{"id":131737,"date":"2018-03-26T06:30:04","date_gmt":"2018-03-25T22:30:04","guid":{"rendered":"\/\/m.iemloyee.com\/?p=131737"},"modified":"2018-03-26T02:01:03","modified_gmt":"2018-03-25T18:01:03","slug":"%e8%8e%ab%e7%84%b6%e9%a1%be%e8%87%bbnano-letters%ef%bc%9a%e5%88%86%e5%b1%82%e7%ba%b3%e7%b1%b3%e7%bb%84%e8%a3%85%e6%8a%80%e6%9c%af%e7%94%a8%e4%ba%8e%e4%bc%a0%e9%80%92%e6%af%92%e6%80%a7%e8%9b%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=131737","title":{"rendered":"\u83ab\u7136&\u987e\u81fbNano Letters\uff1a\u5206\u5c42\u7eb3\u7c73\u7ec4\u88c5\u6280\u672f\u7528\u4e8e\u4f20\u9012\u6bd2\u6027\u86cb\u767d\u548c\u6297\u751f\u7d20\u8fdb\u884c\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u764c\u75c7\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u6b7b\u56e0\uff0c2015\u5e74\u5bfc\u81f4880\u4e07\u4eba\u6b7b\u4ea1\u3002\u9884\u8ba1\u4eca\u540e\u4e8c\u5341\u5e74\u65b0\u53d1\u75c5\u4f8b\u6570\u5c06\u589e\u52a0\u7ea670%\u3002\u5982\u4f55\u6709\u6548\u7684\u6cbb\u7597\u764c\u75c7\u662f\u4f17\u591a\u79d1\u7814\u5de5\u4f5c\u8005\u81f4\u529b\u4e8e\u7814\u7a76\u89e3\u51b3\u7684\u95ee\u9898\u3002\u5176\u4e2d\uff0c\u901a\u8fc7\u6709\u6548\u7684\u7279\u5b9a\u6d3b\u52a8\u548c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u6765\u9769\u65b0\u764c\u75c7\u6cbb\u7597\u7684\u86cb\u767d\u8d28\u7597\u6cd5\u5438\u5f15\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8005\u7684\u6ce8\u610f\u529b\u3002\u6b64\u5916\uff0c\u540c\u65f6\u6e05\u9664\u5927\u91cf\u80bf\u7624\u7ec6\u80de\u548c\u9ad8\u81f4\u7624\u6027\u80bf\u7624\u5e72\u7ec6\u80de(CSCs)\u5df2\u7ecf\u88ab\u8bc1\u5b9e\u53ef\u4ee5\u663e\u8457\u6539\u5584\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u7684\u83ab\u7136\u6559\u6388\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5206\u6821\u7684\u987e\u81fb\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5f00\u53d1\u4e86\u4e00\u79cd\u7531\u6838\u58f3\u805a\u5408\u7269\u7eb3\u7c73\u51dd\u80f6\u5206\u5c42\u7ec4\u88c5\u800c\u6210\u7684\u7eb3\u7c73\u590d\u5408\u6750\u6599(aNG)\uff0c\u4ee5\u54cd\u5e94\u80bf\u7624\u7684\u76f8\u5173\u6d3b\u6027\u523a\u6fc0\uff0c\u8fd9\u662f\u7b2c\u4e00\u9636\u6bb5\u7684\u7eb3\u7c73\u8f7d\u4f53\uff0c\u800c\u8f7d\u7740\u5de5\u7a0b\u86cb\u767d\u7eb3\u7c73\u80f6\u56ca\u4f5c\u4e3a\u7b2c\u4e8c\u9636\u6bb5\u7684\u7eb3\u7c73\u8f7d\u4f53\u3002\u7531\u4e8e\u7eb3\u7c73\u590d\u5408\u6750\u6599\u5bf9\u5185\u6e90\u6027\u80bf\u7624\u7684\u7279\u5f02\u6027\u4fe1\u53f7\u6709\u81ea\u9002\u5e94\u80fd\u529b\uff0c\u80fd\u591f\u6709\u6548\u5730\u514b\u670d\u9488\u5bf9\u9776\u5411\u86cb\u767d\u4f20\u9012\u7684\u8fde\u7eed\u751f\u7406\u969c\u788d\uff0c\u5e76\u901a\u8fc7\u6297CSC\u8bd5\u5242\u7684\u7ec4\u5408\u4f20\u9012\u6d88\u9664\u80bf\u7624\u7ec6\u80de\u548cCSCs\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cHierarchical Nanoassemblies-Assisted Combinational Delivery of Cytotoxic Protein and Antibiotic for Effective Cancer Treatment<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNano Letters<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1.\u6750\u6599\u7684\u5236\u5907\u548c\u5c0f\u9f20\u4f53\u5185\u7684\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09Doc\/R-rNC\/aNG\u6750\u6599\u7684\u5236\u5907\u8fc7\u7a0b\u53ca\u9178\uff08pH=6.5\uff09\u54cd\u5e94\u91ca\u653e\uff1b<\/p>\n

\uff08b\uff09Doc\/R-rNC\/aNG\u6750\u6599\u5728\u8840\u6db2\u4e2d\u7684\u957f\u5faa\u73af\u4ee5\u53ca\u4f5c\u7528\u80bf\u7624\u7ec6\u80de\u548cCSCs\u7684\u673a\u5236\u3002<\/p>\n

\u56fe2.\u6750\u6599\u7684\u7406\u5316\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09R-rNC\u7684\u7c92\u5f84\u5206\u5e03\u56fe\u548cTEM\u56fe\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u6d53\u5ea6GSH\u4e0b\u6cbb\u75972h\u540eR-nNC\u548cR-rNC\u7684\u7c92\u5f84\u53d8\u5316\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540c\u914d\u6bd4\u4e0b\u7684\u7c92\u5f84\u548czeta\u7535\u4f4d\uff1b<\/p>\n

\uff08d\uff09Doc\/R-rNC\/aNG\u7684\u7c92\u5f84\u5206\u5e03\u56fe\u548cTEM\u56fe\uff1b<\/p>\n

\uff08e\uff09pH = 7.4\u548c6.5\u65f6\uff0cDoc\/R-rNC\/aNG\u7684\u7c92\u5f84\u53d8\u5316\u56fe\uff1b<\/p>\n

\uff08f\uff09R-rNC\/aNG\u548cDoc\/R-rNC\/nNG\u5728pH = 6.5\u7684\u53cd\u5e9424h\u540e\u7684TEM\u56fe\uff1b<\/p>\n

\uff08g\uff09\u4e0d\u540cpH\u503c\u4e0b\uff0cRho-R\u548cDoc\u7684\u91ca\u653e\u56fe\uff1b<\/p>\n

\uff08h\uff09\u5728pH = 7.4\u548c6.5\u4e0b\uff0c\u7531aNG\u5b75\u80b2\u6709\u6216\u6ca1\u6709HAase\u3002<\/p>\n

\u56fe3.\u7ec6\u80de\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u52a0\u6216\u4e0d\u52a0HA\u7684Rho-R-rNC\/aNG\u5904\u7406\u7684\u7ec6\u80de\u5bf9\u6bd4\u56fe\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u7684Rho\u6807\u8bb0\u5236\u5242\u5bf93D\u80bf\u7624\u7403\u4f53\u5b75\u80b2\u7684Z-stack\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540cpH\u503c\u4e0b\uff0cRho-R-rNC\u4eceaNG\u4e2d\u7684\u91ca\u653e\u56fe\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540cpH\u503c\u4e0b\uff0cDoc\u4eceaNG\u4e2d\u7684\u91ca\u653e\u56fe\uff1b<\/p>\n

\uff08e\uff09\u7528Rho-R-rNC\u5b75\u80b2\u7684\u7ec6\u80de\u8367\u5149\u56fe\u3002<\/p>\n

\u56fe4.\u6750\u6599\u7ec6\u80de\u6bd2\u6027\u8bd5\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u4e0d\u540c\u7684RNase A\u5236\u5242\u5904\u7406\u7684\u7ec6\u80de\u6bd2\u6027\u5b9e\u9a8c\uff1b<\/p>\n

\uff08b\uff09Doc\u6cbb\u7597\u4e73\u817a\u5fae\u7403\u7ec6\u80de10 d\u540e\uff0c\u5f62\u6210\u7684\u5fae\u7403\u4f53\u7c92\u5f84\u53d8\u5316\u56fe\uff1b<\/p>\n

\uff08c\uff09\u91ca\u653e\u7684R-rNC\u3001Doc\u53ca\u5b83\u4eec\u7684\u6df7\u5408\u7269\u6cbb\u7597\u4e73\u817a\u5fae\u7403\u7ec6\u80de48 h\u540e\u7684\u56fe\uff1b<\/p>\n

\uff08d\uff09R-rNC\u3001Doc\u53ca\u5b83\u4eec\u7684\u6df7\u5408\u7269\u6cbb\u7597\u4e73\u817a\u5fae\u7403\u7ec6\u80de\u56fe\uff1b<\/p>\n

\uff08e\uff09\u91ca\u653e\u7684R-rNC\u3001Doc\u53ca\u5b83\u4eec\u7684\u6df7\u5408\u7269\u6cbb\u7597\u4e73\u817a\u5fae\u7403\u7ec6\u80de10 d\u540e\u7684\u56fe\uff1b<\/p>\n

\uff08f\uff09\u91ca\u653e\u7684R-rNC\u3001Doc\u53ca\u5b83\u4eec\u7684\u6df7\u5408\u7269\u6cbb\u7597\u4e73\u817a\u5fae\u7403\u7ec6\u80de10 d\u540e\u7684\u5178\u578b\u56fe\uff1b<\/p>\n

\uff08g\uff09\u91ca\u653e\u7684R-rNC\u3001Doc\u53ca\u5b83\u4eec\u7684\u6df7\u5408\u7269\u6cbb\u7597CD133+<\/sup>\u7ec6\u80de48h\u540e\u7684\u6d41\u5f0f\u56fe\uff1b<\/p>\n

\uff08h\uff09\u91ca\u653e\u7684R-rNC\u3001Doc\u53ca\u5b83\u4eec\u7684\u6df7\u5408\u7269\u6cbb\u7597\u4e73\u817a\u5fae\u7403\u7ec6\u80de48 h\u540e\u7684\u6d41\u5f0f\u56fe\u3002<\/p>\n

\u56fe5.\u52a8\u7269\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5c0f\u9f20\u80bf\u7624\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n

\uff08b\uff09\u4f53\u5185\u5404\u7ec4\u7ec7\u7684\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n

\uff08c\uff09\u80bf\u7624\u5207\u7247\u8367\u5149\u6210\u50cf\u56fe\uff1b<\/p>\n

\uff08d\uff09\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08e\uff09\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u6bd4\u7387\u56fe\uff1b<\/p>\n

\uff08f\uff09\u80bf\u7624\u4e2dCD133+<\/sup>\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u79cd\u5206\u5c42\u7ed3\u6784\u7684\u7eb3\u7c73\u590d\u5408\u6750\u6599\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u5bf9\u5185\u751f\u80bf\u7624\u76f8\u5173\u4fe1\u53f7\u7684\u54cd\u5e94\u6765\u81ea\u9002\u5e94\u8c03\u8282\u5176\u81ea\u8eab\u7684\u6027\u80fd\uff0c\u4ece\u800c\u8fbe\u5230\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u79cd\u7eb3\u7c73\u590d\u5408\u6750\u6599\u53ef\u8fde\u7eed\u5ef6\u957f\u7cfb\u7edf\u5faa\u73af\u65f6\u95f4\uff0c\u589e\u52a0\u80bf\u7624\u5904\u7684\u79ef\u7d2f\uff0c\u63d0\u9ad8\u80bf\u7624\u704c\u6ce8\uff0c\u589e\u5f3a\u7ec6\u80de\u6444\u53d6\uff0c\u4fc3\u8fdb\u7ec6\u80de\u5185\u7ec6\u80de\u6bd2\u6027\u86cb\u767d\u7684\u91ca\u653e\uff0c\u5e76\u4e0e\u4e00\u79cd\u5e38\u7528\u6297\u751f\u7d20\u7684CSC-\u6839\u9664\u6d3b\u6027\u7ed3\u5408\uff0c\u4ea7\u751f\u66f4\u597d\u7684\u6297\u80bf\u7624\u6548\u679c\u3002\u4e3a\u9488\u5bf9CSCs\u548c\u5927\u91cf\u80bf\u7624\u7ec6\u80de\u7684\u8054\u5408\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u7b56\u7565\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aHierarchical Nanoassemblies-Assisted Combinational Delivery of Cytotoxic Protein and Antibiotic for Effective Cancer Treatment<\/a>\uff08Nano Lett., 2018,DOI: 10.1021\/acs.nanolett.7b04976\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5411\u798f\u6e05\u7f16\u8bd1\uff0c\u5468\u68a6\u9752\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u764c\u75c7\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u6b7b\u56e0\uff0c2015\u5e74\u5bfc\u81f4880\u4e07\u4eba\u6b7b\u4ea1\u3002\u9884\u8ba1\u4eca\u540e\u4e8c\u5341\u5e74\u65b0\u53d1\u75c5\u4f8b\u6570\u5c06\u589e\u52a0\u7ea670%\u3002\u5982\u4f55\u6709\u6548\u7684\u6cbb\u7597\u764c\u75c7\u662f\u4f17\u591a\u79d1\u7814\u5de5\u4f5c\u8005\u81f4\u529b\u4e8e\u7814\u7a76\u89e3\u51b3\u7684\u95ee\u9898\u3002\u5176…<\/p>\n","protected":false},"author":230,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[],"class_list":["post-131737","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/131737"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/230"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=131737"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/131737\/revisions"}],"predecessor-version":[{"id":132105,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/131737\/revisions\/132105"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=131737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=131737"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=131737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}