{"id":105217,"date":"2017-10-04T14:00:34","date_gmt":"2017-10-04T06:00:34","guid":{"rendered":"\/\/m.iemloyee.com\/?p=105217"},"modified":"2017-10-03T20:14:23","modified_gmt":"2017-10-03T12:14:23","slug":"%e4%b8%ad%e7%a7%91%e9%99%a2%e4%b8%8a%e6%b5%b7%e6%9c%89%e6%9c%ba%e6%89%80%ef%bc%9a%e5%9c%a8%e5%a4%8d%e6%9d%82%e8%81%9a%e9%85%ae%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9%e4%bb%bf%e7%94%9f%e5%90%88%e6%88%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=105217","title":{"rendered":"\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u6240\uff1a\u5728\u590d\u6742\u805a\u916e\u5929\u7136\u4ea7\u7269\u4eff\u751f\u5408\u6210\u9886\u57df\u53d6\u5f97\u8fdb\u5c55"},"content":{"rendered":"<p><strong><b>\u3010<\/b><\/strong><strong><b>\u6210\u679c\u7b80\u4ecb<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p>\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u5929\u7136\u4ea7\u7269\u6709\u673a\u5408\u6210\u5316\u5b66\u9662\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u6d2a\u7136\u8bfe\u9898\u7ec4\uff0c\u5b8c\u6210\u4e86\u5170\u5361\u6740\u83cc\u7d20\u5bb6\u65cflankacidinol\u548clankacyclinol\u7684\u4eff\u751f\u5168\u5408\u6210\u3002\u7814\u7a76\u56e2\u961f\u53d7\u5230\u751f\u7269\u5408\u6210\u8def\u5f84\u4e2d\u72ec\u7279\u7684\u5927\u73af\u6784\u5efa\u7b56\u7565\u7684\u542f\u53d1\uff0c\u9488\u5bf9\u73b0\u6709\u5316\u5b66\u5408\u6210\u7b56\u7565\u4e2dC3\u7fb0\u57fa\u7684\u6c27\u5316\u6001\u8c03\u6574\u53ca\u4fdd\u62a4\u57fa\u64cd\u4f5c\u8fc7\u4e8e\u7e41\u7410\u7684\u95ee\u9898\uff0c\u91c7\u53d6\u4e86\u9884\u7f6eC3\u548cC18\u4f4d\u6c27\u5316\u6001\u4ee5\u53ca\u6c2e\u539f\u5b50\u53d6\u4ee3\u57fa\u7684Mannich\u5927\u73af\u73af\u5316\u7b56\u7565\uff0c\u8bbe\u8ba1\u4f7f\u7528\u56db\u4e2a\u4ece\u5546\u54c1\u5316\u539f\u6599\u51fa\u53d1\u53ef\u5feb\u901f\u5927\u91cf\u83b7\u5f97\u7684\u624b\u6027\u6a21\u5757\uff0c\u901a\u8fc7\u53ef\u9760\u7684\u516d\u6b65\u53cd\u5e94\uff0c\u514b\u7ea7\u89c4\u6a21\u5730\u5236\u5907\u4e86\u957f\u94fe\u4e9a\u80fa\u524d\u4f53\u3002\u5728\u524d\u671f\u5206\u5b50\u95f4\u6a21\u578b\u53cd\u5e94\u63a2\u7d22\u7684\u6700\u4f18\u6761\u4ef6\u4e0b\uff0c\u8be5\u5316\u5408\u7269\u5728\u975e\u6781\u6027\u6eb6\u5242\u4e2d\u5efa\u7acb\u70ed\u89e3\u5e73\u8861\uff0c\u4ea7\u751f\u7684N-\u9170\u57fa\u5171\u8f6d\u4e9a\u80fa\u4e2d\u95f4\u4f53\u88ab\u957f\u94fe\u78b3\u7aef\u7684b-\u916e\u57fa-d-\u620a\u5185\u916f\u7ed3\u6784\u5355\u5143\u6355\u83b7\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u5730\u5f62\u6210\u76ee\u6807\u5206\u5b50\u6838\u5fc3\u7ed3\u6784\u7684C2-C18\u952e\u3002\u901a\u8fc7\u7ec6\u5fc3\u5730\u4f18\u5316\u8131\u9664\u7845\u57fa\u4fdd\u62a4\u57fa\u6761\u4ef6\uff0c\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u5408\u6210\u4e24\u4e2a\u5929\u7136\u4ea7\u7269\uff0c\u5e76\u5728\u6b64\u8fc7\u7a0b\u4e2d\u9996\u6b21\u53d1\u73b0\u4e86lankacidinol\u5728\u9178\u6027\u6761\u4ef6\u4e0bC7-OH\u7684\u7acb\u4f53\u9009\u62e9\u60271,5-\u8f6c\u4f4d\u5e73\u8861\u73b0\u8c61\u3002\u8be5\u4eff\u751f\u5408\u6210\u5de5\u4f5c\u7684\u5b8c\u6210\u4e3a\u8fdb\u4e00\u6b65\u63a2\u7d22lankacidin\u5bb6\u65cf\u5929\u7136\u4ea7\u7269\u7684\u751f\u7269\u5408\u6210\u673a\u5236\u548c\u6784\u6548\u5173\u7cfb\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6301\u3002\u7814\u7a76\u6210\u679c\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cBiomimetic Synthesis of Lankacidin Antibiotics\u201d\u53d1\u8868\u5728JACS\u4e0a\uff0c\u7814\u7a76\u5de5\u4f5c\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u3001\u4e0a\u6d77\u5e02\u79d1\u59d4\u3001\u4e2d\u79d1\u9662\u524d\u6cbf\u79d1\u5b66\u91cd\u70b9\u7814\u7a76\u9879\u76ee\u548c\u4e2d\u79d1\u9662\u6218\u7565\u6027\u5148\u5bfc\u79d1\u6280\u4e13\u9879\uff08B\u7c7b\uff09\u7684\u652f\u6301\u3002<\/p>\n<p><strong><b>\u3010<\/b><\/strong><strong><b>\u56fe\u6587\u5bfc\u8bfb<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>1 \u5170\u5361\u6740\u83cc\u7d20\u7684\u4eff\u751f\u5168\u5408\u6210\u00a0<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-105218\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/1-6.jpg\" alt=\"\" width=\"600\" height=\"195\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/1-6.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/1-6-300x98.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u56fe2 Lankacidinol\u548cLankacyclinol\u7684\u5408\u6210<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-105219\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/2-2.png\" alt=\"\" width=\"600\" height=\"360\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/2-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/10\/2-2-300x180.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u3010\u7814\u7a76\u5185\u5bb9\u3011<\/b><\/strong><\/p>\n<p>\u5361\u6740\u83cc\u7d20\u5bb6\u65cf\uff08lankacidins\uff09\u662f\u4e0a\u4e16\u7eaa\u516d\u5341\u5e74\u4ee3\u5230\u4e03\u5341\u5e74\u4ee3\u5148\u540e\u4ece\u7d2b\u9ed1\u94fe\u9709\u83cc\uff08Streptomyces vioaceoniger\uff09\u3001\u7070\u8910\u94fe\u9709\u83cc\uff08Streptomyces griseofuscus\uff09\u3001\u5a04\u5f7b\u6c0f\u94fe\u9709\u83cc\u65cb\u5377\u53d8\u79cd\uff08Streptomyces rochei var. volubilis\uff09\u7684\u53d1\u9175\u6db2\u4e2d\u5206\u79bb\u51fa\u7684\u4e00\u7c7b\u5177\u6709\u5341\u4e03\u5143\u5927\u73af\u5185\u916f\u7ed3\u6784\u7684\u805a\u916e\u80bd\u6742\u5408\u7c7b\u6297\u751f\u7d20\u3002\u751f\u7269\u6d3b\u6027\u6d4b\u8bd5\u8868\u660e\uff0c\u8be5\u5bb6\u65cf\u5929\u7136\u4ea7\u7269\u5bf9\u82e5\u5e72\u9769\u5170\u6c0f\u9633\u6027\u83cc\u5177\u6709\u751f\u957f\u6291\u5236\u4f5c\u7528\uff0c\u8fd8\u5177\u6709\u8f83\u5f3a\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5176\u4f5c\u7528\u673a\u5236\u8fd1\u671f\u88ab\u8bc1\u660e\u4e0e\u6297\u5fae\u7ba1\u7c7b\u836f\u7269\u7d2b\u6749\u9187\u76f8\u4f3c\u3002Lankacidin A\uff08\u836f\u7528\u540dsedecamycin\uff0c\u897f\u5730\u9709\u7d20\uff09\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u732a\u5bc6\u87ba\u65cb\u4f53\u75e2\u75be\uff08Swine dysentery, SD\uff09\u7684\u9884\u9632\u548c\u6cbb\u7597\u3002\u8be5\u5bb6\u65cf\u5929\u7136\u4ea7\u7269\u5bf9\u5e03\u6c0f\u9525\u866b\uff08Trypanosoma brucei\uff09\u548c\u4f2f\u6c0f\u758f\u87ba\u65cb\u4f53\uff08Borrelia burgdorferi\uff09\u6709\u6740\u706d\u4f5c\u7528\uff0c\u6709\u671b\u5728\u975e\u6d32\u9525\u866b\u75c5\uff08Human African trypanosomiasis\uff09\u4e0e\u83b1\u59c6\u75c5\uff08Lyme disease\uff09\u7b49\u4eba\u755c\u5171\u60a3\u5bc4\u751f\u866b\u75c5\u7684\u9632\u6cbb\u4e2d\u5f97\u5230\u5e94\u7528\u3002\u5170\u5361\u6740\u83cc\u7d20\u5e7f\u6cdb\u800c\u91cd\u8981\u7684\u751f\u7406\u6d3b\u6027\u4f7f\u5176\u53ef\u80fd\u6210\u4e3a\u65b0\u4e00\u4ee3\u7684\u6297\u751f\u7d20\u3002\u5170\u5361\u6740\u83cc\u7d20\u5bb6\u65cf\u5929\u7136\u4ea7\u7269\u53ef\u901a\u8fc7\u751f\u7269\u53d1\u9175\u83b7\u5f97\uff0c\u4f46\u7531\u4e8e\u5176\u5316\u5b66\u7ed3\u6784\u5bf9\u9178\u78b1\u8f83\u4e3a\u654f\u611f\uff0c\u9650\u5236\u4e86\u57fa\u4e8e\u540e\u671f\u5316\u5b66\u884d\u751f\u5316\u7684\u534a\u5408\u6210\u7b56\u7565\u7684\u5b9e\u65bd\uff0c\u96be\u4ee5\u6df1\u5165\u5f00\u5c55\u6784\u6548\u5173\u7cfb\u7814\u7a76\u3002\u56e0\u6b64\uff0c\u53d1\u5c55\u9ad8\u6548\u7684\u5408\u6210\u8def\u7ebf\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002\u591a\u5e74\u4ee5\u6765\uff0c\u56fd\u9645\u4e0a\u591a\u4e2a\u7814\u7a76\u7ec4\u81f4\u529b\u4e8elankacidins\u7684\u5408\u6210\u7814\u7a76\uff0cKende\u5c0f\u7ec4\u4e8e1993\u5e74\u9996\u6b21\u5b9e\u73b0\u4e86lankacidin C\u7684\u5168\u5408\u6210\uff0c\u8def\u7ebf\u5197\u957f\uff08\u7ebf\u6027\u6700\u957f34\u6b65\uff0c\u603b46\u6b65\uff09\uff0c2000\u5e74Williams\u5c0f\u7ec4\u5b8c\u6210\u4e86\u8131\u7fa7\u5bb6\u65cf\u6210\u5458lankacyclinol\u7684\u5168\u5408\u6210\uff08\u7ebf\u6027\u6700\u957f25\u6b65\uff0c\u603b39\u6b65\uff09\u3002<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<a href=\"http:\/\/www.cas.cn\/syky\/201709\/t20170930_4616666.shtml\" target=\"_blank\" rel=\"noopener\">http:\/\/www.cas.cn\/syky\/201709\/t20170930_4616666.shtml<\/a><\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.7b08500\" target=\"_blank\" rel=\"noopener\">Biomimetic Synthesis of Lankacidin Antibiotics <\/a>(J. Am. Chem. Soc., 2017, DOI:<\/p>\n<p>10.1021\/jacs.7b08500)<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u77f3\u5c0f\u6885\u7f16\u8f91\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011 \u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u5929\u7136\u4ea7\u7269\u6709\u673a\u5408\u6210\u5316\u5b66\u9662\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u6d2a\u7136\u8bfe\u9898\u7ec4\uff0c\u5b8c\u6210\u4e86\u5170\u5361\u6740\u83cc\u7d20\u5bb6\u65cflankacidinol\u548clankacyclinol\u7684&#8230;<\/p>\n","protected":false},"author":2832,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-105217","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/105217"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2832"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=105217"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/105217\/revisions"}],"predecessor-version":[{"id":105257,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/105217\/revisions\/105257"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=105217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=105217"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=105217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}