{"id":123651,"date":"2018-02-01T14:00:02","date_gmt":"2018-02-01T06:00:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=123651"},"modified":"2018-01-29T12:12:09","modified_gmt":"2018-01-29T04:12:09","slug":"adv-mater-%ef%bc%9a%e5%8f%8c%e9%87%8d%e8%8d%af%e7%89%a9%e9%aa%a8%e6%9e%b6%e8%81%9a%e5%90%88%e8%b6%85%e5%88%86%e5%ad%90%e7%ba%b3%e7%b1%b3%e8%8d%af%e7%89%a9%e5%8d%8f%e5%90%8c%e6%a0%b9%e9%99%a4%e8%82%ba","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=123651","title":{"rendered":"Adv. Mater.\uff1a\u53cc\u91cd\u836f\u7269\u9aa8\u67b6\u805a\u5408\u8d85\u5206\u5b50\u7eb3\u7c73\u836f\u7269\u534f\u540c\u6839\u9664\u80ba\u764c"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u76ee\u524d\u57fa\u4e8e\u7eb3\u7c73\u9897\u7c92\u7684\u6cbb\u7597\u65b9\u6cd5\u5927\u591a\u6570\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5931\u8d25\uff0c\u4e14\u9762\u4e34\u4e09\u5927\u6311\u6218\uff1a\uff08i\uff09\u7f3a\u4e4f\u5177\u6709\u7cbe\u786e\u7ec4\u6210\u7684\u6700\u4f73\u836f\u7269\u9012\u9001\u5e73\u53f0\uff1b\uff08ii\uff09\u7f3a\u4e4f\u76f4\u63a5\u76d1\u6d4b\u7279\u5b9a\u836f\u7269\u7684\u547d\u8fd0\u7684\u65b9\u6cd5\uff1b\uff08iii\uff09\u7f3a\u4e4f\u53ef\u9760\u7684\u5bf9\u836f\u7269\u7b5b\u9009\u548c\u8bc4\u4f30\u5177\u6709\u9ad8\u5ea6\u7684\u4f9d\u8d56\u6027\u7684\u764c\u75c7\u6a21\u578b\u3002\u672c\u6587\u4e2d\u4ecb\u7ecd\u4e86\u4e00\u79cd\u5177\u6709\u7cbe\u786e\u7ec4\u6210\u7684DMC\/ Pt\u6bd4\u7387\u7684\u7cbe\u786e\u7eb3\u7c73\u836f\u7269\u7684\u53cc\u91cd\u654f\u611f\u53cc\u836f\u7269\u9aa8\u67b6\u7c89\u788e\u805a\u5408\u7269\uff08DDBSP\uff09\u7684\u8bbe\u8ba1\u601d\u8def\u3002DDBSP\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7c92\u5b50\uff08DD-NP\uff09\u53ef\u4ee5\u5728\u7ec6\u80de\u5185\u89e6\u53d1\uff0c\u4ee5\u6253\u65ad\u7684\u65b9\u5f0f\u5206\u89e3\u91ca\u653e\u53cc\u91cd\u836f\u7269\u6709\u6548\u8f7d\u8377\u3002\u6b64\u5916\uff0c\u5728\u805a\u5408\u7269\u94fe\u4e2d\u5177\u6709\u6781\u9ad8Pt\u91cd\u91d1\u5c5e\u542b\u91cf\u7684DD-NP\uff0c\u53ef\u4ee5\u901a\u8fc7\u57fa\u4e8ePt\u7684\u836f\u7269\u4ecb\u5bfc\u7684\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\u548cICP-MS\u5728\u4f53\u5916\u548c\u4f53\u5185\u76f4\u63a5\u8ffd\u8e2a\u836f\u7269\u672c\u8eab\u3002\u8be5D-NP\u9996\u6b21\u7528\u4e8e\u6839\u9664\u9ad8\u5371\u60a3\u8005\u80ba\u764c\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u8d1f\u8377\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u4e3a\u4e86\u5728\u5355\u4e00\u836f\u7269\u3001\u836f\u7269\/\u836f\u7269\u6216\u836f\u7269\/\u57fa\u56e0\u7ec4\u5408\u7684\u8f93\u9001\u7cfb\u7edf\u4e2d\u5b9e\u73b0\u5bf9\u8f7d\u4f53\u7ed3\u6784\u548c\u836f\u7269\u7ec4\u6210\u7684\u7cbe\u786e\u63a7\u5236\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u836f\u7269\u5f15\u53d1\u7684\u805a\u5408\u7269\uff0c\u5305\u542b\u4e3b\u8981\u836f\u7269\u7684\u94fe\u7834\u788e\u805a\u5408\u7269 \u94fe\u4ee5\u53ca\u591a\u529f\u80fd\u6df7\u5408\u836f\u7269\u4e0e\u591a\u79cd\u836f\u7269\u5728\u4e00\u4e2a\u5206\u5b50\u7684\u836f\u7269\u8f93\u9001\u3002\u4e3a\u4e86\u6df1\u5165\u4e86\u89e3\u7eb3\u7c73\u9897\u7c92\u836f\u7269\u7684\u673a\u5236\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u5f00\u53d1\u4e86\u591a\u79cd\u8ddf\u8e2a\u65b9\u6cd5\uff0c\u901a\u8fc7\u8367\u5149\u6210\u50cf\u3001\u7898\u6216\u57fa\u4e8e\u91cd\u91d1\u5c5e\u7684\u9020\u5f71\u5242\/\u7eb3\u7c73\u9897\u7c92\u6765\u6807\u8bb0\u836f\u7269\u548c\/\u6216\u8f7d\u4f53\u4e0e\u8367\u5149\u5206\u5b50\u7684\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\/\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\/ CT\u6210\u50cf\u3001\u4e0a\u8f6c\u6362\u6210\u50cf\u7b49\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u4e2d\u6ca1\u6709\u4e00\u4e2a\u80fd\u591f\u76d1\u6d4b\u836f\u7269\u672c\u8eab\u3002\u5f53\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u5b9e\u73b0\u6709\u6548\u7684\u5316\u7597\u3002\u4e0d\u540c\u673a\u5236\u7684\u836f\u7269\u8054\u5408\u4f7f\u7528\u53ef\u4ee5\u534f\u540c\u4f5c\u7528\u6216\u514b\u670d\u764c\u75c7\u7684\u8010\u836f\u6027\u3002\u987a\u94c2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u4e34\u5e8a\uff0c\u6cbb\u759750\uff05\u4ee5\u4e0a\u7684\u764c\u75c7\u3002\u8fd1\u6765\uff0c\u4f5c\u4e3a\u86cb\u767d\u78f7\u9178\u91762A\uff08PP2A\uff09\u6291\u5236\u5242\u7684\u53bb\u7532\u57fa\u6591\uff08\u7d20\uff08DMC\uff09\u901a\u8fc7\u7279\u5f02\u6027\u6291\u5236PP2A\u800c\u663e\u793a\u51fa\u4e0eDNA-\u6291\u5236\u5242\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u800c\u6ca1\u6709\u660e\u663e\u7684\u6025\u6027\u6216\u6162\u6027\u6bd2\u6027\u3002\u4ee5\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u8054\u5408\u4f7f\u7528\u987a\u94c2\u548cDMC\u53ef\u4ee5\u534f\u540c\u6cbb\u7597\u764c\u75c7\u3002<\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u7528\u5316\u5b66\u7814\u7a76\u6240<\/strong>\/<\/strong>\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3<\/strong>\u7684\u6881\u5174\u6770<\/strong>\u548c\u5468\u4e1c\u65b9<\/strong>\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\uff09<\/strong>\u5728Adv. Mater.<\/strong>\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201cDual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer<\/strong>\u201d\u7684\u6587\u7ae0\u3002\u8be5\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u53cc\u91cd\u836f\u7269\u9aa8\u67b6\u53cc\u91cd\u836f\u7269\u9aa8\u67b6\u964d\u89e3\u805a\u5408\u7269\uff08DDBSP\uff09\u3002\u5c06DMC\u5f15\u5165\u5230Pt\uff08IV\uff09\u836f\u7269\u4e2d\uff0c\u7136\u540e\u5c06\u5176\u4e0e\u4e59\u4e8c\u80fa\uff08EDA\uff09\u805a\u5408\u6210\u81ea\u7ec4\u88c5\u6210NP\u7684DDBSP\u3002\u7814\u7a76\u7ed3\u679c\u7b2c\u4e00\u6b21\u63d0\u4f9b\u4e86\u7cbe\u786e\u7684\u7eb3\u7c73\u533b\u5b66\u4f8b\u5b50\u6765\u89e3\u51b3\u9ad8\u4fdd\u771fPDLC\u7684\u4e09\u4e2a\u6311\u6218\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1<\/strong> \u53cc\u91cd\u836f\u7269\u9aa8\u67b6\u805a\u5408\u7269\u6cbb\u7597\u7eb3\u7c73\u533b\u5b66\uff08<\/strong>DDBSP<\/strong>\uff09\u534f\u540c\u6839\u9664\u80ba\u764c<\/strong>(PDLC)<\/strong>\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09Pt\uff08IV\uff09-1\u7684\u7ed3\u6784\uff0cDDBSP\u7684\u805a\u5408\uff0cDD-NP\u7684\u81ea\u7ec4\u88c5\u548c\u94fe\u7834\u788e\u91ca\u653e\u6d3b\u6027Pt\uff08II\uff09\u548cDMC\u7684\u7ed3\u6784\u56fe\uff0c\u4ee5\u53caDDBSP\u548cDD-NP\u7684\u5173\u952e\u7279\u5f81\uff1b<\/p>\n

B\uff09\u5728DD-NP\u9759\u8109\u6ce8\u5c04\u540e\u5efa\u7acbPDLC\u6a21\u578b\u548cPt\u57faDMCT\u7684\u8bf4\u660e\uff1b<\/p>\n

C\uff09\u764c\u7ec6\u80de\u5185\u541eDD-NP\u540e\u53ef\u80fd\u7684\u53cc\u91cd\u6297\u764c\u673a\u5236\u3002<\/p>\n

\u56fe<\/strong>2<\/strong> \u8fd8\u539f\u654f\u611f\u7684<\/strong>DDBSP<\/strong>\u81ea\u7ec4\u88c5<\/strong>DD-NP<\/strong>\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09DD-NP\u57280.1m KCl\u6eb6\u6db2\u4e2d\u7684(pH=7.4)\u7684\u5faa\u73af\u4f0f\u5b89\u56fe\uff1b<\/p>\n

B\uff09DD-NP\u57280.1m KCl\u6eb6\u6db2\u4e2d\u7684(pH=5.0)\u7684\u5faa\u73af\u4f0f\u5b89\u56fe\uff1b<\/p>\n

C\uff09TEM\u56fe\u50cf\uff1b<\/p>\n

D\uff09\u6d41\u4f53\u529b\u5b66\u76f4\u5f84\uff1b<\/p>\n

E\uff09\u54cd\u5e94\u4e8e\u6297\u574f\u8840\u9178\u94a0\u7684DD-NP\u7684GPC\u8ff9\u7ebf\uff0c\uff08SA\uff0c5\u00d710-3<\/sup> m\uff090,2,8,24 h\uff1b<\/p>\n

F\uff09\u542b\u6709\u6216\u4e0d\u542bSA\uff085\u00d710-3<\/sup> m\uff09\u7684\u6c34\u4e2d\u7684DD-NP\u548cSD-NP\u7684Pt\u91ca\u653e\u66f2\u7ebf\uff1b<\/p>\n

G\uff09\u4e0eSA\uff085\u00d710 -3 m\uff09\u5b75\u80b224\u5c0f\u65f6\u4e4b\u524d\u548c\u4e4b\u540e\u7684Pt 4f\u7684XPS\u66f2\u7ebf\u3002<\/p>\n

\u56fe<\/strong>3<\/strong> DD-NP<\/strong>\u7684\u4f53\u5916\u7ec6\u80de\u6bd2\u4f5c\u7528\u548c\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u987a\u94c2\u3001DMC\uff0cPt\uff08IV\uff09-1\u3001DD-NP\u3001Pt -2\u548cSD-NP\u5bf9HeLa\u548cA549\u7ec6\u80de\u4f5c\u752872\u5c0f\u65f6\u540e\uff0c HeLa\u548cA549\u7ec6\u80de\u5b75\u80b2\u540e\u7ec6\u80de\u5185\u6444\u53d6Pt\uff08IV\uff09-1\u548cDD-NP\uff08\u7528ICP-MS\u68c0\u6d4b\uff09\uff0c\u3002<\/p>\n

B\uff09DMC\uff0865\u00d710 -6 m\uff09\u548cDD-NP\uff0865\u00d710 -6 m DMC\uff09\u5b75\u80b26\u5c0f\u65f6\u540eHeLa\u548cA549\u7ec6\u80de\u7684PP2A\u6d3b\u6027\u3002<\/p>\n

C\uff09\u63a5\u89e6\u987a\u94c2\uff082.5\u00d710-6m\uff09\uff0cDMC\uff085\u00d710-6m\uff09\uff0cDD-NP\uff082.5\u00d710-6m Pt\uff09\u540e\uff0cA549\u7ec6\u80de\u4e2dAkt\uff0cP-Akt\u548c\u03b3H2AX\u7684\u514d\u75ab\u8367\u5149 \u548cSD-NP\uff082.5\u00d710 -6 m Pt\uff0924\u5c0f\u65f6\u3002<\/p>\n

D\uff09\u66b4\u9732\u4e8e\u987a\u94c2\uff082.5\u00d710 -6 m\uff09\uff0cDMC\uff085\u00d710 -6 m\uff09\uff0cDD-NP\uff082.5\u00d710 -6 m Pt \/ 5\u00d710 -4 m 2\uff09\u540eHeLa\u7ec6\u80de\u7684Western\u5370\u8ff9\u548c\u76f8\u5bf9\u7684P-Akt\u8868\u8fbe 10-6m DMC\uff09\u548cSD-NP\uff082.5\u00d710-6m Pt\uff0924\u5c0f\u65f6\u3002 \u663e\u7740\u6027\u5b9a\u4e49\u4e3a* p <0.05\u3002<\/p>\n

\u56fe<\/strong>4 DD-NP<\/strong>\u5bf9<\/strong>KM<\/strong>\u5c0f\u9f20\u76ae\u4e0b<\/strong>U14<\/strong>\u80bf\u7624\u6a21\u578b\u7684\u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u6bd2\u6027\u53ca\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u8bd5\u9a8c\u671f\u95f4\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

B\uff09\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

C\uff09\u5b58\u6d3b\u7387\uff1b<\/p>\n

D\uff09\u5728\u7b2c18\u5929\u5c0f\u9f20\u7684CREA\u3001UA\u548cUREA\u7684\u6539\u53d8\uff1b<\/p>\n

E\uff09\u5728\u7b2c18\u5929\u4ece\u5c0f\u9f20\u5206\u79bb\u7684U14\u80bf\u7624\u7684\u7167\u7247\uff1b<\/p>\n

F\uff09\u80bf\u7624\u91cd\u91cf\u3002<\/p>\n

\u56fe<\/strong>5\u00a0<\/strong>\u8ffd\u8e2a<\/strong>DD-NP<\/strong>\u7684\u836f\u7269\u8fd0\u884c\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u572812\u5c0f\u65f6\u4e4b\u524d\u548c\u4e4b\u540e\u7684\u5c0f\u9f20\u7684\u4f53\u5185CT\u56fe\u50cf\uff1b<\/p>\n

B\uff09\u5206\u522b\u7ed9\u4e88DD-NP\uff0810 mg Pt kg-1<\/sup>\uff091\uff0c6\uff0c12\uff0c24 h\u540e\u5206\u79bb\u5c0f\u9f20\u7ec4\u7ec7\u7684\u4f53\u5916\u7167\u7247\u548cCT\u56fe\u50cf\uff1b<\/p>\n

C\uff09\u5728DD-NP\uff0810mg Pt kg-1\uff09\u5355\u6b21\u9759\u8109\u5185\u7ed9\u836f1,6,12\u548c24\u5c0f\u65f6\u540e\u7684CT\uff1b<\/p>\n

D\uff09\u5728DD-NP\uff0810mg Pt kg-1\uff09\u5355\u6b21\u9759\u8109\u5185\u7ed9\u836f1,6,12\u548c24\u5c0f\u65f6\u540e\uff0cICP-MS\u68c0\u6d4b\u7684\u5c0f\u9f20\u4e2d\u94c2\u7684\u751f\u7269\u5206\u5e03\u3002<\/p>\n

\u56fe<\/strong>6 DD-NP<\/strong>\u5bf9<\/strong>PDLC<\/strong>\u6a21\u578b<\/strong>BALB \/ c<\/strong>\u5c0f\u9f20\u7684\u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u6bd2\u6027\u53ca\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u8bd5\u9a8c\u671f\u95f4\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

B\uff09\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

C\uff09\u5728\u7b2c51\u5929\u4ece\u5c0f\u9f20\u5206\u79bb\u7684PDX\u80bf\u7624\u7684\u7167\u7247\uff1b<\/p>\n

D\uff09\u80bf\u7624\u91cd\u91cf\uff1b<\/p>\n

E\uff09\u5728\u7b2c51\u5929\u5728\u80bf\u7624\u4e2d\u7d2f\u79ef\u94c2\uff1b<\/p>\n

F\uff09DNA-Pt\u52a0\u5408\u7269\u3002\u6570\u636e\u4ee3\u8868\u5e73\u5747\u503c\u00b1SD\uff08n = 5\uff09\uff1b<\/p>\n

G\uff09H\uff06E\u3001TUNEL\u548c\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u5206\u6790\u5728\u7b2c51\u5929\u4ece\u5c0f\u9f20\u5206\u79bb\u7684\u80bf\u7624\u5207\u7247\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5<\/strong>\uff1aDual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer<\/a> \uff08Adv. Mater.\uff0c2018\uff0cDOI: 10.1002\/adma.201706220\uff09<\/p>\n

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