u589e\u5f3a\u5149\u81f4\u8fc7\u70ed\u6548\u5e94\u3002\u5728\u5bf9B-TiO2-x<\/sub> PEG\u5316\u540e\u5176\u751f\u7269\u76f8\u5bb9\u6027\u53ca\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u4fdd\u7559\u80fd\u529b\u589e\u9ad8\u3002\u8fd9\u79cd\u7eb3\u7c73\u6750\u6599\u5728\u88f8\u9f20\u76844T1\u5f02\u4f53\u79fb\u690d\u80bf\u7624\u6a21\u578b\u4e0a\u4f53\u73b0\u51fa\u4e86\u58f0\u52a8\u529b\u7ed3\u5408\u5149\u70ed\u6d88\u878d\u8054\u5408\u6cbb\u7597\u7684\u6548\u679c\uff0c\u4e3a\u80bf\u7624\u7eb3\u7c73\u533b\u5b66\u9886\u57df\u63d0\u4f9b\u4e00\u9879\u58f0\u52a8\u529b\u7ed3\u5408\u5149\u70ed\u9ad8\u6548\u6cbb\u7597\u7684\u8303\u4f8b\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cOxygen-Deficient Black Titania for Synergistic\/Enhanced Sonodynamic and Photo-Induced Cancer Therapy at Near Infrared-II Biowindow<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe1 B-TiO2-x<\/sub>-PEG\u5408\u6210\u793a\u610f\u56fe<\/strong><\/p>\n \u56fe2 B-TiO2<\/sub>-x\u7406\u5316\u8868\u5f81<\/strong><\/p>\n (b) B-TiO2-x<\/sub>\u7684\u9ad8\u5206\u8fa8\u7387TEM\uff1b<\/p>\n (c) B-TiO2-x<\/sub>\u7684\u666e\u901aTEM\u56fe(50nm)\uff1b<\/p>\n (d) B-TiO2-x<\/sub>\u7684EDS\u56fe\uff1b<\/p>\n (e) B-TiO2-x<\/sub>\u7684EELS\u56fe\uff1b<\/p>\n (f) TiO2<\/sub> \u548cB-TiO2-x<\/sub>\u7684XRD\u56fe\uff1b<\/p>\n (g) TiO2<\/sub> \u548cB-TiO2-x<\/sub>\u7684\u62c9\u66fc\u5149\u8c31\uff1b<\/p>\n (h) TiO2<\/sub> \u548cB-TiO2-x<\/sub>\u7684XPS\u56fe\u3002<\/p>\n \u56fe3 B-TiO2-x<\/sub>\u4f53\u5916\u7684SDT\u4e0ePTT\u6548\u5e94<\/strong><\/p>\n \uff08a\uff09TiO2<\/sub>\u6eb6\u6db2\u5728\u8d85\u58f0\uff081.5 W cm-2<\/sup> Duty cycle: 50%)\u5904\u7406\u65f6\u4e8e1,2,3,4min\u65f6\uff0c\u6d4b\u5f97ROS\u63a2\u9488DPBF\u7684UV\u56fe\uff1b<\/p>\n \uff08b\uff09B-TiO2-x<\/sub>\u6eb6\u6db2\u5728\u8d85\u58f0\uff081.5 W cm-2<\/sup>; Duty cycle: 50%)\u5904\u7406\u65f6\u4e8e1,2,3,4min\u65f6\uff0c\u6d4b\u5f97ROS\u63a2\u9488DPBF\u7684UV\u56fe\uff1b<\/p>\n \uff08c\uff09DPBF\u76f8\u5bf9\u5438\u6536\u56fe\uff1b<\/p>\n \uff08d\uff09B-TiO2-x<\/sub>\u5355\u5206\u6563\u6eb6\u6db2\uff08\u4e0d\u540c\u6d53\u5ea6\uff09UV\u56fe\uff1b<\/p>\n \uff08e\uff09NIR-II (1064 nm) 1.5W cm-2<\/sup>\u5149\u7167\u4e0b\uff0cTiO2<\/sub>\u548c\u4e0d\u540c\u6d53\u5ea6B-TiO2-x<\/sub>\u7684\u65f6\u95f4-\u6e29\u5ea6\u66f2\u7ebf\uff1b<\/p>\n \uff08f\uff09B-TiO2-x<\/sub>\u5728\u4e0d\u540c\u5149\u7167\u529f\u7387\u4e0b\u7684\u65f6\u95f4\u6e29\u5ea6\u66f2\u7ebf\u3002<\/p>\n \u56fe4 \u7ec6\u80de\u5185B-TiO2-x<\/sub>-PEG\u7684SDT\/PTT\u534f\u540c\u6548\u5e94<\/strong><\/p>\n \uff08a\uff09\u7ec6\u80de\u5185SDT\/PTT\u534f\u540c\u6cbb\u7597\u539f\u7406\u56fe\uff1b<\/p>\n \uff08b\uff09\u65e0\u5149\u7167\u3001\u8d85\u58f0\u6ce2\u5904\u7406\u4e0bB-TiO2-x<\/sub>-PEG\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff1b<\/p>\n \uff08c\uff09\u5728\u5149\u7167\u3001\u8d85\u58f0\u5904\u7406\u4e0bB-TiO2-x<\/sub>-PEG\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n \uff08d\uff09B-TiO2-x<\/sub>-PEG\u5728\u4e0d\u540c\u5904\u7406\u4e0b\u7684\u51cb\u4ea1\u6d41\u5f0f\u7ec6\u80de\u56fe\uff1b<\/p>\n \uff08e\uff09B-TiO2-x<\/sub>-PEG\u5728\u4e0d\u540c\u5904\u7406\u4e0b\u7684\u6d3b\u6b7b\u67d3\u8272CLSM\u56fe\uff1b<\/p>\n \uff08f\uff09B-TiO2-x<\/sub>-PEG\u5728\u4e0d\u540c\u5904\u7406\u4e0bDCFH-DA\u67d3\u8272CLSM\u56fe\uff1b<\/p>\n \uff08g\uff09B-TiO2-x<\/sub>-PEG\u5728\u4e0d\u540c\u5904\u7406\u4e0b\u63a2\u6d4bROS\u7684\u6d41\u5f0f\u7ec6\u80de\u56fe\u3002<\/p>\n \u56fe5 \u6d3b\u4f53\u4ee3\u8c22\u52a8\u529b\u5b66\u3001\u751f\u7269\u5206\u5e03\u4ee5\u53ca\u5149\u70ed\u6548\u5e94<\/strong><\/p>\n (a) \u9759\u8109\u6ce8\u5c04B-TiO2-x<\/sub>-PEG\u540e\u7684\u8840\u6db2\u5faa\u73af\u66f2\u7ebf\uff1b<\/p>\n (b) \u7531\u8840\u6db2\u5faa\u73af\u66f2\u7ebf\u63a8\u5bfc\u51fa\u7684\u6d88\u9664\u7387\u66f2\u7ebf\uff1b<\/p>\n (c) \u9759\u8109\u6ce8\u5c04B-TiO2-x<\/sub>-PEG\u540e2\uff0c24\u548c48\u5c0f\u65f6\u540e\uff0cTi( Ti \u5728\u6bcf\u514b\u7ec4\u7ec7\u4e2d\u7684% ID)\u5728\u4e3b\u8981\u5668\u5b98\u548c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u751f\u7269\u5206\u5e03\uff1b<\/p>\n (d) B-TiO2-x<\/sub>-PEG SDT\u4e0ePTT\u534f\u540c\u6d88\u878d\u80bf\u7624\u7684\u539f\u7406\u56fe\uff1b<\/p>\n (e) \u6d3b\u4f53\u6cbb\u7597\u4e2d\u7684\u8d85\u58f0\u5904\u7406\u65b9\u6848\uff1b<\/p>\n (f) 4T1\u80bf\u7624\u5f02\u4f53\u79fb\u690d\u6a21\u578b\u5c0f\u9f20\u80bf\u7624\u90e8\u4f4d\u5728B-TiO2-x<\/sub>-PEG \u5b58\u5728\u6216\u6ca1\u6709\u72b6\u6001\u4e0b\uff0c\u4e8e1064nm 1.5Wcm-2<\/sup>\u6fc0\u5149\u7167\u5c04600s\u7684\u65f6\u95f4-\u6e29\u5ea6\u66f2\u7ebf\uff1b<\/p>\n (g) \u5728\u5149\u7167\u4e0b4T1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u4e8e\u4e0d\u540c\u65f6\u95f4\u70b9\uff080\uff0c2,4,6,8\uff0c\u548c10min\uff09\u5bf9\u5e94\u7684\u8fd1\u7ea2\u5916\u6210\u50cf\u56fe\u3002<\/p>\n \u56fe6 NIR-II\u751f\u7269\u7a97\u53e3\u4e2dB-TiO2-x<\/sub>-PEG\u7684SDT\/PTT\u534f\u540c\u6cbb\u7597\u6548\u5e94<\/strong><\/p>\n \uff08a\uff09\u65f6\u95f4-\u4f53\u91cd\u66f2\u7ebf\uff1b<\/p>\n \uff08b\uff09\u65f6\u95f4-\u80bf\u7624\u4f53\u79ef\u66f2\u7ebf\uff1b<\/p>\n \uff08c\uff09\u80bf\u7624\u533a\u57df\u6570\u7801\u56fe\u50cf\uff1b<\/p>\n \uff08d\uff09\u80bf\u7624\u6d88\u878d\u6bd4\u7387\uff1b<\/p>\n \uff08e\uff09\u751f\u5b58\u66f2\u7ebf\uff1b<\/p>\n \uff08f\uff09H&E\u67d3\u8272\uff1b<\/p>\n \uff08g\uff09TUNEL\u67d3\u8272\u548cAntigen Ki-67\u514d\u75ab\u7ec4\u5316\u67d3\u8272\u3002<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u7814\u7a76\u4f7f\u7528\u4e86\u4e00\u79cd\u5408\u7406\u7684\u8bbe\u8ba1\uff0c\u4f7f\u4f20\u7edf\u65e0\u673a\u534a\u5bfc\u4f53TiO2<\/sub>\u8868\u9762\u5f62\u6210\u4e00\u5c42\u6709\u7740\u5927\u91cf\u6c27\u7f3a\u9677\u7684TiO2-x<\/sub>\u5c42\u3002\u8fd9\u79cd\u5fae\u5999\u7684\u6539\u53d8\uff0c\u4f7fB-TiO2-x<\/sub>\u65e2\u5728\u8d85\u58f0\u4f5c\u7528\u4e0b\u80fd\u591f\u6709\u826f\u597d\u7684\u58f0\u52a8\u529b\u4f5c\u7528\uff0c\u5728\u80bf\u7624\u73af\u5883\u4e2d\u4ea7\u751fROS\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u548c\u574f\u6b7b\uff1b\u540c\u65f6\uff0c\u5176\u4e5f\u5177\u6709\u826f\u597d\u7684\u5149\u70ed\u6027\u80fd\uff0839.8%\uff09\uff0c\u8fbe\u5230\u70ed\u6d88\u878d\u80bf\u7624\u7684\u76ee\u7684\u3002SDT\u4e0ePTT\u7684\u534f\u540c\u6548\u5e94\u663e\u8457\u589e\u52a0B-TiO2-x<\/sub>-PEG\u7684\u80bf\u7624\u6cbb\u7597\u6548\u5e94\u3002\u8fd9\u9879\u7814\u7a76\u6210\u679c\u4e3a\u4f20\u7edf\u65e0\u673a\u534a\u5bfc\u4f53\u5728\u751f\u7269\u533b\u5b66\u7684\u5e94\u7528\u4e2d\u6253\u5f00\u4e86\u65b0\u601d\u8def\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1aOxygen-Deficient Black Titania for Synergistic\/Enhanced Sonodynamic and Photo-Induced Cancer Therapy at Near Infrared-II Biowindow<\/a>.<\/strong>\uff08ACS Nano,2018,DOI: 10.1021\/acsnano.8b00899\uff09<\/p>\n \u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead<\/a>\u3002<\/p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\u3002<\/p>\n<\/p>\n
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