{"id":120077,"date":"2018-01-05T06:30:03","date_gmt":"2018-01-04T22:30:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=120077"},"modified":"2018-01-04T23:32:51","modified_gmt":"2018-01-04T15:32:51","slug":"nature-%e5%ad%90%e5%88%8a-%e5%90%88%e6%88%90%e7%9a%84%e4%bd%8e%e8%81%9a%e5%9b%9b%e6%b0%a7%e5%8c%96%e6%b0%ae%e8%83%bd%e5%9c%a8%e6%9c%ba%e6%a2%b0%e8%b4%9f%e8%bd%bd%e4%b8%8b%e6%8a%98%e5%8f%a0%e6%97%b6","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=120077","title":{"rendered":"Nature \u5b50\u520a : \u5408\u6210\u7684\u4f4e\u805a\u56db\u6c27\u5316\u6c2e\u80fd\u5728\u673a\u68b0\u8d1f\u8f7d\u4e0b\u6298\u53e0\u65f6\uff0c\u53d1\u6325\u5f3a\u5927\u7684\u4f5c\u7528\u529b"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"Folding is a ubiquitous process that nature uses to control the conformations of its molecular machines, allowing them to perform chemical and mechanical tasks.\">\u6298\u53e0\u662f\u4e00\u4e2a\u65e0\u5904\u4e0d\u5728\u7684\u5f62\u6001\uff0c\u5927\u81ea\u7136\u7528\u4ee5\u63a7\u5236\u5176\u5206\u5b50\u673a\u5668\u7684\u6784\u8c61\uff0c\u4f7f\u5176\u80fd\u591f\u6267\u884c\u5316\u5b66\u548c\u673a\u68b0\u4efb\u52a1\u3002<\/span><span title=\"Over the years, chemists have synthesized foldamers that adopt well-defined and stable folded architectures, mimicking the control expressed by natural systems .\">\u591a\u5e74\u6765\uff0c\u5316\u5b66\u5bb6\u5df2\u7ecf\u5408\u6210\u4e86\u591a\u79cd\u6298\u53e0\u4f53\uff0c\u5229\u7528\u5b9a\u4e49\u660e\u786e\u548c\u7a33\u5b9a\u7684\u6298\u53e0\u7ed3\u6784\uff0c\u6a21\u4eff\u81ea\u7136\u7cfb\u7edf\u8868\u8fbe\u63a7\u5236\u3002<\/span><span title=\"Mechanically interlocked molecules, such as rotaxanes and catenanes, are prototypical molecular machines that enable the controlled movement and positioning of their component parts .\">\u673a\u68b0\u4e92\u9501\u5206\u5b50\uff0c\u5982\u8f6e\u70f7\u548c\u7d22\u70c3\uff0c\u662f\u539f\u578b\u5206\u5b50\u673a\u5668\uff0c\u5176\u7ec4\u6210\u90e8\u5206\u53d7\u63a7\u53ef\u4ee5\u79fb\u52a8\u548c\u5b9a\u4f4d\u3002<\/span><span title=\"Recently, combining the exquisite complexity of these two classes of molecules, donor\u2013acceptor oligorotaxane foldamers have been synthesized,in which interactions between the mechanically interlocked component parts dictate the single-molecule assembly into a folded secondary structure .\">\u6700\u8fd1\uff0c\u7ed3\u5408\u8fd9\u4e24\u7c7b\u5206\u5b50\u7684\u7cbe\u5de7\u590d\u6742\u6027\uff0c\u5df2\u7ecf\u5408\u6210\u4e86\u4f9b\u4f53 &#8211; \u53d7\u4f53\u5be1\u805a\u8f6e\u70f7\u6298\u53e0\u805a\u4f53\uff0c\u5176\u4e2d\u673a\u68b0\u4e92\u9501\u7ec4\u5206\u90e8\u5206\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u51b3\u5b9a\u4e86\u5355\u5206\u5b50\u7ec4\u88c5\u6210\u6298\u53e0\u4e8c\u7ea7\u7ed3\u6784\u3002<\/span><span title=\"Here we report on the mechanochemical properties of these molecules.\">\u672c\u6587\u62a5\u9053\u4e86\u8fd9\u4e9b\u5206\u5b50\u7684\u673a\u68b0\u5316\u5b66\u6027\u8d28\u3002<\/span><span title=\"1,5-dioxynaphthalene units encircled by cyclobis(paraquat-p-phenylene) rings.\">\u7531\u73af\u53cc\uff08\u5bf9 &#8211; \u5bf9 &#8211; \u4e9a\u82ef\u57fa\uff09\u73af\u5305\u56f4\u76841,5-\u4e8c\u6c27\u4ee3\u8418\u5355\u5143<span title=\"We use atomic force microscopy-based single-molecule force spectroscopy to mechanically unfold oligorotaxanes, made of oligomeric dumbbells incorporating\n\">\u4f4e\u805a\u7269\u7531<span class=\"\">\u539f\u5b50\u529b\u663e\u5fae\u955c\u7684\u5355\u5206\u5b50\u529b\u5149\u8c31\u5b66\u673a\u68b0\u5c55\u5f00<\/span><\/span>\u3002<\/span><span title=\"Real time capture of fluctuations between unfolded and folded states reveals that the molecules exert forces of up to 50 pN against a mechanical load of up to 150 pN, and displays transition times of less than 10 \u03bcs.\">\u5b9e\u65f6\u6355\u83b7\u5c55\u5f00\u72b6\u6001\u548c\u6298\u53e0\u72b6\u6001\u4e4b\u95f4\u7684\u6ce2\u52a8\u663e\u793a\uff0c\u5206\u5b50\u5bf9\u9ad8\u8fbe150 pN\u7684\u673a\u68b0\u8d1f\u8f7d\u53ef\u65bd\u52a0\u9ad8\u8fbe50 pN\u7684\u529b\uff0c\u5e76\u663e\u793a\u5c0f\u4e8e10\u03bcs\u7684\u8fc7\u6e21\u65f6\u95f4\u3002<\/span><span title=\"While the folding is at least as fast as that observed in proteins, it is remarkably more robust, thanks to the mechanically interlocked structure.\">\u867d\u7136\u8be5\u6298\u53e0\u901f\u5ea6\u4e0e\u86cb\u767d\u8d28\u4e2d\u7684\u6298\u53e0\u901f\u5ea6\u4e00\u6837\u5feb\uff0c\u4f46\u7531\u4e8e\u673a\u68b0\u4e92\u9501\u7ed3\u6784\uff0c\u8fd9\u79cd\u6298\u53e0\u975e\u5e38\u7a33\u5065\u3002<\/span><span title=\"Our results show that synthetic oligorotaxanes have the potential to exceed the performance of natural folding proteins.\">\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5408\u6210\u7684<span title=\"Recently, combining the exquisite complexity of these two classes of molecules, donor\u2013acceptor oligorotaxane foldamers have been synthesized,in which interactions between the mechanically interlocked component parts dictate the single-molecule assembly into a folded secondary structure .\">\u5be1\u805a\u8f6e\u70f7<\/span>\u6709\u8d85\u8fc7\u5929\u7136\u6298\u53e0\u86cb\u767d\u7684\u6027\u80fd\u3002<\/span><\/span><\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\">\u5929\u7136\u590d\u5408\u529f\u80fd\u5206\u5b50\u548c\u673a\u5668\u7684\u7ed3\u6784\u3001\u52a8\u529b\u5b66\u548c\u64cd\u4f5c\u65b9\u9762\u7684\u5927\u90e8\u5206\u4fe1\u606f\u5df2\u7ecf\u4ece\u5355\u5206\u5b50\u529b\u8c31\u83b7\u5f97\u3002\u5728\u8fd9\u4e9b\u5b9e\u9a8c\u4e2d\uff0c\u5206\u5b50\u88ab\u6355\u83b7\u5e76\u88ab\u62c9\u5230\u57fa\u5e95\u548c\u663e\u5fae\u63a2\u9488\u4e4b\u95f4\uff0c\u6d4b\u91cf\u5176\u6062\u590d\u529b\u3002 \u4ee5\u539f\u5b50\u529b\u663e\u5fae\u955c\uff08AFM\uff09\u4e3a\u57fa\u7840\u7684\u529b\u5b66\u5149\u8c31\u5b66\u80fd\u591f\u4ee5\u4e9a\u7eb3\u7c73\u7ea7\u7684\u5206\u8fa8\u7387\u63a2\u6d4b\u5206\u5b50\u7684\u529b\u5b66\u6027\u80fd\uff0c\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u9610\u660e\uff08\u751f\u7269\uff09\u5927\u5206\u5b50\u7684\u6784\u8c61\u3001<span class=\"\">\u7814\u7a76\u751f\u7269\u673a\u68b0\u7684\u529b\u5b66\u5316\u5b66\u3001<\/span><span class=\"\">\u4e86\u89e3\u5206\u5b50\u4f34\u4fa3\u4e4b\u95f4\u7684\u7ed3\u5408\u8fc7\u7a0b;<\/span> <span class=\"\">\u5e76\u7814\u7a76\u8f6e\u70f7\u3001\u7d22\u70c3\u548c\u5176\u4ed6\u673a\u68b0\u4e92\u9501\u5316\u5408\u7269\u7684\u673a\u68b0\u5316\u5b66\u8fc7\u7a0b\u3002<\/span><\/span><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u5217\u65e5\u5927\u5b66<\/strong>\u7684<strong>Anne-Sophie Duwez<\/strong>\u6559\u6388\u5728<strong>Nat. Nanotech.<\/strong>\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8e\u5408\u6210\u7684\u4f4e\u805a\u56db\u6c27\u5316\u6c2e\u80fd\u5728\u673a\u68b0\u8d1f\u8f7d\u4e0b\u6298\u53e0\u65f6\u7684\u6587\u7ae0\uff0c\u9898\u4e3a\u201c<strong>Synthetic oligorotaxanes exert high forces when folding under mechanical load<\/strong>\u201d\u3002\u8be5\u7814\u7a76<span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"Taking inspiration from nature\u2019s molecular machinery, which makes use of well-defined, stable, but highly dynamic systems, the emerging class of synthetic oligorotaxanes reported here reveal themselves to be efficient, robust and intricately regulated by their dynamics.\">\u4ece\u5927\u81ea\u7136\u7684\u5206\u5b50\u673a\u5668\u4e2d\u83b7\u5f97\u7075\u611f\uff0c\u5f62\u6210\u4e00\u79cd\u5b9a\u4e49\u660e\u786e\u3001\u7a33\u5b9a\u800c\u9ad8\u5ea6\u52a8\u6001\u7684\u7cfb\u7edf\u7684\u5206\u5b50\u673a\u5236\uff0c\u65b0\u5174\u7684\u5408\u6210\u5be1\u805a\u534a\u80f1\u6c28\u9178\u7c7b\u5316\u5408\u7269\u663e\u793a\u51fa\u6709\u6548\u6027\u3001\u7a33\u5b9a\u6027\u548c\u9519\u7efc\u590d\u6742\u7684\u52a8\u529b\u5b66\u8c03\u8282\u6027\u80fd\u3002<\/span><\/span><\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>1 <\/strong><strong><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"Structure formula and co-conformation of the [5]rotaxane of the [0.5(n\u00a0\u2013\u00a01)\u00a0+\u00a02] family\">[0.5\uff08n-1\uff09+ 2]\u65cf[5]\u8f6e\u70f7\u7684\u7ed3\u6784\u5f0f\u548c\u5171\u6784\u8c61<\/span><\/span>\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-120079 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/01\/1-3-e1515079861394.jpg\" alt=\"\" width=\"600\" height=\"259\" \/><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"AFM-based mechanical unfolding of the [5]rotaxane in DMF\"><strong>\u56fe<\/strong><strong>2 \u57fa\u4e8eAFM\u7684[5]\u8f6e\u70f7\u5728DMF\u4e2d\u7684\u673a\u68b0\u5c55\u5f00<\/strong><\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-120080 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/01\/2-5-e1515079878391.jpg\" alt=\"\" width=\"600\" height=\"702\" \/><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\">a\uff09\u62c9\u52a8\u5b9e\u9a8c\u7684\u63d2\u56fe\u3002 \u901a\u8fc7\u4ee5\u6052\u5b9a\u7684\u901f\u5ea6\u6536\u56de\u60ac\u81c2\u800c\u53d1\u751f\u673a\u68b0\u5c55\u5f00\u3002 <span class=\"\">\u65ad\u5f00\u6e38\u79bbDNP\u548c\u8fde\u7eed\u73af\u4e4b\u95f4\u7684\u4e00\u4e2a\u76f8\u4e92\u4f5c\u7528\u4e4b\u540e\u957f\u5ea6\u7684\u7406\u8bba\u53d8\u5316<\/span><span class=\"\">\u7ea6\u4e3a1.2\u7eb3\u7c73\u3002<\/span><\/span><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\">b\uff09\u572840 nm\u00b7s<sup>-1<\/sup>\uff0810<sup>3<\/sup> pN\u00b7s<sup>-1<\/sup>\uff09\u4e0b\u83b7\u5f97\u7684\u529b- \u8ddd\u79bb\u66f2\u7ebf\u7684\u5b9e\u4f8b<span class=\"\">\u3002<\/span><\/span><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\">c\uff09\u8fde\u7eed\u5cf0\u503c\u4e4b\u95f4\u7684\u8f6e\u5ed3\u957f\u5ea6\u589e\u91cf\u5206\u5e03\uff08\u0394L<sub>c<\/sub>\uff09\uff08N = 1712\uff09<span class=\"\">\u3002<\/span><\/span><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span class=\"\">d\uff09\u5728350 nm\u00b7s<sup>-1<\/sup>\uff0810<sup>4<\/sup> pN\u00b7s<sup> -1<\/sup>\uff09\u4e0b\u83b7\u5f97\u7684\u529b &#8211; \u8ddd\u79bb\u66f2\u7ebf\u7684\u5b9e\u4f8b\u3002<\/span><\/span><\/p>\n<p><strong>\u56fe<\/strong><strong>3<\/strong> <strong><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"Pulling\u2013relaxing cycles showing the reformation of one interaction under mechanical load\">\u7275\u62c9 &#8211; \u677e\u5f1b\u5faa\u73af\u663e\u793a\u673a\u68b0\u8f7d\u8377\u4e0b\u4e00\u6b21\u76f8\u4e92\u4f5c\u7528\u7684\u6539\u53d8<\/span><\/span><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-120081 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/01\/3-5-e1515079897763.jpg\" alt=\"\" width=\"600\" height=\"715\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>4 \u00a0<\/strong><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"Pulling\u2013relaxing experiments showing the numerous fluctuations between folded and unfolded states and determination of the force exerted by the molecule.\"><strong>\u62c9\u4f38\u653e\u677e\u5b9e\u9a8c\u663e\u793a\u4e86\u6298\u53e0\u72b6\u6001\u548c\u672a\u6298\u53e0\u72b6\u6001\u4e4b\u95f4\u7684\u5927\u91cf\u6ce2\u52a8<\/strong><\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-120082 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/01\/4-4-e1515079912821.jpg\" alt=\"\" width=\"600\" height=\"1353\" \/><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\">a\uff09\u5728DMF\u4e2d\u7684\u4e2a\u522b[5]\u8f6e\u70f7\u5206\u5b50\u4e0a\u83b7\u5f97\u7684\u62c9 &#8211; \u677e\u5f1b\u5faa\u73af<span class=\"\">\u3002<\/span><\/span><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span class=\"\">b\uff09\u5728\u4ece\u5c40\u90e8\u5c55\u5f00\u5230\u5c40\u90e8\u6298\u53e0\u72b6\u6001\uff08N = 115\uff09\u7684\u6ce2\u52a8\u4e4b\u524d\u65bd\u52a0\u7684\u5916\u529b\u7684\u5206\u5e03\u3002<\/span><\/span><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span class=\"\">c\uff09\u6ce2\u52a8\u8fc7\u7a0b\u4e2d\u529b\u589e\u91cf\uff08\u0394F\uff09\u7684\u5206\u5e03\uff08N = 115\uff09\u3002\u5728\u5c40\u90e8\u6298\u53e0\u671f\u95f4\uff0c\u5be1\u805a\u534a\u80f1\u6c28\u9178\u5e73\u5747\u65bd\u52a025 pN\u7684\u529b\uff0c\u8fbe\u523050 pN\uff08\u52a0\u8f7d\u901f\u7387\u4e3a10<sup>4<\/sup> pN\u00b7s<sup>-1<\/sup>\uff09\u3002<\/span><\/span><\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span class=\"\">d\uff09\u529b &#8211; \u65f6\u95f4\u66f2\u7ebf\uff08\u52a0\u8f7d\u901f\u7387\uff1a10<sup>4<\/sup> pN\u00b7s<sup>-1<\/sup>\uff08350 nm\u00b7s<sup>-1<\/sup>\uff09\uff09\u3002\u0394F\u662f\u7531\u5206\u5b50\u91cd\u65b0\u83b7\u5f97\u5176\u5c40\u90e8\u6298\u53e0\u72b6\u6001\u6240\u65bd\u52a0\u7684\u529b\u3002<\/span><\/span><\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u672c\u7814\u7a76<span id=\"result_box\" class=\"\" lang=\"zh-CN\"><span title=\"Our results show that donor\u2013acceptor oligorotaxanes, wherein the dumbbells are composed of oligoether chains interrupted by 1,5-dioxynaphthalene units, half of which are encircled by cyclobis(paraquat-p-phenylene) rings, are able to exert significant force in refolding\">\u7ed3\u679c\u663e\u793a\uff0c\u4f9b\u4f53 &#8211; \u53d7\u4f53\u5be1\u805a\u56db\u6c22\u5316\u7269\uff0c\u54d1\u94c3\u7ed3\u6784\u7531\u88ab1,5-\u4e8c\u6c27\u4ee3\u8418\u5355\u5143\u95f4\u9694\u7684\u5be1\u805a\u919a\u94fe\u7ec4\u6210\uff0c\u4e00\u534a\u88ab\u73af\u53cc\uff08\u767e\u8349\u67af &#8211; \u5bf9 &#8211; \u4e9a\u82ef\u57fa\uff09\u73af\u5305\u56f4\uff0c\u80fd\u591f\u5728\u91cd\u6298\u53e0\u4e2d\u65bd\u52a0\u663e\u7740\u7684\u529b<\/span><span title=\"against a high external load.\">\u62b5\u6297\u9ad8\u5916\u90e8\u8d1f\u8377\u3002<\/span><span title=\"The observation of fluctuations, even at high loading rates, implies that the thermal dynamics of these molecules are very high, making them the fastest ever measured at such high loading rates.\">\u5373\u4f7f\u5728\u9ad8\u8d1f\u8f7d\u7387\u4e0b\u4e5f\u89c2\u5bdf\u5230\u6ce2\u52a8\u3002\u8fd9\u610f\u5473\u7740\u8fd9\u4e9b\u5206\u5b50\u7684\u70ed\u52a8\u529b\u5b66\u975e\u5e38\u9ad8\uff0c\u4f7f\u5f97\u5b83\u4eec\u662f\u5728\u8d85\u9ad8\u7684\u52a0\u8f7d\u901f\u7387\u4e0b\u8fd8\u80fd\u6d4b\u5f97\u5feb\u901f\u7684\u6298\u53e0\u901f\u5ea6\u3002<\/span><span title=\"The mechanically interlocked structure is most likely responsible for this remarkably robust and highly dynamic folding.\">\u673a\u68b0\u4e92\u9501\u7ed3\u6784\u6700\u6709\u53ef\u80fd\u662f\u9020\u6210\u8fd9\u79cd\u975e\u5e38\u5f3a\u52b2\u548c\u9ad8\u5ea6\u52a8\u6001\u6298\u53e0\u7684\u539f\u56e0\u3002\u8be5\u7814\u7a76<\/span><span title=\"Taking inspiration from nature\u2019s molecular machinery, which makes use of well-defined, stable, but highly dynamic systems, the emerging class of synthetic oligorotaxanes reported here reveal themselves to be efficient, robust and intricately regulated by their dynamics.\">\u4ece\u5927\u81ea\u7136\u7684\u5206\u5b50\u673a\u5668\u4e2d\u83b7\u5f97\u7075\u611f\uff0c\u8fd9\u79cd\u5206\u5b50\u673a\u5236\u5229\u7528\u4e86\u5b9a\u4e49\u660e\u786e\u3001\u7a33\u5b9a\u800c\u9ad8\u5ea6\u52a8\u6001\u7684\u7cfb\u7edf\u3002\u8be5\u7bc7\u62a5\u9053\u7684\u65b0\u5174\u5408\u6210\u7684\u5be1\u805a\u534a\u80f1\u6c28\u9178\u7c7b\u5316\u5408\u7269\u5177\u6709\u6709\u6548\u6027\u3001\u7a33\u5b9a\u6027\u548c\u9519\u7efc\u590d\u6742\u7684\u52a8\u529b\u5b66\u8c03\u8282\u6027\u80fd\u3002<\/span><span title=\"Our results show that oligorotaxanes have the potential to exceed the performance of natural folding proteins.\">\u79cd\u79cd\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u7269\u8d28\u6709\u671b\u8d85\u8fc7\u5929\u7136\u6298\u53e0\u86cb\u767d\u7684\u6027\u80fd\u3002<\/span><\/span><\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41565-017-0033-7\" target=\"_blank\" rel=\"noopener\">Synthetic oligorotaxanes exert high forces when folding under mechanical load<\/a>\uff08Nat. Nanotech.\uff0c2018\uff0cDOI: 10.1038\/s41565-017-0033-7\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u9ad8\u5206\u5b50\u5b66\u672f\u7ec4\u6c34\u624b\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\"><strong>\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/strong><\/a>\u3002\u53c2\u4e0e\u9ad8\u5206\u5b50\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u9ad8\u5206\u5b50\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u9ad8\u5206\u5b50\u4ea4\u6d41\u7fa4\uff08298064863\uff09\u3002<\/p>\n<p><strong>\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong><a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\"><strong>\u6d4b\u8bd5\u8c37<\/strong><\/a><strong>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u6298\u53e0\u662f\u4e00\u4e2a\u65e0\u5904\u4e0d\u5728\u7684\u5f62\u6001\uff0c\u5927\u81ea\u7136\u7528\u4ee5\u63a7\u5236\u5176\u5206\u5b50\u673a\u5668\u7684\u6784\u8c61\uff0c\u4f7f\u5176\u80fd\u591f\u6267\u884c\u5316\u5b66\u548c\u673a\u68b0\u4efb\u52a1\u3002\u591a\u5e74\u6765\uff0c\u5316\u5b66\u5bb6\u5df2\u7ecf\u5408\u6210\u4e86\u591a\u79cd\u6298\u53e0\u4f53\uff0c\u5229\u7528\u5b9a\u4e49\u660e\u786e\u548c\u7a33\u5b9a\u7684\u6298\u53e0\u7ed3\u6784&#8230;<\/p>\n","protected":false},"author":3247,"featured_media":120079,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[42],"class_list":["post-120077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-gaofenzi"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/120077"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/3247"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=120077"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/120077\/revisions"}],"predecessor-version":[{"id":120213,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/120077\/revisions\/120213"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/120079"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=120077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=120077"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=120077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}