{"id":135594,"date":"2018-05-03T06:30:14","date_gmt":"2018-05-02T22:30:14","guid":{"rendered":"\/\/m.iemloyee.com\/?p=135594"},"modified":"2018-05-03T12:29:38","modified_gmt":"2018-05-03T04:29:38","slug":"acs-nano-%e7%94%a8%e4%ba%8e%e9%ab%98%e6%80%a7%e8%83%bd%e8%b6%85%e5%a3%b0%e6%88%90%e5%83%8f%e5%92%8c%e6%8a%97%e7%99%8c%e8%8d%af%e7%89%a9%e4%bc%a0%e9%80%92%e7%9a%84%e5%b0%ba%e5%af%b8%e5%8f%af%e8%b0%83","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=135594","title":{"rendered":"ACS Nano: \u7528\u4e8e\u9ad8\u6027\u80fd\u8d85\u58f0\u6210\u50cf\u548c\u6297\u764c\u836f\u7269\u4f20\u9012\u7684\u5c3a\u5bf8\u53ef\u8c03\u7684\u7eb3\u7c73\u5b54"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u5728\u4e34\u5e8a\u533b\u5b66\u5f71\u50cf\u5b66\u4e2d\uff0c\u8d85\u58f0\u662f\u6700\u65b9\u4fbf\u3001\u6700\u4fbf\u5b9c\u3001\u65e0\u8f90\u5c04\u3001\u6700\u5e38\u89c1\u7684\u8bbe\u5907\u3002\u5fae\u7c73\u5c3a\u5bf8\u7684\u5168\u6c1f\u5316\u78b3\u6ce1\u6cab\u88ab\u7528\u4f5c\u8840\u7ba1\u5185\u8d85\u58f0\u7684\u6709\u6548\u5bf9\u6bd4\uff0c\u4f46\u5bf9\u80bf\u7624\u7684\u7a7f\u900f\u4f5c\u7528\u592a\u5927\u3002\u5fae\u6ef4\uff08250-1000 nm\uff09\u5c01\u88c5\u5168\u6c1f\u5316\u78b3\u548c\u836f\u7269\u90fd\u88ab\u7528\u4f5c\u8d85\u58f0\u5f15\u8d77\u91ca\u653e\u6297\u764c\u836f\u7269\u4ea4\u4ed8\u5e73\u53f0\uff0c\u4f46\u5b83\u4eec\u901a\u5e38\u4e0d\u4f1a\u662f\u6709\u7528\u7684\u80bf\u7624\u663e\u50cf\u5242\u3002\u7eb3\u7c73\u6c14\u6ce1\uff08NBs\uff09\u751f\u6210\u548c\u805a\u7ed3\u7684\u968f\u673a\u77ac\u6001\u7279\u6027\u4f7f\u5f97\u5229\u7528\u7eb3\u7c73\u6db2\u6ef4\u4f5c\u4e3a\u8d85\u58f0\u9020\u5f71\u5242\u5bf9\u80bf\u7624\u6210\u50cf\u662f\u4e0d\u53ef\u9760\u7684\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5927\u591a\u6570\u7eb3\u7c73\u5fae\u6ef4\u7684\u7814\u7a76\u90fd\u4e0e\u5b83\u4eec\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u8d85\u58f0\u89e6\u53d1\u836f\u7269\u91ca\u653e\u6709\u5173\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u4e2d\u5c71\u5927\u5b66\u7684\u5e05\u5fc3\u6d9b\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b66\u7b2c\u4e09\u9644\u5c5e\u533b\u9662\u7684\u90d1\u8363\u7434\u548c\u52a0\u5dde\u5927\u5b66\u7684Kit S. Lam\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5f00\u53d1\u4e00\u79cd\u5177\u6709PH\u654f\u611f\u6027\u7684\u3001\u57fa\u4e8e\u805a\u5408\u7269\u7684\u3001\u5168\u6c1f\u5316\u78b3\u5c01\u88c5\u7684\u8d85\u58f0\u7eb3\u7c73\u63a2\u9488\uff0c\u5728\u5faa\u73af\u8fc7\u7a0b\u4e2d\u80fd\u591f\u7ef4\u6301\u5728178 nm\uff0c\u5728\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u589e\u52a0\u5230437 nm\u3002\u5176\u4f53\u79ef\u5c0f\uff0c\u53ef\u88ab\u80bf\u7624\u5438\u6536\u3002\u5728\u80bf\u7624\u90e8\u4f4d\u81a8\u80c0\uff0c\u4ece\u800c\u964d\u4f4e\u4e86\u5168\u6c1f\u5316\u78b3\u7684\u84b8\u53d1\u9608\u503c\uff0c\u6709\u6548\u5730\u5c06\u7eb3\u7c73\u9897\u7c92\u8f6c\u5316\u4e3a\u8d85\u58f0\u663e\u50cf\u7684\u8d85\u58f0\u7eb3\u7c73\u5fae\u6c14\u6ce1\uff0c\u5e76\u5229\u7528\u4f4e\u9891\u7387\u8d85\u58f0\u5f15\u8d77\uff0c\u6700\u7ec8\u4ece\u70ed\u7eb3\u7c73\u63a2\u9488\u4e2d\u91ca\u653e\u51fa\u7528\u4e8e\u6df1\u5c42\u7ec4\u7ec7\u5316\u5b66\u6cbb\u7597\u7684DOX\uff0c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cSize-Modulable Nanoprobe for HighPerformance Ultrasound Imaging and Drug Delivery against Cancer\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>ACS Nano<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u4ece\u591a\u523a\u6fc0\u654f\u611f\u6027\u4e2d\u63d0\u53d6\u7684\u4f53\u5185\u53ef\u8c03\u8282\u5c3a\u5bf8\u548c\u6027\u80fd\u7684\u6750\u6599\u7eb3\u7c73\u7ba1\u793a\u610f\u56fe\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-135596\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/1-52.jpg\" alt=\"\" width=\"600\" height=\"546\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/1-52.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/1-52-300x273.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e8c\u3001PH\u654f\u611f\u5171\u805a\u7269\u7684\u8868\u5f81\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-135597\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/2-48.jpg\" alt=\"\" width=\"600\" height=\"560\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/2-48.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/2-48-300x280.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09 \u5316\u5b66\u7ed3\u6784\u6709\u4e24\u4e2a\u4e0d\u540c\u7684PH\u503c\uff1b<\/p>\n<p>\uff08b\uff09 DMSO-d<sub>6<\/sub>\u4e2dPH\u654f\u611f\u5171\u805a\u7269\u76841H NMR\u8c31\uff1b<\/p>\n<p>\uff08c\uff09 D<sub>2<\/sub>O\u6eb6\u6db2\u4e2dmPEG-PAsp(DEA-co-His-co-DIP)\u5728\u4e0d\u540cpD\u4e0b\u76841H NMR\u8c31\u5bf9\u6bd4\u56fe\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001\u57fa\u4e8e\u805a\u5408\u4f53\u7684\u9010\u6b65\u523a\u6fc0\u3001\u9010\u6b65\u8c03\u8282\u7eb3\u7c73\u63a2\u9488\u7684\u5f62\u8c8c\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-135598\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/3-46.jpg\" alt=\"\" width=\"600\" height=\"825\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/3-46.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/3-46-218x300.jpg 218w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u4e0d\u540cPH\u503c\u7684TEM\u56fe\uff0c\u53ca\u6e29\u5ea6\u5bf9\u6750\u6599\u7684\u5f71\u54cd\uff1b<\/p>\n<p>\uff08b\uff09\u6750\u6599\u5f62\u6001\u8bf4\u660e\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08c\uff09\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684PFP\/PFB\/DOX-PPEHD\u7eb3\u7c73\u63a2\u9488\u7684\u4f53\u5916\u529f\u7387\u591a\u666e\u52d2\u6210\u50cf\uff1b<\/p>\n<p>\uff08d\uff09DOX\u7684\u8367\u5149\u5f3a\u5ea6\u56fe\uff1b<\/p>\n<p>\uff08e\uff09\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684PFP\/PFB\/DOX-PPEHD\u7eb3\u7c73\u9897\u7c92\u6c34\u6eb6\u6db2\u7684\u7c92\u5f84\u53d8\u5316\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001\u7eb3\u7c73\u86cb\u767d\u5728\u4f53\u5185\u589e\u5f3a\u80bf\u7624\u6210\u50cf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-135599\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/4-44.jpg\" alt=\"\" width=\"600\" height=\"383\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/4-44.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/4-44-300x192.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\u00a0<\/p>\n<p>\uff08a\uff09DiR\u8367\u5149\u6210\u50cf\u663e\u793aPFP\/PFB\/DiR-PPEHD\u7eb3\u7c73\u5b54\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u80bf\u7624\u79ef\u7d2f\uff0c\u540e\u9759\u8109\u6ce8\u5c04\u5165\u88f8\u9f20C6\u80f6\u8d28\u80bf\u7624\uff1b<\/p>\n<p>\uff08b\uff09\u572837<sup>o<\/sup>C\u548c45<sup>o<\/sup>C\u65f6\uff0c\u4ee5\u80bf\u7624\u4e3a\u4e2d\u5fc3\u7684\u80fd\u91cf\u591a\u666e\u52d2\u8d85\u58f0\u5bf9\u52a8\u7269\u7684\u5c3e\u9759\u8109\u6ce8\u5c04PFP\/PFB\/DOX-PPEHD\u7eb3\u7c73\u9897\u7c92\u3002<\/p>\n<p><strong>\u56fe\u4e94\u3001\u4f4e\u9891\u8d85\u58f0\u5f15\u53d1\u5185\u542b\u5b50\u836f\u7269\u91ca\u653e\u548c\u80bf\u7624\u7a7f\u900f\u836f\u7269\u7684\u4f20\u9012<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-135600\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/5-37.jpg\" alt=\"\" width=\"600\" height=\"648\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/5-37.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/5-37-278x300.jpg 278w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\u00a0<\/p>\n<p>\uff08a\uff09 \u4f4e\u9891\u8d85\u58f0\uff08LFUS\uff09\u4fc3\u8fdb\u4f53\u5185\u836f\u7269\u91ca\u653e\u548c\u6e17\u900f\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 DiR\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf\uff1b<\/p>\n<p>\uff08c\uff09 \u5728\u66b4\u9732\u524d\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u5bf9\u80bf\u7624\u7684\u8367\u5149\u5f3a\u5ea6\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n<p>\uff08d\uff09\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\u89c2\u5bdfC6\u795e\u7ecf\u80f6\u8d28\u7624\u7684\u51b7\u51bb\u5207\u7247\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001\u4f4e\u9891\u8d85\u58f0\uff08LFUS\uff09\u6539\u5584\u7eb3\u7c73\u5b54\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-135601\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/6-22.jpg\" alt=\"\" width=\"600\" height=\"627\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/6-22.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/04\/6-22-287x300.jpg 287w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\u00a0<\/p>\n<p>\uff08a\uff09 PFP\/PFB\/DOX-PPEHD\u548c\u4f4e\u9891\u8d85\u58f0\uff08LFUS\uff09\u8054\u5408\u6cbb\u7597\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 \u80bf\u7624\u6291\u5236\u7387\uff1b<\/p>\n<p>\uff08c\uff09 \u4e0d\u540c\u6cbb\u7597\u914d\u65b9\u7684\u5c3e\u9759\u8109\u6ce8\u5c04\u540e\u7684\u88f8\u9f20\u7684\u7d2f\u79ef\u5b58\u6d3b\u7387\uff1b<\/p>\n<p>\uff08d\uff09\u7b2c\u4e00\u6b21\u6cbb\u7597\u540e30\u5929\u7684C6\u80f6\u8d28\u7624\u5207\u7247\u7684\u7ec4\u7ec7\u5b66H&amp;E\u5206\u6790\uff08\u84dd\u8272\uff1a\u7ec6\u80de\u6838\uff0c \u7ea2\u8272\uff1a\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u7ec6\u80de\u8d28\uff09\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u7814\u7a76\u4e86\u4e00\u79cdPH\u654f\u611f\u7684\u805a\u5408\u4f53\u6765\u5305\u88f9\u6db2\u4f53PFC\u548cDOX\uff0c\u5f62\u6210\u4e00\u4e2a178 nm\u7684\u7eb3\u7c73\u7c92\u5b50\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7EPR\u6548\u5e94\u6709\u6548\u7684\u8fdb\u5165\u80bf\u7624\uff0c\u7136\u540e\u5728\u8fdb\u5165\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u6269\u5c55\u7684437 nm\u3002\u540c\u65f6\uff0c\u5229\u7528\u76ae\u4e0bC6\u80f6\u8d28\u7624\u5f02\u79cd\u79fb\u690d\u6a21\u578b\uff0c\u8bc1\u660e\u4e86\u8fd9\u79cd\u7eb3\u7c73\u9897\u7c92\u5177\u6709\u901a\u8fc7EPR\u6548\u5e94\u7ef4\u6301\u957f\u65f6\u95f4\u5faa\u73af\u548c\u80bf\u7624\u79ef\u7d2f\u7684\u7eb3\u7c73\u5c3a\u5bf8\u7684\u80fd\u529b\u3002\u5728\u80bf\u7624\u5fae\u9178\u73af\u5883\uff08PH=6.8\uff09\uff0c\u8fd9\u79cd\u7eb3\u7c73\u9897\u7c92\u81ea\u6211\u81a8\u80c0\uff0c\u901a\u8fc7\u7ea2\u5916\u7ebf\u6216\u4f4e\u9891\u8d85\u58f0\uff0c\u5728\u5c40\u90e8\u52a0\u70ed\u7684\u60c5\u51b5\u4e0b\uff0c\u88ab\u56ca\u5316\u7684\u78b3\u6c1f\u5316\u5408\u7269\u53d1\u751f\u4e86\u4e0e\u6e29\u5ea6\u6709\u5173\u7684\u76f8\u53d8\uff0c\u8fdb\u5165\u6c14\u4f53\uff0c\u8d85\u58f0\u6210\u50cf\u53ef\u68c0\u6d4b\u5230\u56de\u58f0\u7684\u663e\u8457\u589e\u52a0\u3002\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u4f4e\u9891\u8d85\u58f0\u7167\u5c04\uff0c\u4f7f\u5f97DOX\u5feb\u901f\u91ca\u653e\u548c\u80bf\u7624\u5438\u6536\uff0c\u6709\u66f4\u597d\u7684\u80bf\u7624\u6cbb\u7597\u6548\u679c\u3002\u6b64\u5916\uff0c\u4f4e\u9891\u8d85\u58f0\uff08LFUS\uff09\u534f\u52a9\u91ca\u653e\u663e\u793a\u4e86\u80bf\u7624\u7a7f\u900f\u836f\u7269\u6269\u6563\uff0c\u514b\u670d\u4e86\u7eb3\u7c73\u8f7d\u4f53\u53ef\u80fd\u65e0\u6cd5\u6709\u6548\u7684\u5c06\u836f\u7269\u8f93\u9001\u5230\u8fdc\u79bb\u8840\u7ba1\u7684\u80bf\u7624\u7ec4\u7ec7\u7684\u6311\u6218\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.8b00076\" target=\"_blank\" rel=\"noopener\"><strong>Size-Modulable Nanoprobe for HighPerformance Ultrasound Imaging and Drug Delivery against Cancer<\/strong><\/a>\uff08ACS Nano, 2018, DOI: 10.1021\/acsnano.8b00076\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5c0f\u80d6\u7eb8\u7f16\u8bd1\uff0c <strong><a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a><\/strong>\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<strong><a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a><\/strong>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 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