{"id":121335,"date":"2018-01-14T14:00:03","date_gmt":"2018-01-14T06:00:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=121335"},"modified":"2018-01-14T08:03:43","modified_gmt":"2018-01-14T00:03:43","slug":"%e4%ba%ac%e9%83%bd%e5%a4%a7%e5%ad%a6nature%e5%ad%90%e5%88%8a%ef%bc%9a%e4%b8%80%e7%a7%8d%e5%85%b7%e5%a4%87%e8%87%aa%e5%88%86%e9%80%89%e5%8a%9f%e8%83%bd%e5%8f%8c%e7%ba%b3%e7%b1%b3%e7%ba%a4%e7%bb%b4","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=121335","title":{"rendered":"\u4eac\u90fd\u5927\u5b66Nature\u5b50\u520a\uff1a\u4e00\u79cd\u5177\u5907\u81ea\u5206\u9009\u529f\u80fd\u53cc\u7eb3\u7c73\u7ea4\u7ef4\u7f51\u7edc\u7684\u81ea\u9002\u5e94\u8d85\u5206\u5b50\u6c34\u51dd\u80f6"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5728\u751f\u547d\u7cfb\u7edf\u4e2d\uff0c\u65e0\u6570\u7684\u751f\u7269\u5206\u5b50(\u5982\u86cb\u767d\u8d28\uff0c\u8102\u8d28\uff0cDNA\u548cRNA)\u662f\u901a\u8fc7\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\u81ea\u53d1\u5f62\u6210\u4e0d\u540c\u7684\u8d85\u5206\u5b50\u7ec4\u88c5\u4f53\u3002\u8fd9\u4e9b\u7ec4\u4ef6\u662f\u591a\u6837\u7684\uff0c\u6b63\u4ea4\u7684\uff0c\u7cbe\u786e\u5730\u8c03\u8282\u5b83\u4eec\u7684\u5f62\u6210\u548c\u7834\u574f\uff0c\u5bf9\u6d3b\u7ec6\u80de\u7684\u591a\u529f\u80fd\u6027\u548c\u81ea\u4e3b\u6027\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\u4f18\u8d28\u8f6f\u6750\u6599\u5e94\u8be5\u5305\u62ec\u591a\u4e2a\u8d85\u5206\u5b50\u7eb3\u7c73\u7ed3\u6784\uff0c\u7ec4\u88c5\u548c\u62c6\u5378\u7b49\u54cd\u5e94\u53ef\u4ee5\u72ec\u7acb\u5730\u63a7\u5236\u3002\u8fd9\u6837\u7684\u4f53\u7cfb\u5e38\u89c1\u4e8e\u6d3b\u7ec6\u80de\u4e2d\u5e76\u63a7\u5236\u7531\u86cb\u767d\u8d28\u3001\u8102\u8d28\u3001DNA\u548cRNA\u7ec4\u6210\u7684\u5404\u79cd\u8d85\u5206\u5b50\u7ec4\u4ef6\u7684\u5f62\u6210\u548c\u7834\u88c2\uff0c\u4ee5\u54cd\u5e94\u5916\u90e8\u523a\u6fc0\u3002\u800c\u4eba\u5de5\u5236\u9020\u8fd9\u6837\u7684\u8f6f\u6750\u6599\u5341\u5206\u5177\u6709\u6311\u6218\u6027\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4eac\u90fd\u5927\u5b66Itaru Hamachi\u6559\u6388(\u901a\u8baf\u4f5c\u8005)<\/strong>\u7814\u7a76\u56e2\u961f\u5728Nature Nanotechnology<\/strong>\u53d1\u8868\u9898\u4e3a\u201cAn adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks<\/strong>\u201d\u7684\u6587\u7ae0\u3002\u8be5\u7814\u7a76\u56e2\u961f\u5236\u5907\u4e86\u4e00\u79cd\u5177\u5907\u81ea\u5206\u9009\u529f\u80fd\u7684\u7eb3\u7c73\u7ea4\u7ef4\u53cc\u7f51\u7ec4\u6210\u7684\u6df7\u5408\u6c34\u51dd\u80f6\uff0c\u5176\u4e2d\u6bcf\u4e2a\u7f51\u7edc\u5355\u5143\u53ef\u4ee5\u5bf9\u88ab\u72ec\u7acb\u65bd\u52a0\u7684\u5916\u90e8\u523a\u6fc0\u4f5c\u51fa\u54cd\u5e94\u3002\u540c\u65f6\u53ef\u4ee5\u901a\u8fc7\u52a0\u5165Na2<\/sub>S2<\/sub>O4<\/sub>\u6216\u7ec6\u83cc\u78b1\u6027\u78f7\u9178\u9176\u6765\u6539\u53d8\u5176\u673a\u68b0\u6027\u8d28\u548c\u5305\u5c01\u86cb\u767d\u8d28\u7684\u91ca\u653e\u901f\u7387\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 SDN\u6c34\u51dd\u80f6\u5f62\u6210\u793a\u610f\u56fe\uff0c\u4ee5\u53ca\u6c34\u51dd\u80f6\u548c\u8367\u5149\u63a2\u9488\u7684\u5206\u5b50\u7ed3\u6784<\/strong><\/p>\n

\"\"<\/p>\n

a.<\/strong> \u4e24\u4e2a\u4f4e\u5206\u5b50\u91cf\u7684\u80bd\u548c\u8102\u8d28\u578b\u6c34\u51dd\u80f6\u6b63\u4ea4\u805a\u96c6\u6210\u4e24\u4e2a\u4e0d\u540c\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7ea4\u7ef4\uff0c\u5f62\u6210\u4e00\u4e2aSDN\u6c34\u51dd\u80f6(\u84dd\u8272\u5206\u5b50\u4ee3\u8868\u80bd\u548c\u9ec4\u8272\u4ee3\u8868\u8102\u8d28\u7c7b\u578b\u7684\u6c34\u51dd\u80f6;\u84dd\u8272\u548c\u9ec4\u8272\u7f51\u7edc\u5206\u522b\u8868\u793a\u7531\u81ea\u7ec4\u88c5\u7684\u80bd\u548c\u8102\u8d28\u578b\u6c34\u51dd\u80f6\u5242\u7ec4\u6210\u7684\u7eb3\u7c73\u7ea4\u7ef4)<\/p>\n

b.<\/strong> \u80bd,\u8102\u7c7b\u578b\u51dd\u80f6\u5242(NPmoc-FF\uff0cNPmoc-F(4-F)F\u548cPhos-cycc6)\u548c\u8367\u5149\u63a2\u9488(NP-Alexa647\u548cNBD-cycc6)\u7684\u5316\u5b66\u7ed3\u6784\uff1b<\/p>\n

\u56fe2 \u81ea\u5206\u9009NPmoc-F(4-F)F\u548cPhos-cycc6\u7684\u8bc4\u4f30<\/strong><\/p>\n

\"\"<\/p>\n

a-c.<\/strong> NPmoc-F(4-F)F\u7684CD\u8c31;<\/p>\n

d-e.<\/strong> NPmoc-F(4-F)F\u548cPhos-cycc6\u7684CLSM\u56fe\u50cf;<\/p>\n

f.<\/strong> \u5206\u522b\u7528NP-Alexa647\u548cNBD-cycc6\u67d3\u8272\u7684\u81ea\u5206\u9009NPmoc-F(4-F)F\u548cPhos-cycc6\u7ea4\u7ef4\u7684\u9ad8\u5206\u8fa8\u7387CLSM\u56fe\u50cf(\u5177\u6709Airyscan\u5355\u5143);<\/p>\n

\u56fe3 NPmoc-F(4-F)F\u548cPhos-cycc6\u7684\u5e94\u6fc0\u54cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

a.<\/strong>NPmoc-F(4-F)F\u548cNa2<\/sub>S2<\/sub>O4<\/sub>\u4e4b\u95f4\u7684\u5316\u5b66\u53cd\u5e94;<\/p>\n

b.<\/strong>NPmoc-F(4-F)F\u51dd\u80f6\u7684\u5149\u5b66\u7167\u7247\u548c\u52a0\u5165Na2<\/sub>S2<\/sub>O4<\/sub>(10\u5206\u949f)\u540e\u7684\u6eb6\u80f6\u7167\u7247\uff1b<\/p>\n

c.<\/strong>\u52a0\u5165Na2<\/sub>S2<\/sub>O4<\/sub>\u4e4b\u524d\u548c\u4e4b\u540e(10\u5206\u949f)\u7684NPmoc-F(4-F)F\u51dd\u80f6\u7684HPLC\u56fe\uff1b<\/p>\n

d.<\/strong>NPmoc-F(4-F)F\u51dd\u80f6(\u7070\u8272)\u548c\u901a\u8fc7\u6dfb\u52a0Na2<\/sub>S2<\/sub>O4<\/sub>(\u7ea2\u8272)\u4eceNPmoc-F(4-F)F\u51dd\u80f6\u83b7\u5f97\u7684\u6eb6\u80f6\u7684CD\u8c31\uff1b<\/p>\n

e.<\/strong>Phos-cycc6\u548cBAP\u4e4b\u95f4\u7684\u5316\u5b66\u53cd\u5e94\uff1b<\/p>\n

f.<\/strong>\u6dfb\u52a0BAP\u540e\u7684Phos-cycc6\u6eb6\u6db2\u7684\u5149\u5b66\u7167\u7247\uff1b<\/p>\n

g.<\/strong>\u6dfb\u52a0BAP(0-180\u5206\u949f)\u540ePhos-cycc6\u6eb6\u6db2\u7684\u6d41\u53d8\u5b66\u7279\u6027\u65f6\u7a0b\uff1b<\/p>\n

h.<\/strong>\u6dfb\u52a0BAP(3\u5c0f\u65f6)\u540ePhos-cycc6\u6eb6\u6db2\u6216\u51dd\u80f6\u7684HPLC\u56fe\uff1b<\/p>\n

i.<\/strong>Phos-cycc6\u6eb6\u6db2\u548c\u901a\u8fc7\u52a0\u5165BAP\u83b7\u5f97\u7684\u51dd\u80f6\u7684CD\u8c31\uff1b<\/p>\n

\u56fe4 \u5fae\u7c92\u5728Phos-cycc 6\u6eb6\u6db2\u548cPhos\/Ho-cycc 6\u51dd\u80f6\u4e2d\u7684\u5e03\u6717\u8fd0\u52a8<\/strong><\/p>\n

\"\"<\/p>\n

a.<\/strong>\u7f13\u51b2\u6eb6\u6db2\u4e2dPhos-cycc6\u548c\u8367\u5149\u5fae\u7c92(800nm)\u6df7\u5408\u7269\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

b.<\/strong>\u5728Phos-cycc6\u6eb6\u6db2(\u4e0a\u90e8)\u548cPhos\/Ho-cycc6\u51dd\u80f6(\u4e0b\u90e8)\u4e2d\u7684\u5fae\u7c92(\u76f4\u5f84\uff1a300nm)\u7684\u5e03\u6717\u8fd0\u52a8CLSM\u56fe\u50cf\uff1b<\/p>\n

c.<\/strong>\u52a0\u5165BAP(3h)\u540e\uff0c\u5728Phos-cycc6\u6eb6\u6db2\u548cPhos\/Ho-cycc6\u51dd\u80f6\u4e2d\u7684\u5fae\u7c92(\u76f4\u5f84\uff1a70-800nm)\u7684\u5e03\u6717\u8fd0\u52a8\uff1b<\/p>\n

\u56fe5 \u81ea\u5206\u9009\u53cc\u7f51\u7edc(SDN)\u6c34\u51dd\u80f6\u7684\u523a\u6fc0\u54cd\u5e94\u6027<\/strong><\/p>\n

\"\"<\/p>\n

a.<\/strong>NPmocF(4-F)F\u548cPhos-cycc6\u7f51\u7edc\u7684\u6b63\u4ea4\u6742\u4ea4\u793a\u610f\u56fe\uff0c\u4ee5\u53ca\u5bf9SDN\u6c34\u51dd\u80f6\u4e2dNa2<\/sub>S2<\/sub>O4<\/sub>\u548cBAP\u7684\u9884\u671f\u54cd\u5e94(\u84dd\u8272\uff0c\u9ec4\u8272\u548c\u7ea2\u8272\u8868\u793aNPmoc-F(4-F)F\uff0cPhos-cycc6\u548cPhos\/Ho-cycc6\u7f51\u7edc)\uff1b<\/p>\n

b.<\/strong>SDN\u6c34\u51dd\u80f6(\u4e2d)\uff0c\u4ee5\u53ca\u7c98\u6027\u6db2\u4f53\u548c\u5728\u5206\u522b\u6dfb\u52a0Na2<\/sub>S2<\/sub>O4<\/sub>(\u5de6)\u548cBAP(\u53f3)\u4e4b\u540e\u5f62\u6210\u51dd\u80f6\u7684\u5149\u5b66\u7167\u7247<\/p>\n

c.<\/strong>\u9891\u738710 rad s-1\u524d\u540eSDN\u6c34\u51dd\u80f6\u7684\u6d41\u53d8\u6027\u80fd(\u5de6\uff1aNa2<\/sub>S2<\/sub>O4<\/sub>(30\u5206\u949f)\uff0c\u4e2d\uff1a\u65e0\u523a\u6fc0\uff1b\u53f3\uff1aBAP(3\u5c0f\u65f6))<\/p>\n

d.<\/strong>SDN\u6c34\u51dd\u80f6(\u4e0a\u90e8\uff1a\u52a0\u5165\u523a\u6fc0\u524d\uff0c\u4e2d\u90e8\uff1aNa2<\/sub>S2<\/sub>O4<\/sub>(30\u5206\u949f)\uff0c\u4e0b\u90e8\uff1aBAP(3\u5c0f\u65f6))\u7684HPLC\u56fe;<\/p>\n

e.<\/strong>\u5728\u6dfb\u52a0\u523a\u6fc0\u7269(\u5de6\uff1aIgG\uff0c\u4e2d\u7b49\uff1aMb\uff0c\u53f3\uff1aConA\uff0c\u7ea2\u8272\uff1aNa2<\/sub>S2<\/sub>O4<\/sub>(30\u5206\u949f)\uff0c\u7070\u8272\uff1a\u65e0\u523a\u6fc0\uff0c\u84dd\u8272\uff1aBAP(3h))\u540e\uff0cSDN\u6c34\u51dd\u80f6\u7684\u86cb\u767d\u91ca\u653e\u901f\u7387;<\/p>\n

\u56fe6 \u523a\u6fc0SDN\u6c34\u51dd\u80f6\u7684\u547d\u4ee4\u8bc6\u522b<\/strong><\/p>\n

\"\"<\/p>\n

a.<\/strong>\u7531SDN\u6c34\u51dd\u80f6\u8bc6\u522b\u523a\u6fc0\u987a\u5e8f\u7684\u793a\u610f\u56fe(SDN\u6c34\u51dd\u80f6\u523a\u6fc0\u8bc6\u522b\u8def\u5f84\u8bbe\u8ba1\uff1a\u8def\u7ebfA\u663e\u793a\u4e86\u5728\u52a0\u5165Na2<\/sub>S2<\/sub>O4<\/sub>\uff0c\u968f\u540e\u52a0\u5165BAP\u7684SDN\u6c34\u51dd\u80f6\u7684\u9884\u671f\u53d8\u5316\uff1b\u8def\u7ebfB\u663e\u793a\u98a0\u5012\u52a0\u5165\u987a\u5e8f\u7684\u60c5\u51b5\u3002\u84dd\u8272(\u9ec4\u8272\u548c\u7ea2\u8272\u5206\u522b\u8868\u793aNPmoc-F(-F)F\uff0cPhos-cycc6\u548cPhos \/ Ho-cycc6\u7f51\u7edc))\uff1b<\/p>\n

b-c.<\/strong> \u52a0\u5165\u523a\u6fc0\u540eSDN\u6c34\u51dd\u80f6\u7684\u5149\u5b66\u7167\u7247(b\uff1a\u8def\u7ebfA\uff0cc\uff1a\u8def\u7ebfB);<\/p>\n

d.<\/strong>\u5728UV\u5149(254nm)\u4e0b\uff0c\u5fae\u7c92\u5c01\u88c5\u5b9e\u9a8c\u7684\u5149\u5b66\u7167\u7247(\u4e0a\u90e8\uff1a\u8def\u7ebfA\uff0c\u4e0b\u90e8\uff1a\u8def\u7ebfB)\uff1b<\/p>\n

e-f.<\/strong> \u5728\u6dfb\u52a0\u523a\u6fc0\u4e4b\u524d\u548c\u4e4b\u540e\uff0c\u5728SDN\u6c34\u51dd\u80f6\u4e2d\u5fae\u7c92(\u76f4\u5f84\uff1a300nm)\u7684\u5e03\u6717\u8fd0\u52a8(e\uff1a\u8def\u7ebfA\uff0cf\uff1a\u8def\u7ebfB)\uff1b<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u8be5\u5de5\u4f5c\u5c55\u793a\u4e86\u4e00\u79cd\u81ea\u8eab\u5177\u6709\u81ea\u5206\u9009\u529f\u80fd\u7684\u8d85\u5206\u5b50\u7eb3\u7c73\u7ea4\u7ef4\u5bf9\u3002\u4e0d\u540c\u7684\u7eb3\u7c73\u7ea4\u7ef4\u53ef\u4ee5\u5236\u5907\u6210\u5408\u7406\u8bbe\u8ba1\u7684\u81ea\u5206\u9009\u6c34\u51dd\u80f6\uff0c\u5e76\u80fd\u5bf9\u4e24\u4e2a\u6b63\u4ea4\u523a\u6fc0\u7684\u53cc\u5411\u6d41\u53d8\u5b66\u548c\u86cb\u767d\u91ca\u653e\u5206\u5e03\u53d8\u5316\u4f5c\u51fa\u54cd\u5e94\u3002\u6b64\u5916\uff0c\u6c34\u51dd\u80f6\u901a\u8fc7\u533a\u5206\u6240\u65bd\u52a0\u7684\u523a\u6fc0\u7684\u987a\u5e8f\u5c55\u73b0\u51fa\u9002\u5e94\u6027\u7684\u51dd\u80f6-\u6eb6\u80f6\u54cd\u5e94\u3002\u8be5\u7c7b\u6c34\u51dd\u80f6\u53ef\u4ee5\u4e0e\u6240\u5e0c\u671b\u7684\u529f\u80fd\u8fdb\u884c\u7f16\u7a0b\uff0c\u6784\u5efa\u4e3a\u591a\u7ec4\u5206\u667a\u80fd\u8f6f\u8d28\u6750\u6599\u5e76\u7528\u4e8e\u5305\u62ec\u6cbb\u7597\uff0c\u8bca\u65ad\uff0c\u836f\u7269\u9012\u9001\uff0c\u548c\u518d\u751f\u533b\u5b66\u5728\u5185\u7684\u81ea\u4e0b\u800c\u4e0a\u8bbe\u8ba1\u7684\u81ea\u5206\u62e3\u7cfb\u7edf\u5e76\u9002\u7528\u4e8e\u8bbe\u8ba1\u65b0\u9896\u7684\u9002\u5e94\u6027\u6750\u6599\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aAn adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks<\/a><\/strong>\u00a0(Nature Nanotechnology, 2018, doi:10.1038\/s41565-017-0026-6)<\/p>\n

\n \u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u8fde\u5a77\u5a77\u7f16\u8bd1\uff0c\u9648\u70b3\u65ed\u5ba1\u6838\uff0c \u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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