{"id":105542,"date":"2017-10-14T06:30:15","date_gmt":"2017-10-13T22:30:15","guid":{"rendered":"\/\/m.iemloyee.com\/?p=105542"},"modified":"2017-10-13T22:34:05","modified_gmt":"2017-10-13T14:34:05","slug":"nature%e5%ad%90%e5%88%8a%ef%bc%9a%e9%80%9a%e8%bf%87%e6%9c%ba%e6%a2%b0%e7%ba%a6%e6%9d%9f%e8%b0%83%e8%8a%82%e7%94%b1%e8%bd%af%e9%aa%a8%e7%bb%86%e8%83%9e%e5%bd%a2%e6%88%90%e7%9a%84%e8%bd%af%e9%aa%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=105542","title":{"rendered":"Nature\u5b50\u520a\uff1a\u901a\u8fc7\u673a\u68b0\u7ea6\u675f\u8c03\u8282\u7531\u8f6f\u9aa8\u7ec6\u80de\u5f62\u6210\u7684\u8f6f\u9aa8\u57fa\u8d28"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

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\"\"<\/p>\n

a\uff0c\u57283kPa\u6c34\u51dd\u80f6\u4e2d\u57f9\u517b21\u5929\u7684\u8f6f\u9aa8\u7ec6\u80de\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272<\/p>\n

b\uff0c\u5728\u5feb\u901f\u677e\u5f1b\u51dd\u80f6\uff08\u03c41\/2<\/sub> = 63s\uff09\u57f9\u517b21\u5929\u7684\u900f\u660e\u8f6f\u9aa8\u4e2d\u7684\u7ec6\u80de\u5468\u8d28\u57fa\u8d28\u548c\u8c46\u5f62\u8f6f\u9aa8\u7ec6\u80de\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272<\/p>\n

c\uff0c\u8f6f\u9aa8\u7ec6\u80de\u6784\u5efa\u7684\u6bcf\u4e2a\u7ec6\u80deII\u578b\u80f6\u539f\u7684\u9762\u79ef<\/p>\n

d\uff0ce\uff0c\u57f9\u517b21\u5929\u7684\u8f6f\u9aa8\u7ec6\u80de\u4ea7\u751f\u7684\u80f6\u539f\u86cb\u767d\uff08d\uff09\u548c\u786b\u9178\u5316\u7cd6\u80fa\u805a\u7cd6\uff08sGAG\uff09\uff08e\uff09\u7684\u5b9a\u91cf<\/p>\n

f\uff0cg\uff0c21\u5929\u540e\u79ef\u7d2f\u7684\u80f6\u539f\u86cb\u767d\uff08f\uff09\u548csGAG\uff08g\uff09\u7684\u5b9a\u91cf<\/p>\n

\u56fe2 \u8f83\u6162\u7684\u5e94\u6fc0\u677e\u5f1b\u8bf1\u5bfcIL-1\u03b2\u7684\u5206\u6ccc<\/strong><\/p>\n

\"\"<\/p>\n

a\uff0c7\u5929\u540e\u5bf9\u8f6f\u9aa8\u7ec6\u80de\u7684IL-1\u03b2\u57fa\u56e0\u8868\u8fbe\u7684\u5b9a\u91cf<\/p>\n

b\uff0c7\u5929\u540e\u5206\u6ccc\u5230\u6c34\u51dd\u80f6\u4e2d\u7684IL-1\u03b2\u7684\u5b9a\u91cf<\/p>\n

c\uff0c\u5728IL-1Ra\u5b58\u5728\uff08IL-1Ra\uff09\u6216\u4e0d\u5b58\u5728\uff08CNTR\uff09\u7684\u6700\u7f13\u6162\u51dd\u80f6\u4e2d\u57f9\u517b\u7684\u8f6f\u9aa8\u7ec6\u80de\u7684\u57f9\u517b\u57fa\u4e2d\u7684LDH\u6c34\u5e73<\/p>\n

d\uff0ce\uff0c\u5728IL-1Ra\u5b58\u5728\u4e0b\uff08IL-1Ra\uff09\u6216\u4e0d\u5b58\u5728\uff08CNTR\uff09\u7684MMP13<\/sub>\u548cADAMTS4<\/sub>\u7684\u76f8\u5bf9\u57fa\u56e0\u8868\u8fbe<\/p>\n

\u56fe3 \u6c34\u51dd\u80f6\u5e94\u6fc0\u677e\u5f1b\u901a\u8fc7\u9650\u5236\u7ec6\u80de\u4f53\u79ef\u81a8\u80c0\u548c\u8f6f\u9aa8\u57fa\u8d28\u5f62\u6210\u6765\u8c03\u8282\u8f6f\u9aa8\u7ec6\u80de\u8868\u578b<\/strong><\/p>\n

\"\"<\/p>\n

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\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

IL-1\u03b2\uff0c\u4e00\u79cd\u5728\u9aa8\u5173\u8282\u708e\u53d1\u75c5\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u53c2\u4e0e\u4ecb\u5bfc\u6c34\u51dd\u80f6\u677e\u5f1b\u7684\u5f71\u54cd\uff0c\u8fd9\u8868\u660e\u4e0e\u9aa8\u5173\u8282\u708e\u6709\u5185\u5728\u7684\u8054\u7cfb\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u5728\u9aa8\u5173\u8282\u708e\u7814\u7a76\u671f\u95f4\uff0cPCM\u7684\u751f\u7269\u7269\u7406\u6027\u8d28\u548c\u7ec6\u80de\u6269\u589e\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/strong>\uff1aMechanical confinement regulates cartilage matrix formation by chondrocytes<\/a>\uff08Nat. Mater.,2017,DOI:10.1038\/nmat4993\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4Allen\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n

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\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c<\/b><\/strong>\u4e0a<\/b><\/strong>\u6d4b\u8bd5\u8c37<\/b><\/strong><\/a>\uff01<\/b><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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