{"id":135959,"date":"2018-04-29T06:30:44","date_gmt":"2018-04-28T22:30:44","guid":{"rendered":"\/\/m.iemloyee.com\/?p=135959"},"modified":"2018-04-27T22:11:58","modified_gmt":"2018-04-27T14:11:58","slug":"%e7%be%8e%e5%9b%bd%e5%be%b7%e5%85%8b%e8%90%a8%e6%96%af%e5%86%9c%e5%b7%a5%e5%a4%a7%e5%ad%a6proc-natl-acad-sci-%ef%bc%9a%e4%ba%8c%e7%bb%b4%e7%ba%b3%e7%b1%b3%e7%a1%85%e9%85%b8%e7%9b%90%e8%af%b1","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=135959","title":{"rendered":"\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u519c\u5de5\u5927\u5b66Proc. Natl. Acad. Sci.\uff1a\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u8bf1\u5bfc\u4eba\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u53d8\u5316"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u4f5c\u4e3a\u4e00\u79cd\u8d85\u8584\u7684\u6750\u6599\uff0c\u6bd4\u5982\u77f3\u58a8\u70ef\u3001\u7eb3\u7c73\u9ecf\u571f\u548c\u8fc7\u6e21\u91d1\u5c5e\u6c27\u5316\u7269\u7b49\uff0c\u56e0\u4e3a\u6240\u5177\u6709\u7684\u4e00\u7cfb\u5217\u4f18\u826f\u6027\u80fd\u800c\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\uff0c\u4f46\u662f\u8fd9\u7c7b\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u7684\u7269\u7406\u548c\u5316\u5b66\u6027\u8d28\u5bf9\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u7ec6\u80de\u6bd2\u6027\u3001\u751f\u7269\u6d3b\u6027\u548c\u6cbb\u7597\u6548\u679c\u7b49\u7b49\uff0c\u5374\u4e0d\u5f97\u800c\u77e5\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u519c\u5de5\u5927\u5b66<\/b><\/strong>\u7684Akhilesh K. Gaharwar<\/b><\/strong>\u6559\u6388<\/b><\/strong>\u548c\u7f8e\u56fd\u5eb7\u5948\u5c14\u5927\u5b66<\/b><\/strong>\u7684Iritisha Singh\u6559\u6388<\/strong>\uff0c\u901a\u8fc7\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684\u65b9\u6cd5\u7814\u7a76\u4e86\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u5bf9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u5f71\u54cd\u3002\u901a\u8fc7\u7814\u7a76\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u53d8\u5316\u6765\u5206\u6790\u7ec6\u80de\u4e0e\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u63ed\u793a\u4e86\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u6240\u8bf1\u5bfc\u7684\u7ec6\u80de\u5185\u751f\u7269\u5316\u5b66\u548c\u751f\u7269\u7269\u7406\u8fc7\u7a0b\u3002\u8fd9\u4e2a\u5de5\u4f5c\u53ef\u4ee5\u901a\u8fc7\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u5bf9\u8f6c\u5f55\u7ec4\u7684\u5f71\u54cd\u6765\u9884\u6d4b\u7ec6\u80de\u4e4b\u540e\u7684\u52a8\u6001\u53d8\u5316\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Widespread Changes in Transcriptome Profile of Human Mesenchymal Stem Cells Induced by Two-Dimensional Nanosilicates<\/b><\/strong>“\u53d1\u8868\u5728Proc. Natl. Acad. Sci.<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1 <\/b><\/strong>\u7eb3\u7c73\u7845\u9178\u76d0\u548c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e4b\u95f4\u7684\u751f\u7269\u7269\u7406\u4f5c\u7528<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u4e8c\u7ef4\u7845\u9178\u76d0\u6750\u6599\u901a\u8fc7\u9759\u7535\u4f5c\u7528\u4e0e\u751f\u7269\u6d41\u4f53\u4e2d\u7684\u86cb\u767d\u8d28\u76f8\u7ed3\u5408\uff0c\u518d\u4ee5\u5185\u541e\u7684\u65b9\u5f0f\u8fdb\u5165\u7ec6\u80de<\/p>\n

(b).\u4e8c\u7ef4\u7845\u9178\u76d0\u6750\u6599\u901a\u8fc7\u5185\u541e\u7684\u65b9\u5f0f\u8fdb\u5165\u7ec6\u80de\u540e\u5728\u7ec6\u80de\u5185\u7684\u5206\u5e03<\/p>\n

(c).\u6d41\u5f0f\u7ed3\u679c\u8bc1\u660e\u7f57\u4e39\u660e\u6807\u8bb0\u7684\u7eb3\u7c73\u7845\u9178\u76d0\u53ef\u4ee5\u901a\u8fc7\u5242\u91cf\u8c03\u8282\u80de\u541e\u91cf<\/p>\n

(d).LAMP1\u67d3\u6eb6\u9176\u4f53\u819c\u8ffd\u8e2a\u7eb3\u7c73\u7845\u9178\u76d0<\/p>\n

(e).\u7eb3\u7c73\u7845\u9178\u76d0\u5904\u7406\u7ec6\u80de\u540e\uff0c\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316<\/p>\n

(f).\u7eb3\u7c73\u7845\u9178\u76d0\u5904\u7406\u7ec6\u80de\u540e\uff0c\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316<\/p>\n

\u56fe<\/b><\/strong>2 <\/b><\/strong>\u7eb3\u7c73\u7845\u9178\u76d0\u5bfc\u81f4\u538b\u529b\u8bf1\u5bfc\u7684MAPK\u4fe1\u53f7\u4f20\u9012<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u7eb3\u7c73\u7845\u9178\u76d0\u6fc0\u6d3b\u538b\u529b\u76f8\u5173\u7684\u54cd\u5e94<\/p>\n

(b).\u4e0e\u538b\u529b\u6d3b\u5316\u7684\u6fc0\u9176\u4fe1\u53f7\u4f20\u9012\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\u51fa\u73b0\u4e0d\u540c<\/p>\n

(c).MAP4K4\u548cTAOK1\u57fa\u56e0\u8868\u8fbe\u7684\u6539\u53d8<\/p>\n

(d).TAOK1\u57fa\u56e0\u8868\u8fbe\u7684\u5bf9\u6bd4<\/p>\n

(e).\u7eb3\u7c73\u7845\u9178\u76d0\u5904\u7406\u540e\uff0c\u7ec6\u80deROS\u7684\u4ea7\u751f\uff0c\u76f8\u5173RNA\u8f6c\u5f55\u548c\u86cb\u767d\u8d28\u5408\u6210<\/p>\n

(f).\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u7ed3\u679c<\/p>\n

(g).\u7eb3\u7c73\u7845\u9178\u76d0\u5904\u7406\u540e\uff0cp-MEK1\/2\u4ea7\u751f<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>\u00a0<\/b><\/strong>\u8f6c\u5f55\u7ec4\u5206\u6790\u89e3\u91ca\u4e86\u7eb3\u7c73\u7845\u9178\u76d0\u8bf1\u5bfc\u7684\u751f\u7269\u6d3b\u6027<\/b><\/strong><\/p>\n

\"\"<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>\u00a0<\/b><\/strong>\u7eb3\u7c73\u7845\u9178\u76d0\u8bf1\u5bfc\u4eba\u7c7b\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u7eb3\u7c73\u7845\u9178\u76d0\u8bf1\u5bfc\u7ec6\u80de\u4ea7\u751fCOL1A1\u548cCOMP<\/p>\n

(b).\u7eb3\u7c73\u7845\u9178\u76d0\u8bf1\u5bfc\u7ec6\u80de\u4ea7\u751fGAGs<\/p>\n

(c).\u7eb3\u7c73\u7845\u9178\u76d0\u5bf9\u6210\u9aa8\u5206\u5316\u7684\u5f71\u54cd<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u901a\u8fc7\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684\u65b9\u6cd5\u7814\u7a76\u4e86\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u5bf9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u5f71\u54cd\u3002\u901a\u8fc7\u7814\u7a76\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u53d8\u5316\u6765\u5206\u6790\u7ec6\u80de\u4e0e\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u63ed\u793a\u4e86\u4e8c\u7ef4\u7eb3\u7c73\u7845\u9178\u76d0\u6750\u6599\u6240\u8bf1\u5bfc\u7684\u7ec6\u80de\u5185\u751f\u7269\u5316\u5b66\u548c\u751f\u7269\u7269\u7406\u8fc7\u7a0b\uff0c\u5bf9\u540e\u7eed\u7ec6\u80de\u7684\u884c\u4e3a\u53ef\u8fdb\u884c\u4e00\u5b9a\u7684\u9884\u6d4b\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Widespread Changes in Transcriptome Profile of Human Mesenchymal Stem Cells Induced by Two-Dimensional Nanosilicates<\/a>(Proc. Natl. Acad. Sci., 2018,\u00a0DOI: 10.1073\/pnas.1716164115)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead<\/a>\u3002 \u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/b><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u4f5c\u4e3a\u4e00\u79cd\u8d85\u8584\u7684\u6750\u6599\uff0c\u6bd4\u5982\u77f3\u58a8\u70ef\u3001\u7eb3\u7c73\u9ecf\u571f\u548c\u8fc7\u6e21\u91d1\u5c5e\u6c27\u5316\u7269\u7b49\uff0c\u56e0\u4e3a\u6240\u5177\u6709\u7684\u4e00\u7cfb\u5217\u4f18\u826f\u6027\u80fd\u800c\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\uff0c\u4f46\u662f\u8fd9\u7c7b\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u7684\u7269\u7406\u548c\u5316\u5b66…<\/p>\n","protected":false},"author":7336,"featured_media":135961,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-135959","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/135959"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=135959"}],"version-history":[{"count":6,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/135959\/revisions"}],"predecessor-version":[{"id":136685,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/135959\/revisions\/136685"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/135961"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=135959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=135959"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=135959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}