{"id":111893,"date":"2017-11-16T14:00:27","date_gmt":"2017-11-16T06:00:27","guid":{"rendered":"\/\/m.iemloyee.com\/?p=111893"},"modified":"2017-11-14T19:45:02","modified_gmt":"2017-11-14T11:45:02","slug":"%e5%8d%97%e5%bc%80%e5%a4%a7%e5%ad%a6%e7%a8%8b%e6%b4%a5%e5%9f%b9%e8%96%9b%e5%b0%8f%e6%9d%be%e5%9b%a2%e9%98%9f-%e5%a4%a9%e7%84%b6%e9%87%91%e9%b8%a1%e7%ba%b3%e7%a2%b1%e5%82%ac%e5%8c%96%e4%b8%8d","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=111893","title":{"rendered":"\u5357\u5f00\u5927\u5b66\u7a0b\u6d25\u57f9&amp;\u859b\u5c0f\u677e\u56e2\u961f: \u5929\u7136\u91d1\u9e21\u7eb3\u78b1\u50ac\u5316\u4e0d\u5bf9\u79f0\u4eb2\u7535\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u53cd\u5e94\u673a\u7406\u7814\u7a76"},"content":{"rendered":"<p><strong><b>\u3010<\/b><\/strong><strong><b>\u6210\u679c\u7b80\u4ecb<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p>2013\u5e74\uff0cRueping\u8bfe\u9898\u7ec4\u548c\u6c88\u5176\u9f99\u8bfe\u9898\u7ec4\u540c\u65f6\u72ec\u7acb\u62a5\u9053\u4e86\u5728\u5929\u7136\u91d1\u9e21\u7eb3\u78b1\u50ac\u5316\u5242\u548c\u4eb2\u7535\u4e09\u6c1f\u7532\u786b\u57fa\u8bd5\u5242\u5171\u540c\u4f5c\u7528\u4e0b\uff0c\u4ee5\u9ad8\u4ea7\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5b9e\u73b0\u5bf9\u03b2-\u916e\u916f\u7684\u4e0d\u5bf9\u79f0\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u3002\u8fd9\u4e24\u7bc7\u5de5\u4f5c\u662f\u4e0d\u5bf9\u79f0\u4eb2\u7535\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u9886\u57df\u6700\u5177\u4ee3\u8868\u6027\u7684\u5de5\u4f5c\uff0c\u4e3a\u5408\u6210\u5bf9\u6620\u7eaf\u7684\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u5408\u7269\u63d0\u4f9b\u4e86\u4fbf\u6377\u9ad8\u6548\u7684\u624b\u6bb5\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u76f8\u5173\u53cd\u5e94\u7684\u50ac\u5316\u673a\u7406\u548cSCF<sub>3<\/sub>\u8f6c\u79fb\u8fc7\u7a0b\u7684\u624b\u6027\u5982\u4f55\u8bf1\u5bfc\u8fd9\u4e24\u4e2a\u5173\u952e\u95ee\u9898\u4ecd\u7136\u6709\u5f85\u9610\u660e\u3002\u7a0b\u6d25\u57f9\u3001\u859b\u5c0f\u677e\u56e2\u961f\u8fd1\u5e74\u6765\u56f4\u7ed5\u7269\u7406\u6709\u673a\u6c1f\u5316\u5b66\u5f00\u5c55\u4e86\u7cfb\u7edf\u6027\u7684\u7814\u7a76\u5de5\u4f5c\uff08Org. Lett. 2016, 18, 6128.; Org. Lett. 2016, 18, 264. J. Org. Chem. 2016, 81, 3119. J. Org. Chem. 2016, 81, 4280.; J. Org. Chem. 2016, 81, 9006.; J. Org. Chem. 2016, 81, 7486.; Asian J. Org. Chem. 2017. 6, 235.; J. Org. Chem. 2017. 82, 8697.\uff1bJ. Org. Chem. 2017, 82, 4129.\uff09\u3002\u8fd1\u671f\uff0c\u8be5\u56e2\u961f\u91c7\u7528\u91cf\u5316\u8ba1\u7b97\u7684\u624b\u6bb5\u5bf9Rueping\u8bfe\u9898\u7ec4\u62a5\u9053\u7684\u4e0d\u5bf9\u79f0\u4eb2\u7535\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u53cd\u5e94\u673a\u7406\u548c\u5bf9\u6620\u9009\u62e9\u6027\u8d77\u6e90\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff1a1\uff09 Wynberg\u79bb\u5b50\u5bf9-\u6c22\u952e\u6a21\u578b\u662f\u8be5\u53cd\u5e94\u7684\u6700\u4f18\u50ac\u5316\u6a21\u5f0f\uff1b 2\uff09SCF<sub>3<\/sub>\u00a0\u8f6c\u79fb\u901a\u8fc7\u7c7bSN2\u673a\u7406\u8fdb\u884c\uff1b3\uff09\u53cd\u5e94\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7531\u8fc7\u6e21\u6001\u4e2d\u7684\u591a\u91cd\u5f31\u76f8\u4e92\u4f5c\u7528\uff08\u5305\u62ecC-H\u00b7\u00b7\u00b7O, C-H\u00b7\u00b7\u00b7F\uff0cC-H\u00b7\u00b7\u00b7S\uff0cC-H\u00b7\u00b7\u00b7p\uff0cp\u00b7\u00b7\u00b7p \u4f5c\u7528\u53ca\u7a7a\u95f4\u6392\u65a5\u7b49\uff09\u534f\u540c\u8bf1\u5bfc\u3002\u8be5\u7406\u8bba\u7814\u7a76\u5de5\u4f5c\u5c06\u4e3a\u65b0\u53cd\u5e94\u548c\u65b0\u50ac\u5316\u4f53\u7cfb\u7684\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u63d0\u4f9b\u7406\u8bba\u4f9d\u636e\u3002\u674e\u66fc\u535a\u58eb\u4e3a\u8be5\u5de5\u4f5c\u7684\u7b2c\u4e00\u4f5c\u8005\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u9898\u4e3a\u201cMechanism and Origins of Stereoinduction in Natural Cinchona Alkaloid Catalyzed Asymmetric Electrophilic Trifluoromethylthiolation of\u00a0\u03b2-Ketoesters with N-Trifluoromethylthiophthalimide as Electrophilic SCF<sub>3<\/sub>\u00a0Source\u201d\u53d1\u8868\u4e8e\u00a0ACS Catalysis\u4e0a\u3002\u00a0\u00a0<\/p>\n<p><strong><b>\u3010<\/b><\/strong><strong><b>\u56fe\u6587\u5bfc\u8bfb<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>1 <\/b><\/strong><strong><b>\u793a\u610f\u56fe<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-111895\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/11\/\u859b\u6653\u677e\u3001\u7a0b\u6d25\u57f9\u65b0\u95fb\u7a3f.png\" alt=\"\" width=\"600\" height=\"331\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/11\/\u859b\u6653\u677e\u3001\u7a0b\u6d25\u57f9\u65b0\u95fb\u7a3f.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/11\/\u859b\u6653\u677e\u3001\u7a0b\u6d25\u57f9\u65b0\u95fb\u7a3f-300x166.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u56fe2 <\/b><\/strong><strong><b>\u4e0d\u5bf9\u79f0\u4eb2\u7535\u5b50\u6c1f\u5316\u4e0e\u91d1\u9e21\u7eb3\u751f\u7269\u78b1\u50ac\u5316\u4e09\u6c1f\u7532\u57fa\u786b\u9187\u5316<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-111896\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/11\/2-28.png\" alt=\"\" width=\"600\" height=\"344\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/11\/2-28.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/11\/2-28-300x172.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u3010\u7814\u7a76\u5185\u5bb9\u3011<\/b><\/strong><\/p>\n<p>\u4e09\u6c1f\u7532\u786b\u57fa(SCF<sub>3<\/sub>)\u57fa\u56e2\u5177\u6709\u5f3a\u5438\u7535\u6027\u548c\u9ad8\u4eb2\u8102\u6027\uff0c\u5c06\u5176\u5f15\u5165\u751f\u7406\u6d3b\u6027\u5206\u5b50\u53ef\u589e\u5f3a\u5176\u5728\u751f\u7269\u4f53\u5185\u8de8\u819c\u8fd0\u8f93\u7684\u80fd\u529b\uff0c\u63d0\u9ad8\u5438\u6536\u7387\u5e76\u589e\u5f3a\u836f\u6548\u3002\u56e0\u6b64\uff0c\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u5408\u7269\u5728\u533b\u836f\u548c\u519c\u836f\u7b49\u9886\u57df\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\uff0c\u5176\u5408\u6210\u65b9\u6cd5\u4e5f\u6210\u4e3a\u5f53\u524d\u7814\u7a76\u7684\u70ed\u95e8\u9886\u57df\u3002\u4f9d\u8d56\u4e8e\u5c42\u51fa\u4e0d\u7a77\u7684\u4e09\u6c1f\u7532\u786b\u57fa\u5316\u8bd5\u5242\uff0c\u5408\u6210\u5316\u5b66\u5bb6\u5df2\u6210\u529f\u5b9e\u73b0\u5bf9\u5404\u7c7b\u5e95\u7269\u7684\u4e09\u6c1f\u7532\u786b\u57fa\u5316\uff0c\u4f46\u5bf9\u6620\u9009\u62e9\u6027\u7684\u5f15\u5165SCF<sub>3<\/sub>\u4f9d\u7136\u662f\u4e00\u9879\u6781\u5177\u6311\u6218\u6027\u7684\u8bfe\u9898\u3002<\/p>\n<p>\u4e0a\u8ff0\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u5143\u7d20\u6709\u673a\u5316\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u3001\u5316\u5b66\u5b66\u9662\u3001\u5929\u6d25\u5316\u5b66\u5316\u5de5\u534f\u540c\u521b\u65b0\u4e2d\u5fc3\u548c\u4e2d\u592e\u9ad8\u6821\u57fa\u672c\u79d1\u7814\u57fa\u91d1\u7684\u8d44\u52a9\u3002<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<a href=\"http:\/\/chem.nankai.edu.cn\/ejymzhylm.aspx?t=4&amp;m=5&amp;n=3460\" target=\"_blank\" rel=\"noopener\">http:\/\/chem.nankai.edu.cn\/ejymzhylm.aspx?t=4&amp;m=5&amp;n=3460<\/a><\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"http:\/\/pubs.acs.org\/doi\/pdfplus\/10.1021\/acscatal.7b03007\" target=\"_blank\" rel=\"noopener\">Mechanism and Origins of Stereoinduction in Natural Cinchona Alkaloid Catalyzed Asymmetric Electrophilic Trifluoromethylthiolation of \u03b2-Ketoesters with N-Trifluoromethylthiophthalimide as Electrophilic SCF3 Source <\/a>(ACS Catal., 2017, DOI:http:\/\/pubs.acs.org\/doi\/pdfplus\/10.1021\/acscatal.7b03007)<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u77f3\u5c0f\u6885\u7f16\u8f91\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011 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