{"id":131937,"date":"2018-03-26T06:30:39","date_gmt":"2018-03-25T22:30:39","guid":{"rendered":"\/\/m.iemloyee.com\/?p=131937"},"modified":"2018-03-26T01:53:55","modified_gmt":"2018-03-25T17:53:55","slug":"%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6%e5%88%98%e5%ba%84%e6%9d%8e%e6%96%8cnano-letters-ph%e5%93%8d%e5%ba%94%e7%9a%84%e6%99%ba%e8%83%bd%e7%ba%b3%e7%b1%b3%e5%8f%8d%e5%ba%94%e5%99%a8%e7%94%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=131937","title":{"rendered":"\u82cf\u5dde\u5927\u5b66\u5218\u5e84&\u674e\u658cNano Letters: pH\u54cd\u5e94\u7684\u667a\u80fd\u7eb3\u7c73\u53cd\u5e94\u5668\u7528\u4e8e\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u82cf\u5dde\u5927\u5b66\u5218\u5e84\u6559\u6388\u548c\u674e\u658c\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5f00\u53d1\u4e86\u4e00\u79cd\u591a\u9636\u6bb5\u54cd\u5e94\u7684\u667a\u80fd\u7eb3\u7c73\u7c92\u5b50\u7cfb\u7edf\uff0c\u901a\u8fc7\u89e3\u51b3\u4f20\u7edfPDT\u4e2d\u7684\u4e00\u4e9b\u95ee\u9898\u6765\u63d0\u9ad8PDT\u7684\u6cbb\u7597\u6548\u679c\u3002\u5c06\u8fc7\u6c27\u5316\u6c22\u9176(CAT)\u548c\u4e00\u79cd\u6c34\u6eb6\u6027\u7684H2<\/sub>O2<\/sub>\u5206\u89e3\u9176\u5c01\u88c5\u5728\u7a7a\u5fc3\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\u5185\u90e8\u7a7a\u8154\u91cc\uff0c\u548cCe6\uff08\u4e00\u79cd\u5149\u654f\u5242\uff09\u4e00\u8d77\u63ba\u6742\u5230\u4e8c\u6c27\u5316\u7845\u6676\u683c\u7ed3\u6784\u4e2d\uff0c\u901a\u8fc7\u7b80\u5355\u7684\u201c\u4e00\u9505\u6cd5\u201d\u53cd\u5e94\u5236\u5907\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cSmart nano-reactors for pH-responsive tumor homingmitochondria-targeting, andenhanced photodynamic-immunotherapy of cancer<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNano Letters<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1.\u6750\u6599\u7684\u5236\u5907\u4e0e\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CAT@S\/Ce6-CTPP\/DPEG\u7684\u5236\u5907\u8fc7\u7a0b\uff1b<\/p>\n

\uff08b\uff09CAT@S\/Ce6-CTPP\/DPEG\u7684TEM\u56fe\uff1b<\/p>\n

\uff08c\uff09CAT@S\/Ce6-CTPP\/DPEG\u7684HAADF-STEM\u56fe\u548c\u5143\u7d20\u56fe\uff1b<\/p>\n

\uff08d\uff09CAT@S\/Ce6-CTPP\/SPEG\u548cCAT@S\/Ce6-CTPP\/DPEG\u5728\u4e0d\u540cpH\u503c\u65f6\u7684zeta\u7535\u4f4d\u503c\uff1b<\/p>\n

\uff08e\uff09BSA@S\/Ce6-CTPP\/DPEG\u548cCAT@S\/Ce6-CTPP\/DPEG\u751f\u6210\u6c27\u6c14\u91cf\u7684\u53d8\u5316\u56fe\uff1b<\/p>\n

\uff08f\uff09\u4e0d\u540c\u6d53\u5ea6\u7684CAT@S\/Ce6-CTPP\/DPEG\u7684\u751f\u6210\u6c27\u6c14\u91cf\u7684\u53d8\u5316\u56fe\uff1b<\/p>\n

\uff08g\uff09\u5b75\u80b2\u86cb\u767d\u9176K\u540e\uff0c\u6e38\u79bb\u8fc7\u6c27\u5316\u6c22\u9176\u548cCAT@S\/Ce6-CTPP\/DPEG\u7684\u9176\u6d3b\u6027\u53d8\u5316\u56fe\u3002<\/p>\n

\u56fe2.PDT\u7684\u4f53\u5916\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CAT@S\/Ce6-CTPP\/DPEG\u589e\u5f3aPDT\u4f5c\u7528\u7684\u8fc7\u7a0b\u539f\u7406\u56fe\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u6d53\u5ea6\u7684CAT@S\/Ce6-CTPP\/DPEG\u5bf94T1\u7684\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540c\u6d53\u5ea6Ce6\u7684BSA@S\/Ce6-CTPP\/DPEG \u548cCAT@S\/Ce6-CTPP\/DPEG\u5bf94T1\u7684\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n

\uff08d\uff09CAT@S\/Ce6-CTPP\/SPEG \u548cCAT@S\/Ce6-CTPP\/DPEG\u5728\u4e0d\u540cPH\u503c\u7684\u5171\u805a\u7126\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u4e0d\u540c\u6d53\u5ea6Ce6\u7684CAT@S\/Ce6-CTPP\/SPEG \u548c CAT@S\/Ce6-CTPP\/DPEG\u5728\u4e0d\u540cPH\u503c\u4e0b\u5bf94T1\u7684\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n

\uff08f\uff09CAT@S\/Ce6\/DPEG \u548c CAT@S\/Ce6-CTPP\/DPEG\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7ec6\u80de\u91cc\u7684\u4f4d\u7f6e\u7684\u5171\u805a\u7126\u56fe\u50cf\uff1b<\/p>\n

\uff08g\uff09\u6839\u636e\uff08f\uff09\u4e2d\u7684\u76ae\u5c14\u900a\u76f8\u5173\u7cfb\u6570\uff08Rr\uff09\u7edf\u8ba1\u503c\uff1b<\/p>\n

\uff08h\uff09\u4e0d\u540c\u6d53\u5ea6Ce6\u7684CAT@S\/Ce6\/DPEG \u548c CAT@S\/Ce6-CTPP\/DPEG\u5bf94T1\u7684\u6bd2\u6027\u5b9e\u9a8c\u3002<\/p>\n

\u56fe3.\u4f53\u5185\u6210\u50cf\u548c\u80bf\u7624\u6c27\u5316\u8c03\u5236\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09CAT@S\/Ce6-CTPP\/SPEG \u548cCAT@S\/Ce6-CTPP\/DPEG\u7684\u5c0f\u9f20\u4f53\u5185\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n

\uff08b\uff09\u6b63\u5e38\u5668\u5b98\u548c\u80bf\u7624\u5904\u7684\u4f53\u5916\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n

\uff08c\uff09\u4e3b\u8981\u5668\u5b98\u548c\u80bf\u7624\u7684\u4f53\u5916\u8367\u5149\u6210\u50cf\u7684\u91cf\u5316\u56fe\uff1b<\/p>\n

\uff08d\uff09\u5c0f\u9f20\u80bf\u7624\u5207\u7247\u7684\u5171\u805a\u7126\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u5c0f\u9f204T1\u80bf\u7624\u7684\u80bf\u7624\u6c27\u5408\u72b6\u6001\u7684PA\u56fe\u50cf\uff1b<\/p>\n

\uff08f\uff09\u57fa\u4e8e\uff08e\uff09PA\u6210\u50cf\u7684\u80bf\u7624\u8840\u6c27\u9971\u548c\u5ea6\u7684\u91cf\u5316\u56fe\uff1b<\/p>\n

\uff08g\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u7684\u80bf\u7624\u5207\u7247\u514d\u75ab\u8367\u5149\u67d3\u8272\u663e\u5fae\u56fe\u3002<\/p>\n

\u56fe4.CAT@S\/Ce6-CTPP\/DPEG\u8fdb\u884cPDT\u6d3b\u4f53\u6cbb\u7597\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff094T1\u6a21\u578b\u4e0b\uff0cPDT\u6cbb\u7597\u540e\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08b\uff09\u6cbb\u7597\u7ed3\u675f\u540e\uff0c\u4e0d\u540c\u7ec4\u7684\u5e73\u5747\u80bf\u7624\u91cd\u91cf\u56fe\uff1b<\/p>\n

\uff08c\uff09\u5728\u7814\u7a76\u7ed3\u675f\u540e\uff0c\u4ece\u4e0d\u540c\u7ec4\u5c0f\u9f20\u4f53\u5185\u53d6\u51fa\u7684\u6240\u6709\u80bf\u7624\u7167\u7247\u56fe\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540c\u65f6\u95f4\u4e0b\uff0c\u4e0d\u540c\u7ec4\u7684\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u56fe\uff1b<\/p>\n

\uff08e\uff09H&E \u548cTUNEL\u67d3\u8272\u7684\u80bf\u7624\u5207\u7247\u56fe\u3002<\/p>\n

\u56fe5.\u7ed3\u5408PDT\u4e0eCAT@S\/Ce6-CTPP\/DPEG\u68c0\u67e5\u70b9\u963b\u585e\u514d\u75ab\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u68b3\u7406PDT\u4e0e\u6297-PD-L1\u6cbb\u7597\u5b9e\u9a8c\u8bbe\u8ba1\u56fe\uff1b<\/p>\n

\uff08b\uff09\u5de6\u8fb9\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08c\uff09\u5de6\u8fb9\u7b2c18\u5929\u65f6\uff0c\u5e73\u5747\u80bf\u7624\u91cd\u91cf\u56fe\uff1b<\/p>\n

\uff08d\uff09\u5de6\u8fb9\u7b2c18\u5929\u65f6\uff0cCTL\u6e17\u900f\u767e\u5206\u6bd4\u56fe\uff1b<\/p>\n

\uff08e\uff09\u53f3\u8fb9\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08f\uff09\u53f3\u8fb9\u7b2c18\u5929\u65f6\uff0c\u5e73\u5747\u80bf\u7624\u91cd\u91cf\u56fe\uff1b<\/p>\n

\uff08g\uff09\u53f3\u8fb9\u7b2c18\u5929\u65f6\uff0cCTL\u6e17\u900f\u767e\u5206\u6bd4\u56fe\uff1b<\/p>\n

\uff08h\uff09\u4e0d\u540c\u6cbb\u75977\u5929\u540e\uff0c\u4ece\u5c0f\u9f20\u8840\u6e05\u4e2d\u68c0\u6d4bIFN-\u03b3\u6c34\u5e73\uff1b<\/p>\n

\uff08i\uff09\u6cbb\u7597\u671f\u95f4\uff0c\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u56fe\uff1b<\/p>\n

\uff08j\uff09PDT\u4e0e\u6297-PD-L1\u8054\u5408\u6cbb\u7597\u7684\u673a\u7406\u8bf4\u660e\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7814\u7a76\u5f00\u53d1\u4e86\u5177\u6709pH\u54cd\u5e94\u80fd\u529b\u7684\u7535\u8377\u8f6c\u6362\u3001\u7ebf\u7c92\u4f53\u9776\u5411\u548c\u5305\u5c01\u8fc7\u6c27\u5316\u6c22\u9176\u7684\u4e2d\u7a7a\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff0c\u5e76\u5c06Ce6\u63ba\u6742\u4f5c\u4e3a\u4e00\u79cd\u7528\u4e8e\u6539\u8fdb\u764c\u75c7PDT\u6cbb\u7597\u7684\u667a\u80fd\u7eb3\u7c73\u53cd\u5e94\u5668\u3002\u4f7f\u5f97\u80bf\u7624\u5fae\u9178\u73af\u5883\u5904\u7535\u8377\u7531\u8d1f\u53d8\u6b63\uff0c\u6709\u5229\u4e8e\u7ec6\u80de\u5185\u5316\u548c\u80bf\u7624\u5904\u6ede\u7559\uff0c\u589e\u5f3a\u5bf9\u7ebf\u7c92\u4f53\u7684\u9776\u5411\u548cPDT\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u529b\uff0c\u540c\u65f6\u4ea7\u751fROS\u3002\u4e3a\u5236\u5907\u6297\u80bf\u7624\u7eb3\u7c73\u6750\u6599\u63d0\u4f9b\u4e00\u4e9b\u65b0\u7684\u7b56\u7565\u4e0e\u65b9\u6cd5\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSmart nano-reactors for pH-responsive tumor homing, mitochondria-targeting,and enhanced photodynamic-immunotherapy of cancer<\/a>\uff08Nano Letters, 2018,DOI: 10.1021\/acs.nanolett.8b00040\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5411\u798f\u6e05\u7f16\u8bd1\uff0c\u5468\u68a6\u9752\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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