{"id":129963,"date":"2018-03-15T06:30:29","date_gmt":"2018-03-14T22:30:29","guid":{"rendered":"\/\/m.iemloyee.com\/?p=129963"},"modified":"2018-03-15T09:36:28","modified_gmt":"2018-03-15T01:36:28","slug":"%e5%8d%8e%e4%b8%9c%e7%90%86%e5%b7%a5%e4%b8%8a%e6%b5%b7%e5%ba%94%e7%89%a9%e6%89%80angew-chem-int-ed-%e5%8f%af%e6%bf%80%e6%b4%bb%e7%9a%84%e8%bf%91%e7%ba%a2%e5%a4%96%e4%ba%8c%e5%8c%ba%e8%8d%a7","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=129963","title":{"rendered":"\u534e\u4e1c\u7406\u5de5&\u4e0a\u6d77\u5e94\u7269\u6240Angew. Chem. Int. Ed.: \u53ef\u6fc0\u6d3b\u7684\u8fd1\u7ea2\u5916\u4e8c\u533a\u8367\u5149\u63a2\u9488\u7528\u4e8e\u7ed3\u76f4\u80a0\u764c\u6210\u50cf"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7531\u4e8e\u4ef7\u683c\u4f4e\u5ec9\u3001\u64cd\u4f5c\u7b80\u4fbf\u3001\u65e0\u521b\u624b\u672f\u548c\u5b9e\u65f6\u6210\u50cf\u80fd\u529b\u7684\u70ed\u70b9\uff0c\u5149\u5b66\u6210\u50cf\u6210\u4e3a\u751f\u7269\u7814\u7a76\u548c\u751f\u7269\u533b\u5b66\u5e94\u7528\u7684\u4e00\u4e2a\u91cd\u8981\u5de5\u5177\uff0c\u6b64\u5916\u5b83\u8fd8\u53ef\u4ee5\u5bf9\u65e9\u671f\u7684\u6076\u6027\u80bf\u7624\u63d0\u4f9b\u68c0\u6d4b\u548c\u7ba1\u7406\u3002\u4f20\u7edf\u7684\u8367\u5149\u63a2\u9488\u7531\u4e8e\u7ec4\u7ec7\u6e17\u900f\u6027\u6709\u9650\uff0c\u6df1\u5c42\u7ec4\u7ec7\u7684\u7a7a\u95f4\u5206\u8fa8\u7387\u8f83\u5dee\u548c\u6d3b\u4f53\u7684\u8f83\u5f3a\u81ea\u8367\u5149\u5e72\u6270\u800c\u65e0\u6cd5\u5728\u533b\u5b66\u6210\u50cf\u9886\u57df\u5927\u663e\u8eab\u624b\u3002\u8fd1\u671f\u7814\u7a76\u8bc1\u660e\uff0c\u8fd1\u7ea2\u5916\u4e8c\u533a\u7684\u8367\u5149\u6210\u50cf\uff08NIR-II, 1000-1700 nm\uff09\u53ef\u4ee5\u89e3\u51b3\u4f20\u7edf\u8367\u5149\u6210\u50cf\u5b58\u5728\u7684\u4e0a\u8ff0\u95ee\u9898\uff0c\u4f46\u662f\u7531\u4e8e\u7f3a\u4e4f\u76ee\u6807\u7279\u5f02\u6027\uff0c\u73b0\u5b58\u7684\u8fd1\u7ea2\u5916\u4e8c\u533a\u63a2\u9488\uff08NIR-II\uff09\u4fe1\u53f7-\u80cc\u666f\u6bd4\u975e\u5e38\u4f4e\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u534e\u4e1c\u7406\u5de5\u5927\u5b66\u8d75\u6625\u5e38\u6559\u6388\u548c\u4e2d\u79d1\u9662\u4e0a\u6d77\u5e94\u7269\u6240\u6a0a\u6625\u6d77\u6559\u6388<\/strong>\u8054\u5408\u62a5\u9053\u4e00\u79cd\u53ef\u6fc0\u6d3b\u7684\u8fd1\u7ea2\u5916\u4e8c\u533a\u8367\u5149\u63a2\u9488\uff08NIR-II@Si\uff09\u7528\u4e8e\u7ed3\u76f4\u80a0\u764c\u7684\u53ef\u89c6\u5316\u7814\u7a76\uff0c\u8be5\u63a2\u9488\u53ef\u5728900-1300 nm\u5904\u663e\u793aH2<\/sub>S\u6fc0\u6d3b\u7684\u6bd4\u7387\u8367\u5149\u548cNIR-II\u53d1\u5c04\u3002\u901a\u8fc7\u4f7f\u7528\u8be5\u53ef\u6fc0\u6d3b\u548c\u9776\u5411\u7279\u5f02\u6027\u63a2\u9488\u7528\u4e8e\u5bcc\u542bH2<\/sub>S\u7684\u7ed3\u80a0\u764c\u7ec6\u80de\u7684\u6df1\u5c42\u7ec4\u7ec7\u6210\u50cf\uff0c\u53ef\u4ee5\u5bf9\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u7ed3\u80a0\u76f4\u80a0\u80bf\u7624\u8fdb\u884c\u51c6\u786e\u9274\u5b9a\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cImaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1a<\/strong>\u63a2\u9488\u7684\u7ed3\u6784\u548c\u539f\u7406\u56fe<\/strong><\/p>\n

\"\"(a) \u5728\u8fd1\u7ea2\u5916\u4e8c\u533a\u6784\u5efa\u5177\u6709\u53ef\u6fc0\u53d1\u53d1\u5c04\u7684\u591a\u6ce2\u957f\u7eb3\u7c73\u63a2\u9488\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(b) \u7528\u4e8e\u5408\u7406\u8bbe\u8ba1\u786b\u5316\u6c22\u63a2\u9488\u7684\u67d3\u6599\u7b5b\u9009\u65b9\u6cd5\u3002<\/p>\n

\u56fe\u4e8c\uff1a<\/strong>\u7eb3\u7c73\u63a2\u9488\u7684\u7d2b\u5916\u5438\u6536\u4e0e\u4f53\u5916\u8367\u5149\u5b9e\u9a8c<\/strong><\/p>\n

\"\"(a) PBS\u6eb6\u6db2\u4e2d\u52a0\u5165100 \u03bcM NaHS\u540eNIR-II@Si\u7684\u7d2b\u5916\u53d8\u5316\uff1b<\/p>\n

(b) PBS\u6eb6\u6db2\u4e2d\u52a0\u5165100 \u03bcM NaHS\u540eNIR-II@Si\u7684\u8367\u5149\u53d8\u5316\uff1b<\/p>\n

(c) \u52a0\u5165100 \u03bcM NaHS\u540e\uff0c\u65f6\u95f4\u4f9d\u8d56\u7684NIR-II@Si\u5728\u8fd1\u7ea2\u5916\u4e8c\u533a\u7684\u53d1\u5c04\u5149\u8c31\uff0c\u63d2\u56fe\uff1aH2<\/sub>S\u6fc0\u6d3b\u7684\u8fd1\u7ea2\u5916\u4e8c\u533a\u53d1\u5c04\u7684\u7167\u7247\uff1b<\/p>\n

(d) \u4e0d\u540c\u539a\u5ea6\u732a\u8089\u7ec4\u7ec7\u8986\u76d6\u7684\u8fd1\u7ea2\u5916\u4e00\u533a\u548c\u8fd1\u7ea2\u5916\u4e8c\u533a\u7684\u8367\u5149\u6210\u50cf\u5bf9\u6bd4\u3002<\/p>\n

\u56fe\u4e09\uff1a<\/strong>\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u6210\u50cf\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

 <\/p>\n

(a) HCT116\u7ec6\u80de\u4e0eNIR-II@Si (ZX-NIR 10 \u03bcM) \u5b75\u80b230 min\uff1b<\/p>\n

(b) HCT116\u7ec6\u80de\u7ecfAOAA (1 mM) \u5904\u74061 h\u540e\u518d\u52a0\u5165NIR-II@Si\u5b75\u80b230 min\uff1b<\/p>\n

(c) HCT116\u7ec6\u80de\u7ecfSAM (3 mM) \u5904\u74061 h\u540e\u518d\u52a0\u5165NIR-II@Si\u5b75\u80b230 min\uff1b<\/p>\n

(d) HepG2\u7ec6\u80de\u4e0eNIR-II@Si \u5b75\u80b230 min\u3002<\/p>\n

\u56fe\u56db\uff1a<\/strong>\u6d3b\u4f53\u80bf\u7624\u53ef\u89c6\u5316<\/strong><\/p>\n

\"\"(a) \u8d1f\u8f7dHCT116\u80bf\u7624\u7684\u88f8\u9f20\uff1b<\/p>\n

(b) \u6291\u5236\u5242AOAA\u548c\u6fc0\u6d3b\u5242SAM\u5bf9\u4e8e\u8d1f\u8f7dHCT116\u80bf\u7624\u88f8\u9f20\u6210\u50cf\u7684\u5f71\u54cd\uff1b<\/p>\n

(c) \u6b63\u5e38\u7684\u4f4d\u7f6e\uff1b<\/p>\n

(d) \u8d1f\u8f7dHepG2\u80bf\u7624\u7684\u88f8\u9f20\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u4f5c\u8005\u5236\u5907\u4e86\u53ef\u6fc0\u6d3b\u7684\u8fd1\u7ea2\u5916\u4e8c\u533a\u7eb3\u7c73\u63a2\u9488\uff0c\u7528\u4e8e\u89c2\u5bdf\u7ed3\u76f4\u80a0\u764c\u3002\u8be5\u7eb3\u7c73\u63a2\u9488\u663e\u793a\u51fa\u5bf9H2<\/sub>S\u4f18\u5f02\u7684\u7279\u5f02\u6027\u548c\u6bd4\u7387\u8367\u5149\u54cd\u5e94\u6027\uff0c\u4ece\u800c\u80fd\u591f\u6839\u636e\u53cc\u8272\u6210\u50cf\u6a21\u5f0f\u4e2dH2<\/sub>S\u542b\u91cf\u7684\u5dee\u5f02\u9009\u62e9\u6027\u8868\u73b0\u5bcc\u542bH2<\/sub>S\u7684\u7ed3\u80a0\u764c\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u5dee\u5f02\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0cH2<\/sub>S\u7279\u5f02\u6027\u5730\u6fc0\u6d3b\u4e86NIR-II\u533a\u57df\u4e2d\u7684\u8367\u5149\uff0c\u901a\u8fc7\u6df1\u5ea6\u548c\u7a7a\u95f4\u5206\u8fa8\u7387\u5145\u5206\u5229\u7528NIR-II\u6210\u50cf\u7684\u4f18\u70b9\uff0c\u5141\u8bb8\u4f53\u5185\u68c0\u6d4b\u548c\u5206\u5316\u764c\u75c7\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission<\/a> (Angew. Chem. Int. Ed., 2018, DOI: 10.1002\/anie.201712528)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u674e\u5175\u7f16\u8bd1\uff0c\u5218\u5b87\u9f99\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c<\/strong>\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u7531\u4e8e\u4ef7\u683c\u4f4e\u5ec9\u3001\u64cd\u4f5c\u7b80\u4fbf\u3001\u65e0\u521b\u624b\u672f\u548c\u5b9e\u65f6\u6210\u50cf\u80fd\u529b\u7684\u70ed\u70b9\uff0c\u5149\u5b66\u6210\u50cf\u6210\u4e3a\u751f\u7269\u7814\u7a76\u548c\u751f\u7269\u533b\u5b66\u5e94\u7528\u7684\u4e00\u4e2a\u91cd\u8981\u5de5\u5177\uff0c\u6b64\u5916\u5b83\u8fd8\u53ef\u4ee5\u5bf9\u65e9\u671f\u7684\u6076\u6027\u80bf\u7624\u63d0\u4f9b\u68c0\u6d4b\u548c\u7ba1\u7406\u3002\u4f20…<\/p>\n","protected":false},"author":230,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2940,2939],"class_list":["post-129963","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-2940","tag-2939"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/129963"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/230"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=129963"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/129963\/revisions"}],"predecessor-version":[{"id":129975,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/129963\/revisions\/129975"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=129963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=129963"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=129963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}