{"id":117212,"date":"2017-12-16T06:30:41","date_gmt":"2017-12-15T22:30:41","guid":{"rendered":"\/\/m.iemloyee.com\/?p=117212"},"modified":"2017-12-15T12:12:29","modified_gmt":"2017-12-15T04:12:29","slug":"angew-chem-int-ed-%ef%bc%9a%e6%b9%96%e5%8d%97%e5%a4%a7%e5%ad%a6%e8%b0%ad%e8%94%9a%e6%b3%93%e9%99%a2%e5%a3%ab%e5%9b%a2%e9%98%9f%e5%8f%91%e6%98%8e%e5%85%bc%e5%85%b7%e5%85%89%e7%83%ad%e6%b2%bb","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=117212","title":{"rendered":"Angew. Chem. Int. Ed.\uff1a\u6e56\u5357\u5927\u5b66\u8c2d\u851a\u6cd3\u9662\u58eb\u56e2\u961f\u53d1\u660e\u517c\u5177\u5149\u70ed\u6cbb\u7597\u548c\u62b5\u6297\u708e\u75c7\u53cd\u5e94\u7684AuNR@G-P-aspirin\u7eb3\u7c73\u80f6\u56ca"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5bf9\u4e8e\u4f20\u7edf\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u800c\u8a00\uff0c\u5149\u70ed\u7597\u6cd5\uff08Photothermal therapy\uff0c\u4ee5\u4e0b\u7b80\u5199\u4e3aPTT\uff09\u662f\u4e00\u79cd\u6709\u6f5c\u529b\u7684\u66ff\u4ee3\u6216\u8005\u8f85\u52a9\u6cbb\u7597\u624b\u6bb5\u3002PTT\u662f\u5229\u7528\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u5149\u5438\u6536\u5242\u6765\u6740\u6b7b\u764c\u75c7\u7ec6\u80de\uff0c\u5e76\u4e14\u8fd1\u5e74\u6765\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u5f71\u54cd\u5b9e\u4f53\u7624\u5149\u70ed\u6d88\u878d\u6548\u679c\u7684\u56e0\u7d20\u4e3b\u8981\u662f\u5149\u70ed\u6cbb\u7597\u5242\u5728NIR\u533a\u57df\u7684\u5438\u6536\u548c\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u7a7f\u900f\u6df1\u5ea6\u3002\u5728\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u6e29\u5ea6\u901a\u5e38\u572841-48\u2103\u6216\u751a\u81f3\u66f4\u9ad8\u7684\u8303\u56f4\u5185\u5347\u9ad8\u3002\u7136\u800c\uff0c\u8fd9\u6837\u7684\u6e29\u5ea6\u6761\u4ef6\u901a\u5e38\u4f1a\u5f15\u8d77\u7ec6\u80de\u7684\u574f\u6b7b\uff08\u5305\u62ec\u7834\u574f\u7ec6\u80de\u819c\u7684\u5b8c\u6574\u6027\uff0c\u91ca\u653e\u7ec6\u80de\u5185\u7269\u8d28\uff09\uff0c\u8fdb\u800c\u5f15\u53d1\u7ec6\u80de\u7684\u708e\u75c7\u53cd\u5e94\u3002\u708e\u75c7\u53cd\u5e94\u7684\u53d1\u751f\u4f1a\u53cd\u8fc7\u6765\u523a\u6fc0\u80bf\u7624\u518d\u751f\u800c\u963b\u788d\u540e\u7eed\u6cbb\u7597\u3002\u9488\u5bf9\u8fd9\u79cd\u76f8\u4e92\u5236\u7ea6\u7684\u764c\u75c7\u5149\u70ed\u6cbb\u7597\u6cbb\u7597\u73b0\u72b6\uff0c\u7814\u53d1\u4e00\u79cd\u53ef\u5b9e\u73b0\u5149\u70ed\u6cbb\u7597\u7684\u589e\u5f3a\u5e76\u540c\u65f6\u6291\u5236PTT\u8bf1\u5bfc\u708e\u75c7\u53cd\u5e94\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u6210\u4e3a\u7814\u7a76\u7684\u70ed\u70b9\u65b9\u5411\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u6e56\u5357\u5927\u5b66\u8c2d\u851a\u6cd3\u9662\u58eb\u548c\u9648\u5353\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u56e2\u961f\u5728Angewandte Chemie International Edition<\/strong>\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201cSimultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene\u2013Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules\u201d<\/strong>\u7684\u6587\u7ae0\uff0c\u4ecb\u7ecd\u4e86\u53ef\u5b9e\u73b0\u5149\u70ed\u6cbb\u7597\u548c\u62b5\u6297\u708e\u75c7\u53cd\u5e94\u534f\u540c\u4f5c\u7528\u7684\u7eb3\u7c73\u80f6\u56ca\u3002\u8be5\u7814\u7a76\u6700\u5927\u7684\u521b\u65b0\u70b9\u5728\u4e8e\u7814\u7a76\u8005\u53d1\u660e\u7684\u7eb3\u7c73\u80f6\u56ca\u5728\u517c\u5177\u91d1\u7eb3\u7c73\u68d2\u5149\u70ed\u6548\u5e94\uff0c\u540c\u65f6\u5176\u8868\u9762\u643a\u5e26\u7684\u963f\u53f8\u5339\u6797\u53ef\u4ee5\u5bf9PTT\u5f15\u8d77\u7684\u708e\u75c7\u53cd\u5e94\u8fdb\u884c\u6291\u5236\u3002\u4e0d\u4ec5\u5b9e\u73b0\u4e86\u5bf9\u764c\u75c7\u7684\u5149\u70ed\u6cbb\u7597\uff0c\u8fd8\u53ef\u4ee5\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u8fdb\u800c\u6291\u5236\u764c\u75c7\u7684\u590d\u53d1\u4e0e\u518d\u751f\uff0c\u5b9e\u73b0\u764c\u75c7\u7684\u5f7b\u5e95\u6cbb\u7597\u3002\u8fd9\u4e00\u6750\u6599\u7684\u53d1\u660e\u4e3a\u540e\u7eed\u764c\u75c7\u6cbb\u7597\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u5411\u548c\u601d\u8def\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1. AuNR@G\u7684\u8fdb\u4e00\u6b65\u8868\u5f81\u548c\u5149\u70ed\u6548\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09AuNR@G\u7684TEM\u8868\u5f81\u548c\u793a\u610f\u56fe\u3002<\/p>\n

b\uff09AuNR@G\u7684HR-TEM\u8868\u5f81\u3002<\/p>\n

c\uff09AuNR@G\u7684\u7d2b\u5916\u53ef\u89c1\u5149\u8c31\u3002<\/p>\n

d\uff09AuNR@G\u7684\u62c9\u66fc\u5149\u8c31\u3002<\/p>\n

e\uff09\u901a\u8fc7AuNR@G\u67d3\u8272\u7684Hela \u7ec6\u80de\u7684\u62c9\u66fc\u6210\u50cf\u7167\u7247\uff08BF\uff0c\u660e\u573a\uff09\u3002<\/p>\n

f\uff09\u4e0d\u540c\u6d53\u5ea6AuNR@G\u6eb6\u6db2\u548c0.25mg\/mL\u7684GIAN\u7684\u52a0\u70ed\u5347\u6e29\u66f2\u7ebf\u3002<\/p>\n

g\uff09AuNR@G \uff080.25mg\/mL\uff09\u548cGIAN\uff080.25mg\/mL\uff09\u6eb6\u6db2\u5728\u4e0d\u540c\u6fc0\u5149\u5f3a\u5ea6\u4e0b\u52a0\u70ed\u7684\u5347\u6e29\u66f2\u7ebf\u3002<\/p>\n

h\uff09\u901a\u8fc7AuNR@G\u67d3\u8272\u5e76\u6fc0\u5149\u7167\u5c04\u540e\u5e76\u7ecf\u8fc7\u7898\u5316\u4e19\u5576\u67d3\u8272\u7684Hela \u7ec6\u80de\u7684CLSM\u7167\u7247\u3002<\/p>\n

\u56fe2. AuNR@G-P-aspirin\u7684\u5408\u6210\u8fc7\u7a0b\u4ee5\u53ca\u4f53\u5916\u6cbb\u7597\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

a) \u00a0P-aspirin\u7684\u5408\u6210\u8fc7\u7a0b\u3002<\/p>\n

b) \u8868\u9762\u4fee\u9970\u8fc7\u7a0b\u548cP-apirin\u4eceAuNR@G\u4e0a\u91ca\u653e\u7684\u56fe\u89e3\u8fc7\u7a0b\u3002\u00a0<\/p>\n

c) \u7ecf\u8fc7P-aspirin, AuNR@G\u548cAuNR@G-P-aspirin \u590d\u5408\u7269\u5904\u7406\u540eHela \u7ec6\u80de\u7684\u6d3b\u6027\u3002<\/p>\n

d-e) \u4e0d\u540cHela\u7ec6\u80de\u7ecf\u8fc7LPS\u6216\u57f9\u517b\u57fa\u5904\u7406\u540e\uff0cRAW264.7\u5de8\u566c\u7ec6\u80de\u7684TNF-a\u548cIL- 6\u6c34\u5e73\u53d8\u5316\u3002\u00a0<\/p>\n

\u56fe3. \u4f53\u5185\u52a8\u7269\u6c34\u5e73\u6297\u764c\u548c\u6297\u708e\u75c7\u53cd\u5e94\u6548\u679c\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

a) \u5728\u8001\u9f20\u79fb\u690d\u7624\u6a21\u578b\u4e0a\u8bc4\u4ef7AuNR@G-P-aspirin\u590d\u5408\u7269\u6cbb\u7597\u6548\u679c\u7684\u6b65\u9aa4\u3002\u00a0<\/p>\n

b) \u4e0d\u540c\u7ec4\u8001\u9f20\u4f53\u91cd\u53d8\u5316\u3002\u00a0<\/p>\n

c) \u4e0d\u540c\u5904\u7406\u7ec4\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u66f2\u7ebf\u3002\u00a0<\/p>\n

d) \u6cbb\u75977\u5929\u540e\u4e0d\u540c\u7ec4\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u66f2\u7ebf\u548c\u6291\u5236\u66f2\u7ebf\u3002<\/p>\n

e-f) \u4e0d\u540c\u5904\u7406\u7ec4\u8001\u9f20\u8840\u6e05\u4e2d\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u8bc4\u4ef7\u3002\uff081#: d-PBS, 2#: d-PBS + laser, 3#: AuNR@G + laser, 4#: AuNR@G-P-aspirin + laser\uff09<\/p>\n

\u56fe4. AuNR@G-P-aspirin\u590d\u5408\u7269\u6291\u5236PTT\u76f8\u5173\u708e\u75c7\u7684\u6297\u708e\u673a\u5236\u7684\u56fe\u89e3\u8fc7\u7a0b<\/strong><\/p>\n

\"\"<\/p>\n

PTT\u6cbb\u7597\u540e\u80bf\u7624\u7ec6\u80de\u7684\u574f\u6b7b\u662f\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u7684\u4e3b\u8981\u5f62\u5f0f\u3002\u6fc0\u5149\u7167\u5c04\u540e\uff0c\u5728AuNR@G-P-aspirin \u590d\u5408\u7269\u4f5c\u7528\u4e0b\uff0caspirin\u7684\u91ca\u653e\u4f1a\u4f7f\u7ec6\u80de\u708e\u75c7\u56e0\u5b50\u7684\u8868\u8fbe\u964d\u4f4e\uff08\u5982\uff1a\u767d\u7ec6\u80de\u4ecb\u7d20-6\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\u8868\u8fbe\u964d\u4f4e\uff09\uff0c\u8fdb\u800c\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u6291\u5236\u80bf\u7624\u7684\u590d\u53d1\u548c\u518d\u751f\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u5229\u75281-\u8298\u7532\u9187\u5408\u6210\u6297\u708e\u75c7\u524d\u836f : \u8298-\u963f\u53f8\u5339\u6797\uff08P-aspirin\uff09\uff0c\u524d\u836f\u4e0a\u643a\u5e26\u7684\u53ef\u5206\u88c2\u916f\u952e\uff0c\u6709\u5229\u4e8e\u4e0e\u91d1\u7eb3\u7c73\u68d2\u5c01\u88c5\u7684\u77f3\u58a8\u7eb3\u7c73\u80f6\u56ca\uff08AuNR@G\uff09\u7684\u7ed3\u5408\u3002\u901a\u8fc7\u03c0-\u03c0\u952e\u76f8\u4e92\u4f5c\u7528\u5f97\u5230\u7684\u5149\u70ed\u6cbb\u7597\u5242\uff0cAuNR@G-P-aspirin \u590d\u5408\u7269\u53ef\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u6fc0\u53d1\u4e0b\u5b9e\u4f53\u79cd\u7624\u7684\u5149\u70ed\u6d88\u878d\u6cbb\u7597\uff0c\u4e0e\u6b64\u540c\u65f6\uff0c\u963f\u53f8\u5339\u6797\u5728\u80bf\u7624\u73af\u5883\u4e0b\u7684\u91ca\u653e\u53ef\u4ee5\u5b9e\u73b0\u5bf9PTT\u5f15\u53d1\u7684\u708e\u75c7\u53cd\u5e94\u7684\u6291\u5236\u3002\u5728\u5b9e\u73b0\u764c\u75c7\u6cbb\u7597\u7684\u540c\u65f6\uff0c\u963f\u53f8\u5339\u6797\u7684\u91ca\u653e\u6291\u5236\u4e86PTT\u5e26\u6765\u7684\u708e\u75c7\u53cd\u5e94\u7b49\u4e00\u7cfb\u5217\u5f71\u54cd\u764c\u75c7\u6cbb\u7597\u6548\u679c\u7684\u526f\u53cd\u5e94\uff0c\u4e3a\u764c\u75c7\u6cbb\u7597\u5f00\u8f9f\u4e86\u65b0\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene\u2013Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules<\/a>\uff08Angew. Chem. Int. Ed.\uff0c2017\uff0cDOI: 10.1002\/anie.201709648\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5357\u6e21\u7f16\u8bd1\uff0c\u5468\u68a6\u9752\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a><\/span>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u5bf9\u4e8e\u4f20\u7edf\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u800c\u8a00\uff0c\u5149\u70ed\u7597\u6cd5\uff08Photothermal therapy\uff0c\u4ee5\u4e0b\u7b80\u5199\u4e3aPTT\uff09\u662f\u4e00\u79cd\u6709\u6f5c\u529b\u7684\u66ff\u4ee3\u6216\u8005\u8f85\u52a9\u6cbb\u7597\u624b\u6bb5\u3002PTT\u662f\u5229\u7528\u6fc0\u5149\u7167…<\/p>\n","protected":false},"author":230,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[],"class_list":["post-117212","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/117212"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/230"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=117212"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/117212\/revisions"}],"predecessor-version":[{"id":117312,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/117212\/revisions\/117312"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=117212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=117212"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=117212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}