{"id":130143,"date":"2018-03-17T14:00:03","date_gmt":"2018-03-17T06:00:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=130143"},"modified":"2018-03-14T09:39:12","modified_gmt":"2018-03-14T01:39:12","slug":"%e9%99%88%e5%b0%8f%e5%85%83%e6%9d%a8%e9%bb%84%e6%b5%a9angew-chem-int-ed-%e5%9f%ba%e4%ba%8emno2%e7%9a%84%e7%ba%b3%e7%b1%b3%e8%8d%af%e7%89%a9%e6%b6%88%e8%80%97%e8%b0%b7%e8%83%b1%e7%94%98","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=130143","title":{"rendered":"\u9648\u5c0f\u5143&\u6768\u9ec4\u6d69Angew. Chem. Int. Ed.: \u57fa\u4e8eMnO2\u7684\u7eb3\u7c73\u836f\u7269\u6d88\u8017\u8c37\u80f1\u7518\u80bd\u540c\u65f6\u589e\u5f3a\u5316\u5b66\u52a8\u529b\u5b66\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u6d3b\u6027\u6c27\uff08ROS\uff09\u53ef\u4ee5\u7834\u574f\u751f\u7269\u5206\u5b50\u5982\u8102\u8d28\uff0c\u86cb\u767d\u8d28\u548cDNA\u7b49\u5927\u5206\u5b50\u4ece\u800c\u5177\u6709\u6740\u6b7b\u7ec6\u80de\u7684\u80fd\u529b\u3002\u8fd1\u5e74\u6765\uff0c\u79d1\u7814\u5de5\u4f5c\u8005\u81f4\u529b\u4e8e\u5f00\u53d1\u57fa\u4e8eROS\u6cbb\u7597\u764c\u75c7\u7684\u7b56\u7565\uff0c\u5c24\u5176\u662f\u5316\u5b66\u52a8\u529b\u5b66\u7597\u6cd5\uff08CDT\uff09\uff0c\u8b6c\u5982\u5229\u7528\u94c1\u4ecb\u5bfc\u7684Fenton\u53cd\u5e94\u901a\u8fc7\u5c06\u80bf\u7624\u7ec6\u80de\u8fc7\u8868\u8fbe\u5185\u6e90\u7684H2O2\u8f6c\u5316\u4e3a\u2022OH\u6765\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002\u7136\u800c\uff0c\u764c\u7ec6\u80de\u4e2d\u4e5f\u6709\u8fc7\u5ea6\u8868\u8fbe\u7684GSH\uff0c\u4f5c\u4e3a\u7ec6\u80de\u5185\u6297\u6c27\u5316\u5242\uff0cGSH\u5bf9\u7531\u5316\u5b66\u52a8\u529b\u5b66\u7597\u6cd5\u4ea7\u751f\u7684\u9ad8\u6d3b\u5e94\u6027\u2022OH\u5177\u6709\u5f3a\u6548\u7684\u6e05\u9664\u4f5c\u7528\uff0c\u56e0\u6b64\u6781\u5927\u5730\u589e\u52a0\u4e86\u764c\u7ec6\u80de\u5bf9\u6c27\u5316\u5e94\u6fc0\u7684\u6297\u6027\u5e76\u964d\u4f4eCDT\u7684\u7597\u6548\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u9662\u9648\u5c0f\u5143\u6559\u6388\u548c\u798f\u5dde\u5927\u5b66\u6768\u9ec4\u6d69\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u9996\u6b21\u62a5\u9053\u4e86\u57fa\u4e8eMnO2\u7684\u81ea\u589e\u5f3aCDT\u7eb3\u7c73\u5242\uff0c\u5b83\u5728\u6d88\u8017GSH\u7684\u540c\u65f6\u8fd8\u80fd\u4ea7\u751fMn2+\uff0c\u540c\u65f6\u5728\u751f\u7406\u4ecb\u8d28\u4e2d\u5bcc\u542bHCO3-\u7684\u60c5\u51b5\u4e0b\uff0cMn2+\u80fd\u53d1\u751f\u7c7bFenton\u53cd\u5e94\u5c06H2O2\u8f6c\u5316\u4e3a\u2022OH\u3002\u5f53MnO2\u5305\u88ab\u7684\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\uff08MS@MnO2 NPs\uff09\u88ab\u764c\u7ec6\u80de\u6444\u53d6\u65f6\uff0cMnO2\u58f3\u4e0eGSH\u53d1\u751f\u53cd\u5e94\uff0c\u751f\u6210\u6c27\u5316\u578b\u8c37\u80f1\u7518\u80bd\u548cMn2+\uff0c\u5bfc\u81f4\u4e86GSH\u6d88\u8017\u589e\u5f3a\u7684CDT\u3002\u540c\u65f6\uff0cGSH\u81f4\u4f7fMnO2\u89e3\u79bb\u589e\u5f3a\u4e86MRI\u5bf9\u6bd4\u6548\u679c\uff0c\u5b9e\u73b0MRI\u76d1\u6d4b\u7684\u5316\u5b66\u52a8\u529b\u5b66\u7ec4\u5408\u7597\u6cd5\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cSimultaneous Fenton-Like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent Enhances Chemodynamic Therapy<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1a\u7eb3\u7c73\u836f\u7269MS@MnO2 NPs\u7684\u4f5c\u7528\u673a\u7406\u56fe\u793a<\/strong><\/p>\n

\"\"<\/p>\n

(a) MnO2\u4f5c\u4e3a\u4e00\u79cd\u667a\u80fd\u5316\u5b66\u52a8\u529b\u5b66\u7684\u589e\u5f3a\u5242\u589e\u5f3aCDT\u6548\u679c\uff1b<\/p>\n

(b) MS@MnO2 NPs\u5728\u7ec6\u80de\u5185\u8bca\u7597\u4e00\u4f53\u6548\u679c\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u4e8c\uff1a\u7eb3\u7c73\u836f\u7269\u7684\u5c3a\u5bf8\u548c\u7ec4\u6210\u8868\u5f81<\/strong>
\n \"\"<\/p>\n

(a) MS@MnO2 NPs\u548cSH-MS NPs\uff08\u63d2\u56fe\uff09\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(b) MS@MnO2 NPs\u548cSH-MS NPs\u7684\u5c0f\u89d2XRD\u884d\u5c04\u56fe\u50cf\uff1b<\/p>\n

(c) MS@MnO2 NPs\u548cSH-MS NPs\u7684\u6c2e\u6c14\u5438\u9644-\u89e3\u5438\u7b49\u6e29\u7ebf\u548c\u5b54\u5f84\u5206\u5e03\u66f2\u7ebf\uff08\u63d2\u56fe\uff09\uff1b<\/p>\n

(d) MS@MnO2 NPs\u7684EDS\u56fe\u8c31\u3002<\/p>\n

\u56fe\u4e09\uff1a\u6eb6\u6db2\u6027\u8d28\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0d\u540c\u6eb6\u6db2\u4e2dMB\u88abMn2+\u4ecb\u5bfc\u7684\u7c7bFenton\u53cd\u5e94\u964d\u89e3\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

(b) \u6709\u65e0GSH\u6761\u4ef6\u4e0bMB\u88abMn2+\u4ecb\u5bfc\u7684\u7c7bFenton\u53cd\u5e94\u964d\u89e3\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

(c) H2O2\u548c\u4e0d\u540c\u6d53\u5ea6GSH\u5904\u7406\u7684MS@MnO2 NPs\u5bf9MB\u7684\u5f71\u54cd\uff1b<\/p>\n

(d) \u76f8\u540c\u6761\u4ef6\u4e0bMn2+\u548cMS@MnO2 NPs\u964d\u89e3MB\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

(e) \u6709\u65e0GSH\u6761\u4ef6\u4e0bMS@MnO2 NPs\u7684r1\u503c\uff1b<\/p>\n

(f) \u4e0d\u540c\u6d53\u5ea6\u7684GSH\u5f15\u8d77\u7684CPT\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u56db\uff1a\u7ec6\u80de\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6709\u65e0L-BSO\uff08GSH\u6291\u5236\u5242\uff09\u6761\u4ef6\u4e0bMn2+\u7684\u5316\u5b66\u52a8\u529b\u5b66\u6bd2\u6027\uff1b<\/p>\n

(b) 24 h\u65f6MnCl2, MS@MnO2 NPs\u548cMS@MnO2-CPT\u5bf9U87MG\u7ec6\u80de\u7684\u6bd2\u6027\uff1b<\/p>\n

(c) \u4e0d\u540c\u6750\u6599\u5b75\u80b2\u7684\u7ec6\u80deDCF\u8367\u5149\u6210\u50cf\u56fe\u3002<\/p>\n

\u56fe\u4e94\uff1a\u6d3b\u4f53\u5b9e\u9a8c\u4e0e\u7ec4\u7ec7\u5207\u7247<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6ce8\u5c04MS@MnO2 NPs\u540e\u4e0d\u540c\u65f6\u95f4\u7684T1\u52a0\u6743\u6210\u50cf\uff08\u7ea2\u8272\u6307\u793a\u80bf\u7624\uff09\uff1b<\/p>\n

(b) \u6ce8\u5c04\u4e0d\u540c\u6750\u6599\u540e\u80bf\u7624\u4f53\u79ef\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(c) PBS\u548cMS@MnO2 NPs\u7684TUNEL\u67d3\u8272\u5bf9\u6bd4\uff1b<\/p>\n

(d) \u4e0d\u540c\u6750\u6599\u80bf\u7624\u533a\u57df\u7684H&E\u67d3\u8272\u5bf9\u6bd4\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u9996\u6b21\u5236\u5907\u4e86\u4e00\u79cd\u57fa\u4e8eMnO2\u81ea\u589e\u5f3a\u7684CDT\u7eb3\u7c73\u836f\u7269\uff0c\u5728\u6d88\u8017GSH\u540e\uff0c\u5176\u4ea7\u751f\u7684Mn2+\u53ef\u4ee5\u53d1\u751f\u7c7bFenton\u53cd\u5e94\u3002\u5728\u751f\u7406HCO3-\u4f5c\u7528\u4e0b\uff0cMn2+\u80fd\u66f4\u591a\u7684\u5c06\u5185\u6e90H2O2\u8f6c\u5316\u4e3a\u6d3b\u6027\u8f83\u5f3a\u7684\u2022OH\uff0c\u8fbe\u5230\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u7684\u76ee\u7684\u3002\u5728\u5185\u90e8\u5305\u8f7dCPT\u540e\uff0cGSH\u4e5f\u80fd\u5f15\u53d1\u5185\u90e8\u7684CPT\u91ca\u653e\uff0c\u5728\u89e3\u79bbMnO2\u7684\u540c\u65f6\uff0c\u589e\u5f3a\u5176T1\u6210\u50cf\uff0c\u8fbe\u5230\u8bca\u7597\u4e00\u4f53\u7684\u76ee\u7684\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Simultaneous Fenton-Like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent Enhances Chemodynamic Therapy<\/a>\u00a0(Angew. Chem. Int. Ed., 2018, DOI: 10.1002\/anie.201712027)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5927\u5175\u54e5\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u6d3b\u6027\u6c27\uff08ROS\uff09\u53ef\u4ee5\u7834\u574f\u751f\u7269\u5206\u5b50\u5982\u8102\u8d28\uff0c\u86cb\u767d\u8d28\u548cDNA\u7b49\u5927\u5206\u5b50\u4ece\u800c\u5177\u6709\u6740\u6b7b\u7ec6\u80de\u7684\u80fd\u529b\u3002\u8fd1\u5e74\u6765\uff0c\u79d1\u7814\u5de5\u4f5c\u8005\u81f4\u529b\u4e8e\u5f00\u53d1\u57fa\u4e8eROS\u6cbb\u7597\u764c\u75c7\u7684\u7b56\u7565\uff0c\u5c24\u5176\u662f\u5316\u5b66…<\/p>\n","protected":false},"author":1004,"featured_media":130146,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2949,75,1045],"class_list":["post-130143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-2949","tag-biomaterial","tag-chenxiaoyuan"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/130143"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=130143"}],"version-history":[{"count":5,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/130143\/revisions"}],"predecessor-version":[{"id":130213,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/130143\/revisions\/130213"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/130146"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=130143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=130143"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=130143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}