{"id":135527,"date":"2018-04-23T06:30:56","date_gmt":"2018-04-22T22:30:56","guid":{"rendered":"\/\/m.iemloyee.com\/?p=135527"},"modified":"2018-04-22T21:44:16","modified_gmt":"2018-04-22T13:44:16","slug":"%e7%be%8e%e5%9b%bd%e5%9b%bd%e7%ab%8b%e5%8d%ab%e7%94%9f%e7%a0%94%e7%a9%b6%e9%99%a2%e9%99%88%e5%b0%8f%e5%85%83angew-chem-int-ed-%e8%81%9a%e5%90%88%e7%89%a9%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=135527","title":{"rendered":"\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u9648\u5c0f\u5143Angew. Chem. Int. Ed.\uff1a\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u8d1f\u8f7d\u8c37\u80f1\u7518\u80bd\u54cd\u5e94\u7684\u4e8c\u805a\u4f53\u524d\u836f\u5728\u4f53\u5185\u836f\u7269\u8ffd\u8e2a\u548c\u534f\u540c\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u5728\u764c\u75c7\u7eb3\u7c73\u836f\u7269\u4e2d\u662f\u4e00\u79cd\u91cd\u8981\u7684\u836f\u7269\u8f7d\u4f53\u3002\u8fd9\u79cd\u80f6\u675f\u7684\u7ed3\u6784\u4e3b\u8981\u662f\u7531\u7528\u4e8e\u8f7d\u836f\u7684\u758f\u6c34\u5185\u6838\u548c\u7528\u4e8e\u63d0\u9ad8\u80f6\u675f\u7a33\u5b9a\u6027\u7684\u4eb2\u6c34\u805a\u4e59\u4e8c\u9187\u7ec4\u6210\u3002\u4e00\u4e9b\u80f6\u675f\uff0c\u6bd4\u5982Genexol-PM\u3001NK012\u548cNK105\u88ab\u5c1d\u8bd5\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528\uff0c\u4f46\u76ee\u524d\u90fd\u6ca1\u6709\u6210\u529f\u3002\u8fd9\u4e9b\u80f6\u675f\u6240\u9762\u4e34\u7684\u95ee\u9898\u6709\u8f83\u4f4e\u7684\u8f7d\u836f\u91cf\u3001\u8fc7\u65e9\u7684\u836f\u7269\u91ca\u653e\u3001\u65e0\u6cd5\u5b9e\u73b0\u836f\u7269\u8ffd\u8e2a\u4ee5\u53ca\u80bf\u7624\u7ec4\u7ec7\u5185\u6709\u9650\u7684\u836f\u7269\u79ef\u7d2f\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u66f4\u591a\u7c7b\u578b\u7684\u80f6\u675f\u88ab\u8bbe\u8ba1\u548c\u5f00\u53d1\uff0c\u4f46\u662f\u5176\u7ed3\u6784\u4e0a\u7684\u590d\u6742\u6027\u9650\u5236\u4e86\u5176\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528\u3002\u4e0e\u805a\u5408\u7269\u80f6\u675f\u76f8\u6bd4\uff0c\u5bf9\u5c0f\u5206\u5b50\u836f\u7269\u7684\u4fee\u9970\u66f4\u4e3a\u7b80\u5355\u3002\u4e8c\u805a\u4f53\u524d\u836f\u5177\u6709\u66f4\u9ad8\u7684\u8f7d\u836f\u91cf\u548c\u66f4\u957f\u7684\u836f\u7269\u91ca\u653e\u65f6\u95f4\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662<\/b><\/strong>\u7684\u9648\u5c0f\u5143\u6559\u6388<\/b><\/strong>\u8bfe\u9898\u7ec4\u6210\u5458\u5f20\u798f\u6b66\u535a\u58eb\u548c\u6731\u8d35\u5fd7\u535a\u58eb\u7b49\u901a\u8fc7\u5c06\u5bf9\u8c37\u80f1\u7518\u80bd\u54cd\u5e94\u7684\u4e8c\u805a\u4f53\u524d\u836f\uff08HDMP\uff09\u8d1f\u8f7d\u5728\u805a\u5408\u7269\u80f6\u675f\u5185\u800c\u5b9e\u73b0\u4e86\u8d85\u9ad8\u7684\u8f7d\u836f\u7387\uff0859%\uff09\u3002HDMP\u5c06\u5316\u5b66\u836f\u7269\u559c\u6811\u78b1\uff08CPT\uff09\u548c\u5149\u654f\u5242\uff08HPPH\uff09\uff0c\u901a\u8fc7\u8c37\u80f1\u7518\u80bd\u54cd\u5e94\u7684\u4e8c\u786b\u952e\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u5b9e\u73b0\u4e86\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u548c\u5316\u5b66\u836f\u7269\u6cbb\u7597\u7684\u80bf\u7624\u534f\u540c\u6cbb\u7597\uff0c\u4ee5\u53ca\u8367\u5149\u6210\u50cf\u548cPET\u6210\u50cf\u7684\u836f\u7269\u8ffd\u8e2a\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Polymeric Nanoparticles with Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for <\/b><\/strong>In Vivo<\/i><\/b><\/em><\/strong>\u00a0Drug Monitoring and Synergistic Cancer Therapy<\/b><\/strong>“\u53d1\u8868\u5728Angew. Chem. Int. Ed.<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1 <\/b><\/strong>\u5bf9GSH\u54cd\u5e94\u7684\u524d\u836fHDMP\u7684\u8bbe\u8ba1\u548c\u5de5\u4f5c\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>2<\/b><\/strong>\u00a0<\/b><\/strong>CPT-ss-HPPH\u7eb3\u7c73\u7c92\u5b50\u7684\u8868\u5f81\u7ed3\u679c<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).CPT-ss-HPPH\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe<\/p>\n

(b).CPT-ss-HPPH\u7eb3\u7c73\u7c92\u5b50\u5728\u4f53\u5916\u7684\u836f\u7269\u91ca\u653e<\/p>\n

(c-d).\u5404\u79cd\u4e0d\u540c\u7269\u8d28\u5728\u6fc0\u5149\u7167\u5c04\u6216\u4e0d\u7167\u5c04\u6761\u4ef6\u4e0b\u7684\u7ec6\u80de\u6bd2\u6027<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>\u00a0<\/b><\/strong>\u8d1f\u8f7dHDMP\u7684\u7eb3\u7c73\u7c92\u5b50\u5bf9\u80bf\u7624\u7684\u5316\u7597\u4e0e\u5149\u52a8\u529b\u6cbb\u7597\u7684\u534f\u540c\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u542b\u6709HCT116\u80bf\u7624\u7684\u5c0f\u9f20\u5728\u6ce8\u5c04CPT-ss-HPPH\u7eb3\u7c73\u7c92\u5b50\u548cHPPH\u7eb3\u7c73\u7c92\u5b50\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684PET\u56fe\u50cf<\/p>\n

(b).\u901a\u8fc7\u8870\u51cf\u77eb\u6b63\u7684PET\u6210\u50cf\u5b9a\u91cf\u80bf\u7624\u5185\u836f\u7269\u79ef\u7d2f\u91cf<\/p>\n

(c).\u6ce8\u5c0448\u5c0f\u65f6\u540e\u5668\u5b98\u4e2d\u7684\u836f\u7269\u5206\u5e03<\/p>\n

(d).\u5728\u7ecf\u8fc7\u4e0d\u540c\u5904\u7406\u540e\uff0c\u80bf\u7624\u7684\u589e\u957f\u66f2\u7ebf<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5bf9\u8c37\u80f1\u7518\u80bd\u54cd\u5e94\u7684\u524d\u836f\uff0cHDMP\u3002\u8fd9\u79cd\u836f\u7269\u901a\u8fc7\u7eb3\u7c73\u7c92\u5b50\u7684\u5f62\u5f0f\u8fdb\u5165\u80bf\u7624\u4e2d\uff0c\u540c\u65f6\u5b9e\u73b0\u5316\u5b66\u836f\u7269\u6cbb\u7597\u548c\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u3002HDMP\u901a\u8fc7\u7b80\u5355\u7684\u4e24\u6b65\u53cd\u5e94\u5408\u6210\uff0c\u5c01\u88c5\u5728\u751f\u7269\u76f8\u5bb9\u5f88\u597d\u7684PEG-b-PLA\u7eb3\u7c73\u8f7d\u4f53\u4e2d\uff0c\u8868\u73b0\u51fa\u5f88\u9ad8\u7684\u8f7d\u836f\u91cf\u3002\u540c\u65f6\uff0c\u5176\u836f\u7269\u91ca\u653e\u901f\u5ea6\u6bd4\u4f20\u7edf\u7684\u7eb3\u7c73\u7c92\u5b50\u616210\u500d\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u66f4\u957f\u6548\u7684\u836f\u7269\u91ca\u653e\uff1b\u901a\u8fc7\u8367\u5149\u6210\u50cf\u548cPET\u6210\u50cf\u6765\u8ffd\u8e2a\u836f\u7269\u91ca\u653e\u3002\u6700\u540e\uff0c\u8fd9\u79cd\u5316\u5b66\u6cbb\u7597\u548c\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u534f\u540c\u7684\u6cbb\u7597\u65b9\u6cd5\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u6548\u679c\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Polymeric Nanoparticles with Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo<\/i><\/em>\u00a0Drug Monitoring and Synergistic Cancer Therapy<\/a>(Angew. Chem. Int. Ed., 2018,\u00a0DOI: 10.1002\/anie.201801984)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8\u5927\u5bb6\u5ead<\/a>\u3002 \u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1aRDD-2011-CHERISH\uff0c\u4efb\u4e39\u4e39\uff0c\u6211\u4eec\u4f1a\u9080\u8bf7\u5404\u4f4d\u8001\u5e08\u52a0\u5165\u4e13\u5bb6\u7fa4\u3002 \u00a0<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/b><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u5728\u764c\u75c7\u7eb3\u7c73\u836f\u7269\u4e2d\u662f\u4e00\u79cd\u91cd\u8981\u7684\u836f\u7269\u8f7d\u4f53\u3002\u8fd9\u79cd\u80f6\u675f\u7684\u7ed3\u6784\u4e3b\u8981\u662f\u7531\u7528\u4e8e\u8f7d\u836f\u7684\u758f\u6c34\u5185\u6838\u548c\u7528\u4e8e\u63d0\u9ad8\u80f6\u675f\u7a33\u5b9a\u6027\u7684\u4eb2\u6c34\u805a\u4e59\u4e8c\u9187\u7ec4\u6210\u3002\u4e00\u4e9b\u80f6\u675f\uff0c\u6bd4\u5982Ge…<\/p>\n","protected":false},"author":7336,"featured_media":135528,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-135527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/135527"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=135527"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/135527\/revisions"}],"predecessor-version":[{"id":135977,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/135527\/revisions\/135977"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/135528"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=135527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=135527"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=135527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}