{"id":132275,"date":"2018-03-30T06:30:37","date_gmt":"2018-03-29T22:30:37","guid":{"rendered":"\/\/m.iemloyee.com\/?p=132275"},"modified":"2018-03-28T10:50:04","modified_gmt":"2018-03-28T02:50:04","slug":"jacs-%e5%85%b7%e6%9c%89%e5%8f%af%e8%b0%83%e8%b0%90%e5%8e%9a%e5%ba%a6%e5%92%8c%e7%a3%81%e5%af%bc%e7%8e%87%e7%9a%84%e5%85%b1%e7%bb%84%e8%a3%85%e7%a3%81%e6%80%a7%e7%ba%b3%e7%b1%b3%e5%9b%8a%e6%b3%a1","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=132275","title":{"rendered":"JACS: \u5177\u6709\u53ef\u8c03\u8c10\u539a\u5ea6\u548c\u78c1\u5bfc\u7387\u7684\u5171\u7ec4\u88c5\u78c1\u6027\u7eb3\u7c73\u56ca\u6ce1\u7528\u4e8eMRI\u6210\u50cf\u7684\u836f\u7269\u4f20\u9012\u76d1\u6d4b"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7531\u4e8e\u5177\u6709\u826f\u597d\u7684\u7a33\u5b9a\u6027\u3001\u751f\u7269\u76f8\u5bb9\u6027\u3001\u5408\u9002\u7684\u5c3a\u5bf8\u53ca\u78c1\u54cd\u5e94\u6027\uff0c\u8d85\u987a\u78c1\u6027\u7684\u6c27\u5316\u94c1\u7eb3\u7c73\u7c92\u5b50\uff08SPIONs\uff09\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u6bd4\u5982\u751f\u7269\u6210\u50cf\u3001\u514d\u75ab\u5206\u6790\u3001\u7ec6\u80de\u5206\u79bb\u3001\u80bf\u7624\u6210\u50cf\u548c\u6cbb\u7597\u7b49\u3002\u4f46\u662f\u5c3a\u5bf8\u8f83\u5c0f\u7684SPIONs\u6bcf\u9897\u7684\u78c1\u5316\u5f3a\u5ea6\u6709\u9650\uff0c\u9650\u5236\u4e86\u5176\u5728\u6df1\u5c42\u7ec4\u7ec7\u6210\u50cf\u65b9\u9762\u7684\u5e94\u7528\u3002\u589e\u52a0\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\uff08NP\uff09\u7684\u5c3a\u5bf8\uff08>26nm\uff09\u5bfc\u81f4\u66f4\u9ad8\u7684\u78c1\u77e9\uff0c\u4f46\u56e0\u6b64\u53ef\u80fd\u5bfc\u81f4\u7eb3\u7c73\u9897\u7c92\u7684\u80f6\u4f53\u4e0d\u7a33\u5b9a\u6027\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u9662\u9648\u5c0f\u5143\u6559\u6388\u8054\u5408\u9a6c\u91cc\u5170\u5927\u5b66\u5e15\u514b\u5206\u6821\u8042\u5fd7\u5b8f\u6559\u6388\u548c\u963f\u535c\u675c\u62c9\u56fd\u738b\u79d1\u6280\u5927\u5b66Niveen M. Khashab\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u62a5\u9053\u4e86\u53ef\u8c03\u5c42\u7ed3\u6784\u7684\u7531SPIONs\u7d27\u5bc6\u5305\u88f9\u6784\u6210\u7684\u78c1\u6027\u56ca\u6ce1\uff0c\u901a\u8fc7\u8c03\u6574PS-b-PAA\u548cSPIONs\u7684\u6bd4\u4f8b\uff0c\u53ef\u4ee5\u63a7\u5236\u819c\u7684\u539a\u5ea6\u75319.8\u53d8\u5316\u4e3a93.2 nm\uff0c\u540c\u65f6\u89c2\u6d4b\u5230\u78c1\u6027\u56ca\u6ce1\u7531\u5355\u5c42\u53d8\u4e3a\u591a\u5c42\u7ed3\u6784\u3002\u968f\u7740\u78c1\u6027\u56ca\u6ce1\u819c\u53d8\u539a\u7684\u540c\u65f6\uff0cSPIONs\u5bc6\u5ea6\u589e\u5927\uff0c\u78c1\u5316\u5f3a\u5ea6\u53d8\u9ad8\uff0c\u6a2a\u5411\u5f1b\u8c6b\u7387\u5927\u5927\u589e\u52a0\u3002\u540e\u7eed\u7684\u7ec6\u80de\u52a8\u7269\u5b9e\u9a8c\u8bc1\u5b9e\u8be5\u56ca\u6ce1\u5728\u8bca\u65ad\u6cbb\u7597\u9886\u57df\u6709\u8f83\u597d\u7684\u5e94\u7528\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cCooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aJACS<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1a\u7eb3\u7c73\u56ca\u6ce1\u7684\u5f62\u6210\u8fc7\u7a0b\u4ee5\u53ca\u751f\u7269\u5e94\u7528\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"
\n (a) \u901a\u8fc7BCP\u5ac1\u63a5SPIONs\u548c\u6e38\u79bbPS-b-PAA\u7684\u534f\u540c\u7ec4\u88c5\uff0c\u5236\u9020\u58c1\u539a\u53ef\u8c03\u7684\u78c1\u6027\u56ca\u6ce1\uff08MV\uff09\uff1b<\/p>\n

(b) MVs\u7528\u4e8e\u6210\u50cf\u5f15\u5bfc\u9012\u9001DOX\u8fdb\u5165\u8377\u7624\u5c0f\u9f20\u3002<\/p>\n

\u56fe\u4e8c\uff1aMV\u7684\u5c3a\u5bf8\u4ee5\u53ca\u58c1\u539a<\/strong><\/p>\n

\"\"<\/p>\n

(a) MVs\u7684SEM\u56fe\u50cf\uff1b<\/p>\n

(b) MVs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(c) \u4e0d\u540c\u6e29\u5ea6\u4e0bMVs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(d) MuMVs\u7684STEM\u56fe\u50cf\u548c\u5bf9\u5e94\u7684Fe\u5f3a\u5ea6\u626b\u63cf\u7ebf\uff1b<\/p>\n

(e) MoMVs\u7684STEM\u56fe\u50cf\u548c\u5bf9\u5e94\u7684Fe\u5f3a\u5ea6\u626b\u63cf\u7ebf\u3002<\/p>\n

\u56fe\u4e09\uff1a\u4e0d\u540c\u819c\u539a\u5ea6\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a-d) \u4e0d\u540c\u819c\u539a\u5ea6MVs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(e) PS-b-PAA \u548c BCP-SPIONs\u6bd4\u4f8b\u4e0e\u819c\u539a\u5ea6\u7684\u5173\u7cfb\uff1b<\/p>\n

(f) \u4e0d\u540c\u6bd4\u4f8b\u7684SPIONs\u548cBCP-PS-b-PAA\u7684\u81ea\u7ec4\u88c5\u7ed3\u679c\u56fe\u3002<\/p>\n

\u56fe\u56db\uff1a\u4e0d\u540c\u819c\u539a\u5ea6\u7684\u5f62\u6210\u539f\u56e0<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0d\u540c\u6bd4\u4f8bWBCP<\/sub>\/WSPION<\/sub>\u5f62\u6210\u4e0d\u540c\u819c\u539a\u5ea6\u7684MVs\u673a\u7406\uff1b<\/p>\n

(b) \u6c34\u548c\u534a\u5f84\u4e0eWBCP<\/sub>\/WSPION<\/sub>\u7684\u5173\u7cfb\uff1b<\/p>\n

(c) \u603bBCPs\u7684\u91cd\u91cf\u5206\u6570\u4e0eWBCP<\/sub>\/WSPION<\/sub>\u7684\u5173\u7cfb\u3002<\/p>\n

\u56fe\u4e94\uff1a\u4f53\u5916\u78c1\u6027\u8d28\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) 300K\u548c2K\u4e0bMuMVs\u7684\u6ede\u56de\u66f2\u7ebf\uff1b<\/p>\n

(b) \u5355\u4e2aSPION\u548cMV\u4e2d\u6bcf\u4e2a\u7eb3\u7c73\u7c92\u5b50\u7684\u78c1\u5316\u5f3a\u5ea6\u4ee5\u53caSPION\u548cMV\u7684\u76f8\u5e94\u51c0\u78c1\u5316\u5f3a\u5ea6\uff1b<\/p>\n

(c) \u4e0d\u540c\u6750\u6599\u7684\u78c1\u5316\u5f3a\u5ea6\u5bf9\u6bd4\uff1b<\/p>\n

(d) \u4e0d\u540c\u6750\u6599\u4e0d\u540c\u6d53\u5ea6\u7684T2\u52a0\u6743MRI\u6210\u50cf\u56fe\u3002<\/p>\n

\u56fe\u516d\uff1a\u4e0d\u540c\u6750\u6599\u8d1f\u8f7dDOX\u6eb6\u6db2\u548c\u7ec6\u80de\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0d\u540c\u6750\u6599\u8d1f\u8f7dDOX\u7684\u4f53\u5916\u91ca\u653e\u56fe\uff1b<\/p>\n

(b) \u4e0d\u540c\u6750\u6599\u7684\u7ec6\u80de\u6bd2\u6027\u5bf9\u6bd4\uff1b<\/p>\n

(c) \u4e0d\u540c\u6750\u6599\u7684\u7ec6\u80de\u8367\u5149\u6210\u50cf\u5bf9\u6bd4\u3002<\/p>\n

\u56fe\u4e03\uff1a\u4f53\u5916\u78c1\u6027\u8d28\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6d3b\u4f53\u80bf\u7624\u533a\u57df\u7684T2\u52a0\u6743\u6210\u50cf\uff1b<\/p>\n

(b) \u6d3b\u4f53\u80bf\u7624\u533a\u57df\u7684DOX\u8367\u5149\u6210\u50cf\u6210\u50cf\uff1b<\/p>\n

(c) b\u4e2d\u76f8\u5e94\u80bf\u7624\u533a\u57df\u7684\u8367\u5149\u5f3a\u5ea6\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(d) \u6ce8\u5c04\u4e0d\u540c\u6750\u6599\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(e) \u6ce8\u5c04\u4e0d\u540c\u6750\u6599\u7684\u5c0f\u9f20\u5b58\u6d3b\u7387\u66f2\u7ebf\uff1b<\/p>\n

(f) \u6ce8\u5c04\u4e0d\u540c\u6750\u6599\u7684\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u78c1\u6027\u56ca\u6ce1\uff08MV\uff09\uff0c\u56ca\u6ce1\u7684\u5f62\u6001\u53ef\u4ee5\u4ece\u5355\u5c42\uff0c\u53cc\u5c42\u5230\u591a\u5c42\u56ca\u6ce1\u8fdb\u884c\u63a7\u5236\uff0c\u968f\u7740PS-b-PAA\u4e0eSPIONs\u6bd4\u4f8b\u7684\u589e\u52a0\uff0c\u819c\u7684\u539a\u5ea6\u663e\u7740\u589e\u52a0\u3002\u540c\u65f6\u53d1\u73b0\u5177\u6709\u8f83\u539a\u819c\u548c\u8f83\u9ad8SPION\u5bc6\u5ea6\u7684MuMV\u5177\u6709\u72ec\u7279\u7684\u7279\u5f81\uff0c\u4f8b\u5982\u589e\u5f3a\u7684MRI\u5bf9\u6bd4\u5ea6\uff0c\u6bcf\u4e2a\u56ca\u6ce1\u7684\u9ad8\u78c1\u5316\u7387\u548c\u6cbb\u7597\u5242\u7684\u53ef\u8c03\u91ca\u653e\u7279\u5f81\u3002\u5728\u9759\u8109\u5185\u7ed9\u836f\u540e\uff0c\u7531\u4e8e\u5177\u6709\u534f\u540c\u7684\u78c1\u6027\u548c\u6d3b\u6027\u80bf\u7624\u9776\u5411\u6548\u5e94\uff0c\u5728\u5916\u90e8\u78c1\u573a\u7684\u5e2e\u52a9\u4e0b\uff0c\u53ef\u4ee5\u5728\u4f53\u5185\u80bf\u7624\u4f4d\u70b9\u6709\u6548\u5bcc\u96c6\u4e0eRGD\u9776\u5411\u90e8\u5206\u7f00\u5408\u7684MuMV\u3002MuMVs\u589e\u5f3a\u7684\u80bf\u7624\u7d2f\u79ef\u4f7f\u5f97\u80fd\u591f\u901a\u8fc7MRI\u6709\u6548\u5730\u6210\u50cf\u80bf\u7624\uff0c\u5e76\u589e\u5f3a\u80bf\u7624\u6291\u5236\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aCooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery <\/a><\/strong>(JACS, 2018, DOI: 10.1021\/jacs.8b00884)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5927\u5175\u54e5\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u7531\u4e8e\u5177\u6709\u826f\u597d\u7684\u7a33\u5b9a\u6027\u3001\u751f\u7269\u76f8\u5bb9\u6027\u3001\u5408\u9002\u7684\u5c3a\u5bf8\u53ca\u78c1\u54cd\u5e94\u6027\uff0c\u8d85\u987a\u78c1\u6027\u7684\u6c27\u5316\u94c1\u7eb3\u7c73\u7c92\u5b50\uff08SPIONs\uff09\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u6bd4\u5982\u751f\u7269\u6210\u50cf\u3001\u514d\u75ab\u5206\u6790\u3001…<\/p>\n","protected":false},"author":1004,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2992,2993,1045],"class_list":["post-132275","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-mri","tag-2993","tag-chenxiaoyuan"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/132275"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=132275"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/132275\/revisions"}],"predecessor-version":[{"id":132357,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/132275\/revisions\/132357"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=132275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=132275"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=132275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}