{"id":125331,"date":"2018-02-09T06:30:54","date_gmt":"2018-02-08T22:30:54","guid":{"rendered":"\/\/m.iemloyee.com\/?p=125331"},"modified":"2018-02-09T09:06:23","modified_gmt":"2018-02-09T01:06:23","slug":"%e6%96%b0%e5%8a%a0%e5%9d%a1%e5%9b%bd%e7%ab%8b%e5%a4%a7%e5%ad%a6pnas-%e6%b4%bb%e4%bd%93%e6%97%a0%e7%ba%bf%e7%94%b5%e5%85%89%e5%ad%90%e5%85%89%e5%8a%a8%e5%8a%9b%e7%96%97%e6%b3%95","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=125331","title":{"rendered":"\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66PNAS: \u6d3b\u4f53\u65e0\u7ebf\u7535\u5149\u5b50\u5149\u52a8\u529b\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u81ea\u65e9\u671f\u5e94\u7528\u5149\u6cbb\u7597\u94f6\u5c51\u75c5\u4ee5\u6765\uff0c\u5728\u7406\u89e3\u548c\u8bbe\u8ba1\u5149-\u7ec4\u7ec7\u76f8\u4e92\u4f5c\u7528\u65b9\u9762\u7684\u8fdb\u5c55\u4f7f\u5f97\u4e00\u7c7b\u5177\u6709\u65e0\u4e0e\u4f26\u6bd4\u7684\u65f6\u7a7a\u5206\u8fa8\u7387\u7684\u9776\u5411\u6cbb\u7597\u6210\u4e3a\u53ef\u80fd\u3002\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u662f\u5149\u654f\u836f\u7269\uff08\u5149\u654f\u5242\uff09\u88ab\u5149\u9009\u62e9\u6027\u6fc0\u6d3b\uff0c\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\u53ef\u7528\u4e8e\u6740\u6b7b\u6076\u6027\u7ec6\u80de\u7684\u4e34\u5e8a\u5b9e\u4f8b\uff0c\u5b83\u80fd\u591f\u6740\u6b7b\u6076\u6027\u80bf\u7624\u800c\u907f\u514d\u50cf\u5316\u7597\u7b49\u6cbb\u7597\u65b9\u6cd5\u5e26\u6765\u7684\u5168\u8eab\u6cbb\u7597\u76f8\u5173\u7684\u526f\u4f5c\u7528\u3002\u7136\u800c\uff0c\u7531\u4e8e\u7ec4\u7ec7\u4e0d\u662f\u5149\u5b66\u900f\u660e\u7684\uff0cPDT\u7684\u4e34\u5e8a\u5e94\u7528\u4e00\u76f4\u53d7\u5230\u751f\u7269\u7ec4\u7ec7\u7684\u4f4e\u5149\u7a7f\u900f\u6027\u7684\u9650\u5236\uff0c\u5373\u4f7f\u5728\u8fd1\u7ea2\u5916\u6ce2\u957f\u7167\u5c04\u4e0b\uff0c\u6cbb\u7597\u6df1\u5ea6\u4e5f\u9650\u5236\u57281 cm\u4ee5\u5185\u3002\u76ee\u524d\uff0c\u5411\u66f4\u6df1\u7684\u7ec4\u7ec7\u533a\u57df\u8f93\u9001\u5149\u7ebf\u4f9d\u8d56\u4e8e\u901a\u8fc7\u624b\u672f\u6216\u5185\u7aa5\u955c\u68c0\u67e5\u63d2\u5165\u7684\u5149\u7ea4\uff0c\u4f46\u662f\u4e0e\u957f\u671f\u690d\u5165\u7684\u4e0d\u517c\u5bb9\u6027\u5141\u8bb8\u4ec5\u8f93\u9001\u5355\u4e00\u5149\u5242\u91cf\u3002\u5149\u4f20\u9012\u7684\u8fd9\u79cd\u9650\u5236\u6392\u9664\u4e86\u4f7f\u7528PDT\u8fdb\u884c\u957f\u671f\u6cbb\u7597\u4ee5\u6291\u5236\u80bf\u7624\u590d\u53d1\u6216\u8c03\u6574\u80bf\u7624\u5e94\u7b54\u7684\u5242\u91cf\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5f20\u52c7\u6559\u6388\u548c<\/strong>John S. Ho<\/strong>\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u62a5\u5bfc\u4e00\u79cd\u5c0f\u578b\uff0830 mg\uff0c15 mm3<\/sup>\uff09\u690d\u5165\u5f0f\u8bbe\u5907\u548c\u65e0\u7ebf\u4f9b\u7535\u7684\u65b9\u6cd5\u6765\u4f20\u9012\u5149\u3002\u6211\u4eec\u901a\u8fc7\u7167\u5c04\u96be\u4ee5\u5230\u8fbe\u539a\u5ea6\u7684\u7ec4\u7ec7\uff08> 3cm\uff09\u6765\u6fc0\u6d3b\u5149\u654f\u5242\uff08Ce6\uff09\u901a\u8fc7\u76f4\u63a5\u7167\u5c04\u4e0d\u53ef\u63a5\u8fd1\u7684\u6df1\u5c42\u7ec4\u7ec7\uff0c\u4ee5\u53ca\u901a\u8fc7\u9012\u9001\u591a\u4e2a\u53d7\u63a7\u5242\u91cf\u7684\u5149\u6765\u6291\u5236\u52a8\u7269\u80bf\u7624\u6a21\u578b\u4e2d\u80bf\u7624\u7684\u751f\u957f\u6765\u8bc1\u660e\u8fd9\u79cd\u65b9\u6cd5\u7684\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u79cd\u5149\u8f93\u9001\u7684\u591a\u529f\u80fd\u6027\u514b\u670d\u4e86PDT\u4e34\u5e8a\u5e94\u7528\u7684\u7f3a\u9677\uff0c\u5e76\u4e14\u53ef\u80fd\u4e3a\u5176\u4ed6\u5149\u7597\u6cd5\u63d0\u4f9b\u5e0c\u671b\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cIn vivo wireless photonic photodynamic therapy<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aPNAS<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00<\/strong> \u65e0\u7ebf\u7535\u6fc0\u53d1\u7684<\/strong>PDT<\/strong><\/p>\n

\"\"(A) \u6cbb\u7597\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(B) \u65e0\u7ebf\u5149\u5b50\u5668\u4ef6\u53d1\u5149\u7684\u56fe\u50cf\uff0c\u7167\u5c04\u5916\u690d\u80bf\u7624\u7684\u88c5\u7f6e\uff08\u63d2\u56fe\uff09\uff1b<\/p>\n

(C) \u8bbe\u5907\u548c\u4e2a\u4f53\u7535\u5b50\u5143\u4ef6\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(D) \u6765\u81ea\u4e24\u4e2aLED\u7684\u5668\u4ef6\u7684\u53d1\u5c04\u5149\u8c31\uff1b<\/p>\n

(E) \u8be5\u88c5\u7f6e\u53d1\u51fa\u7684\u5149\uff08\u8f90\u5c04\u529f\u73871.3 mW\uff09\u7a7f\u900f\u4e0d\u540c\u4f53\u79ef\u7684\u80bf\u7624\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e8c<\/strong> \u5149\u5206\u5e03\u4e0e\u65e0\u7ebf\u7535\u5149\u4f20\u8f93<\/strong><\/p>\n

\"\"(A) \u5728\u5408\u6210\u7ec4\u7ec7\u5e73\u677f\u4e0a\u7684\u88c5\u7f6e\u5468\u56f4\u7684\u7d2b\u5149\u5206\u5e03\uff1b<\/p>\n

(B) \u5728\u5408\u6210\u7ec4\u7ec7\u5e73\u677f\u4e0a\u7684\u88c5\u7f6e\u5468\u56f4\u7684\u7ea2\u5149\u5206\u5e03\uff1b<\/p>\n

(C) \u5d4c\u5165\u5728\u5747\u8d28\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u88c5\u7f6e\u5468\u56f4\u7684\u5149\u8f90\u7167\u5ea6\u7684\u6570\u503c\u6a21\u62df\uff0c\u03a6e\uff0c\u53d1\u5c04\u7684\u8f90\u5c04\u529f\u7387\u6216\u7b49\u540c\u7684\u5149\u5242\u91cf\u7387\uff1b<\/p>\n

(D) \u4ece1\u523030\u5206\u949f\u66dd\u5149\u7684\u5149\u5242\u91cf\u8f6e\u5ed3\uff082 J\/cm2<\/sup>\uff09\uff1b<\/p>\n

(E) \u65e0\u7ebf\u5149\u4f20\u8f93\u7cfb\u7edf\u7684\u539f\u7406\u56fe\uff1b<\/p>\n

(F) \u6700\u5927\u8f90\u5c04\u529f\u7387\u03a6e\u53ef\u4f5c\u4e3a\u7ec4\u7ec7\u6a21\u62df\u6c34\u4e2d\u88c5\u7f6e\u6df1\u5ea6\u7684\u51fd\u6570\u4f20\u9012\uff1b<\/p>\n

(G) \u5728\u6709\u548c\u6ca1\u6709\u4f4d\u7535\u8def\u7684\u60c5\u51b5\u4e0b\uff0c\u6539\u53d8\u03a6e\u4f5c\u4e3aPRF<\/sub>\u53d8\u5316\u7684\u51fd\u6570\u6765\u8c03\u8282\u53d1\u5149\uff1b<\/p>\n

(H) \u5728\u5149\u7167\u4e0b\u80bf\u7624\u7ec4\u7ec7\u7684\u4f53\u5185\u5c40\u90e8\u52a0\u70ed\u3002<\/p>\n

\u56fe\u4e09<\/strong> \u80bf\u7624\u7ec6\u80de\u7684\u6df1\u7ec4\u7ec7<\/strong>PDT<\/strong><\/p>\n

\"\"(A) \u6210\u5e74\u732a\u6a21\u578b\u8179\u90e8\u533a\u57df\u65e0\u7ebf\u5149\u4f20\u9012\u7684\u4e09\u7ef4CT\u91cd\u5efa\uff1b<\/p>\n

(B) \u5c04\u9891\u53d1\u5c04\u673a\u4f4d\u7f6e\uff1b<\/p>\n

(C) \u6a2a\u622a\u9762\u56fe\uff0c\u8be5\u8bbe\u5907\u5728\u6df1\u5ea65.1 cm\u5904\u3002\uff08\u6bd4\u4f8b\u5c3a2 cm\uff09\uff1b<\/p>\n

(D) \u5728\u5668\u4ef6\u5468\u56f4\u7684Ce6\u6eb6\u6db2\u4e2d\u4ea7\u751f\u7684ROS\uff1b<\/p>\n

(E) \u6fc0\u5149\u5728MB49\u7ec6\u80de\u4e2d\u7684\u7684\u5149\u4f20\u9012\u7ed3\u6784\u7684\u56fe\u89e3\uff1b<\/p>\n

(F) \u88c5\u7f6e\u7167\u5c04\u5728MB49\u7ec6\u80de\u4e2d\u7684\u7684\u5149\u4f20\u9012\u7ed3\u6784\u7684\u56fe\u89e3\uff1b<\/p>\n

(G) \u5728\u4e0a\u8ff0\u5149\u4f20\u9012\u6784\u578b\u4e2d\u7167\u5c0420\u5206\u949f\u540e\u7ec6\u80de\u6d3b\u529b\uff08MTS\u6d4b\u5b9a\uff09\u7684\u53d8\u5316\uff1b<\/p>\n

(H) \u7ec6\u80de\u51cb\u4ea1\u6307\u6570\uff08TUNEL\u6d4b\u5b9a\uff09\u5305\u62ec\u6765\u81ea\u6d4b\u5b9a\u7684\u9633\u6027\u548c\u9634\u6027\u5bf9\u7167\uff1b<\/p>\n

(I) \u7ec6\u80de\u4e2d\u5904\u7406\u540e\u7684\u8367\u5149\u56fe\u50cf\uff0c\u5728\u4e0eCe6\u5b75\u80b2\u5e76\u4e14\u5728\u4e24\u79cd\u5149\u4f20\u9012\u6784\u578b\uff1b<\/p>\n

(J) \u5bf9\u7167\u7ec6\u80de\u4e2d\u7167\u5c04\u4e4b\u540e\u5904\u7406\u7ec6\u80de\u7559\u4e0b\u672a\u7ecf\u5904\u7406\u6216\u4ec5\u65bd\u7528\u5149\u6216Ce6\u3002<\/p>\n

\u56fe\u56db<\/strong> \u4f53\u5185<\/strong>PDT<\/strong><\/p>\n

\"\"(A) \u7b2c\u4e00\u6b21\u6cbb\u7597\u540e13 d\uff0c\u5bf9\u5404\u7ec4\u4ee3\u8868\u6027\u5c0f\u9f20\u8fdb\u884cCT\u91cd\u5efa\uff1b<\/p>\n

(B) \u5404\u7ec4\u67d3\u8272\u7684\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\uff1b<\/p>\n

(C) \u5728\u76d1\u6d4b\u671f\u95f4\u5c06\u80bf\u7624\u4f53\u79ef\u5f52\u4e00\u5316\u4e3a\u65f6\u95f4\u7684\u51fd\u6570\uff1b<\/p>\n

(D) \u6cbb\u7597\u671f\u95f4\u7684\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

(E) \u5728\u4f7f\u7528\u65e0\u7ebf\u5149\u4f20\u8f93\uff08\u65e0\u7ebf\u7167\u660e\uff09\u6216\u6fc0\u5149\uff08660 nm\uff09\u4f20\u8f93\uff08\u76f4\u63a5\u7167\u5c04\uff09\u8fdb\u884c\u4e00\u8f6e\u6cbb\u7597\u4e4b\u540e\uff0c\u80bf\u7624\u7ec4\u7ec7\u67d3\u8272\u5bf9\u6bd4\uff1b<\/p>\n

(F) \u4e0e\u80bf\u7624\u76f8\u90bb\u7684\u5065\u5eb7\u7ec4\u7ec7\u67d3\u8272\u5207\u7247\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u4f5c\u8005\u5c55\u793a\u4e86\u4e00\u79cd\u65e0\u7ebf\u53ef\u690d\u5165\u5149\u5b50\u5668\u4ef6\uff0c\u53ef\u4ee5\u4e3a\u764c\u75c7PDT\u5b9e\u73b0\u6cbb\u7597\u6027\u5149\u4f20\u8f93\u3002\u901a\u8fc7\u65e0\u7ebf\u4f9b\u7535\u548c\u76d1\u63a7\u5149\u5242\u91cf\u7684\u5c04\u9891\u7cfb\u7edf\u4f7f\u88c5\u7f6e\u5728\u8eab\u4f53\u6df1\u5904\u7684\u64cd\u4f5c\u6210\u4e3a\u53ef\u80fd\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u5728\u7ec4\u7ec7\u7684\u732a\u6a21\u578b\u4e2d\u539f\u4f4d\u65e0\u7ebf\u6fc0\u6d3b\u5149\u654f\u5242\uff0c\u901a\u8fc7\u9012\u9001PDT\u7684\u8f7b\u91cf\u5242\u91cf\uff0c\u5728\u9f20\u7c7b\u764c\u75c7\u6a21\u578b\u4e2d\u4f53\u5185\u6291\u5236\u80bf\u7624\u6d3b\u6027\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\u5b9e\u73b0\u7684\u5149\u8f93\u9001\u7684\u591a\u529f\u80fd\u6027\uff0c\u514b\u670d\u4e86\u4f20\u7edfPDT\u7684\u6df1\u5ea6\u9650\u5236\uff0c\u5e76\u5c06\u5176\u65f6\u7a7a\u7cbe\u5ea6\u6269\u5c55\u5230\u4e0d\u80fd\u76f4\u63a5\u8fdb\u5165\u5149\u7684\u533a\u57df\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>In vivo wireless photonic photodynamic therapy<\/a> (PNAS, 2018, DOI: 10.1073\/pnas.1717552115)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u674e\u5175\u7f16\u8bd1\uff0c\u5218\u5b87\u9f99\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c<\/strong>\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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