{"id":136059,"date":"2018-04-28T14:00:11","date_gmt":"2018-04-28T06:00:11","guid":{"rendered":"\/\/m.iemloyee.com\/?p=136059"},"modified":"2018-04-27T22:27:03","modified_gmt":"2018-04-27T14:27:03","slug":"%e3%80%90%e6%9c%aa%e5%9b%9e%e5%a4%8d%e3%80%91%e5%8a%a0%e5%b7%9e%e5%a4%a7%e5%ad%a6%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%88%86%e6%a0%a1adv-funct-mater-%ef%bc%9a%e8%bf%9c%e7%a8%8b%e8%b4%9f%e8%bd%bd","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=136059","title":{"rendered":"\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821Adv. Funct. Mater.\uff1a\u8fdc\u7a0b\u8d1f\u8f7d\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u7528\u4e8e\u75be\u75c5\u9776\u5411\u9012\u9001\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7eb3\u7c73\u533b\u5b66\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u5bf9\u4eba\u7c7b\u75be\u75c5\u7684\u4e34\u5e8a\u6cbb\u7597\u5df2\u7ecf\u4ea7\u751f\u4e86\u91cd\u8981\u7684\u5f71\u54cd\uff0c\u5176\u4e2d\u57fa\u4e8e\u7eb3\u7c73\u7c92\u5b50\u7684\u836f\u7269\u9012\u9001\u4f53\u7cfb\u4e00\u5927\u4f18\u52bf\u662f\u80fd\u591f\u63d0\u9ad8\u836f\u7269\u6548\u529b\u548c\u9776\u5411\u6548\u7387\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63d0\u9ad8\u836f\u7269\u9012\u9001\u4f53\u7cfb\u7684\u529f\u80fd\u6027\uff0c\u7eb3\u7c73\u7c92\u5b50\u4e0e\u4eba\u4f53\u5185\u590d\u6742\u751f\u7269\u73af\u5883\u7684\u754c\u9762\u63a2\u7d22\u6210\u4e3a\u7814\u7a76\u70ed\u70b9\u3002\u901a\u8fc7\u66f4\u597d\u5730\u7406\u89e3\u548c\u6539\u8fdb\u7eb3\u7c73\u9897\u7c92\u7684\u751f\u7269\u754c\u9762\u7c98\u9644\uff0c\u6709\u671b\u8fdb\u4e00\u6b65\u964d\u4f4e\u975e\u7279\u5f02\u6027\u76f8\u4e92\u4f5c\u7528\uff0c\u540c\u65f6\u589e\u52a0\u5bf9\u9776\u5411\u76ee\u6807\u7684\u7279\u5f02\u6027\u8bc6\u522b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821<\/strong>\u7684\u5f20\u826f\u65b9\u6559\u6388<\/strong>\u8bfe\u9898\u7ec4\uff0c\u5229\u7528\u5bcc\u542b\u80c6\u56fa\u9187\u7684\u8840\u5c0f\u677f\u819c\u884d\u751f\u7684\u56ca\u6ce1\u8fdc\u7a0b\u8d1f\u8f7d\u963f\u9709\u7d20\u548c\u4e07\u53e4\u9709\u7d20\u4e24\u79cd\u6a21\u578b\u836f\u7269\uff0c\u57fa\u4e8e\u8840\u5c0f\u677f\u819c\u5b58\u5728\u7684\u8868\u9762\u6807\u8bb0\u7269\uff0c\u6240\u5236\u5f97\u7684\u7eb3\u7c73\u5236\u5242\u5bf9\u4e8e\u4e73\u817a\u764c\u7ec6\u80de\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u5c55\u73b0\u51fa\u4f18\u5f02\u7684\u4eb2\u548c\u6027\u8d28\u3002\u8be5\u5de5\u4f5c\u8868\u660e\u5c06\u836f\u7269\u8fdc\u7a0b\u8d1f\u8f7d\u5230\u8840\u5c0f\u677f\u819c\u884d\u751f\u7684\u56ca\u6ce1\u4e2d\u662f\u83b7\u5f97\u9776\u5411\u7eb3\u7c73\u5236\u5242\u662f\u4e00\u79cd\u6709\u6548\u7684\u9014\u5f84\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Remote-Loaded Platelet Vesicles for Disease-Targeted Delivery of Therapeutics<\/strong>“\u53d1\u8868\u5728Advanced Functional Materials<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\u8fdc\u7a0b\u8d1f\u8f7d\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u7528\u4e8e\u9776\u5411\u836f\u7269\u9012\u9001\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u4f7f\u7528\u8840\u5c0f\u677f\u4f5c\u4e3a\u8d77\u59cb\u6750\u6599\uff0c\u5236\u5907\u5bcc\u542b\u80c6\u56fa\u9187\u7684\u819c\u56ca\u6ce1\uff0c\u5e76\u8fdc\u7a0b\u8d1f\u8f7d\u5c0f\u5206\u5b50\u6cbb\u7597\u5242\u3002\u6240\u5f97\u7684\u836f\u7269\u7eb3\u7c73\u5236\u5242\u5177\u6709\u8840\u5c0f\u677f\u7ed3\u5408\u6807\u8bb0\u7269\uff0c\u56e0\u800c\u53ef\u4ee5\u7528\u4e8e\u9776\u5411\u5404\u79cd\u75be\u75c5\u76f8\u5173\u5e95\u7269\uff0c\u5305\u62ec\u764c\u7ec6\u80de\u548c\u7ec6\u83cc\u3002<\/p>\n

\u56fe2 \u5bcc\u542b\u80c6\u56fa\u9187\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0d\u540c\u80c6\u56fa\u9187\u8f93\u5165\u65f6\u5236\u5907\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u5927\u5c0f\uff1b<\/p>\n

(b) \u4e0d\u540c\u80c6\u56fa\u9187\u8f93\u5165\u65f6\u8840\u5c0f\u677f\u56ca\u6ce1\u7684\u8367\u5149\u56fe\uff1b<\/p>\n

(c) \u6709\u65e05%\u80c6\u56fa\u9187\u8f93\u5165DID\u6807\u8bb0\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u7684\u5171\u805a\u7126\u8367\u5149\u6210\u50cf\u5bf9\u6bd4\u56fe\uff1b<\/p>\n

(d) \u7ea2\u7ec6\u80de\u6216\u8005\u8840\u5c0f\u677f\u56ca\u6ce1\u4e0a\u591a\u79cd\u8868\u9762\u7c98\u9644\u6807\u8bb0\u7269\u7684western blots\u63a2\u6d4b\u3002<\/p>\n

\u56fe3 DOX\u8d1f\u8f7d\u8fdb\u8840\u5c0f\u677f\u56ca\u6ce1<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u8840\u5c0f\u677f\u56ca\u6ce1\u4e2d\u4e0d\u540cDOX\u8f93\u5165\u65f6\u7684\u8d1f\u8f7d\u91cf\uff1b<\/p>\n

(b) \u8840\u5c0f\u677f\u56ca\u6ce1\u4e2d\u4e0d\u540cDOX\u8f93\u5165\u65f6\u7684\u8d1f\u8f7d\u6548\u7387\uff1b<\/p>\n

(c) \u8d1f\u8f7dDOX\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u7684\u5c3a\u5bf8\uff1b<\/p>\n

(d) \u8d1f\u8f7dDOX\u524d\u540e\u8840\u5c0f\u677f\u56ca\u6ce1\u7684Zeta\u7535\u4f4d\uff1b<\/p>\n

(e) \u5355\u4e2a\u8d1f\u8f7dDOX\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u7c92\u5b50\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe\u7247\uff1b<\/p>\n

(f) 3\u5929\u5185\u5728pH5.0\u548c7.4\u6761\u4ef6\u4e0b\u8d1f\u8f7dDOX\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\u56fe4 \u5229\u7528\u8d1f\u8f7dDOX\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u8fdb\u884c\u80bf\u7624\u9776\u5411\u8f93\u9001<\/strong><\/p>\n

\"\"<\/p>\n

(a) 4T1\u4e73\u817a\u764c\u7ec6\u80de\u4e0eDOX-RBC\u6216DOX-PLT\u57f9\u517b1\u5c0f\u65f6\u7684\u5171\u805a\u7126\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

(b) 4T1\u4e73\u817a\u764c\u7ec6\u80de\u30014T1\u4e73\u817a\u764c\u7ec6\u80de\u4e0eDOX-RBC\u6216DOX-PLT\u57f9\u517b1\u5c0f\u65f6\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u76f4\u65b9\u56fe\uff1b<\/p>\n

(c) (b)\u56fe\u4e2d\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

(d) \u6e38\u79bbDOX\u3001DOX-RBC\u6216DOX-PLT\u7ed9\u836f4\u5c0f\u65f6\u540e\u5c0f\u9f20\u80bf\u7624\u7684\u5b8f\u89c2\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

(e) (d)\u56fe\u4e2dDOX\u8367\u5149\u7684\u5b9a\u91cf\u3002<\/p>\n

\u56fe5 DOX-PLT\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

(a) 4T1\u4e73\u817a\u764c\u7ec6\u80de\u5206\u522b\u4e8e\u6e38\u79bbDOX\u3001DOX-RBC\u6216DOX-PLT\u5728\u4f53\u5916\u57f9\u517b24\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u6d3b\u529b\uff1b<\/p>\n

(b) 4T1\u80bf\u7624\u539f\u4f4d\u690d\u5165\u5c0f\u9f20\u4ee5\u53ca\u5206\u522b\u7528\u6e38\u79bbDOX\u3001DOX-RBC\u6216DOX-PLT\u5904\u7406\u7684\u751f\u957f\u52a8\u529b\u5b66\uff1b<\/p>\n

(c) (b)\u4e2d\u968f\u65f6\u95f4\u63a8\u79fb\u5c0f\u9f20\u7684\u5b58\u6d3b\u60c5\u51b5\uff1b<\/p>\n

(d) \u5206\u522b\u7528\u6e38\u79bbDOX\u3001DOX-RBC\u6216DOX-PLT\u5904\u7406\u540e\u5c0f\u9f20\u80ba\u7ec4\u7ec7\u5207\u7247\u7684H&E\u67d3\u8272\u56fe\u7247\uff1b<\/p>\n

(e) (b)\u4e2d\u968f\u65f6\u95f4\u63a8\u79fb\u5c0f\u9f20\u7684\u76f8\u5bf9\u4f53\u91cd\uff1b<\/p>\n

(f) \u5206\u522b\u7528\u6e38\u79bbDOX\u3001DOX-RBC\u6216DOX-PLT\u5904\u7406\u540e\u5fc3\u810f\u7ec4\u7ec7\u5207\u7247\u7684H&E\u67d3\u8272\u56fe\u7247\u3002<\/p>\n

\u56fe6 Vanc\u8d1f\u8f7d\u8fdb\u8840\u5c0f\u677f\u56ca\u6ce1<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u8840\u5c0f\u677f\u56ca\u6ce1\u4e2d\u4e0d\u540cVanc\u8f93\u5165\u65f6\u7684\u8d1f\u8f7d\u91cf\uff1b<\/p>\n

(b) \u8840\u5c0f\u677f\u56ca\u6ce1\u4e2d\u4e0d\u540cVanc\u8f93\u5165\u65f6\u7684\u8d1f\u8f7d\u6548\u7387\uff1b<\/p>\n

(c) \u8d1f\u8f7dVanc\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u7684\u5c3a\u5bf8\uff1b<\/p>\n

(d) \u8d1f\u8f7dVanc\u524d\u540e\u8840\u5c0f\u677f\u56ca\u6ce1\u7684Zeta\u7535\u4f4d\uff1b<\/p>\n

(e) 2\u5929\u5185\u5728pH5.0\u548c7.4\u6761\u4ef6\u4e0b\u8d1f\u8f7dVanc\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\u56fe7 \u5229\u7528\u8d1f\u8f7dVanc\u7684\u8840\u5c0f\u677f\u56ca\u6ce1\u8fdb\u884c\u4f53\u5916\u7ec6\u83cc\u9776\u5411\u8f93\u9001<\/strong><\/p>\n

\"\"<\/p>\n

(a) MRSA252\u7ec6\u83cc\u4e0eRBC\u6216PLT\u56ca\u6ce1\u57f9\u517b10\u5206\u949f\u540e\u7684\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

(b) (a)\u4e2d\u79bb\u5fc3\u540e\u7167\u7247\uff1b<\/p>\n

(c) \u4f53\u5916\u5206\u522b\u7528\u6e38\u79bbVanc\u3001Vanc-RBC\u6216Vanc-PLT\u5904\u74061\u5c0f\u65f6\u7ec6\u83cc\u6570\u76ee\u7edf\u8ba1\u3002<\/p>\n

\u56fe8 Vanc-PLT\u7684\u4f53\u5185\u6297\u83cc\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\u5bf9\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04MRSA252\u7ec6\u83cc\uff0c\u7136\u540e\u6bcf\u5929\u4f7f\u7528\u6e38\u79bbVanc\u3001Vanc-RBC\u6216Vanc-PLT\u5904\u7406\uff0c3\u5929\u540e\u7edf\u8ba1\u4e0d\u540c\u7ec4\u7ec7\u5185\u90e8\u7ec6\u83cc\u6570\u76ee\u3002<\/p>\n

(a) \u5fc3\u810f\u90e8\u4f4d\uff1b<\/p>\n

(b) \u809d\u810f\u90e8\u4f4d\uff1b<\/p>\n

(c) \u813e\u810f\u90e8\u4f4d\uff1b<\/p>\n

(d) \u80ba\u90e8\uff1b<\/p>\n

(e) \u80be\u810f\u90e8\u4f4d\uff1b<\/p>\n

(f) \u8840\u6db2\u4e2d\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u62a5\u9053\u4e86\u57fa\u4e8e\u8840\u5c0f\u677f\u819c\u7684\u56ca\u6ce1\u5236\u5907\u4ee5\u53ca\u8fdc\u7a0b\u836f\u7269\u8d1f\u8f7d\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u7684\u9776\u5411\u6cbb\u7597\u3002\u963f\u9709\u7d20\u548c\u4e07\u53e4\u9709\u7d20\u4e24\u79cd\u836f\u7269\u80fd\u591f\u8fdc\u7a0b\u8d1f\u8f7d\u5230\u56ca\u6ce1\u4e2d\uff0c\u5e76\u4e14\u6240\u5f97\u7eb3\u7c73\u5236\u5242\u7684\u9776\u5411\u9012\u9001\u6548\u679c\u597d\u4e8e\u6e38\u79bb\u836f\u7269\u548c\u975e\u9776\u5411\u56ca\u6ce1\uff0c\u56e0\u800c\u63d0\u9ad8\u5728\u6297\u80bf\u7624\u548c\u6297\u83cc\u5e94\u7528\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\u3002\u672a\u6765\uff0c\u57fa\u4e8e\u4e0d\u540c\u7ec6\u80de\u819c\u7684\u56ca\u6ce1\u6709\u671b\u7528\u4e8e\u8fdc\u7a0b\u836f\u7269\u8d1f\u8f7d\u548c\u9776\u5411\u9012\u9001\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aRemote-Loaded Platelet Vesicles for Disease-Targeted Delivery of Therapeutics<\/a>\u00a0\u00a0(Adv. Funct. Mater. 2018, DOI: 10.1002\/adfm.201801032)<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u5206\u5b50\u548c\u751f\u7269\u5b66\u672f\u7ec4Gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u7ad9\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u53ca\u884c\u4e1a\u4ece\u4e1a\u5458\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

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\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c<\/strong>\u4e0a<\/strong><\/a>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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