{"id":136741,"date":"2018-05-03T14:00:21","date_gmt":"2018-05-03T06:00:21","guid":{"rendered":"\/\/m.iemloyee.com\/?p=136741"},"modified":"2018-04-29T19:34:37","modified_gmt":"2018-04-29T11:34:37","slug":"%e6%9e%97%e6%96%87%e6%96%8c-jacs-%e7%ba%b3%e7%b1%b3%e9%87%91%e5%b1%9e%e6%9c%89%e6%9c%ba%e6%a1%86%e6%9e%b6-%e5%8f%af%e6%9c%8d%e7%bc%ba%e6%b0%a7%e7%9a%84%e5%85%89%e5%8a%a8%e5%8a%9b%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=136741","title":{"rendered":"\u6797\u6587\u658c JACS : \u7eb3\u7c73\u91d1\u5c5e\u6709\u673a\u6846\u67b6-\u53ef\u670d\u7f3a\u6c27\u7684\u5149\u52a8\u529b\u6cbb\u7597\u764c\u75c7\u514d\u75ab\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u6210\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002\u514d\u75ab\u68c0\u70b9\u5c01\u9501\uff08ICB\uff09\u5229\u7528\u6297\u4f53\u963b\u65ad\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u901a\u8def\uff0c\u5df2\u7ecf\u5728\u51e0\u4e2a\u665a\u671f\u764c\u75c7\u4e2d\u83b7\u5f97\u4e86\u4e34\u5e8a\u6210\u529f\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u6fc0\u6d3b\u4e0d\u8db3\uff0c\u5bfc\u81f4ICB\u5bf9\u8bb8\u591a\u764c\u75c7\u7684\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u53cd\u5e94\u7684\u6bd4\u7387\u662f\u6709\u9650\u7684\u3002\u5c06ICB\u4e0e\u5176\u4ed6\u514d\u75ab\u539f\u6027\u6cbb\u7597\u76f8\u7ed3\u5408\u53ef\u63d0\u9ad8\u975e\u708e\u75c7\u6027\u80bf\u7624\u7684\u53cd\u5e94\u7387\u3002\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u4f1a\u5f15\u8d77\u6025\u6027\u708e\u75c7\u53cd\u5e94\uff0c\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5e76\u6709\u5e0c\u671b\u663e\u8457\u63d0\u9ad8ICB\u7684\u7597\u6548\u3002\u7136\u800c\uff0cPDT\u548cICB\u7684\u534f\u540c\u6cbb\u7597\u5f88\u5c11\u88ab\u63a2\u7d22\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u7684\u6797\u6587\u658c\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u4e00\u79cd\u7eb3\u7c73\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6(Fe-TBP)\uff0c\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u7eb3\u7c73\u5149\u654f\u5242\u6765\u514b\u670d\u80bf\u7624\u7f3a\u6c27\u548c\u63d0\u9ad8PDT\u7684\u654f\u611f\u6548\u7387\uff0c\u7528\u4e8e\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u975e\u708e\u75c7\u6027\u80bf\u7624\u3002Fe-TBP\u662f\u542b\u6c27\u91cf\u6b63\u5e38\u548c\u4f4e\u6c27\u6761\u4ef6\u4e0b\u7531\u94c1\u6c27\u7c07\u3001\u535f\u5549\u914d\u4f53\u548c\u654f\u5316PDT\u6784\u5efa\u7684\u3002Fe-TBP\u8c03\u89e3\u7684PDT\u663e\u8457\u6539\u5584\u4e86\u6297-\u7a0b\u5e8f\u6027\u6b7b\u4ea1-\u914d\u4f531\uff08\u03b1-PD-L1\uff09\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u5f15\u8d77\u4e86\u7ed3\u76f4\u80a0\u764c\u5c0f\u9f20\u6a21\u578b\u7684\u8fdc\u4f4d\u6548\u5e94\uff0c\u5bfc\u81f4\u4e8690%\u7684\u80bf\u7624\u9000\u5316\u3002\u673a\u68b0\u7814\u7a76\u8868\u660e\uff0cFe-TBP\u8c03\u89e3\u7684PDT\u8bf1\u5bfc\u4e86\u7ec6\u80de\u6bd2\u7d20T\u7ec6\u80de\u7684\u80bf\u7624\u6d78\u6da6\u662f\u6709\u91cd\u5927\u610f\u4e49\u7684\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aJACS<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001Fe-TBP\u4f5c\u7528\u6d41\u7a0b\u548c\u7406\u5316\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 Fe-TBP\u514b\u670d\u7f3a\u6c27\u7684PDT\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u7684\u539f\u7406\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09 Fe-TBP\u7684TEM\u56fe(500 nm)\uff1b<\/p>\n

\uff08c\uff09 Fe-TBP\u7684\u9ad8\u5206\u8fa8TEM\u548c\u5feb\u901f\u5085\u91cc\u53f6\u53d8\u6362\u56fe\uff1b<\/p>\n

\uff08d\uff09 Fe-TBP\u7684TEM\u56fe(100 nm);<\/p>\n

\uff08e\uff09 \u4e0ePCN-600\u76f8\u6bd4\uff0cFe-TBP\u7684PXRD\u56fe\uff1b<\/p>\n

\uff08f\uff09 Fe-TBP\u548cH4<\/sub>TBP\u7684\u7d2b\u5916\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

\uff08g\uff09 EXAFS\u62df\u5408\u7684Fe-TBP\uff0c\u663e\u793a\u4e86Fe\u4f5c\u4e3aFe3<\/sub>O(-COO-)6<\/sub>(H2O)3<\/sub>+<\/sup>\u534f\u8c03\u73af\u5883\u3002<\/p>\n

\u56fe\u4e8c\u3001Fe-TBP\u5c06H2<\/sub>O2<\/sub>\u8f6c\u5316\u4e3aO2<\/sub>\u6765\u514b\u670d\u7f3a\u6c27\u00a0<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 \u6c27\u4f20\u611f\u5668\u68c0\u6d4b\u5230\u7684\u65f6\u95f4–<\/sup>O2<\/sub>\u751f\u4ea7\u91cf\u56fe\uff1b<\/p>\n

\uff08b\uff09 SOSG\u5206\u6790\u68c0\u6d4b\u5230\u6b63\u5e38\u6761\u4ef6\u4e0b\u76841<\/sup>O2<\/sub>\u7684\u751f\u6210\uff1b<\/p>\n

\uff08c\uff09 SOSG\u5206\u6790\u68c0\u6d4b\u5230\u7f3a\u6c27\u6761\u4ef6\u4e0b\u76841<\/sup>O2<\/sub>\u7684\u751f\u6210\uff1b<\/p>\n

\uff08d\uff09 \u7eff\u8272\u8367\u5149\u68c0\u6d4b\u7ec6\u80de\u5185H2<\/sub>O2<\/sub>\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09 \u7eff\u8272\u8367\u5149\u8868\u793a\u7ec6\u80de\u6838\u5185HIF-1\u03b1\u5728\u7ec6\u80de\u5185\u7684\u8868\u8fbe\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

\uff08f\uff09 \u901a\u8fc7CT26\u578b\u5c0f\u9f20\u80bf\u7624\u5207\u7247\u8bc4\u4f30\u4f53\u5185HIF-1\u03b1\u7684\u8868\u8fbe\uff1b<\/p>\n

\uff08g\uff09 \u6b63\u5e38\u6761\u4ef6\u4e0b\u7684\u7ec6\u80de\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n

\uff08h\uff09 \u7f3a\u6c27\u6761\u4ef6\u4e0b\u7684\u7ec6\u80de\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n

\uff08i\uff09 \u7528PBS\u3001H4<\/sub>TBP\u3001Hf-TBP\u6216Fe-TBP\u5904\u7406\u8fc7\u7684\uff0c\u8fdb\u884c\u5149\u7167\u6216\u975e\u5149\u7167\u5c04\u6cbb\u7597\u7684CT26\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08N=6\uff09\u3002<\/p>\n

\u56fe\u4e09\u3001Fe-TBP\u8c03\u89e3\u7684PDT\u5f15\u8d77ICD\u548c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u00a0<\/strong><\/p>\n

\"\"
\n \uff08a\uff09 \u7eff\u8272\u8367\u5149\u663e\u793aCRT\u66b4\u9732\u7684\u4f53\u5185\u514d\u75ab\u8367\u5149\uff1b<\/p>\n

\uff08b\uff09 \u4e24\u4fa7\u7684CT26\u578b\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u539f\u53d1\u6027\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08c\uff09 \u4e24\u4fa7\u7684CT26\u578b\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u8fdc\u5904\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09 CT26\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff0cT\u7ec6\u80de\u6216B\u7ec6\u80de\u8017\u7aed\uff1b<\/p>\n

\uff08e\uff09 \u5728CT26\u7ec6\u80de\u5904\u7406\u540e\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u56fe\u3002N = 6. *P < 0.05, **P < 0.01, and ***P < 0.001.<\/p>\n

\u56fe\u56db\u3001\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u00a0<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 ELISPOT\u5206\u6790\u8fdb\u884c\u68c0\u6d4bIFN-\u03b3\u4ea7\u751fT\u7ec6\u80de\uff1b<\/p>\n

\uff08b\uff09 \u80bf\u7624\u6d78\u6da6\u7684CD45+<\/sup>\u7ec6\u80de\u5360\u80bf\u7624\u603b\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

\uff08c\uff09 \u80bf\u7624\u6d78\u6da6\u7684CD4+<\/sup>T\u7ec6\u80de\u5360\u80bf\u7624\u603b\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

\uff08d\uff09 \u80bf\u7624\u6d78\u6da6\u7684CD8+<\/sup>T\u7ec6\u80de\u5360\u80bf\u7624\u603b\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002n = 5. *P < 0.05, **P < 0.01, and ***P < 0.001<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7814\u7a76\u91c7\u7528\u4e86\u4e00\u79cd\u65b0\u7684\u7eb3\u7c73\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08nMOF\uff09\u6765\u514b\u670dPDT\u7684\u80bf\u7624\u7f3a\u6c27\uff0c\u63d0\u9ad8\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u6548\u679c\u3002Fe-TBP\u7ed3\u5408\u03b1-PD-L1\u6cbb\u7597\u5f15\u53d1CD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u7ec6\u80de\u6bd2\u6027\u663e\u8457\u6269\u5f20\uff0c\u6e17\u900f\u5230\u9065\u8fdc\u7684\u80bf\u7624\u90e8\u4f4d\u5f15\u8d77\u8fdc\u4f4d\u7684\u6548\u5e94\u3002\u901a\u8fc7\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u7b56\u7565\uff0c\u5c06PDT\u4e0eICB\u7ed3\u5408\u4ee5\u5f15\u8d77\u5168\u8eab\u7684\u6297\u80bf\u7624\u514d\u75ab\u6548\u679c\uff0c\u4e3a\u764c\u75c7\u534f\u540c\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3001\u65b0\u65b9\u5411\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy<\/a>\uff08JACS, 2018, DOI: 10.1021\/jacs.8b01072\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1<\/strong>\uff0c\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/strong><\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenkefu.<\/strong><\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u6700\u8fd1\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u6210\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002\u514d\u75ab\u68c0\u70b9\u5c01\u9501\uff08ICB\uff09\u5229\u7528\u6297\u4f53\u963b\u65ad\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u901a\u8def\uff0c\u5df2\u7ecf\u5728\u51e0\u4e2a\u665a\u671f\u764c\u75c7\u4e2d\u83b7\u5f97\u4e86\u4e34\u5e8a\u6210\u529f\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5bbf\u4e3b\u514d…<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[3125,3126,3130],"class_list":["post-136741","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-nmof","tag-pdt","tag-3130"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/136741"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=136741"}],"version-history":[{"count":7,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/136741\/revisions"}],"predecessor-version":[{"id":136873,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/136741\/revisions\/136873"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=136741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=136741"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=136741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}