{"id":106361,"date":"2017-10-16T06:30:45","date_gmt":"2017-10-15T22:30:45","guid":{"rendered":"\/\/m.iemloyee.com\/?p=106361"},"modified":"2017-10-16T12:13:44","modified_gmt":"2017-10-16T04:13:44","slug":"%e5%8d%8e%e4%b8%9c%e5%b8%88%e8%8c%83%e5%a4%a7%e5%ad%a6%e9%ab%98%e6%a0%93%e8%99%8e%e8%af%be%e9%a2%98%e7%bb%84%ef%bc%9a%e5%9c%a8%e5%85%89%e4%bf%83%e8%bf%9bdiels-alder%e5%8f%8d%e5%ba%94%e5%af%b9%e5%a4%9a","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=106361","title":{"rendered":"\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u9ad8\u6813\u864e\u8bfe\u9898\u7ec4\uff1a\u5728\u5149\u4fc3\u8fdbDiels-Alder\u53cd\u5e94\u5bf9\u591a\u73af\u84bd\u9187\u5316\u5408\u7269\u7684\u6709\u6548\u5408\u6210\u65b9\u9762\u53d6\u5f97\u91cd\u8981\u7a81\u7834"},"content":{"rendered":"<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u5316\u5b66\u4e0e\u5206\u5b50\u5de5\u7a0b\u5b66\u9662\u9ad8\u6813\u864e\u6559\u6388\u7814\u7a76\u56e2\u961f\u5728\u5149\u4fc3\u8fdbDiels-Alder\u53cd\u5e94\u5bf9\u591a\u73af\u84bd\u9187\u5316\u5408\u7269\u7684\u6709\u6548\u5408\u6210\u65b9\u9762\u53d6\u5f97\u91cd\u8981\u7a81\u7834\uff0c\u7814\u7a76\u6210\u679c\u4ee5\u201cTi(Oi-Pr)4-promoted photoenolization Diels\u2013Alder reaction to construct polycyclic rings and its synthetic applications\u201d\u4e3a\u9898\u5728\u7ebf\u53d1\u8868\u5728Nature Communications\u4e0a\uff08DOI:10.1038\/s41467-017-00440-8\uff09\u3002\u8fd9\u4e00\u7814\u7a76\u5de5\u4f5c\u662f\u8be5\u8bfe\u9898\u7ec4\u57fa\u4e8e\u5bf9\u5149\u8bf1\u5bfc\u7684\u6d3b\u6cfc\u4e2d\u95f4\u4f53\u7684\u6355\u6349\uff0c\u5728\u8bfb\u535a\u58eb\u7814\u7a76\u751f\u6768\u9c8d\u6f6e\u4e3a\u8be5\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\uff0c\u6b64\u5916\u5728\u8bfb\u7855\u58eb\u751f\u6797\u5feb\u5feb\u548c\u535a\u58eb\u540e\u53f2\u82f1\u535a\u5bf9\u8be5\u7814\u7a76\u6210\u679c\u505a\u51fa\u4e86\u91cd\u8981\u8d21\u732e\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe1. \u542b\u84bd\u9187\u6216\u84bd\u918c\u7c7b\u9aa8\u67b6\u7684\u5929\u7136\u4ea7\u7269\u53ca\u6d3b\u6027<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-106362\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/1-35.jpg\" alt=\"\" width=\"600\" height=\"331\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/1-35.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/1-35-300x166.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe2. Ti(Oi-Pr)4 \u4fc3\u8fdb\u7684PEDA\u53cd\u5e94\u53ef\u80fd\u7684\u673a\u7406\u8fc7\u7a0b<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-106363\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/2-35.jpg\" alt=\"\" width=\"600\" height=\"223\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/2-35.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/2-35-300x112.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe3.\u542b\u84bd\u7c7b\u548c\u84bd\u918c\u7c7b\u7684\u5929\u7136\u4ea7\u54c1<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-106364\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/3-3.png\" alt=\"\" width=\"600\" height=\"493\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/3-3.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/3-3-300x247.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><br \/>\n a. \u7f9f\u57fa\u84bd\u918c\u7684\u57fa\u672c\u9aa8\u67b6\u548c\u5305\u542b\u7ebf\u6027\u7194\u878d\u7684\u5404\u79cd\u6c27\u5316\u6001\u548c\u8fde\u7eed\u624b\u6027\u4e2d\u5fc3\u7684\u516d\u5143\u73af\u7684\u7f9f\u57fa\u84bd\u918c\u3002<br \/>\n b. (1) \u963f\u9709\u7d20\u548c (2) \u56db\u73af\u7d20\u662f\u5206\u522b\u542b\u6709\u84bd\u918c\u548c\u84bd\u915a\u7684\u6297\u764c\u548c\u6297\u83cc\u836f\u7269\u3002(3) A-74528 \u548c(4) JBIR-85 \uff0c(5) \u7070\u4fa7\u8033\u83cc\u7d20\u548c(6) oncocalyxone B\u662f\u4e0e\u7ed3\u6784\u76f8\u5173\u7684\u591a\u916e\u7c7b\u5316\u5408\u7269\u3002<\/p>\n<p><strong>\u3010\u7814\u7a76\u5185\u5bb9\u3011<\/strong><\/p>\n<p>\u84bd\u9187\u84bd\u918c\u7c7b\u7684\u591a\u73af\u5316\u5408\u7269\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u6d3b\u6027\u836f\u7269\u5206\u5b50\u4e2d\u3002\u5176\u4e2d\uff0c\u6700\u4e3a\u8457\u540d\u5f53\u5c5e\u6297\u80bf\u7624\u6297\u751f\u7d20\u963f\u9709\u7d20\uff08doxorubicin\uff09\u4ee5\u53ca\u6297\u83cc\u6297\u751f\u7d20\u56db\u73af\u7d20\uff08tetracycline\uff09\uff1b\u6b64\u5916\uff0c\u4ece\u7d2b\u8349\u79d1\uff08Boraginaceae\uff09\u690d\u7269\u4e2d\u5206\u79bb\u51fa\u7684Oncocalyxone B\uff0c\u5177\u6709\u9547\u75db\u3001\u6297\u708e\u3001\u6297\u6c27\u5316\u6291\u5236\u8840\u5c0f\u677f\u6fc0\u6d3b\u7b49\u6d3b\u6027\uff1b\u4fa7\u8033\u5c5e\u83cc\u79cd\u4e2d\u5206\u79bb\u51fa\u7684Pleurotin\uff0c\u5bf9\u9769\u5170\u6c0f\u9633\u6027\u83cc\u5177\u6709\u8f83\u597d\u7684\u6291\u5236\u6d3b\u6027\uff08\u5982\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff09\uff0c\u540c\u65f6\u4e5f\u5bf9\u591a\u79cd\u764c\u75c7\u7ec6\u80de\uff08\u4e73\u817a\u764c\u548c\u7ed3\u80a0\u764c\u7b49\uff09\u6709\u8f83\u597d\u7684\u6291\u5236\u4f5c\u7528\u3002\u8fd9\u4e9b\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5747\u5177\u6709\u84bd\u9187\u84bd\u918c\u7c7b\u9aa8\u67b6\uff0c\u800c\u7acb\u4f53\u9009\u62e9\u6027\u7684\u6784\u5efa\u542b\u4e00\u4e2a\u6216\u8fde\u7eed\u5b63\u78b3\u4e2d\u5fc3\u7684\u591a\u73af\u84bd\u9187\u5316\u5408\u7269\u4e00\u76f4\u662f\u6709\u673a\u5408\u6210\u9886\u57df\u7684\u96be\u70b9\u3002<\/p>\n<p>\u9ad8\u6813\u864e\u8bfe\u9898\u7ec4\u53d1\u73b0Lewis\u9178\u4fc3\u8fdb\u7684PEDA\u53cd\u5e94\u80fd\u591f\u9ad8\u6548\u5730\u6784\u5efa\u84bd\u9187\u84bd\u918c\u7c7b\u5316\u5408\u7269\u6838\u5fc3\u9aa8\u67b6\u3002\u8be5\u9879\u7814\u7a76\u4e3b\u8981\u662f\u5229\u7528\u949b\u9178\u56db\u5f02\u4e19\u916f\u4f5cLewis\u9178\uff0c\u5728\u7d2b\u5916\u5149\u6fc0\u53d1\u4e0b\uff0c\u4fc3\u8fdb2-\u7532\u6c27\u57fa\u53d6\u4ee3\u7684\u90bb\u7532\u57fa\u82ef\u7532\u919b\u7c7b\u5e95\u7269\u5f62\u6210\u6d3b\u6cfc\u7684\u7f9f\u57fa\u90bb\u82ef\u78b3\u918c\u4e2d\u95f4\u4f53\uff0c\u4e0e\u53d6\u4ee3\u76843-\u7532\u57fa\u73af\u5df1\u70ef\u916e\u53d1\u751fphotoenolization Diels\u2013Alder\uff08PEDA\uff09\u53cd\u5e94\uff0c\u4ece\u800c\u4e00\u6b65\u9ad8\u6548\u5730\u6784\u5efa\u542b\u4e00\u4e2a\u6216\u8fde\u7eed\u5b63\u78b3\u4e2d\u5fc3\u7684\u84bd\u9187\u7c7b\u5316\u5408\u7269\uff0c\u6709\u6548\u89e3\u51b3\u4e86\u6b64\u7c7b\u53cd\u5e94\u5b58\u5728\u7684\u6311\u6218\u6027\u95ee\u9898\u3002\u5177\u6709\u8f83\u597d\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\uff0c\u5e95\u7269\u666e\u9002\u6027\u548c\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u7b49\u4f18\u70b9\u3002\u6df1\u5165\u7684\u673a\u7406\u7814\u7a76\u53d1\u73b0\uff0c\u7532\u6c27\u57fa\u6709\u52a9\u4e8e\u5e2e\u52a9\u7a33\u5b9a\u5149\u6fc0\u53d1\u4e0b\u4ea7\u751f\u7684\u7f9f\u57fa\u90bb\u82ef\u78b3\u918c\u4e2d\u95f4\u4f53\uff0c\u4ece\u800c\u4e0eLewis\u9178\u949b\u9178\u56db\u5f02\u4e19\u916f\u5f62\u6210\u4e00\u4e2a\u76f8\u5bf9\u7a33\u5b9a\u7684\u5355\u4f53\u6216\u4e8c\u805a\u4f53\u7684\u7edc\u5408\u7269\uff0c\u5ef6\u957f\u6d3b\u6027\u4e2d\u95f4\u4f53\u5bff\u547d\uff0c\u8fdb\u800c\u4e0e\u4eb2\u53cc\u70ef\u4f53\u5f88\u597d\u7684\u87af\u5408\u6d3b\u5316\u4e0d\u9971\u548c\u70ef\u916e\u5316\u5408\u7269\uff0c\u5e76\u5c06\u5206\u5b50\u95f4\u53cd\u5e94\u8f6c\u5316\u4e3a\u5206\u5b50\u5185\u53cd\u5e94\uff0c\u6709\u5229\u4e8e\u4fc3\u8fdb\u53cd\u5e94\u7684\u53d1\u751f\u53ca\u63a7\u5236\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002\u5e94\u7528\u8be5\u53cd\u5e94\uff0c\u8be5\u8bfe\u9898\u7ec4\u5b8c\u6210\u4e86\u5929\u7136\u4ea7\u7269Oncocalyxone B \u7684\u5168\u5408\u6210\u3002Oncocalyxone B \u662fcordiachrome\u5bb6\u65cf\u5929\u7136\u4ea7\u7269\u4e2d\u8f83\u4e3a\u590d\u6742\u7684\u4e00\u4e2a\uff0c\u542b\u6709\u84bd\u9187\u7684\u57fa\u672c\u9aa8\u67b6\uff0c\u62e5\u6709\u4e94\u4e2a\u8fde\u7eed\u7684\u624b\u6027\u4e2d\u5fc3\u4e14\u5728C-8a\u4f4d\u6709\u4e00\u4e2a\u5b63\u78b3\u4e2d\u5fc3\uff0c\u540c\u65f6\u6709\u4e00\u4e2a\u7b3c\u72b6\u7684\u7f29\u919b\u7ed3\u6784\uff0c\u4e3a\u6b64\u7c7b\u5929\u7136\u4ea7\u7269\u7684\u540e\u7eed\u529f\u80fd\u7814\u7a76\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<p>\u8fd9\u4e00\u7814\u7a76\u53d1\u73b0\u5c06\u6781\u5927\u5730\u63a8\u52a8\u8be5\u5149\u53cd\u5e94\u5728\u6709\u673a\u5408\u6210\u9886\u57df\u4e2d\u7684\u5e94\u7528\uff0c\u4e3a\u65b0\u578b\u6297\u751f\u7d20\u5f00\u53d1\u4ee5\u53ca\u591a\u73af\u578b\u84bd\u9187\u7c7b\u884d\u751f\u7269\u7684\u5408\u6210\u548c\u529f\u80fd\u7814\u7a76\u5960\u5b9a\u57fa\u7840\u3002\u9488\u5bf9\u8be5\u9879\u7814\u7a76\u7684\u76f8\u5173\u540e\u7eed\u5de5\u4f5c\u4e5f\u5728\u79ef\u6781\u5f00\u5c55\u4e2d\u3002<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<a href=\"http:\/\/news.ecnu.edu.cn\/8d\/79\/c1837a101753\/page.htm\" target=\"_blank\" rel=\"noopener\">http:\/\/news.ecnu.edu.cn\/8d\/79\/c1837a101753\/page.htm<\/a><\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-017-00440-8\" target=\"_blank\" rel=\"noopener\">Ti(Oi-Pr)4-promoted photoenolization Diels\u2013Alder reaction to construct polycyclic rings and its synthetic applications<\/a>\uff08Nature Communications\uff0c2017\uff0cDOI:10.1038\/s41467-017-00440-8\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5b5f\u4ee4\u6653\u7f16\u8f91\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011 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