{"id":104442,"date":"2017-10-02T06:30:53","date_gmt":"2017-10-01T22:30:53","guid":{"rendered":"\/\/m.iemloyee.com\/?p=104442"},"modified":"2017-09-28T13:28:37","modified_gmt":"2017-09-28T05:28:37","slug":"j-am-chem-soc-%ef%bc%9a%e4%b8%8a%e8%bd%ac%e6%8d%a2%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e5%92%8c%e9%87%91%e5%b1%9e%e6%9c%89%e6%9c%ba%e6%a1%86%e6%9e%b6%e6%9e%84%e6%88%90%e7%9a%84%e5%bc%82%e6%ba%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=104442","title":{"rendered":"J. Am. Chem. Soc.\uff1a\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\u548c\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u6784\u6210\u7684\u5f02\u6e90\u4e8c\u805a\u4f53"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u4f5c\u4e3a\u6742\u5316\u7eb3\u7c73\u7ed3\u6784\u5bb6\u65cf\u7684\u91cd\u8981\u6210\u5458\uff0c\u7eb3\u7c73\u9897\u7c92\u4e8c\u805a\u4f53\u5982\u5f02\u6e90\u4e8c\u805a\u4f53\u7b49\u5f15\u8d77\u4e86\u7814\u7a76\u4eba\u5458\u7684\u5e7f\u6cdb\u5174\u8da3\u3002\u901a\u8fc7\u53d7\u63a7\u7ed3\u5408\u533a\u57df\u8fde\u63a5\uff0c\u5f02\u6e90\u4e8c\u805a\u4f53\u8868\u73b0\u51fa\u4e0d\u540c\u4e8e\u5355\u4e00\u7ec4\u5206\u6216\u5176\u7269\u7406\u6df7\u5408\u7269\u7684\u7279\u6b8a\u5149\u5b66\u3001\u7535\u5b66\u548c\u78c1\u5b66\u6027\u8d28\u3002\u5f02\u6e90\u4e8c\u805a\u4f53\u53ef\u4ee5\u63d0\u4f9b\u5404\u5411\u5f02\u6027\u8868\u9762\u5e73\u53f0\uff0c\u53ef\u7528\u4e8e\u4f4d\u70b9\u7279\u5f02\u6027\u529f\u80fd\u5316\u3001\u7eb3\u7c73\u9897\u7c92\u7684\u53ef\u7f16\u7a0b\u7ec4\u88c5\uff0c\u5728\u592a\u9633\u80fd\u8f6c\u6362\u3001\u50ac\u5316\u548c\u764c\u75c7\u6cbb\u7597\u9886\u57df\u6709\u5de8\u5927\u6f5c\u5728\u4ef7\u503c\u3002\u7136\u800c\uff0c\u53d7\u5236\u4e8e\u5bf9\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u9762\u5316\u5b66\u6027\u8d28\u8c03\u63a7\u3001\u7eb3\u7c73\u9897\u7c92\u7684\u7ec4\u88c5\u548c\u751f\u957f\u65b9\u9762\u7684\u6280\u672f\u74f6\u9888\uff0c\u5408\u6210\u5177\u6709\u4e0d\u5bf9\u79f0\u7ec4\u6210\u548c\u534f\u540c\u589e\u5f3a\u529f\u80fd\u7684\u5f02\u6e90\u4e8c\u805a\u4f53\u4ecd\u662f\u4e00\u4e2a\u5de8\u5927\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3<\/strong>\u7684\u674e\u4e50\u4e50\u7814\u7a76\u5458(\u901a\u8baf\u4f5c\u8005)<\/strong>\u7b49\u5728Journal of the American Chemical Society<\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cHeterodimers Made of Upconversion Nano-particles and Metal Organic Frameworks<\/strong>\u201d\u7684\u6587\u7ae0\uff0c\u62a5\u9053\u4e86\u7531\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\u548c\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u6784\u6210\u7684\u5f02\u6e90\u4e8c\u805a\u4f53\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002\u7814\u7a76\u4eba\u5458\u901a\u8fc7UCNP(\u9567-\u63ba\u6742\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92)\u4e0anMOFs(\u7eb3\u7c73\u7ea7\u91d1\u5c5e\u6709\u673a\u6846\u67b6)\u7684\u5404\u5411\u5f02\u6027\u751f\u957f\uff0c\u6210\u529f\u5236\u5907\u4e86\u5177\u6709\u4e0d\u5bf9\u79f0\u7ed3\u6784\u7684UCNP-MOF\u5f02\u4e8c\u805a\u4f53\u3002\u7814\u7a76\u53d1\u73b0\uff1a\u8fd9\u79cd\u57fa\u4e8eMOF\u7684\u4e0d\u5bf9\u79f0\u7eb3\u7c73\u7ed3\u6784\u663e\u793a\u51fa\u4e0d\u540c\u7684\u5149\u5b50\u4e0a\u8f6c\u6362\u673a\u5236\uff0c\u53ef\u901a\u8fc7\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\u6536\u96c6\u989d\u5916\u7684\u5149\u5b50\uff0c\u5728NIR(\u8fd1\u7ea2\u5916)\u5149\u7167\u5c04\u4e0b\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3002\u5f02\u6e90\u4e8c\u805a\u4f53\u4e3aNIR\u8bf1\u5bfc\u7684\u80bf\u7624\u534f\u540c\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6f5c\u5728\u5e73\u53f0\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\uff1aUCMOF \u5f02\u6e90\u4e8c\u805a\u4f53\u5408\u6210\u793a\u610f\u56fe\u3002<\/strong><\/p>\n

\u901a\u8fc7UCNPs\u4e0anMOF\u7684\u5404\u5411\u5f02\u6027\u751f\u957f\u5408\u6210UCMOF\u5f02\u6e90\u4e8c\u805a\u4f53\uff0cUCNP\u4e2d\u7ea2\u70b9\u8868\u793a\u63ba\u6742\u7684\u9567\u7cfb\u5143\u7d20\u654f\u5316\u5242\u79bb\u5b50\uff08\u5982Yb3+<\/sup>\u548cNd3+<\/sup>)\u548c\u6d3b\u5316\u5242\u79bb\u5b50\uff08\u5982Er3+<\/sup>, Tm3+<\/sup>\u548cHo3+<\/sup>)\u3002<\/p>\n

\"\"<\/strong><\/p>\n

\u56fe2\uff1aUCNPs\u7684\u7535\u5b50\u663e\u5fae\u955c\u56fe\u7247\u548cXRD\u884d\u5c04\u8c31\u56fe\u3002<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

(a)\u539f\u59cbUCNP\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(b, c) UCMOF\u7684TEM\u56fe\u50cf\uff0c\u56fe(b)\u4e2d\u7684\u4e8c\u805a\u4f53\u7528\u7ea2\u8272\u692d\u5706\u7a81\u51fa\u663e\u793a\uff1b<\/p>\n

(d, e) UCMOF\u7684HRTEM\u56fe\u50cf\uff1b<\/p>\n

(f) \u5355\u4e2aUCMOF\u7684HAADF-STEM\u56fe\u50cf\u4ee5\u53ca\u76f8\u5e94\u7684\u5143\u7d20\u6620\u5c04\u56fe\u50cf(\u7eff\u8272\u4e3aZr\uff0c\u7ea2\u8272\u4e3aGd)\uff1b<\/p>\n

(g) \u5355\u4e2aUCMOF\u6cbf\u7740HAADF-STEM\u56fe\u50cf(\u63d2\u56fe)\u4e2d\u6240\u793a\u7684\u7bad\u5934\u7ebf\u7684EDS\u7ebf\u626b\u63cf\u8f6e\u5ed3\uff1b<\/p>\n

(h) UCMOFs\u7684\u7c89\u672bXRD\u884d\u5c04\u8c31\u56fe\u3002<\/p>\n

\u56fe3\uff1a\u6837\u54c1\u7684\u5149\u8c31\u548c\u6027\u80fd\u66f2\u7ebf\u3002<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

(a)PVP\u5305\u8986UCNPs\u7684UCL\u5149\u8c31\u548cUCMOFs\u7684UV-vis (Abs.)\u5149\u8c31\u3002\u5149\u8c31\u91cd\u53e0\u90e8\u5206\u4ee5\u6a59\u8272\u7a81\u51fa\u663e\u793a\uff1b<\/p>\n

(b)\u6ce2\u957f\u4e3a541 nm\u65f6\uff0cPVP\u5305\u8986UCNPs\u548cUCMOFs\u7684UCL\u66f2\u7ebf\uff1b<\/p>\n

(c)\u6ce2\u957f\u4e3a541 nm\u65f6\uff0cPVP\u5305\u8986UCNPs\u548cUCMOFs\u7684UCL\u53d1\u5c04\u8870\u51cf\u66f2\u7ebf\uff1b<\/p>\n

(d)\u901a\u8fc7SOSG\u6d4b\u5b9a\u68c0\u6d4b\u5230\u7684UCMOF\u5728\u4e0d\u540c\u7167\u5c04\u6761\u4ef6\u4e0b\u7684\u5355\u7ebf\u6001\u6c27\u4ea7\u751f\u66f2\u7ebf\u3002(\u7ea2\u8272\u8868\u793a\u5f00\u542fNIR\u7167\u5c04\uff0c\u9ed1\u8272\u8868\u793a\u5173\u95edNIR\u7167\u5c04\u3002)<\/p>\n

\u56fe4\uff1aUCMOF\u7684\u7ed3\u6784\u793a\u610f\u56fe\uff0c\u80fd\u91cf\u8f6c\u79fb\u673a\u5236\u548c\u8868\u5f81\u7ed3\u679c\u3002<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

(a)\u901a\u8fc7\u5c06nMOFs\u751f\u957f\u5230\u591a\u58f3UCNP\u4e0a\u5408\u6210UCMOF\u7684\u7ed3\u6784\u793a\u610f\u56fe\uff1b<\/p>\n

(b)\u5177\u6709\u6fc0\u53d1\u6b63\u4ea4\u591a\u8272UCL\u7684\u56db\u58f3\u5c42UCNP\u7684\u80fd\u91cf\u8f6c\u79fb\u673a\u5236\u793a\u610f\u56fe\uff1b<\/p>\n

(c)\u56db\u58f3\u5c42UCNP\u7684TEM\u56fe\u50cf(\u63d2\u56fe\u4e3aHR-TEM\u56fe\u50cf)\uff1b<\/p>\n

(d)\u56db\u58f3\u5c42UCNP\u7684HAADF-STEM\u56fe\u50cf\uff1b<\/p>\n

(e)UCMOFs\u7684TEM\u56fe\u50cf(\u4e8c\u805a\u4f53\u7528\u7ea2\u8272\u692d\u5706\u4f53\u7a81\u51fa\u663e\u793a)\uff0c\u63d2\u56fe\u4e3a\u5355\u4e2aUCMOF\u7684HAADF-STEM\u56fe\u50cf\uff1b<\/p>\n

(f)\u4f7f\u7528\u6ce2\u957f\u4e3a808 nm\u7684NIR\u6fc0\u5149\u6fc0\u53d1\u540e\uff0cPVP\u5305\u8986\u56db\u58f3\u5c42UCNP\u548cUCMOFs\u7684UCL\u5149\u8c31\uff1b<\/p>\n

(g)\u4f7f\u7528\u6ce2\u957f\u4e3a980 nm\u7684NIR\u6fc0\u5149\u6fc0\u53d1\u540e\uff0cPVP\u5305\u8986\u56db\u58f3\u5c42UCNP\u548cUCMOFs\u7684UCL\u5149\u8c31\u3002<\/p>\n

\u56fe5\uff1aUCMOFs\u7684\u7ec6\u80de\u5b9e\u9a8c\u6027\u80fd\u3002<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

(a)\u7528UCMOF\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

(b)\u5f00\u542f\u548c\u5173\u95edNIR\u7167\u5c04\u6761\u4ef6\u4e0b\u4f7f\u7528UCMOF\u548cDCF-DA\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u5171\u7126\u8367\u5149\u56fe\u50cf\u3002\u6838\u88abHohcest\u67d3\u8272\u3002\u6bd4\u4f8b\u5c3a\uff1a50 \u03bcm\uff1b<\/p>\n

(c)\u4e0d\u540c\u5904\u7406\u65b9\u6cd5\u4e0b4T1\u7ec6\u80de\u4e2d\u751f\u62101<\/sup>O2\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff1b<\/p>\n

(d)\u4e0d\u540c\u5904\u7406\u65b9\u6cd5\u4e0b4T1\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u3002\u6570\u636e\u4e3a\u00b1SD\uff0cN =4\uff1b<\/p>\n

(e)\u4f7f\u7528Annexin V\/PI\u67d3\u8272\uff0c\u901a\u8fc7\u4e0d\u540c\u5904\u7406\u8bf1\u5bfc\u76844T1\u7ec6\u80de\u51cb\u4ea1\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\u3002\u5176\u4e2d(+)\u548c(-)\u5206\u522b\u6307\u5f00\u542f\u548c\u5173\u95edNIR\u8f90\u5c04\u3002NIR\u7167\u5c04\u65f6\uff0c\u5c06\u7ec6\u80de\u66b4\u9732\u4e8e\u6ce2\u957f\u4e3a980 nm\uff0c\u529f\u7387\u5bc6\u5ea6\u4e3a1.2 W\/cm2<\/sup>\u7684\u6fc0\u5149\u4e2d\u3002<\/p>\n

\u56fe6\uff1aUCMOFs\u7684\u80bf\u7624\u5b9e\u9a8c\u6027\u80fd\u3002<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

(a)\u4e0d\u540c\u66b4\u9732\u5904\u7406\u540e\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(b)\u6cbb\u759714\u5929\u540e\u80bf\u7624\u7ec4\u7ec7\u7684\u6700\u7ec8\u91cd\u91cf(\u63d2\u56fe\u4e3a\u4e03\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u5728\u7b2c14\u5929\u7684\u56fe\u50cf(1\uff1a\u76d0\u6c34\uff0c2\uff1aNIR\uff0c3\uff1aDox\uff0c4\uff1aUCMOF\uff0c5\uff1aDox\/UCMOF\uff0c6\uff1aUCMOFs + NIR\uff0c7\uff1aDox\/UCMOFs+NIR)\u3002\u6570\u636e\u4e3a\u00b1SD\uff0cN = 5\u3002*P <0.05\uff0c**P <0.01\u3002)\uff1b<\/p>\n

(c)\u4e0d\u540c\u5904\u7406\u540e\uff0c\u4ee3\u8868\u6027H\uff06E\u67d3\u8272\u7684\u80bf\u7624\u5207\u7247\u3002\u6bd4\u4f8b\u5c3a\uff1a100 \u03bcm\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u901a\u8fc7UCNP\u4e0anMOFs\u7684\u5404\u5411\u5f02\u6027\u751f\u957f\uff0c\u7814\u7a76\u4eba\u5458\u6210\u529f\u5236\u5907\u4e86\u4e0d\u5bf9\u79f0\u7684UCNP-MOF\u5f02\u6e90\u4e8c\u805a\u4f53\u3002\u7531\u4e8e\u4e24\u4e2a\u7eb3\u7c73\u57df\u5149\u8c31\u7684\u91cd\u53e0\u53ca\u7d27\u5bc6\u63a5\u89e6\uff0c\u5f02\u6e90\u4e8c\u805a\u4f53\u53ef\u901a\u8fc7UCNP\u4fd8\u83b7\u6536\u96c6NIR\u8f90\u7167\uff0c\u5e76\u5728\u968f\u540e\u5c06\u80fd\u91cf\u8f6c\u79fb\u81f3nMOFs\uff0c\u7136\u540e\u5c06\u5176\u80fd\u91cf\u8f6c\u79fb\u5230\u5468\u56f4\u7684\u6c27\u5206\u5b50\u5e76\u4ea7\u751f\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u7684\u6d3b\u6027\u6c27\u3002\u901a\u8fc7\u5c06Dox\u8d1f\u8f7d\u5230nMOF\u7ed3\u6784\u57df\u7684\u591a\u5b54\u901a\u9053\u4e2d\uff0c\u5f02\u6e90\u4e8c\u805a\u4f53\u7eb3\u7c73\u5e73\u53f0\u901a\u8fc7\u7ed3\u5408\u5316\u5b66\u7597\u6cd5\u548cNIR\u8bf1\u5bfc\u7684PDT\u5b9e\u73b0\u4e86\u5bf9\u764c\u75c7\u7684\u6709\u6548\u6cbb\u7597\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff1a\u8fd9\u79cd\u601d\u8def\u4e0d\u4ec5\u53ef\u7528\u4e8e\u7eb3\u7c73\u533b\u5b66\u9886\u57df\uff0c\u8fd8\u53ef\u589e\u5f3a\u57fa\u4e8e\u53d1\u8272\u56e2\u7684MOF\u7684\u5149\u5b50\u6355\u83b7\u80fd\u529b\uff0c\u4ece\u800c\u53ef\u80fd\u63d0\u9ad8\u592a\u9633\u80fd\u8f6c\u6362\u7684\u6548\u7387\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Heterodimers Made of Upconversion Nanoparticles and Metal\u2013Organic Frameworks<\/a>\u00a0(J. Am. Chem. Soc., 2017, DOI: 10.1021\/jacs.7b07302)<\/p>\n

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