{"id":136469,"date":"2018-04-26T08:22:39","date_gmt":"2018-04-26T00:22:39","guid":{"rendered":"\/\/m.iemloyee.com\/?p=136469"},"modified":"2018-04-26T08:22:39","modified_gmt":"2018-04-26T00:22:39","slug":"%e5%93%88%e4%bd%9b%e5%a4%a7%e5%ad%a6%e6%9c%80%e6%96%b0nature%ef%bc%9a%e5%af%b9%e6%98%a0%e4%bd%93%e5%82%ac%e5%8c%96sn1%e5%8f%8d%e5%ba%94%e6%9e%84%e5%bb%ba%e5%9b%9b%e5%85%83%e7%ab%8b%e4%bd%93%e4%b8%ad","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=136469","title":{"rendered":"\u54c8\u4f5b\u5927\u5b66\u6700\u65b0Nature\uff1a\u5bf9\u6620\u4f53\u50ac\u5316SN1\u53cd\u5e94\u6784\u5efa\u56db\u5143\u7acb\u4f53\u4e2d\u5fc3"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5355\u5206\u5b50\u4eb2\u6838\u53d6\u4ee3\uff08SN<\/sub>1<\/span>\uff09\u5e38\u53d1\u751f\u4e8e\uff1a\u78b3\u4e0a\u53d6\u4ee3\u57fa\u8f83\u591a\uff0c\u5982\uff1a(CH3<\/sub>)3<\/sub>CX<\/span>\uff0c\u4f7f\u5f97\u76f8\u5e94\u78b3\u6b63\u79bb\u5b50\u7684\u80fd\u91cf\u66f4\u4f4e\uff0c\u66f4\u52a0\u7a33\u5b9a\u3002\u540c\u65f6\u4f4d\u963b\u6548\u5e94\u4e5f\u9650\u5236 SN<\/sub>2 <\/span>\u673a\u7406\u4e2d\u4eb2\u6838\u8bd5\u5242\u7684\u8fdb\u653b\u3002S<\/span>N<\/sub>1\u662f\u53cd\u5e94\u7269\u9996\u5148\u89e3\u79bb\u4e3a\u78b3\u6b63\u79bb\u5b50<\/span>\u4e0e\u5e26\u8d1f\u7535\u8377\u7684\u79bb\u53bb\u57fa\u56e2\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u80fd\u91cf\uff0c\u662f\u63a7\u5236\u53cd\u5e94\u901f\u7387\u7684\u4e00\u6b65\u3002\u5206\u5b50\u89e3\u79bb\u540e\uff0c\u78b3\u6b63\u79bb\u5b50\u7acb\u5373\u4e0e\u4eb2\u6838\u8bd5\u5242\u7ed3\u5408\uff08\u5feb\u901f\u6b65\u9aa4\uff09\u3002\u539f\u5219\u4e0a\uff0c\u4eb2\u6838\u8bd5\u5242\u901a\u8fc7\u78b3\u9633\u79bb\u5b50\u4e2d\u95f4\u4f53\u9010\u6b65\u7f6e\u6362\u79bb\u53bb\u57fa\u56e2\u4f7f\u5f97\u80fd\u591f\u6784\u5efa\u9ad8\u5ea6\u62e5\u585e\u7684\u78b3\u4e2d\u5fc3\u3002\u7136\u800c\uff0c\u78b3\u9633\u79bb\u5b50\u4e2d\u95f4\u4f53\u7684\u56fa\u6709\u4e0d\u7a33\u5b9a\u6027\u548c\u9ad8\u53cd\u5e94\u6027\uff0c\u4f7f\u5f97\u901a\u8fc7SN<\/sub>1<\/span>\u9014\u5f84\u8fdb\u884c\u7684\u53cd\u5e94\u4e2d\u63a7\u5236\u4ea7\u7269\u5206\u5e03\u548c\u7acb\u4f53\u9009\u62e9\u6027\u975e\u5e38\u56f0\u96be\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u54c8\u4f5b\u5927\u5b66<\/strong>Eric N. Jacobsen<\/strong>\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4<\/strong>\u5728Nature<\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cQuaternary stereocentres via an enantioconvergent catalytic SN<\/sub>1 reaction<\/strong>\u201d \u7684\u6587\u7ae0\u3002\u62a5\u544a\u4e86SN<\/sub>1\u578b\u53cd\u5e94\u673a\u7406\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u4f5c\u7528\uff0c\u5bfc\u81f4\u4e86\u7531\u5916\u6d88\u65cb\u524d\u4f53\u5bf9\u6620\u9009\u62e9\u6027\u6784\u5efa\u56db\u5143\u7acb\u4f53\u4e2d\u5fc3\u3002 \u8be5\u8f6c\u5316\u4f9d\u8d56\u4e8e\u624b\u6027\u6c22\u952e\u7ed9\u4f53\u50ac\u5316\u5242\u4e0e\u5f3a\u8def\u6613\u65af\u9178\u4fc3\u8fdb\u5242\u7684\u534f\u540c\u4f5c\u7528\uff0c\u4ee5\u4ecb\u5bfc\u4f4e\u6e29\u4e0b\u4e09\u7ea7\u78b3\u9633\u79bb\u5b50\u4e2d\u95f4\u4f53\u7684\u5f62\u6210\u5e76\u5b9e\u73b0\u5bf9\u53cd\u5e94\u5bf9\u6620\u9009\u62e9\u6027\u548c\u4ea7\u7269\u5206\u5e03\u7684\u9ad8\u6c34\u5e73\u63a7\u5236\u3002 \u8be5\u5de5\u4f5c\u4e3a\u5176\u4ed6\u5b8c\u5168\u53d6\u4ee3\u7684\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u5bf9\u6620\u6d53\u5ea6\u5408\u6210\u63d0\u4f9b\u4e86\u57fa\u7840\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1\u00a0<\/strong>\u56db\u5143\u7acb\u4f53\u4e2d\u5fc3\u7684\u5bf9\u6620\u6784\u5efa\u65b9\u6cd5\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2\u00a0<\/strong>\u7094\u4e19\u57fa\u4e59\u9178\u916f\u7684\u4e0d\u5bf9\u79f0\u70ef\u4e19\u57fa\u5316\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3\u00a0<\/strong>\u52a8\u529b\u5b66\u6570\u636e\u548c\u50ac\u5316\u5faa\u73af\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>4\u00a0<\/strong>\u70ef\u4e19\u57fa\u5316\u53cd\u5e94\u540e\u9650\u901f\u6b65\u9aa4\u7684\u673a\u7406\u7814\u7a76\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Quaternary stereocentres via an enantioconvergent catalytic SN<\/sub>1 reaction<\/a><\/strong>\uff08Nature<\/strong>\uff0cDOI: 10.1038\/s41586-018-0042-1\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u7eb3\u7c73\u6750\u6599\u5b66\u672f\u7ec4<\/strong>Kevin<\/strong>\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406<\/strong>\u3002\u6b22\u8fce\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u7eb3\u7c73\u6750\u6599\u5b66\u672f\u4ea4\u6d41\u7fa4\uff08228686798\uff09\uff01
\n \u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1aRDD-2011-CHERISH<\/strong>\uff0c\u4efb\u4e39\u4e39\uff0c\u6211\u4eec\u4f1a\u9080\u8bf7\u5404\u4f4d\u8001\u5e08\u52a0\u5165\u4e13\u5bb6\u7fa4\u3002<\/p>\n

\n \u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790<\/strong>\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u5355\u5206\u5b50\u4eb2\u6838\u53d6\u4ee3\uff08SN1\uff09\u5e38\u53d1\u751f\u4e8e\uff1a\u78b3\u4e0a\u53d6\u4ee3\u57fa\u8f83\u591a\uff0c\u5982\uff1a(CH3)3CX\uff0c\u4f7f\u5f97\u76f8\u5e94\u78b3\u6b63\u79bb\u5b50\u7684\u80fd\u91cf\u66f4\u4f4e\uff0c\u66f4\u52a0\u7a33\u5b9a\u3002\u540c\u65f6\u4f4d\u963b\u6548\u5e94\u4e5f\u9650\u5236 SN2 \u673a\u7406\u4e2d\u4eb2\u6838\u8bd5…<\/p>\n","protected":false},"author":3440,"featured_media":136470,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[67],"tags":[293,3118],"class_list":["post-136469","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zhoubao","tag-nature","tag-3118"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/136469"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/3440"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=136469"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/136469\/revisions"}],"predecessor-version":[{"id":136486,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/136469\/revisions\/136486"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/136470"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=136469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=136469"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=136469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}