{"id":131371,"date":"2018-03-26T14:00:35","date_gmt":"2018-03-26T06:00:35","guid":{"rendered":"\/\/m.iemloyee.com\/?p=131371"},"modified":"2018-03-26T02:14:48","modified_gmt":"2018-03-25T18:14:48","slug":"%e5%8d%8e%e7%a7%91%e5%88%98%e7%ac%94%e9%94%8badv-funct-mater-%ef%bc%9a%e5%8f%8c%e9%85%8d%e4%bd%93%e4%bf%ae%e9%a5%b0%e5%a4%96%e6%b3%8c%e4%bd%93%e7%9a%84%e5%8c%96%e7%96%97-%e5%85%89%e7%83%ad%e5%8d%8f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=131371","title":{"rendered":"\u534e\u79d1\u5218\u7b14\u950bAdv. Funct. Mater.\uff1a\u53cc\u914d\u4f53\u4fee\u9970\u5916\u6ccc\u4f53\u7684\u5316\u7597-\u5149\u70ed\u534f\u540c\u9776\u5411\u80bf\u7624\u6cbb\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u764c\u75c7\u662f\u4e16\u754c\u4e0a\u6700\u5177\u7834\u574f\u6027\u7684\u75be\u75c5\uff0c\u5316\u7597\u662f\u76ee\u524d\u6cbb\u6108\u764c\u75c7\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u4e4b\u4e00\u3002\u5916\u6ccc\u4f53\u662f\u7531\u7ec6\u80de\u91ca\u653e\u7684\u7eb3\u7c73\u819c\u56ca\u6ce1(\u76f4\u5f8450-150 nm)\uff0c\u53ef\u4ee5\u4ece\u4f53\u6db2\u548c\u7ec6\u80de\u57f9\u517b\u4e0a\u6e05\u6db2\u4e2d\u8f7b\u6613\u5206\u79bb\u5f97\u5230\u3002\u5916\u6ccc\u4f53\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u65e0\u514d\u75ab\u539f\u6027\uff0c\u662f\u4e00\u79cd\u6027\u80fd\u4f18\u5f02\u7684\u836f\u7269\u8f7d\u4f53\u3002\u6b64\u5916\uff0c\u5916\u6ccc\u4f53\u8fd8\u80fd\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u548c\u81f4\u5bc6\u7684\u7ed3\u6784\u7ec4\u7ec7\u3002\u7136\u800c\uff0c\u8d4b\u4e88\u5916\u6ccc\u4f53\u4f18\u5f02\u7684\u80bf\u7624\u9776\u5411\u80fd\u529b\u6781\u5177\u6311\u6218\u6027\uff0c\u56e0\u6b64\u5f88\u5c11\u88ab\u62a5\u9053\u3002\u6b64\u5916\uff0c\u5982\u4f55\u63a7\u5236\u91ca\u653e\u5305\u88ab\u5728\u5916\u6ccc\u4f53\u4e2d\u7684\u836f\u7269\u662f\u4e00\u4e2a\u96be\u9898\uff0c\u76ee\u524d\u5c1a\u672a\u89e3\u51b3\u3002<\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5218\u7b14\u950b\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5229\u7528\u4f9b\u4f53\u7ec6\u80de\u8f85\u52a9\u819c\u6539\u6027\u7684\u65b9\u6cd5\uff0c\u901a\u8fc7\u751f\u7269\u7ec4\u5408\u8bbe\u8ba1\uff0c\u9996\u6b21\u5236\u5907\u4e86\u5177\u6709\u5149\u654f\u529f\u80fd\u7684\u7684\u5916\u6ccc\u4f53\u3002\u5e76\u5728Advanced Functional Materials<\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a”Designer Exosomes for Active Targeted Chemo-Photothermal Synergistic Tumor Therapy<\/strong>“\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u56e2\u961f\u8bbe\u8ba1\u7684\u5916\u6ccc\u4f53\u7ed3\u5408\u4e86\u5408\u6210\u6750\u6599\u548c\u5929\u7136\u7eb3\u7c73\u7c92\u5b50\u7684\u4f18\u70b9\uff0c\u4e0d\u4ec5\u4fdd\u7559\u4e86\u5929\u7136\u5916\u6ccc\u4f53\u56fa\u6709\u7684\u529f\u80fd\uff0c\u800c\u4e14\u8fd8\u50cf\u5408\u6210\u7eb3\u7c73\u8f7d\u4f53\u4e00\u6837\uff0c\u5177\u6709\u591a\u79cd\u6709\u6548\u7684\u80bf\u7624\u9776\u5411\u6027\u548c\u63a7\u91ca\u80fd\u529b\u3002\u901a\u8fc7\u53cc\u914d\u4f53\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\uff0c\u80fd\u591f\u6709\u6548\u5730\u5728\u9776\u80bf\u7624\u90e8\u4f4d\u79ef\u7d2f\uff0c\u7ed3\u5408\u91d1\u7eb3\u7c73\u68d2\u5728\u8fd1\u7ea2\u5916\u7167\u5c04\u4e0b\u4ea7\u751f\u7684\u5c40\u90e8\u70ed\u7597\uff0c\u4f1a\u5f71\u54cd\u5916\u6ccc\u4f53\u819c\u7684\u901a\u900f\u6027\uff0c\u4fc3\u8fdb\u5916\u6ccc\u4f53\u7684\u836f\u7269\u91ca\u653e\uff0c\u8fdb\u800c\u6291\u5236\u80bf\u7624\u7684\u590d\u53d1\u3002\u6b64\u5916\uff0c\u8bbe\u8ba1\u7684\u5168\u80fd\u5916\u6ccc\u4f53\u8fd8\u901a\u8fc7\u5408\u6210\u6750\u6599\u5de5\u7a0b\u83b7\u5f97\u66f4\u7e41\u6742\u529f\u80fd\uff0c\u63d0\u4f9b\u529f\u80fd\u8f7d\u4f53\uff0c\u6709\u671b\u5728\u672a\u6765\u5b9e\u73b0\u4e2a\u6027\u5316\u7684\u3001\u7cbe\u786e\u7684\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 FA-AuNR@RGD-DOX-Exos\u7684\u6027\u80fd\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

A)\u672a\u7ecf\u4fee\u9970\u7684\u5916\u6ccc\u4f53RGD-Exos-SH\u548cFA-AuNR @ RGD-Exos\u7684\u6d41\u4f53\u529b\u5b66\u76f4\u5f84\u5206\u5e03\u56fe\u548cTEM\u56fe\u50cf<\/p>\n

B)\u6d41\u5f0f\u7ec6\u80de\u4eea\u68c0\u6d4b\u672a\u4fee\u9970\u5916\u6ccc\u4f53\u3001AuNR@RGD-Exos\u3001AuNR@RGD-Exos\u548cFA-AuNR@RGD-DOX-Exos\u4e0a\u7684FA\u548cRGD<\/p>\n

C)\u672a\u4fee\u9970\u7684\u5916\u6ccc\u4f53\u3001AuNR-\uff0cRGD-\u548c\u5def\u57fa\u529f\u80fd\u5316\u7684\u5916\u6ccc\u4f53\uff08RGD-Exos-SH\uff09\uff0cNH2<\/sub>-AuNR@RGD-Exos\u548cFA-AuNR@RGD-Exos \u7684\u7d2b\u5916\u53ef\u89c1\u5149\u8c31<\/p>\n

D)\u672a\u4fee\u9970\u7684\u5916\u6ccc\u4f53\u3001RGD-\u548c\u5def\u57fa\u529f\u80fd\u5316\u5916\u6ccc\u4f53(RGD-Exos-SH)\u548cFA-AuNR@RGD-Exos\u7684\u5085\u91cc\u53f6\u53d8\u6362\u7ea2\u5916\u5149\u8c31(FTIR)<\/p>\n

\u56fe2 AuNR@Exos\u7684\u5149\u70ed\u8f6c\u6362\u6548\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

A)\u6c34\u5206\u6563\u7684AuNR@Exos (1.0 mg\u2022mL\u22121<\/sup>)\u5728NIR(808 nm\uff0c1.0 W\u2022cm\u22122<\/sup>)\u8f90\u7167\u4e0b\u7684\u7ea2\u5916\u6210\u50cf<\/p>\n

B)AuNR@Exos (1.0 mg\u2022mL\u22121<\/sup>)\u5728NIR (808 nm, 1.0 W\u2022cm\u22122<\/sup>)\u8f90\u7167\u4e0b\u7684\u5149\u70ed\u52a0\u70ed\u66f2\u7ebf<\/p>\n

C)NIR\u7167\u5c04\u4e0bAuNR@Exos\u91ca\u653e\u836f\u7269\u793a\u610f\u56fe<\/p>\n

D)\u4e0d\u540c\u6d53\u5ea6DOX\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31<\/p>\n

E)AuNR@Exos\u548c\u5916\u6ccc\u4f53\u5728\u4e0d\u540cPH\u503c\u4e0b\u7684\u91ca\u836f\u8c31<\/p>\n

F)AuNR@DOX-Exos \u548cAuNRs\u5728NIR (808 nm\uff0c1.0 W\u2022cm\u22122<\/sup>\uff0c5 min)\u8f90\u7167\u4e0b\u7684\u6297\u80bf\u7624\u6548\u679c\u56fe<\/p>\n

G)AuNR@DOX-Exos\u4f5c\u75284h\u540e\uff0cNIR(808 nm\uff0c1.0 W\u2022cm\u22122<\/sup>\uff0c6 min)\u8f90\u7167\u540e\u7684HeLa\u764c\u7ec6\u80de\u8367\u5149\u56fe\u50cf\u7684\u7814\u7a76<\/p>\n

H)AuNR@DOX-Exos\u5728NIR\u8f90\u7167\u4e0b\u7684\u6297\u80bf\u7624\u6548\u679c\u56fe<\/p>\n

\u56fe3 FA-AuNR@RGD-DOX-Exos\u7684\u4f53\u5916\u764c\u7ec6\u80de\u9776\u5411\u6027<\/strong><\/p>\n

\"\"<\/p>\n

A)\u8367\u5149\u6807\u8bb0\u7684FA-AuNR@RGD-DOX-Exos\u5171\u805a\u7126\u663e\u5fae\u56fe\u50cf\uff0c\u56fe\u4e2d\u84dd\u8272\u662f\u67d3\u8272\u7684\u7ec6\u80de\u6838\uff0c\u7ea2\u8272\u662fDOX\uff0c\u7eff\u8272\u662fFITC\u6807\u8bb0\u7684R-F\/P\/Au-DOX-Exos<\/p>\n

B)\u5b75\u80b2FA-AuNR@RGD-DOX-Exos 4h\u540e\uff0c\u764c\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u68c0\u6d4b\u5206\u6790<\/p>\n

C)\u7528\u819c\u8054\u86cb\u767dV-FITC\/PI\u67d3\u8272\u7684\u4e0d\u540c\u6d53\u5ea6\u7684FA-AuNR@RGD-DOX-Exos\u5b75\u80b2\u7684MCF-7\u548cHeLa\u7ec6\u80de\u51cb\u4ea1\u7684\u6d41\u5f0f\u7ec6\u80de\u68c0\u6d4b\u5206\u6790<\/p>\n

D)\u4e0d\u540c\u6d53\u5ea6DOX\u5305\u5c01\u7684FA-AuNR@RGD-DOX-Exos\u4e2d\u7684MCF-7\u7ec6\u80de\u548cHeLa\u7ec6\u80de\u7684\u5b58\u6d3b\u7387<\/p>\n

E)\u7528ICP-MS\u6cd5\u6d4b\u5b9a\u542b\u6709\u4e0d\u540c\u6d53\u5ea6\u7684FA-AuNR@RGD-DOX-Exos\u7ec6\u80de\u4e2dAu\u7684\u542b\u91cf<\/p>\n

\u56fe4 \u529f\u80fd\u5316\u7684FA-AuNR@RGD-DOX-Exos\u5728\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u7684\u9776\u5411\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

A)\u5de6\u56fe\uff1a\u5c0f\u9f20\u4f53\u5185\u6ce8\u5c04\u5355\u914d\u4f53\u548c\u53cc\u914d\u4f53\u529f\u80fd\u5316AuNR@DOX-Exos\u7684NIR\u8367\u5149\u56fe\u50cf\uff1b\u53f3\u56fe\uff1a\u6ce8\u5c0448h\u540e\uff0c\u80bf\u7624\u53ca\u5176\u4ed6\u4e3b\u8981\u5668\u5b98\u7684\u6d3b\u4f53\u8367\u5149\u56fe\u50cf<\/p>\n

B)\u764c\u7ec4\u7ec7\u548c\u4e3b\u8981\u5668\u5b98\u4e2dDOX\u7684\u6d53\u5ea6\u5206\u5e03\u56fe<\/p>\n

C)\u764c\u7ec4\u7ec7\u548c\u4e3b\u8981\u5668\u5b98\u4e2dAu\u7684\u6d53\u5ea6\u5206\u5e03\u56fe<\/p>\n

\u56fe5 \u6ce8\u5c04FA-AuNR@RGD-DOX-Exos\u540e\u7684HeLa\u5f02\u79cd\u79fb\u690d\u88f8\u9f20\u4f53\u5185\u8367\u5149\u663e\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

A)\u6ce8\u5c04FA-AuNR@RGD-DOX-Exos\u540e\u4e0d\u540c\u65f6\u95f4\u5185HeLa\u5f02\u79cd\u79fb\u690d\u88f8\u9f20\u4f53\u5185\u8367\u5149\u663e\u50cf<\/p>\n

B)\u5c0f\u9f20\u80bf\u7624\u7ec4\u7ec7\u4e2dFA-AuNR@RGD-DOX-Exos\u5728808nm (1.0w\u2022cm-2<\/sup>\uff0c10min)\u5149\u7167\u5c04\u4e0b\u7684\u70ed\u6210\u50cf<\/p>\n

C)\u5c0f\u9f20\u80bf\u7624\u7ec4\u7ec7\u4e2dFA-AuNR@RGD-DOX-Exos\u5728808nm(1.0w\u2022cm-2<\/sup>\uff0c10min) \u5149\u7167\u5c04\u7684\u5149\u70ed\u52a0\u70ed\u66f2\u7ebf<\/p>\n

D)\u6ce8\u5c0448h\u540e\uff0c\u80bf\u7624\u53ca\u5176\u4ed6\u4e3b\u8981\u5668\u5b98\u7684\u6d3b\u4f53\u8367\u5149\u56fe<\/p>\n

\u56fe6 \u8377\u7624\u5c0f\u9f20\u5b9e\u4f53\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

A)\u4e0d\u540c\u7eb3\u7c73\u8f7d\u4f53(\u751f\u7406\u76d0\u6c34\uff0cFA-AuNR\uff0cFA-AuNR@DOX-Exos\uff0cFA-AuNR@RGD-Exos\u548cFA-AuNR@RGD-DOX-Exos\uff09\u548cNIR\u7167\u5c04\u540e\u5c0f\u9f20\u79fb\u690d\u7624\u5728\u7b2c4\u5929(\u5de6)\u548c\u7b2c15\u5929(\u53f3)\u7684\u4ee3\u8868\u6027\u56fe\u50cf<\/p>\n

B)\u5728NIR\u7167\u5c04\u4e0b\uff0c\u9759\u8109\u6ce8\u5c04\u4e0d\u540c\u7684\u7eb3\u7c73\u8f7d\u4f53\u540e\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf<\/p>\n

C)\u5b9e\u9a8c\u7ed3\u675f\u540e\u5178\u578b\u80bf\u7624\u7684\u56fe\u50cf<\/p>\n

D)\u8377\u7624\u88f8\u9f20\u9759\u8109\u6ce8\u5c04\u4e0d\u540c\u7eb3\u7c73\u8f7d\u4f53\u540e\u7684\u7d2f\u79ef\u5b58\u6d3b\u7387<\/p>\n

E)\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5c0f\u9f20\u4f53\u91cd\u7684\u53d8\u5316<\/p>\n

F)\u6ce8\u5c04200L\u4e0d\u540c\u7eb3\u7c73\u8f7d\u4f53(\u751f\u7406\u76d0\u6c34\uff0cFA-AuNR\uff0cFA-AuNR@RGD-Exos\uff0cFA-AuNR@DOX-Exos\u548cFA-AuNR@RGD-DOX-Exos) (5.0mg\u2022mL\u22121<\/sup>)\u7684\u5c0f\u9f20\u80bf\u7624\u5207\u7247\u7684TUNEL\u67d3\u8272\u56fe\u548cNIR (808nm\uff0c 1.0W\u2022cm\u22122<\/sup>\uff0c6min) \u8f90\u5c04\u7684\u5c0f\u9f20\u80bf\u7624\u5207\u7247\u56fe<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aDesigner Exosomes for Active Targeted Chemo\u2010Photothermal Synergistic Tumor Therapy\u00a0<\/a>(Adv. Funct. Mater. 2018, DOI: 10.1002\/adfm.201707360)<\/p>\n

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