{"id":137125,"date":"2018-05-05T14:00:07","date_gmt":"2018-05-05T06:00:07","guid":{"rendered":"\/\/m.iemloyee.com\/?p=137125"},"modified":"2018-05-04T11:50:32","modified_gmt":"2018-05-04T03:50:32","slug":"%e5%9b%bd%e5%ae%b6%e7%ba%b3%e7%b1%b3%e4%b8%ad%e5%bf%83%e8%81%82%e5%b9%bf%e5%86%9b%e5%92%8c%e5%8e%a6%e9%97%a8%e5%a4%a7%e5%ad%a6%e4%bb%bb%e7%a3%8anano-letters-%e9%a1%ba%e5%ba%8f%e5%93%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=137125","title":{"rendered":"\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\u8042\u5e7f\u519b\u548c\u53a6\u95e8\u5927\u5b66\u4efb\u78caNano Letters: \u987a\u5e8f\u54cd\u5e94\u6027\u591a\u80bd\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7c92\u5b50\u7528\u4e8e\u53cc\u91cd\u9776\u5411\u764c\u75c7\u514d\u75ab\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u662f\u4e00\u4e2a\u590d\u6742\u7684\u8fc7\u7a0b\uff0c\u6d89\u53ca\u5230\u514d\u75ab\u7ec6\u80de\u7684\u5b9a\u4f4d\u3001\u589e\u6b96\u548c\u6fc0\u6d3b\u3002\u4e4b\u524d\u7684\u7814\u7a76\u5df2\u7ecf\u8bc1\u660e\u6076\u6027\u80bf\u7624\u7ec6\u80de\u4f1a\u901a\u8fc7\u5404\u79cd\u673a\u5236\u6765\u8eb2\u907f\u514d\u75ab\u76d1\u6d4b\uff0c\u4ece\u800c\u5bfc\u81f4\u591a\u79cd\u6cbb\u7597\u7b56\u7565\u7528\u4e8e\u589e\u5f3a\u80bf\u7624\u514d\u75ab\u6291\u5236\u7684\u5fae\u73af\u5883\u4e2d\u8870\u7aedT\u7ec6\u80de\u7684\u6d3b\u529b\u3002\u76ee\u524d\uff0c\u6709\u6548\u7684\u65b9\u6cd5\u662f\u5229\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u62ee\u6297\u5242\u6765\u63d0\u9ad8T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6fc0\u6d3b\u3002PD-1\u4f5c\u4e3a\u4e00\u79cd\u4f17\u6240\u5468\u77e5\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u53d7\u4f53\uff0c\u5b83\u8868\u8fbe\u5728\u6d3b\u5316\u7684T\u7ec6\u80de\u8868\u9762\u5e76\u4e14\u8fc7\u8868\u8fbe\u4e8e\u8870\u7aed\u7684T\u7ec6\u80de\u3002\u8bb8\u591a\u6076\u6027\u80bf\u7624\u7ec6\u80de\u8868\u9762\u8fc7\u8868\u8fbePD-1\u914d\u4f53PD-L1\uff0c\u4e0ePD-1\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u589e\u6b96\u548c\u6fc0\u6d3b\u3002\u8fd9\u4e2a\u539f\u7406\u88ab\u7528\u6765\u5f00\u53d1\u5355\u514b\u9686\u6297\u4f53\u548c\u9488\u5bf9PD-1\/PD-L1\u7684\u6cbb\u7597\u6027\u591a\u80bd\u3002\u76ee\u524d\uff0c\u4e00\u4e9b\u6297\u4f53\u5df2\u7ecf\u6210\u529f\u5730\u8fd0\u7528\u4e8e\u80bf\u7624\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\uff0c\u5e76\u53d6\u5f97\u4e86\u524d\u6240\u672a\u6709\u7684\u7597\u6548\u3002\u7136\u800c\u53ea\u6709\u4e00\u5c0f\u90e8\u5206\u75c5\u4eba\u4ece\u4e2d\u83b7\u76ca\uff0c\u800c\u5927\u90e8\u5206\u75c5\u4eba\u4ecd\u7136\u6ca1\u80fd\u5f97\u5230\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u901a\u8fc7\u4e0d\u540c\u7684\u7b56\u7565\uff0c\u5c24\u5176\u662f\u8054\u5408\u6cbb\u7597\u7684\u7b56\u7565\u6765\u63d0\u9ad8\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u54cd\u5e94\u7387\u662f\u4e00\u4e2a\u91cd\u8981\u7814\u7a76\u65b9\u5411\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3<\/b><\/strong>\u7684\u8042\u5e7f\u519b\u6559\u6388<\/b><\/strong>\u8bfe\u9898\u7ec4\u4e0e\u53a6\u95e8\u5927\u5b66\u4efb\u78ca<\/b><\/strong>\u6559\u6388<\/b><\/strong>\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u53a6\u95e8\u5927\u5b66\u6750\u6599\u5b66\u9662<\/b><\/strong>2016\u7ea7\u535a\u58eb\u751f\u7a0b\u79d1\u6ee1<\/b><\/strong>\u4e0e\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u4e01\u8273\u840d\u526f\u7814\u7a76\u5458<\/b><\/strong>\u4e3a\u5171\u540c\u4e00\u4f5c\uff0c\u62a5\u9053\u4e86\u4e00\u79cd\u591a\u80bd\u81ea\u7ec4\u88c5\u7684\u7eb3\u7c73\u7c92\u5b50\uff0c\u53ef\u4ee5\u5b9e\u73b0\u5728\u80bf\u7624\u80de\u5916\u57fa\u8d28\u4e2d\u7684\u53cc\u91cd\u54cd\u5e94\uff0c\u4ece\u800c\u91ca\u653ePD-L1\u7684\u77ed\u80bd\u62ee\u6297\u5242\uff08MD<\/sup>PPA-1\uff09\u548c\u5432\u54da\u80fa2,3\u53cc\u52a0\u6c27\u9176\uff08IDO\uff09\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u6291\u5236\u5242\uff08NLG919\uff09\uff0c\u901a\u8fc7\u963b\u65ad\u514d\u75ab\u68c0\u67e5\u70b9\u548c\u964d\u4f4e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8272\u6c28\u9178\u4ee3\u8c22\uff0c\u4f7f\u5f97T\u7ec6\u80de\u5728\u80bf\u7624\u7ec4\u7ec7\u5185\u7684\u6d78\u6da6\u6c34\u5e73\u5f97\u5230\u4e86\u660e\u663e\u7684\u63d0\u5347\uff0c\u540c\u65f6\u6709\u6548\u5730\u6291\u5236\u4e86\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u3002\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4e00\u6bb5\u4e24\u4eb2\u6027\u7684\u591a\u80bd\uff08DEAP-D<\/sup>PPA-1\uff09\u4e0eNLG919\uff08IDO\u9176\u6291\u5236\u5242\uff09\u7ec4\u88c5\u5f62\u6210\u7eb3\u7c73\u7c92\u5b50\u3002\u8fd9\u4e2a\u7eb3\u7c73\u7c92\u5b50\u5728\u80bf\u7624\u7684\u5fae\u9178\u73af\u5883\u4e2d\u7ecf\u8fc7\u521d\u6b65\u81a8\u80c0\uff0c\u4ee5\u53ca\u5728MMP-2\u9176\u7684\u4f5c\u7528\u4e0b\u8fdb\u4e00\u6b65\u89e3\u805a\uff0c\u8fdb\u800c\u91ca\u653e\u6cbb\u7597\u6027\u591a\u80bdMD<\/sup>PPA-1\u548cNLG919\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy<\/b><\/strong>“\u53d1\u8868\u5728Nano Letters<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1<\/b><\/strong>.<\/b><\/strong>\u00a0<\/b><\/strong>DEAP-<\/b><\/strong>D<\/b><\/sup><\/strong>PPA-1\u7684\u7ec4\u6210\u548cNLG919@DEAP-<\/b><\/strong>D<\/b><\/sup><\/strong>PPA-1\u7eb3\u7c73\u7c92\u5b50\u7684\u6297\u80bf\u7624\u673a\u7406<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>2<\/b><\/strong>. <\/b><\/strong>DEAP-<\/b><\/strong>D<\/b><\/sup><\/strong>PPA-1\u7eb3\u7c73\u7c92\u5b50\u7684\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).DEAP-D<\/sup>PPA-1\u7eb3\u7c73\u7c92\u5b50\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684TEM\u56fe\uff1b<\/p>\n

(b).\u7c92\u5f84\u5927\u5c0f<\/p>\n

(c).DEAP-D<\/sup>PPA-1, TRITC\u548cBHQ-1\u7ec4\u88c5\u5f62\u6210\u8367\u5149\u7eb3\u7c73\u63a2\u9488<\/p>\n

(d).DEAP-D<\/sup>PPA-1\uff0cTRITC\u548cBHQ-1\u7ec4\u88c5\u6210\u7684\u8367\u5149\u7eb3\u7c73\u63a2\u9488\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\uff1b<\/p>\n

(e).\u5728\u4f53\u548c\u79bb\u4f53\u7684\u6210\u50cf<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>. <\/b><\/strong>NLG919@DEAP-<\/b><\/strong>D<\/b><\/sup><\/strong>PPA-1\u7eb3\u7c73\u7c92\u5b50\u7684\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u00a0NLG919@DEAP-D<\/sup>PPA-1\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe\u548c\u7c92\u5f84\u5206\u6790\uff1b<\/p>\n

(b).\u00a0\u836f\u7269\u91ca\u653e\u5206\u6790\uff1b<\/p>\n

(c).\u00a0NLG919@DEAP-D<\/sup>PPA-1\u7eb3\u7c73\u7c92\u5b50\u548cNLG919\u5bf9IDO\u9176\u6d3b\u6027\u7684\u6291\u5236\u6548\u679c<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>. <\/b><\/strong>DEAP-<\/b><\/strong>D<\/b><\/sup><\/strong>PPA-1\u7eb3\u7c73\u7c92\u5b50\u5bf9\u9ed1\u8272\u7d20\u7624\u751f\u957f\u7684\u6291\u5236\u6548\u679c\u53ca\u5176\u6240\u8bf1\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u00a0\u7ecf\u8fc7\u4e0d\u540c\u7ed9\u836f\u5904\u7406\u540e\uff0c\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(b). \u80bf\u7624\u7ec4\u7ec7\u5185\u7684CD8+<\/sup>\u00a0T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff1b<\/p>\n

(c). \u80bf\u7624\u7ec4\u7ec7\u5185\u7684IFN-\u03b3-producing T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff1b<\/p>\n

(d). \u80bf\u7624\u7ec4\u7ec7\u4e2dIFN-\u03b3\u8868\u8fbe\u91cf\uff1b<\/p>\n

(e). \u80bf\u7624\u7ec4\u7ec7\u4e2d\u4e2dIL-2\u8868\u8fbe\u91cf<\/p>\n

\u56fe<\/b><\/strong>5<\/b><\/strong>. <\/b><\/strong>NLG919@DEAP-<\/b><\/strong>D<\/b><\/sup><\/strong>PPA-1\u7eb3\u7c73\u7c92\u5b50\u7684\u8054\u5408\u6297\u80bf\u7624\u6548\u679c<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u7ecf\u8fc7\u4e0d\u540c\u7ed9\u836f\u5904\u7406\u540e\uff0c\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u66f2\u7ebf<\/p>\n

(b,c).\u7ecf\u8fc7\u4e0d\u540c\u7ed9\u836f\u5904\u7406\u540e\uff0c\u7b2c7\u5929\u548c14\u5929\u65f6\uff0c\u80bf\u7624\u7ec4\u7ec7\u5185CD8+<\/sup>\u00a0T\u7ec6\u80de\u548cIFN-\u03b3-producing T\u7ec6\u80de\u7684\u6bd4\u4f8b<\/p>\n

(d,e).\u00a0\u7ecf\u8fc7\u4e0d\u540c\u5904\u7406\u540e\uff0c\u80bf\u7624\u7ec4\u7ec7\u5185IFN-\u03b3\u548cIL-2\u7684\u8868\u8fbe\u6c34\u5e73\uff1b(f). \u5c0f\u9f20\u7684\u5b58\u6d3b\u7387<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u62a5\u9053\u4e86\u4e00\u79cd\u591a\u80bd\u81ea\u7ec4\u88c5\u7684\u7eb3\u7c73\u7c92\u5b50\uff0c\u5b83\u4e0d\u4ec5\u53ef\u4ee5\u54cd\u5e94\u80bf\u7624\u5fae\u73af\u5883\u7684\u5fae\u9178\u6027\uff0c\u4f7f\u5f97\u7eb3\u7c73\u7c92\u5b50\u7ed3\u6784\u521d\u6b65\u81a8\u80c0\uff0c\u8fdb\u4e00\u6b65\u4e0e\u54cd\u5e94\u80de\u5916\u57fa\u8d28\u4e2d\u7684MMP-2\u9176\u54cd\u5e94\uff0c\u4f7f\u5f97\u7eb3\u7c73\u9897\u7c92\u7ed3\u6784\u5728\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f02\u6027\u89e3\u805a\uff0c\u4ece\u800c\u91ca\u653ePD-L1\u7684\u77ed\u80bd\u62ee\u6297\u5242\u548cIDO\u9176\u6291\u5236\u5242NLG919\uff0c\u901a\u8fc7\u963b\u65ad\u514d\u75ab\u68c0\u6d4b\u70b9\u548c\u964d\u4f4e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8272\u6c28\u9178\u4ee3\u8c22\uff0c\u4ece\u800c\u589e\u5f3aT\u7ec6\u80de\u5728\u80bf\u7624\u7ec4\u7ec7\u5185\u7684\u6d78\u6da6\u6c34\u5e73\uff0c\u540c\u65f6\u6709\u6548\u5730\u6291\u5236\u4e86\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy<\/a> (Nano Lett., 2018, DOI: 10.1021\/acs.nanolett.8b01071)<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead<\/a>\u3002 \u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\uff0c\u6211\u4eec\u4f1a\u9080\u8bf7\u5404\u4f4d\u8001\u5e08\u52a0\u5165\u4e13\u5bb6\u7fa4\u3002 \u00a0<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/b><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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